CN109843339B - 影响肿瘤杀伤的双重靶向构建体 - Google Patents

影响肿瘤杀伤的双重靶向构建体 Download PDF

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CN109843339B
CN109843339B CN201780046339.7A CN201780046339A CN109843339B CN 109843339 B CN109843339 B CN 109843339B CN 201780046339 A CN201780046339 A CN 201780046339A CN 109843339 B CN109843339 B CN 109843339B
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CN109843339A (zh
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约翰·W·百祺
詹姆斯·M·凯利
亚历杭德罗·埃莫-科尔拉萨
沙希坎特·庞纳拉
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Cornell University
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Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10806806B2 (en) 2016-06-23 2020-10-20 Cornell University Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies
BR112019002560B1 (pt) 2016-08-10 2022-08-16 Cancer Targeted Technology Llc Composto, composição farmacêutica, seus usos e método de preparação do mesmo
EP3544960A1 (en) * 2016-11-23 2019-10-02 Cancer Targeted Technology LLC Albumin-binding psma inhibitors
WO2018204477A1 (en) 2017-05-02 2018-11-08 Cornell University Methods and reagents for tumor targeting with greater efficacy and less toxicity
KR102403970B1 (ko) * 2018-12-27 2022-05-31 (주)퓨쳐켐 카르복시산이 도입된 psma-표적 화합물 및 그의 용도
MX2023006237A (es) * 2020-11-30 2023-08-08 Univ Cornell Inmunoterapias para el cancer para promover el rechazo hiperagudo.
CN114685599A (zh) * 2020-12-30 2022-07-01 南京江原安迪科正电子研究发展有限公司 一种psma靶向抑制剂及放射性核素标记的psma靶向抑制剂、制备方法和用途
JP2024515104A (ja) 2021-04-20 2024-04-04 テラパワー, エルエルシー Ac-225生成のためのチタニアに基づくジェネレータ
CN115448856B (zh) * 2022-09-30 2023-09-22 北京师范大学 一种用于靶向PSMA的EuK二聚体化合物、衍生物及其应用
WO2025213026A1 (en) * 2024-04-04 2025-10-09 Lantheus Medical Imaging, Inc. Astatine-211-labelled psma-binding compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102171187A (zh) * 2008-08-01 2011-08-31 约翰.霍普金斯大学 Psma-结合剂及其用途
WO2017070482A2 (en) * 2015-10-22 2017-04-27 The Johns Hopkins University Psma targeted radiohalogenated ureas for cancer radiotherapy

