KR102196158B1 - Cosmetic composition for improving skin whitening and skin wrinkle comprising Schizandra chinensis Baillon seed oil - Google Patents

Abstract

The present invention relates to a cosmetic composition for skin whitening or wrinkle improvement comprising Omija seed oil, and more particularly, to a cream composition showing the effect of improving wrinkles by improving skin whitening or skin elasticity, including Omija seed oil, which is a natural oil. will be. In addition, it has a great effect on skin whitening or wrinkle improvement, characterized by containing extracts of japonica, angelica, lemon, gardenia, and baekhyang.

Description

Cosmetic composition for improving skin whitening and skin wrinkle comprising Schizandra chinensis Baillon seed oil}

The present invention relates to a cosmetic composition for skin whitening or wrinkle improvement comprising Omija seed oil, and more particularly, to a cosmetic composition showing the effect of improving wrinkles by improving skin whitening or skin elasticity, including Omija seed oil, a natural oil. will be.

The cause of human aging has not yet been clearly identified, but it is thought that the aging phenomenon appears due to the interaction between genetic and environmental factors basically. Recently, many researchers have revealed several mechanisms of aging by combining various research methods with each other, and various hypotheses have been proposed to explain aging. It is largely divided into the non-genetic theory (small theory) including free radical theory, bridging theory, and accumulation theory, somatic mutation theory, and genetic theory of program theory. Among them,'free radicals' was proposed by Harman in 1956, and biocomposition fats, proteins, nucleic acids, etc., are subject to oxidative damage by various reactive oxygen species incidental to the normal metabolic process. Accumulation leads to aging. Therefore, interest in antioxidants in cosmetics is high and occupies an important proportion in the anti-aging part.

Collagen, a representative elastic fiber of the skin, is organized in a network with elastin, and has a unique triple helix structure composed of about 1,500 amino acids as a function of forming the dermal layer. These fibroblastic amino acids cause lipid peroxidation in elastic fibers such as collagen and elastin due to excessively produced reactive oxygen species, resulting in abnormal crosslinking and chain cleavage, resulting in surface aging. In other words, the wrinkles of the skin are due to an imbalance in the synthesis and decomposition of collagen. In particular, in the case of oxidized skin, the ability to synthesize collagen decreases and the activity of decomposing enzymes increases.

Melanin is produced in the melanosomes of melanocytes present in the base layer of the epidermis, and they move to the keratinocytes of the epidermis through dendritic processes to show the color of the skin. Melanin synthesized in the human body has a positive function to protect the skin from ultraviolet rays or external irritants, but excessive pigmentation can cause melasma, freckles and spots in the elderly, and may also exhibit negative functions such as promoting skin aging. .

Schizandra chinensis is a deciduous woody liana belonging to the Schizandra chinensis family. It has a red color and is a medicinal plant used as a herbal medicine and food ingredient. Schisandra chinensis belongs to the family Schisandra chinensis, and 3 species of 2 genera are distributed in Korea, and it is known that its pharmacological action is very diverse. According to Donguibogam, Omija is a herbal medicine that has five flavors: sour, sweet, bitter, spicy, and salty. There are various medicinal effects such as), saengjeonjeongal (to eliminate thirst), and each of the five tastes works differently in the human body. The sour taste protects the liver, the bitter taste protects the heart, and the sweet taste improves the stomach. , Spicy taste protects the lungs, and salty taste is known to improve kidney and uterine function.

On the other hand, the inventors of the present invention have been studying various physiological activities of omija seed oil, while the cosmetic composition containing the omija seed oil and various functional cosmetic ingredients has excellent skin whitening or wrinkle improvement effect, and has excellent formulation stability as a cosmetic composition. Confirmed and completed the present invention.

Korean Patent Registration No. 10-1907921 (Name of the invention: composition for preventing or improving skin wrinkles containing Schisandra chinensis extract as an active ingredient, Applicant: Korean Institute of Oriental Medicine, registration date: 2018.10.08.)

Jae-Chan Yang, The Evaluation on the Effectiveness as a Cosmetic Material of Oil Extracted from Schizandra Chinensis Seed, J. of Korean Oil Chemists' Soc., Vol. 29, No. 2, June, 2012, 231-237 Hannah Kim, A Study on the Cosmetic Application of Gugija and Omija Seed Oil, Master's Thesis, Graduate School of Mokwon University, 2015

It is an object of the present invention to provide a cosmetic composition for skin whitening or wrinkle improvement comprising Schisandra chinensis oil.

The present invention relates to a cosmetic composition for skin whitening or wrinkle improvement comprising Omija seed oil.

The present invention is stearic acid, behenyl alcohol, PEG-100 stearate, glyceryl stearate, shea butter, neopentyl glycol dicaprate, caprylic/capric triglyceride, cyclome Chicon, C14-22 alcohol/C12-20 alkyl glucoside, squalane, glycerin, dipropylene glycol, betaine, tromethamine, 1,2-hexanediol, trisodium EDTA, ammonium acryloyldimethyltaurate, acrylic Rate/C10-30 alkyl acrylate crosspolymer, panthenol, and purified water may be added to prepare a skin whitening or wrinkle-improving undercarriage composition.

The Schisandra seed oil may be extracted using a hexane solvent after crushing Schisandra seeds.

