KR102498515B1 - 마이크로니들 어레이 및 사용 방법 - Google Patents
마이크로니들 어레이 및 사용 방법 Download PDFInfo
- Publication number
- KR102498515B1 KR102498515B1 KR1020177022921A KR20177022921A KR102498515B1 KR 102498515 B1 KR102498515 B1 KR 102498515B1 KR 1020177022921 A KR1020177022921 A KR 1020177022921A KR 20177022921 A KR20177022921 A KR 20177022921A KR 102498515 B1 KR102498515 B1 KR 102498515B1
- Authority
- KR
- South Korea
- Prior art keywords
- article
- microneedle
- microneedles
- tip
- hollow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims abstract description 20
- 230000007704 transition Effects 0.000 claims abstract description 41
- 238000002347 injection Methods 0.000 claims description 68
- 239000007924 injection Substances 0.000 claims description 68
- 238000001802 infusion Methods 0.000 claims description 45
- 239000012530 fluid Substances 0.000 claims description 20
- 230000002093 peripheral effect Effects 0.000 claims description 7
- 238000004891 communication Methods 0.000 claims description 4
- 210000003491 skin Anatomy 0.000 description 73
- 239000000463 material Substances 0.000 description 20
- 210000000434 stratum corneum Anatomy 0.000 description 16
- 239000003814 drug Substances 0.000 description 15
- 238000012384 transportation and delivery Methods 0.000 description 15
- 239000004480 active ingredient Substances 0.000 description 13
- 229920000106 Liquid crystal polymer Polymers 0.000 description 12
- 230000035515 penetration Effects 0.000 description 12
- 239000004977 Liquid-crystal polymers (LCPs) Substances 0.000 description 11
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 10
- 238000004146 energy storage Methods 0.000 description 10
- 229960000907 methylthioninium chloride Drugs 0.000 description 10
- 241001465754 Metazoa Species 0.000 description 9
- 239000010410 layer Substances 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 210000001519 tissue Anatomy 0.000 description 9
- 239000000126 substance Substances 0.000 description 8
- 239000000853 adhesive Substances 0.000 description 7
- 230000001070 adhesive effect Effects 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 238000001746 injection moulding Methods 0.000 description 7
- 239000007787 solid Substances 0.000 description 7
- 241000282898 Sus scrofa Species 0.000 description 6
- 239000012790 adhesive layer Substances 0.000 description 6
- 230000007423 decrease Effects 0.000 description 6
- 238000003780 insertion Methods 0.000 description 5
- 230000037431 insertion Effects 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 5
- 229940043267 rhodamine b Drugs 0.000 description 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- 238000003491 array Methods 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 229920000515 polycarbonate Polymers 0.000 description 4
- 239000004417 polycarbonate Substances 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 239000002195 soluble material Substances 0.000 description 4
- 229940124597 therapeutic agent Drugs 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 229920000954 Polyglycolide Polymers 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 210000004207 dermis Anatomy 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- 239000004633 polyglycolic acid Substances 0.000 description 3
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 208000019300 CLIPPERS Diseases 0.000 description 2
- 229920000089 Cyclic olefin copolymer Polymers 0.000 description 2
- 239000004713 Cyclic olefin copolymer Substances 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 239000004696 Poly ether ether ketone Substances 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 239000013060 biological fluid Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 208000021930 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids Diseases 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 229920001707 polybutylene terephthalate Polymers 0.000 description 2