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672662A (en) 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
EA012622B1 (ru) 2004-06-01 2009-10-30 Домэнтис Лимитед Биспецифичные гибридные антитела с увеличенным периодом полувыведения из сыворотки
US20060252107A1 (en) 2005-02-22 2006-11-09 Acucela, Inc. Compositions and methods for diagnosing and treating retinal diseases
GB0621973D0 (en) * 2006-11-03 2006-12-13 Philogen Spa Binding molecules and uses thereof
ES2847275T3 (es) * 2006-11-08 2021-08-02 Molecular Insight Pharm Inc Heterodímeros de ácido glutámico
WO2010032248A2 (en) 2008-09-17 2010-03-25 Yeda Research And Development Co. Ltd. Multifunctional albumin conjugates
TW201034691A (en) 2008-12-05 2010-10-01 Molecular Insight Pharm Inc Technetium-and rhenium-bis(heteroaryl) complexes and methods of use thereof
WO2010065899A2 (en) 2008-12-05 2010-06-10 Molecular Insight Pharmaceuticals, Inc. Technetium-and rhenium-bis(heteroaryl)complexes and methods of use thereof
WO2013022797A1 (en) 2011-08-05 2013-02-14 Molecular Insight Pharmaceuticals Radiolabeled prostate specific membrane antigen inhibitors
AU2012296937B2 (en) 2011-08-17 2017-10-12 Merck & Cie Folate conjugates of albumin-binding entities
US20140079636A1 (en) 2012-04-16 2014-03-20 Dinesh U. Chimmanamada Targeted therapeutics
LT4095130T (lt) 2013-10-18 2024-04-25 Novartis Ag Žymėti prostatos specifinio membranos antigeno (psma) inhibitoriai, jų naudojimas kaip vizualizavimo medžiagų ir farmacinių medžiagų prostatos vėžiui gydyti
US10140408B2 (en) 2015-09-04 2018-11-27 Qualcomm Incorporated Selectively encrypting content for distribution from a receiver device to a companion device
US10806806B2 (en) 2016-06-23 2020-10-20 Cornell University Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies
IL315062A (en) 2017-04-05 2024-10-01 Univ Cornell Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies
US11400165B2 (en) 2017-11-04 2022-08-02 Advanced Proteome Therapeutics Inc. Composition and method for modifying polypeptides
EP3946320A4 (en) 2019-04-03 2022-12-28 Tva (Abc), Llc CONJUGATES RELATED TO HSP90 AND FORMULATIONS THEREOF
CR20210556A (es) 2019-05-10 2021-12-17 Janssen Biotech Inc Quelantes macrocíclicos y métodos de uso de estos
CA3070610A1 (en) 2020-01-31 2021-07-31 Humphrey FONGE Methods and compositions for targeting disease related cell surface receptors using radiolabeled and/or cytotoxin labelled antibodies
US12151004B2 (en) 2020-01-31 2024-11-26 University Of Saskatchewan Methods and compositions for targeting disease related cell surface receptors using radiolabeled and/or cytotoxin labelled antibodies
US20220143228A1 (en) 2020-10-22 2022-05-12 Actinium Pharmaceuticals, Inc. Her3 radioimmunotherapy for the treatment of solid cancers
IL302759A (en) 2020-11-10 2023-07-01 Janssen Biotech Inc Macrocyclic compounds and methods of use thereof
CA3205707A1 (en) 2021-01-27 2022-08-04 Fei Shen Immunoconjugates comprising kallikrein related peptidase 2 antigen binding domains and their uses
GEAP202316335A (en) 2021-02-01 2023-10-10 Bayer Ag Multimeric chelator compounds for use in targeted radiotherapy
WO2022249089A1 (en) 2021-05-27 2022-12-01 Janssen Biotech, Inc. Compositions and methods for the treatment of prostate cancer
EP4392081A4 (en) 2021-08-27 2025-11-19 Janssen Biotech Inc Anti-PSMA radioconjugates and their uses
MX2024002476A (es) 2021-08-27 2024-05-20 Janssen Biotech Inc Anticuerpos anti-psma y usos de estos.
CN118317957A (zh) 2021-09-29 2024-07-09 墨尔本大学 在靶向放射疗法应用中作为配体的含大环的化合物和其放射性标记的络合物
WO2023084396A1 (en) 2021-11-09 2023-05-19 Janssen Biotech, Inc. Macrocyclic compounds and methods of making the same
US20250145646A1 (en) 2021-11-09 2025-05-08 Janssen Biotech, Inc. Macrocyclic compounds and diagnostic uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102171187A (zh) * 2008-08-01 2011-08-31 约翰.霍普金斯大学 Psma-结合剂及其用途
WO2017070482A2 (en) * 2015-10-22 2017-04-27 The Johns Hopkins University Psma targeted radiohalogenated ureas for cancer radiotherapy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
(2S)-2-(3-(1-Carboxy-5-(4-211At-Astatobenzamido)Pentyl) Ureido)-Pentanedioic Acid for PSMA-Targeted a-Particle Radiopharmaceutical;Ana P. Kiess等;《THE JOURNAL OF NUCLEAR MEDICINE》;20160526;第57卷(第10期);第1570页Figure 1 *
Dual-Target Binding Ligands with Modulated Pharmacokinetics for Endoradiotherapy of Prostate Cancer;James M. Kelly等;《THE JOURNAL OF NUCLEAR MEDICINE》;20170427;第58卷(第9期);第1443页右栏Figure 1、第1442页摘要和第1445页Figure 3 *

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JP2019528243A (ja) 2019-10-10
US12186288B2 (en) 2025-01-07
CN109843339A (zh) 2019-06-04
US20210137860A1 (en) 2021-05-13
US10179117B2 (en) 2019-01-15
JP2025148450A (ja) 2025-10-07
JP2023103205A (ja) 2023-07-26
AU2017281364A1 (en) 2019-01-24
EP3474903A4 (en) 2020-02-26
SG11201811482YA (en) 2019-01-30
EP4520745A2 (en) 2025-03-12
IL263863B (en) 2021-10-31
WO2017223357A1 (en) 2017-12-28
CN117069621A (zh) 2023-11-17
EP3474903B1 (en) 2025-01-22
KR102864909B1 (ko) 2025-09-25
AU2023203581B2 (en) 2025-05-22
AU2017281364B2 (en) 2023-06-22
EP4520745A3 (en) 2025-05-14
US20170368005A1 (en) 2017-12-28
US20260091008A1 (en) 2026-04-02
JP7317505B2 (ja) 2023-07-31
IL263863A (en) 2019-01-31
US20190142770A1 (en) 2019-05-16
NZ789339A (en) 2025-06-27
AU2023203581A1 (en) 2023-07-06
CA3028978A1 (en) 2017-12-28
KR20190039080A (ko) 2019-04-10
NZ749712A (en) 2025-03-28
US10716772B2 (en) 2020-07-21
KR102513698B1 (ko) 2023-03-23
EP3474903A1 (en) 2019-05-01

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