In preparing the cosmetic composition, 0.01 to 0.5% by weight of Omija seed oil, 0.1 to 1% by weight of stearic acid, 0.1 to 2% by weight of behenyl alcohol, 0.1 to 2% by weight of PG-100 stearate, and glyceryl stea Rate 0.1 to 2% by weight, shea butter 1 to 3% by weight, neopentyl glycol dicaprate 2 to 4% by weight, caprylic/capric triglyceride 2 to 4% by weight, cyclomethicone 1 to 3% by weight , C14-22 alcohol/C12-20 alkyl glucoside 3 to 5 wt%, squalane 2 to 4 wt%, glycerin 8 to 10 wt%, dipropylene glycol 4 to 6 wt%, betaine 1 to 3 wt%, trometha Min 1 to 3% by weight, 1,2-hexanediol 0.1 to 1% by weight, trisodium IDTA 0.01 to 0.5% by weight, ammonium acryloyldimethyltaurate 0.01 to 0.5% by weight, acrylate/C10-30 alkyl It may be a mixture of 0.1 to 0.5% by weight of acrylate crosspolymer, 0.01 to 0.5% by weight of panthenol, and 50 to 70% by weight of purified water.

The present invention can provide a cosmetic composition for skin whitening or wrinkle improvement, which is prepared by additionally adding extracts of japonica, angelica, lemon, gardenia, and baekhyang.

The extracts of Japonica, Angelicae, Lemon, Gardenia and Baekhyang may be extracted for 1 minute to 48 hours at 20 to 100° C. using water, C1 to C4 alcohol, butylene glycol, or a mixed solution thereof.

On the other hand, the formulation of the cosmetic composition of the present invention is a mask pack, skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nourishing lotion, massage cream, nourishing cream, moisturizing cream, hand cream, foundation, essence , Cream, nutritional essence, pack, soap, cleansing foam, cleansing lotion, cleansing cream, body lotion and body cleanser.

Hereinafter, the present invention will be described in detail.

The Schisandra seed oil may be washed with water after the dried Schisandra chinensis is crushed with a microwave oven, and the Schisandra seeds and the shell part may be separated. The separated Schisandra seeds are crushed, treated to a size of 0.1 to 1.0 mm, and then extracted for 1 to 5 days by adding a hexane solvent to the crushed raw material and stirring. After filtering and concentrating under reduced pressure, the process of removing foreign substances by centrifugation may be repeated 1 to 3 times. Through this, it is possible to obtain Omija seed oil by removing less than 0.1 ppm of hexane, which is a residual solvent.

The cosmetic composition of the present invention includes stearic acid, behenyl alcohol, PEG-100 stearate, glyceryl stearate, shea butter, neopentyl glycol dicaprate, caprylic/capric triglyceride, Cyclomethicone, C14-22 alcohol/C12-20 alkyl glucoside, squalane, glycerin, dipropylene glycol, betaine, tromethamine, 1,2-hexanediol, trisodium dithia, ammonium acryloyl dimethyl taurate , Acrylate/C10-30 alkyl acrylate crosspolymer, panthenol, and purified water.

In addition, in preparing the cosmetic composition, it may be prepared by additionally adding extracts of japonica, angelica, lemon, gardenia, and baekhyang. At this time, the extracts of japonica, angelica, lemon, gardenia, and baekhyang may contain 0.1 to 1% by weight based on 100% by weight of the cosmetic composition.

The extracts of Japonica, Angelicae, Lemon, Gardenia and Baekhyang may be extracted using water, C1~C4 alcohol, butylene glycol or a mixed solution thereof as a solvent, and the C1~C4 alcohol is methanol, ethanol, propanol, isopropanol, It may be selected from the group consisting of butanol and isobutanol, most preferably ethanol as a solvent.

Water, C1~C4 alcohol, butylene glycol, or a mixed solution thereof used in the preparation of the extracts of Japonica, Angelicae, Lemon, Gardenia, and Baekhyang are 1 to 40 times the volume (1 to 40 ℓ based on 1 kg) It can be, preferably 5 to 40 times the volume can be used. Extraction conditions for the extracts of Japonica, Angelicae, Lemon, Gardenia and Baekhyang may be 1 minute to 48 hours at 20 to 100°C. The process can be repeated up to 1 to 4 times.

On the other hand, the present invention contains the cosmetic composition, while containing the mask pack, skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nourishing lotion, massage cream, nourishing cream, moisture cream, hand cream, foundation, Essence, cream, nutritional essence, pack, soap, cleansing foam, cleansing lotion, cleansing cream, body lotion and body cleanser may be made of a cosmetic composition selected from the group consisting of.

The formulation includes trehalose, homobeta-glucan, dimethylsulfone, sodium hyaluronate, hydroxyacetophenone, butylene glycol, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated caster as excipients. Oil, Bis-Pig-18 methylethyldimethylsilane, dimethicone, fragrance, potassium hydroxide, ethylhexyl glycerin, propanediol, zinc sulfate, retinyl palmitide, or sea water may be included.

The cosmetic composition of the present invention may further include a component selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, polymer peptides, polymer polysaccharides, sphingo lipids, and seaweed extract.