- 229920002530 polyetherether ketone Polymers 0.000 description 2
- 239000004626 polylactic acid Substances 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000008257 shaving cream Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- HSHXDCVZWHOWCS-UHFFFAOYSA-N N'-hexadecylthiophene-2-carbohydrazide Chemical compound CCCCCCCCCCCCCCCCNNC(=O)c1cccs1 HSHXDCVZWHOWCS-UHFFFAOYSA-N 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000001045 blue dye Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 210000000736 corneocyte Anatomy 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 239000013583 drug formulation Substances 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 238000004299 exfoliation Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 238000002493 microarray Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- -1 polybutylene terephthalate Polymers 0.000 description 1
- 229920006149 polyester-amide block copolymer Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical compound [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 description 1
- 239000002987 primer (paints) Substances 0.000 description 1
- 238000007674 radiofrequency ablation Methods 0.000 description 1
- 238000012776 robust process Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000012899 standard injection Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000012385 systemic delivery Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
- A61B5/150396—Specific tip design, e.g. for improved penetration characteristics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
- A61B5/150404—Specific design of proximal end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150977—Arrays of piercing elements for simultaneous piercing
- A61B5/150984—Microneedles or microblades
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Medical Informatics (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Optics & Photonics (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562105987P | 2015-01-21 | 2015-01-21 | |
| US62/105,987 | 2015-01-21 | ||
| PCT/US2016/013820 WO2016118459A1 (en) | 2015-01-21 | 2016-01-19 | Microneedle array and method of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20170108049A KR20170108049A (ko) | 2017-09-26 |
| KR102498515B1 true KR102498515B1 (ko) | 2023-02-09 |
Family
ID=55353292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020177022921A Active KR102498515B1 (ko) | 2015-01-21 | 2016-01-19 | 마이크로니들 어레이 및 사용 방법 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10398885B2 (enExample) |
| EP (1) | EP3247449B1 (enExample) |
| JP (1) | JP6909366B2 (enExample) |
| KR (1) | KR102498515B1 (enExample) |
| CN (1) | CN107206221B (enExample) |
| AU (1) | AU2016209496B2 (enExample) |
| ES (1) | ES2885923T3 (enExample) |
| SG (2) | SG10201809690VA (enExample) |
| WO (1) | WO2016118459A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102498515B1 (ko) * | 2015-01-21 | 2023-02-09 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 마이크로니들 어레이 및 사용 방법 |
| CN107126620A (zh) * | 2017-06-27 | 2017-09-05 | 傅书华 | 一种隐形注射针 |
| WO2019166572A1 (en) | 2018-02-28 | 2019-09-06 | Pharming Intellectual Property B.V. | Pharmaceutical system for transdermal administration of a c1 -esterase inhibitor |
| KR102188397B1 (ko) * | 2018-07-04 | 2020-12-08 | 주식회사 지엘캄퍼니 | 마이크로 니들 |
| KR102186163B1 (ko) * | 2018-10-08 | 2020-12-04 | 연세대학교 산학협력단 | 다기능 마이크로구조체 패치 |
| JP7689708B2 (ja) * | 2019-06-25 | 2025-06-09 | コスメディ製薬株式会社 | 針密度が不均一なマイクロニードルアレイ |
| CN114222603A (zh) * | 2019-07-22 | 2022-03-22 | 印地安纳大学理事会 | 具有微通道的针的技术 |
| KR102290268B1 (ko) | 2019-10-11 | 2021-08-13 | 부산대학교 산학협력단 | 이식형 물질 전달체, 및 이의 제조방법 |
| IL293214A (en) | 2019-11-22 | 2022-07-01 | Veradermics Incorporated | Microneedle patch for immunostimulatory drug delivery |
| JP2023523952A (ja) | 2020-04-28 | 2023-06-08 | ティコナ・エルエルシー | マイクロニードルアセンブリ |
