KR102513698B1 - 종양 사멸에 영향을 주기 위한 이중 표적화 작제물 - Google Patents
종양 사멸에 영향을 주기 위한 이중 표적화 작제물 Download PDFInfo
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- KR102513698B1 KR102513698B1 KR1020197001426A KR20197001426A KR102513698B1 KR 102513698 B1 KR102513698 B1 KR 102513698B1 KR 1020197001426 A KR1020197001426 A KR 1020197001426A KR 20197001426 A KR20197001426 A KR 20197001426A KR 102513698 B1 KR102513698 B1 KR 102513698B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
- A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K51/04—Organic compounds
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- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1072—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from the reproductive system, e.g. ovaria, uterus, testes or prostate
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/22—Tin compounds
- C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
- G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
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- C—CHEMISTRY; METALLURGY
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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- C07B2200/05—Isotopically modified compounds, e.g. labelled
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- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
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- Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020237009535A KR102864909B1 (ko) | 2016-06-23 | 2017-06-22 | 종양 사멸에 영향을 주기 위한 이중 표적화 작제물 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662353735P | 2016-06-23 | 2016-06-23 | |
| US62/353,735 | 2016-06-23 | ||
| PCT/US2017/038832 WO2017223357A1 (en) | 2016-06-23 | 2017-06-22 | Double targeted constructs to affect tumor kill |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237009535A Division KR102864909B1 (ko) | 2016-06-23 | 2017-06-22 | 종양 사멸에 영향을 주기 위한 이중 표적화 작제물 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20190039080A KR20190039080A (ko) | 2019-04-10 |
| KR102513698B1 true KR102513698B1 (ko) | 2023-03-23 |
Family
ID=60675799
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197001426A Active KR102513698B1 (ko) | 2016-06-23 | 2017-06-22 | 종양 사멸에 영향을 주기 위한 이중 표적화 작제물 |
| KR1020237009535A Active KR102864909B1 (ko) | 2016-06-23 | 2017-06-22 | 종양 사멸에 영향을 주기 위한 이중 표적화 작제물 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237009535A Active KR102864909B1 (ko) | 2016-06-23 | 2017-06-22 | 종양 사멸에 영향을 주기 위한 이중 표적화 작제물 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US10179117B2 (https=) |
| EP (2) | EP4520745A3 (https=) |
| JP (3) | JP7317505B2 (https=) |
| KR (2) | KR102513698B1 (https=) |
| CN (2) | CN109843339B (https=) |
| AU (2) | AU2017281364B2 (https=) |
| CA (1) | CA3028978A1 (https=) |
| IL (1) | IL263863B (https=) |
| SG (1) | SG11201811482YA (https=) |
| WO (1) | WO2017223357A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10806806B2 (en) | 2016-06-23 | 2020-10-20 | Cornell University | Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies |
| BR112019002560B1 (pt) | 2016-08-10 | 2022-08-16 | Cancer Targeted Technology Llc | Composto, composição farmacêutica, seus usos e método de preparação do mesmo |
| EP3544960A1 (en) * | 2016-11-23 | 2019-10-02 | Cancer Targeted Technology LLC | Albumin-binding psma inhibitors |
| WO2018204477A1 (en) | 2017-05-02 | 2018-11-08 | Cornell University | Methods and reagents for tumor targeting with greater efficacy and less toxicity |
| KR102403970B1 (ko) * | 2018-12-27 | 2022-05-31 | (주)퓨쳐켐 | 카르복시산이 도입된 psma-표적 화합물 및 그의 용도 |
| MX2023006237A (es) * | 2020-11-30 | 2023-08-08 | Univ Cornell | Inmunoterapias para el cancer para promover el rechazo hiperagudo. |
| CN114685599A (zh) * | 2020-12-30 | 2022-07-01 | 南京江原安迪科正电子研究发展有限公司 | 一种psma靶向抑制剂及放射性核素标记的psma靶向抑制剂、制备方法和用途 |