The water-soluble vitamin may be any one that can be blended in cosmetics, but preferably vitamin B1, vitamin B2, vitamin B6, pyridoxine, pyridoxine hydrochloride, vitamin B12, pantothenic acid, nicotinic acid, nicotinic acid amide, folic acid, vitamin C, vitamin H, etc. And their salts (thiamine hydrochloride, sodium ascorbate, etc.) and derivatives (ascorbic acid-2-phosphate sodium salt, ascorbic acid-2-magnesium salt, etc.) are also included in the water-soluble vitamins that can be used in the present invention. Included. Water-soluble vitamins can be obtained by conventional methods such as a microbial transformation method, a purification method from a culture of microorganisms, an enzyme method or a chemical synthesis method.

As the oil-soluble vitamin, any one may be used as long as it can be blended in cosmetics, but preferably vitamin A, carotene, vitamin D2, vitamin D3, vitamin E (d1-alpha tocopherol, d-alpha tocopherol, d-alpha tocopherol), etc. , Their derivatives (ascorbine palmitate, ascorbine stearate, ascorbine dipalmitate, dl-alpha tocopherol acetate, dl-alpha tocopherol nicotinate, vitamin E, DL-pantotenyl alcohol, D-pantotenyl alcohol, pantotenyl ethyl Ether, etc.) are also included in the oil-soluble vitamin used in the present invention. Oil-soluble vitamins can be obtained by conventional methods such as a microbial transformation method, a purification method from a microorganism culture, an enzyme or a chemical synthesis method.

Other ingredients that may be added include fats and oils, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, fungicides, antioxidants, plant extracts, pH adjusters, alcohols, pigments, fragrances, blood circulation Accelerators, cooling agents, limiting agents, and purified water.

Examples of oil and fat components include ester oils and fats, hydrocarbon oils, silicone oils, fluorine oils, animal oils and vegetable oils.

Examples of ester oils include glyceryl tri2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isocetyl isostearate, stearic acid. Butyl, ethyl linoleate, isopropyl linoleate, ethyl oleate, isocetyl myristate, isostearyl myristate, isostearyl palmitate, octyldodecyl myristate, isocetyl isostearate, diethyl sebacate, adipine Diisopropyl acid, isoalkyl neopentanoate, trimethylolpropane tri2-ethylhexanoate, trimethylolpropane triisostearate, pentaelisitol tetra2-ethylhexanoate, cetyl caprylate, decyl laurate, R Hexyl urate, decyl myristic acid, myristic myristic acid, cetyl myristate, stearyl stearate, decyl oleate, ricinooleate, isostearyl laurate, isotridecyl myristate, isose palmitate Tyl, octyl stearate, isocetyl stearate, isodecyl oleate, octyldodecyl oleate, octyldodecyl linoleate, isopropyl isostearate, cetostearyl 2-ethylhexanoate, stearyl 2-ethylhexanoate, isostear Hexyl acid, ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol dicaprylate, propylene glycol dicaprylate, propylene glycol dicaprylate, neopentyl glycol dicaprylate, neopentyl glycol dioctanoate, Glyceryl tricaprylate, glyceryl triundecylate, glyceryl triisopalmitate, glyceryl triisostearate, octyldodecyl neopentanoate, isostearyl octanoate, octyl isononanoate, hexyldecyl neodecanoate, Octyldodecyl neodecanoate, isocetyl isostearate, isostearyl isostearate, octyldecyl isostearate, polyglycerololeic acid ester, polyglycerin isostearic acid ester, triisocetyl citrate, triisoalkyl citrate, triy citrate Sooctyl, lauryl lactate, myristyl lactate, cetyl lactate, octyldecyl lactate, triethyl citrate, acetyltriethyl citrate, acetyltributyl citrate, trioctyl citrate, diisostearyl malate, 2-ethylhexyl hydroxystearate , Di2-ethylhexyl succinate, diisobutyl adipate, diisopropyl sebacate, dioctyl sebacate, cholesteryl stearate, isostearic acid Cholesteryl, hydroxystearate cholesteryl, cholesteryl oleate, dihydrocholesteryl oleate, pitsteryl isostearate, pitsteryl oleate, 12-stealoylhydroxystearate isocetyl, 12- And esters such as stealoylhydroxystearate stearyl and 12-stealoylhydroxystearate isostearyl.

Examples of hydrocarbon-based fats and oils include hydrocarbon-based fats such as liquid paraffin, alpha-olefin oligomer, isoparaffin, ceresin, paraffin, liquid isoparaffin, polybuden, microcrystalline wax, and petrolatum.

Silicone-based fats and oils include polymethylsilicone, methylphenylsilicone, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, dimethylsiloxane/methylcetyloxysiloxane copolymer, dimethylsiloxane/methylsteaoxysiloxane copolymer, alkyl And modified silicone oil and amino-modified silicone oil.

As fluorine-based fats and oils, perfluoropolyether, etc. are mentioned.

Animal or vegetable oils include avocado oil, almond oil, olive oil, sesame oil, rice bran oil, new flower oil, soybean oil, corn oil, rapeseed oil, almond oil, palm kernel oil, palm oil, castor oil, sunflower oil, grape seed oil. , Cottonseed Oil, Palm Oil, Cucuine Nut Oil, Wheat Germ Oil, Rice Germ Oil, Shea Butter, Walnut Colostrum Oil, Marker Demi Anut Oil, Meadow Home Oil, Egg Yolk Oil, Tallow Oil, Horse Oil, Mink Oil, Orange Rape Oil, Jojoba Oil , Animal or plant fats such as canderry wax, carnauba wax, liquid lanolin, and hydrogenated castor oil.