| KR102742895B1 (ko) * | 2020-11-06 | 2024-12-16 | 연세대학교 산학협력단 | 생체 정보 획득 장치 및 이를 이용한 생체 정보 처리 장치 |
| US11389632B2 (en) | 2020-12-21 | 2022-07-19 | Mediccene Inc. | Intradermal drug delivery device |
| CN112915378B (zh) * | 2021-03-29 | 2022-07-22 | 飞诊医疗科技(南通)有限公司 | 一种智能微针给药器和与智能微针给药器连接的软件 |
| US12214346B2 (en) | 2021-10-13 | 2025-02-04 | Satio, Inc. | Dermal patch with a diagnostic test strip |
| US12053284B2 (en) | 2021-11-08 | 2024-08-06 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US12023156B2 (en) | 2021-10-13 | 2024-07-02 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
| US12029562B2 (en) | 2021-04-14 | 2024-07-09 | Satio, Inc. | Dermal patch system |
| US12048543B2 (en) | 2021-11-08 | 2024-07-30 | Satio, Inc. | Dermal patch for collecting a physiological sample with removable vial |
| US12178979B2 (en) | 2021-10-13 | 2024-12-31 | Satio, Inc. | Dermal patch for delivering a pharmaceutical |
| CN114129889B (zh) * | 2021-11-30 | 2023-12-19 | 温州医科大学 | 一种眼科用环形微针 |
| FR3130167A1 (fr) * | 2021-12-10 | 2023-06-16 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Dispositif d'injection/prélèvement d'un fluide à travers la peau d'un être vivant |
| CN118203752B (zh) * | 2023-05-26 | 2025-10-24 | 重庆金赛星医疗科技有限公司 | 空心微针及微针阵列芯片 |
| CN117547725A (zh) * | 2023-08-14 | 2024-02-13 | 重庆金赛星医疗科技有限公司 | 可溶性空心微针、微针阵列芯片及经皮给药贴片 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012196426A (ja) * | 2010-09-29 | 2012-10-18 | Fujifilm Corp | 針状アレイ経皮吸収シート及び針状アレイ経皮吸収シートの製造方法 |
| JP2013516280A (ja) * | 2010-01-08 | 2013-05-13 | ラティオ, インコーポレイテッド | 薬剤注入装置 |
| WO2014193725A1 (en) * | 2013-05-31 | 2014-12-04 | 3M Innovative Properties Company | Microneedle injection and infusion apparatus and method of using same |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6091975A (en) | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
| TW480759B (en) | 1999-03-18 | 2002-03-21 | Seiko Epson Corp | Electronic machine, charged electronic machine and control method of electronic machine |
| US6379324B1 (en) | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
| US6312612B1 (en) | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
| US6558361B1 (en) | 2000-03-09 | 2003-05-06 | Nanopass Ltd. | Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems |
| US6533949B1 (en) | 2000-08-28 | 2003-03-18 | Nanopass Ltd. | Microneedle structure and production method therefor |
| US6749792B2 (en) * | 2001-07-09 | 2004-06-15 | Lifescan, Inc. | Micro-needles and methods of manufacture and use thereof |
| MXPA05000597A (es) | 2002-07-19 | 2005-04-28 | 3M Innovative Properties Co | Dispositivos de microaguja y aparatos de administracion por microaguja. |
| DE602005021541D1 (de) | 2004-12-07 | 2010-07-08 | 3M Innovative Properties Co | Verfahren zum formen einer mikronadel |
| JP2007190112A (ja) | 2006-01-18 | 2007-08-02 | Toray Ind Inc | マイクロニードル |
| US9119945B2 (en) * | 2006-04-20 | 2015-09-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
| US20090326415A1 (en) * | 2006-08-28 | 2009-12-31 | Agency For Science ,Technology And Research | Microneedles and methods for fabricating microneedles |
| KR100911488B1 (ko) * | 2007-09-07 | 2009-08-11 | 호남석유화학 주식회사 | 미세 바늘 및 미세 바늘 어레이 |
| DE102008052749B4 (de) * | 2008-10-22 | 2012-01-12 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Nadel, Nadelanordnung, Spritzgussform und Verfahren zum Herstellen |
| CN105999538A (zh) | 2008-11-18 | 2016-10-12 | 3M创新有限公司 | 空心微针阵列和方法 |
| US9289925B2 (en) | 2009-04-10 | 2016-03-22 | 3M Innovative Properties Company | Methods of making hollow microneedle arrays and articles and uses therefrom |
| CN102497909B (zh) | 2009-07-31 | 2014-10-29 | 3M创新有限公司 | 中空微针阵列 |
| US8088108B2 (en) * | 2009-08-22 | 2012-01-03 | Joseph Wayne Kraft | Rapid local anesthesia injection cone |
| BR112012014965B1 (pt) | 2009-12-18 | 2020-03-17 | 3M Innovative Properties Company | Método de moldagem de polímeros de cristal líquido termotrópico e artigos moldados |