| JP2024515104A (ja) | 2021-04-20 | 2024-04-04 | テラパワー, エルエルシー | Ac-225生成のためのチタニアに基づくジェネレータ |
| CN115448856B (zh) * | 2022-09-30 | 2023-09-22 | 北京师范大学 | 一种用于靶向PSMA的EuK二聚体化合物、衍生物及其应用 |
| WO2025213026A1 (en) * | 2024-04-04 | 2025-10-09 | Lantheus Medical Imaging, Inc. | Astatine-211-labelled psma-binding compounds |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2010509358A (ja) * | 2006-11-08 | 2010-03-25 | バイオストリーム セラピューティクス インコーポレーティッド | グルタミン酸のヘテロダイマー |
| WO2017070482A2 (en) * | 2015-10-22 | 2017-04-27 | The Johns Hopkins University | Psma targeted radiohalogenated ureas for cancer radiotherapy |
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| US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| EA012622B1 (ru) | 2004-06-01 | 2009-10-30 | Домэнтис Лимитед | Биспецифичные гибридные антитела с увеличенным периодом полувыведения из сыворотки |
| US20060252107A1 (en) | 2005-02-22 | 2006-11-09 | Acucela, Inc. | Compositions and methods for diagnosing and treating retinal diseases |
| GB0621973D0 (en) * | 2006-11-03 | 2006-12-13 | Philogen Spa | Binding molecules and uses thereof |
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| WO2010032248A2 (en) | 2008-09-17 | 2010-03-25 | Yeda Research And Development Co. Ltd. | Multifunctional albumin conjugates |
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| LT4095130T (lt) | 2013-10-18 | 2024-04-25 | Novartis Ag | Žymėti prostatos specifinio membranos antigeno (psma) inhibitoriai, jų naudojimas kaip vizualizavimo medžiagų ir farmacinių medžiagų prostatos vėžiui gydyti |
| US10140408B2 (en) | 2015-09-04 | 2018-11-27 | Qualcomm Incorporated | Selectively encrypting content for distribution from a receiver device to a companion device |
| US10806806B2 (en) | 2016-06-23 | 2020-10-20 | Cornell University | Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies |
| IL315062A (en) | 2017-04-05 | 2024-10-01 | Univ Cornell | Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies |
| US11400165B2 (en) | 2017-11-04 | 2022-08-02 | Advanced Proteome Therapeutics Inc. | Composition and method for modifying polypeptides |
| EP3946320A4 (en) | 2019-04-03 | 2022-12-28 | Tva (Abc), Llc | CONJUGATES RELATED TO HSP90 AND FORMULATIONS THEREOF |
| CR20210556A (es) | 2019-05-10 | 2021-12-17 | Janssen Biotech Inc | Quelantes macrocíclicos y métodos de uso de estos |
| CA3070610A1 (en) | 2020-01-31 | 2021-07-31 | Humphrey FONGE | Methods and compositions for targeting disease related cell surface receptors using radiolabeled and/or cytotoxin labelled antibodies |
| US12151004B2 (en) | 2020-01-31 | 2024-11-26 | University Of Saskatchewan | Methods and compositions for targeting disease related cell surface receptors using radiolabeled and/or cytotoxin labelled antibodies |
| US20220143228A1 (en) | 2020-10-22 | 2022-05-12 | Actinium Pharmaceuticals, Inc. | Her3 radioimmunotherapy for the treatment of solid cancers |
| IL302759A (en) | 2020-11-10 | 2023-07-01 | Janssen Biotech Inc | Macrocyclic compounds and methods of use thereof |
| CA3205707A1 (en) | 2021-01-27 | 2022-08-04 | Fei Shen | Immunoconjugates comprising kallikrein related peptidase 2 antigen binding domains and their uses |
| GEAP202316335A (en) | 2021-02-01 | 2023-10-10 | Bayer Ag | Multimeric chelator compounds for use in targeted radiotherapy |
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| EP4392081A4 (en) | 2021-08-27 | 2025-11-19 | Janssen Biotech Inc | Anti-PSMA radioconjugates and their uses |
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2017
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010509358A (ja) * | 2006-11-08 | 2010-03-25 | バイオストリーム セラピューティクス インコーポレーティッド | グルタミン酸のヘテロダイマー |
| WO2017070482A2 (en) * | 2015-10-22 | 2017-04-27 | The Johns Hopkins University | Psma targeted radiohalogenated ureas for cancer radiotherapy |
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