Examples of the moisturizing agent include a water-soluble low-molecular moisturizer, a fat-soluble molecular moisturizer, a water-soluble polymer, and a fat-soluble polymer.

Water-soluble low molecular weight moisturizers include serine, glutamine, sorbitol, mannitol, pyrrolidone-sodium carboxylate, propylene glycol, 1,3-butylene glycol, ethylene glycol, polyethylene glycol B (polymerization degree n = 2 or more), polypropylene glycol ( Polymerization degree n = 2 or more), polyglycerin B (polymerization degree n = 2 or more), lactic acid, lactate, etc. are mentioned.

As a fat-soluble low molecular weight moisturizer, cholesterol, cholesterol ester, etc. are mentioned.

Examples of the water-soluble polymer include carboxyvinyl polymer, polyaspartic acid salt, tragacanth, xanthan gum, methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, water-soluble chitin, chitosan, dextrin, and the like. I can.

Examples of the oil-soluble polymer include polyvinylpyrrolidone/eicosene copolymer, polyvinylpyrrolidone/hexadecene copolymer, nitrocellulose, dextrin fatty acid ester, and polymer silicone.

Examples of the emollient agent include long-chain acyl glutamate cholesteryl ester, hydroxystearate cholesteryl, 12-hydroxystearic acid, stearic acid, rosin acid, and lanolin fatty acid cholesteryl ester.

Examples of the surfactant include nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants.

Nonionic surfactants include self-emulsifying glycerin monostearate, propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerol fatty acid ester, sorbitan fatty acid ester, POE (polyoxyethylene) sorbitan fatty acid ester, POE sorbit fatty acid ester, POE Glycerin fatty acid ester, POE alkyl ether, POE fatty acid ester, POE hydrogenated castor oil, POE castor oil, POE·POP (polyoxyethylene·polyoxypropylene) copolymer, POE·POP alkyl ether, polyether-modified silicone, lauric acid Alkanolamides, alkylamine oxides, hydrogenated soybean phospholipids, and the like.

As anionic surfactants, fatty acid soap, alpha-acyl sulfonate, alkyl sulfonate, alkyl allyl sulfonate, alkyl naphthalene sulfonate, alkyl sulfate, POE alkyl ether sulfate, alkylamide sulfate, alkyl phosphate, POE alkyl phosphate, alkyl amide Phosphate, alkyloylalkyltaurine salt, N-acylamino acid salt, POE alkylether carboxylate, alkyl sulfosuccinate, sodium alkylsulfoacetate, acylated hydrolyzed collagen peptide salt, perfluoroalkyl phosphate, and the like. have.

Cationic surfactants include alkyl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, stearyl trimethyl ammonium bromide, cetostearyl trimethyl ammonium chloride, distearyl dimethyl ammonium chloride, stearyldimethylbenzyl ammonium chloride, behenyl trimethyl ammonium bromide, and chloride. Benzalkonium, diethylaminoethyl amide stearate, dimethylaminopropyl amide stearate, lanolin derivative quaternary ammonium salt, and the like.

Examples of amphoteric surfactants include carboxybetaine type, amidebetaine type, sulfobetaine type, hydroxysulfobetaine type, amide sulfobetaine type, phosphobetaine type, aminocarboxylate type, imidazoline derivative type, amideamine type, etc. Amphoteric surfactants, and the like.

Examples of organic and inorganic pigments include silicic acid, silicic anhydride, magnesium silicate, talc, sericite, mica, kaolin, bengala, clay, bentonite, titanium coated mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, aluminum oxide. , Inorganic pigments such as calcium sulfate, barium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, iron oxide, ultramarine, chromium oxide, chromium hydroxide, calamine, and complexes thereof; Polyamide, polyester, polypropylene, polystyrene, polyurethane, vinyl resin, urea resin, phenol resin, fluorine resin, silicon resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, divinylbenzene-styrene copolymer, Organic pigments, such as silk powder, cellulose, CI pigment yellow, and CI pigment orange, and complex pigments of these inorganic pigments and organic pigments, etc. are mentioned.

Examples of the organic powder include metal soaps such as calcium stearate; Alkyl phosphate metal salts, such as sodium zinc cetylate, a zinc laurylate, and calcium laurylate; Acylamino acid polyvalent metal salts such as N-lauroyl-beta-alanine calcium, N-lauroyl-beta-alanine zinc, and N-lauroyl glycine calcium; Amide sulfonic acid polyvalent metal salts such as N-lauroyl-taurine calcium and N-palmitoyl-taurine calcium; N, such as N-epsilon-lauroyl-L-lysine, N-epsilon-palmitoyl lizine, N-alpha-paritoylolnitine, N-alpha-lauroylarginine, N-alpha-hardened tallow fatty acid acylarginine, etc. -Acyl basic amino acid; N-acyl polypeptides such as N-lauroylglycylglycine; Alpha-amino fatty acids such as alpha-aminocaprylic acid and alpha-aminolauric acid; Polyethylene, polypropylene, nylon, polymethyl methacrylate, polystyrene, divinylbenzene/styrene copolymer, ethylene tetrafluoride, and the like.