| US20110172609A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Microneedle component assembly for drug delivery device |
| JP5969495B2 (ja) | 2010-12-02 | 2016-08-17 | スリーエム イノベイティブ プロパティズ カンパニー | 液晶ポリマーマイクロニードル |
| JP6423152B2 (ja) | 2011-03-07 | 2018-11-14 | スリーエム イノベイティブ プロパティズ カンパニー | マイクロニードルデバイス及び方法 |
| EP2765927B1 (en) | 2011-10-12 | 2021-02-24 | Vaxxas Pty Limited | Delivery device |
| KR102236575B1 (ko) | 2012-12-21 | 2021-04-05 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 접착제 조립체 및 이를 포함하는 마이크로니들 주사 장치 |
| KR102219636B1 (ko) | 2012-12-27 | 2021-02-23 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 중공형 마이크로니들을 갖는 물품 및 제조 방법 |
| US10384047B2 (en) | 2013-07-16 | 2019-08-20 | 3M Innovative Properties Company | Hollow microneedle with bevel opening |
| EP3021930B1 (en) | 2013-07-16 | 2020-10-07 | 3M Innovative Properties Company | Hollow microneedle with beveled tip |
| WO2015138206A1 (en) * | 2014-03-10 | 2015-09-17 | 3M Innovative Properties Company | Micro-needle device |
| KR102498515B1 (ko) * | 2015-01-21 | 2023-02-09 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 마이크로니들 어레이 및 사용 방법 |
-
2016
- 2016-01-19 KR KR1020177022921A patent/KR102498515B1/ko active Active
- 2016-01-19 SG SG10201809690VA patent/SG10201809690VA/en unknown
- 2016-01-19 SG SG11201705981RA patent/SG11201705981RA/en unknown
- 2016-01-19 US US15/545,029 patent/US10398885B2/en active Active
- 2016-01-19 EP EP16704294.4A patent/EP3247449B1/en active Active
- 2016-01-19 CN CN201680006193.9A patent/CN107206221B/zh active Active
- 2016-01-19 WO PCT/US2016/013820 patent/WO2016118459A1/en not_active Ceased
- 2016-01-19 AU AU2016209496A patent/AU2016209496B2/en active Active
- 2016-01-19 ES ES16704294T patent/ES2885923T3/es active Active
- 2016-01-19 JP JP2017538416A patent/JP6909366B2/ja not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013516280A (ja) * | 2010-01-08 | 2013-05-13 | ラティオ, インコーポレイテッド | 薬剤注入装置 |
| JP2012196426A (ja) * | 2010-09-29 | 2012-10-18 | Fujifilm Corp | 針状アレイ経皮吸収シート及び針状アレイ経皮吸収シートの製造方法 |
| WO2014193725A1 (en) * | 2013-05-31 | 2014-12-04 | 3M Innovative Properties Company | Microneedle injection and infusion apparatus and method of using same |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107206221B (zh) | 2021-02-09 |
| US20180008807A1 (en) | 2018-01-11 |
| WO2016118459A1 (en) | 2016-07-28 |
| AU2016209496A1 (en) | 2017-08-03 |
| SG11201705981RA (en) | 2017-08-30 |
| US10398885B2 (en) | 2019-09-03 |
| CN107206221A (zh) | 2017-09-26 |
| EP3247449B1 (en) | 2021-01-06 |
| KR20170108049A (ko) | 2017-09-26 |
| JP2018506339A (ja) | 2018-03-08 |
| AU2016209496B2 (en) | 2018-06-28 |
| EP3247449A1 (en) | 2017-11-29 |
| JP6909366B2 (ja) | 2021-07-28 |
| ES2885923T3 (es) | 2021-12-15 |
| SG10201809690VA (en) | 2018-12-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102498515B1 (ko) | 마이크로니들 어레이 및 사용 방법 | |
| US10576257B2 (en) | Article comprising a microneedle and methods of use | |
| JP6928735B2 (ja) | 斜角開口部を有する中空マイクロニードル | |
| US10099043B2 (en) | Hollow microneedle array article | |
| US10232157B2 (en) | Hollow microneedle with beveled tip | |
| EP2976126B1 (en) | Microneedle applicator comprising a counter assembly | |
| Kaushik et al. | Microneedles–minimally invasive transdermal delivery technology | |
| Stoeber et al. | Microneedling in Clinical Practice |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20170817 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20201023 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20220628 Patent event code: PE09021S01D |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 20221124 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
Comment text: Registration of Establishment Patent event date: 20230207 Patent event code: PR07011E01D |
|
| PR1002 | Payment of registration fee |
Payment date: 20230207 End annual number: 3 Start annual number: 1 |
|
| PG1601 | Publication of registration |