UV absorbers include paraaminobenzoic acid, ethyl paraaminobenzoate, amyl paraaminobenzoate, octyl paraaminobenzoate, ethylene glycol salicylate, phenyl salicylate, octyl salicylate, benzyl salicate, butyl phenyl salicylate, homomentyl salicylate, benzyl cinnamate , Paramethoxycinnamic acid-2-ethoxyethyl, paramethoxycinnamic acid octyl, diparamethoxycinnamic acid mono-2-ethylhexane glyceryl, paramethoxycinnamic acid isopropyl, diisopropyl·diisopropyl cinnamic acid ester mixture, right Cannic acid, ethyl urocanate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenonesulfonic acid and salts thereof, dihydroxymethoxybenzophenone, sodium dihydroxymethoxybenzophenone disulfonate, dihydroxybenzophenone , Tetrahydroxybenzophenone, 4-tert-butyl-4'-methoxydibenzoylmethane, 2,4,6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxy)-1 ,3,5-triazine, 2-(2-hydroxy-5-methylphenyl)benzotriazole, etc. are mentioned.

As a disinfectant, hinokitiol, triclosan, trichlorohydroxydiphenyl ether, chlorhexidine gluconate, phenoxyethanol, resorcin, isopropylmethylphenol, azulene, salicylic acid, zinphylithione, benzalkonium chloride, photosensitization Sodium No. 301, mononitroguarous sodium, and undecylenic acid.

Examples of the antioxidant include butylhydroxyanisole, propyl gallic acid, and elisorbic acid.

Examples of the pH adjuster include citric acid, sodium citrate, malic acid, sodium malate, pmalic acid, sodium pmarate, succinic acid, sodium succinate, sodium hydroxide, sodium monohydrogen phosphate, and the like.

Examples of alcohol include higher alcohols such as cetyl alcohol.

The present invention relates to a cosmetic composition for skin whitening or wrinkle improvement comprising Omija seed oil, and the cosmetic composition of the present invention has an excellent effect on skin whitening, and also has an effect on skin elasticity and wrinkle improvement.

Hereinafter, a preferred embodiment of the present invention will be described in detail. However, the present invention is not limited to the embodiments described herein and may be embodied in other forms. Rather, it is provided to sufficiently convey the spirit of the present invention to those skilled in the art so that the contents introduced herein are thorough and complete.

Example 1. Preparation of Cream Composition Containing Schisandra Seed Oil

First, dried Schisandra chinensis was crushed with a microwave and washed with water to separate the seeds and shells, which are non-aqueous parts. After the separated seeds were crushed and treated to less than 0.5 mm, a hexane solvent was added to the crushed raw material, stirred for 3 days, extracted for 3 days, filtered, concentrated under reduced pressure, and centrifuged to remove foreign substances. Finally, by repeating the distillation under reduced pressure, hexane, which is a residual solvent, was removed to 0.1 ppm or less, thereby obtaining pure Omija seed oil.

The above omija seed oil and stearic acid, behenyl alcohol, PEG-100 stearate, glyceryl stearate, shea butter, neopentyl glycol dicaprate, caprylic/capric triglyceride, cyclomethicone, C14 -22 Alcohol/C12-20 Alkyl glucoside, squalane, glycerin, dipropylene glycol, betaine, tromethamine, 1,2-hexanediol, trisodium IDTA, ammonium acryloyldimethyltaurate, acrylate/C10 A cream composition was prepared by mixing -30 alkyl acrylate crosspolymer, panthenol, and purified water, which are shown in Table 1 below. * The weight unit of Table 1 is (g).

Raw material sample Example
1-1 Example
1-2 Example
1-3 Example
1-4 Example
1-5 Omija seed oil 0.10 0.30 0.01 0.50 0.40 Stearic Acid 0.50 1.00 0.10 0.30 0.80 Behenyl alcohol 1.00 0.50 2.00 1.30 0.9 PEG-100 Stearate 1.00 0.50 0.10 0.40 2.00 Glyceryl stearate 1.00 0.50 2.00 0.80 1.50 Shea Butter 2.00 1.00 3.00 1.70 2.90 Neopentyl glycol dicaprate 3.00 4.00 2.00 2.60 3.20 Caprylic
/Capric triglyceride 3.00 4.00 2.00 3.50 2.50 Cyclomethicone 2.00 1.00 3.00 1.50 2.70 C14-22 alcohol
/C12-20 alkyl glucoside 4.00 4.00 5.00 3.40 4.70 Squalane 3.00 4.00 2.00 3.80 2.40 glycerin 9.00 8.00 10.00 8.20 9.30 Dipropylene glycol 5.00 4.00 6.00 5.50 4.40 Betaine 2.00 3.00 1.00 1.30 2.60 Tromethamine 2.00 3.00 1.00 1.50 1.50 1,2-hexanediol 0.50 0.80 1.00 0.10 0.20 Trisodium EDTA 0.10 0.50 0.01 0.04 0.30 Ammonium acryloyl dimethyl taurate 0.03 0.50 0.01 0.20 0.08 Acrylate/C10-30 Alkyl Acrylate Crosspolymer 0.20 0.10 0.50 0.30 0.40 Panthenol 0.12 0.50 0.01 0.30 0.40 Purified water 60.45 58.80 59.26 62.76 56.82 Gross weight 100.00 100.00 100.00 100.00 100.00

Comparative Example 1. Preparation of Cream Composition with Comparative Conditions

A cream composition to be compared was prepared under the conditions shown in Table 2 below using the same raw material samples as in Example 1. * The weight unit of Table 2 below is (g).

Raw material sample Comparative example
1-1 Comparative example
1-2 Comparative example
1-3 Comparative example
1-4 Comparative example
1-5 Omija seed oil 0.40 0.005 0.00 0.20 0.70 Stearic Acid 0.01 0.50 3.00 0.10 0.00 Behenyl alcohol 0.01 1.00 0.10 3.00 0.01 PEG-100 Stearate 2.00 3.00 0.01 0.10 1.00 Glyceryl stearate 1.00 1.00 1.00 1.00 1.00 Shea Butter 2.00 2.00 2.00 2.00 2.00 Neopentyl glycol dicaprate 0.00 5.00 2.00 0.50 4.00 Caprylic
/Capric triglyceride 1.00 2.00 4.00 3.00 5.00 Cyclomethicone 0.50 0.00 2.00 4.00 1.00 C14-22 alcohol
/C12-20 alkyl glucoside 2.00 2.80 5.60 0.00 1.50 Squalane 2.00 1.00 4.00 3.00 0.00 glycerin 8.00 10.00 15.00 9.00 2.00 Dipropylene glycol 4.00 5.00 3.00 6.00 5.00 Betaine 0.50 0.00 1.00 5.00 3.00 Tromethamine 2.00 2.00 2.00 2.00 2.00 1,2-hexanediol 0.01 0.10 4.00 0.00 2.00 Trisodium EDTA 0.10 0.60 0.00 0.40 0.50 Ammonium acryloyl dimethyl taurate 0.03 0.03 0.03 0.03 0.03 Acrylate/C10-30 Alkyl Acrylate Crosspolymer 0.70 0.20 0.00 0.05 0.01 Panthenol 0.12 0.12 0.12 0.12 0.12 Purified water 73.62 63.645 51.14 60.50 69.13 Gross weight 100.00 100.00 100.00 100.00 100.00

Experimental Example 1. Sensory test for cream composition

A sensory test was performed on the cream compositions prepared in Example 1 and Comparative Example 1. After preparing the cream composition of Example 1 and Comparative Example 1, it was provided with the cream composition of Example 1 and Comparative Example 1 by 10 targeting 100 female experimenters in their 20s to 40s, each randomly selected, and 4 Each cream was evenly divided and applied to the face twice a day for a week, and after 4 weeks of the experiment period was over, the skin whitening effect was surveyed and evaluated.

As for the evaluation criteria for the skin whitening effect, the higher the score was evaluated as the brightness of the skin color became brighter. Therefore, the sensory evaluation score was evaluated as very effective (10 points), effective (7 points), moderate (5 points), insufficient (3 points), and very insignificant (1 point), and then averaged. This is shown in Table 3 below.

division Skin whitening effect Example 1-1 9.2 Example 1-2 8.5 Example 1-3 8.5 Example 1-4 8.7 Example 1-5 8.3 Comparative Example 1-1 5.2 Comparative Example 1-2 5.4 Comparative Example 1-3 5.1 Comparative Example 1-4 4.9 Comparative Example 1-5 5.3

Referring to Table 3, it can be seen that the skin whitening effect for the cream compositions of Examples 1-1 to 1-5 was evaluated with a higher score than the cream compositions of Comparative Examples 1-1 to 1-5, through which It can be seen that the cream compositions of Examples 1-1 to 1-5 have excellent skin whitening effects.

Experimental Example 2. Checking the effect of improving the elasticity of the cream composition

After applying the cream of Example 1 to the subjects every day for 4 weeks, the elasticity improvement effect was confirmed. Elasticity was measured using a Cutometer (MPA 580, Courage and Khazaka Electronic Co., Germany) at a location 3 cm away from the eye area. Evaluation was performed three times, and the average of the three values was used. The R2 value was selected as a variable, and the higher the value, the better the skin elasticity. In this test, the value of the variable R2 was measured before product use (0 weeks), 2 weeks after product use, and 4 weeks after product use, and the coefficient of measurement is arbitrary unit (A.U.). In addition, the result obtained was confirmed by calculating the elasticity improvement rate (%).

As a result of the test, it can be seen that the skin elasticity significantly increases while applying the cream of Example 1 for 4 weeks as shown in Table 4 below.

Condition Skin elasticity improvement rate after 4 weeks (%) Example 1-1 Cream composition 15.1 Example 1-2 Cream composition 13.2 Example 1-3 Cream composition 13.5 Example 1-4 Cream composition 13.0 Example 1-5 Cream composition 14.3 Comparative Example 1-1 Cream composition 3.6 Comparative Example 1-2 Cream composition 2.7 Comparative Example 1-3 Cream composition 4.3 Comparative Example 1-4 Cream composition 2.9 Comparative Example 1-5 Cream composition 3.8

Referring to Table 4, the cream compositions of Examples 1-1 to 1-5 exhibited about 13% or more of improvement in skin elasticity after 4 weeks, whereas the cream compositions of Comparative Examples 1-1 to 1-5 showed improvement of skin elasticity after 4 weeks. It can be seen that the effect of the cream compositions of Examples 1-1 to 1-5 is more excellent because it shows 5% or less. Therefore, it is considered to be effective in improving wrinkles due to its excellent effect on skin elasticity.

Experimental Example 3. Formulation stability confirmation according to storage conditions

The cream compositions of Example 1 and Comparative Example 1 were stored at 10° C., 25° C. and 40° C. for 6 months to confirm the formulation stability in units of 1, 3, and 6 months.

For each cream composition, the poor conditions of formulation stability were evaluated as delamination, formation of sediment, and property change. * Storage status display-Good: ◎, Bad: ×

Referring to Table 5, it can be seen that the cream compositions prepared in Examples 1-1 to 1-5 are good for long-term storage for 6 months or longer under at least room temperature or below room temperature conditions. Therefore, it can be confirmed that the cream compositions prepared in Examples 1-1 to 1-5 are stable as a cream formulation.

On the other hand, it can be seen that the formulation stability of the cream compositions prepared in Comparative Examples 1-1 to 1-5 is not better when stored for 3 months or longer, and Examples 1-1 to It can be determined that the cream composition prepared in 1-5 has better formulation stability.

Example 2. Preparation of a cream composition to which extracts of japonica, angelica, lemon, gardenia and white fennel were added

A cream composition was prepared in the same manner as in Example 1-1, but was prepared by adding an additional 1 g of extracts of japonica, angelica, lemon, gardenia, and white fennel.

The extracts of Jaweed, Angelica, Lemon, Gardenia, and Baekhyang were mixed in a weight ratio of 1:1:1:1:1 of Jaweed, Angelicae, Lemon, Gardenia and Palecum, and then 70% (v/v) of ethanol aqueous solution was added to 10 It was obtained by adding pear weight and extracting and concentrating at 40° C. for 24 hours.

In this way, the skin elasticity improvement rate experiment and formulation stability were confirmed for the cream composition to which the extracts of Jacho, Angelica, Lemon, Gardenia and Baekhyang were added. The skin elasticity improvement rate did not increase significantly compared to the increased amount of Schisandra chinensis seed oil, even when experimenting with the same amount of Schisandra chinensis seed oil instead of the extracts of Jaweed, Angelicae, lemon, gardenia, and white spice, the skin elasticity improvement rate was 20 % Or more, and it was confirmed that the formulation stability was also stable at room temperature or at room temperature or higher because no layer separation or precipitate was generated for more than 6 months.

Experimental Example 4. Whitening effect experiment for extracts of Japonica, Angelicae, Lemon, Gardenia and Baekhyang

The whitening effect was confirmed by measuring the inhibition of melanin biosynthesis on the same amount of Schisandra chinensis oil as a sample of a mixture of Schisandra chinensis oil contained in the cream composition prepared in Example 2. I did. In more detail, the mixture of the Schisandra chinensis oil, Japonica, Angelicae, Lemon, Gardenia, and Baekhyang extract was mixed in a ratio of 0.1:1:1:1:1, and the total weight was 1.1g, and the Schisandra Seed Oil of the same weight 1.1g was used as a sample in this experiment.

First, B16F10 cells cultured in Dublecco's Modified Eagle Medium (DMEM) medium were dispensed into a 100mm culture dish at 2 × 10 ⁶ cells/dish, and cultured for 24 hours. The final concentration contained in the medium was 10, 50, It was dissolved in DMSO so as to be 100 ng/ml, added to the medium, and washed with phosphate buffer (pH 7.4) on the second day. After detaching the cells with 0.25M trypsin-EDTA solution, the harvested cells were treated with 1 ml of 5% TCA per 1×10 ⁶ cells. Then, after centrifuging twice at 2500 rpm, the separated melanin was washed with phosphate buffered saline (PBS), and then 1 ml of ether: EtOH (1:3) was added, centrifuged twice, and washed with 1 ml of ether. And then dried. After 1N NaOH was added to the dried melanin and reacted at 56° C. for 1 hour, the absorbance was measured at 470 nm using a spectrophotometer (ELISA reader). This is shown in Table 6 below.

division Melanin biosynthesis inhibition rate 10 ng/ml 50 ng/ml 100 ng/ml Mixture of Schisandra chinensis oil, Japonica, Angelicae, lemon, gardenia and white spice extracts 56.8±5.4% 68.2±4.7% 75.2±6.6% Omija seed oil 29.7±6.0% 38.0±6.3% 47.4±5.9%

Referring to Table 6 above, the absorbance reduction rate of the mixture of Schisandra chinensis seed oil, Japonica, Angelicae, lemon, gardenia and whitehense extracts was 56.8±5.4%, 68.2±4.7%, and 75.2±6.6%. On the other hand, Schisandra seed oil also inhibits melanin biosynthesis. I can confirm.

Experimental Example 5. Anti-wrinkle effect experiment for extracts of Japonica, Angelica, Lemon, Gardenia and Baekhyang

A collagen synthesis experiment was performed on the same amount of Schisandra chinensis oil as a sample of the mixture of Schisandra chinensis seed oil included in the cream composition prepared in Example 2 and the extracts of Jaweed, Angelicae, Lemon, Gardenia and Baekhyang to confirm the wrinkle improvement effect. I did. In more detail, the mixture of the Schisandra chinensis oil, Japonica, Angelicae, Lemon, Gardenia, and Baekhyang extract was mixed in a ratio of 0.1:1:1:1:1, and the total weight was 1.1g, and the Schisandra Seed Oil of the same weight 1.1g was used as a sample in this experiment.

First, V79-4 cells (Chinese Hamster, CCL of lung tissue fibroblast) were inoculated on the bottom of the culture dish, and then 1% penicillin-streptomycin (Hyclone) and 3% FBS (fetal bovine serum, Hyclone) were added. DMEM medium was added and cultured in a 5% CO ₂ incubator at 37°C.

The cells were aliquoted into a 48-well plate at 5 × 10 ⁴ per well, and then cultured for 24 hours under cell culture conditions. The medium was removed, washed with 10% phosphate buffered saline (PBS), and then the sample (final cell concentration 5 ng/ml) and a new medium were added and cultured for 24 hours. The amount of collagen was measured by taking the culture medium, which is shown in Table 7 below.

division Collagen synthesis ability Mixture of Schisandra chinensis oil, Japonica, Angelicae, lemon, gardenia and white spice extracts 37.9% Omija seed oil 13.1%

Referring to Table 7 above, the collagen synthesis ability of the sample mixed with Schisandra chinensis oil, Japonica, Angelicae, Lemon, Gardenia, and Baekhyang extract was 37.9% at 5 ng/ml, and Schisandra Seed Oil was 13.1%. It can be seen that it shows a low collagen synthesis rate. Therefore, it can be judged that a mixture of Schisandra seed oil, Japonica, Angelicae, Lemon, Gardenia, and Baekhyang extracts is more effective in improving wrinkles.

Formulation Example 1. Preparation of lotion

A lotion was prepared in the same manner as the cosmetic composition prepared in Example 1.

Raw material sample Content(g) Omija seed oil 0.10 Stearic Acid 0.50 Behenyl alcohol 1.00 PEG-100 Stearate 1.00 Glyceryl stearate 1.00 Shea Butter 1.00 Neopentyl glycol dicaprate 2.50 Caprylic/Capric Triglyceride 2.50 Cyclomethicone 1.00 C14-22 alcohol/C12-20 alkyl glucoside 3.00 Squalane 2.00 glycerin 8.00 Dipropylene glycol 4.00 Betaine 2.00 Tromethamine 1.00 1,2-hexanediol 0.50 Trisodium EDTA 0.01 Ammonium acryloyl dimethyl taurate 0.01 Acrylate/C10-30 Alkyl Acrylate Crosspolymer 0.10 Panthenol 0.10 Purified water 68.68 Gross weight 100.00

Formulation Example 2. Preparation of essence

Essence was prepared in the same manner as in the cosmetic composition prepared in Example 1.

Raw material sample Content(g) Omija seed oil 0.10 Stearic Acid 0.10 Behenyl alcohol 0.10 PEG-100 Stearate 0.10 Glyceryl stearate 0.10 Shea Butter 1.00 Neopentyl glycol dicaprate 2.00 Caprylic/Capric Triglyceride 2.00 Cyclomethicone 1.00 C14-22 alcohol/C12-20 alkyl glucoside 3.00 Squalane 2.00 glycerin 8.00 Dipropylene glycol 4.00 Betaine 1.00 Tromethamine 1.00 1,2-hexanediol 0.10 Trisodium EDTA 0.01 Ammonium acryloyl dimethyl taurate 0.01 Acrylate/C10-30 Alkyl Acrylate Crosspolymer 0.10 Panthenol 0.01 Purified water 74.27 Gross weight 100.00

Claims (6)

Omija seed oil 0.01 to 0.5% by weight, stearic acid 0.1 to 1% by weight, behenyl alcohol 0.1 to 2% by weight, PEG-100 stearate 0.1 to 2% by weight, glyceryl stearate 0.1 to 2% by weight, she 1 to 3% by weight of butter, 2 to 4% by weight of neopentyl glycol dicaprate, 2 to 4% by weight of caprylic/capric triglyceride, 1 to 3% by weight of cyclomethicone, C14-22 alcohol/C12- 20 3 to 5% by weight of alkyl glucoside, 2 to 4% by weight of squalane, 8 to 10% by weight of glycerin, 4 to 6% by weight of dipropylene glycol, 1 to 3% by weight of betaine, 1 to 3% by weight of tromethamine, 1 ,2-hexanediol 0.1 to 1% by weight, trisodium EDTA 0.01 to 0.5% by weight, ammonium acryloyldimethyltaurate 0.01 to 0.5% by weight, acrylate/C10-30 alkyl acrylate crosspolymer 0.1 to 0.5% %, a cosmetic composition for skin whitening or wrinkle improvement, characterized in that it contains 0.01 to 0.5% by weight of panthenol and 50 to 70% by weight of purified water. delete The method of claim 1,
The Schisandra Seed Oil is a cosmetic composition for skin whitening or wrinkle improvement, characterized in that the Schisandra seeds are crushed and then extracted using a hexane solvent. The method of claim 1,
A cosmetic composition for skin whitening or wrinkle improvement, characterized in that the extracts of japonica, angelica, lemon, gardenia, and baekhyang are additionally added. The method of claim 4,
Skin whitening or wrinkle improvement, characterized in that the extracts of Japonica, Angelicae, Lemon, Gardenia, and Baekhyang are extracted for 1 minute to 48 hours at 20 to 100°C using water, C1 to C4 alcohol, butylene glycol, or a mixed solution thereof Cosmetic composition. The method of claim 1,
The formulation of the cosmetic composition is a mask pack, skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, foundation, essence, cream, nutrition. Essence, pack, soap, cleansing foam, cleansing lotion, cleansing cream, body lotion and body cleanser, characterized in that selected from the group consisting of skin whitening or wrinkle improvement cosmetic composition.