KR102485612B1 - Composition for promoting absorption of collagen and synthesis of collagen - Google Patents
Composition for promoting absorption of collagen and synthesis of collagen Download PDFInfo
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- KR102485612B1 KR102485612B1 KR1020200069596A KR20200069596A KR102485612B1 KR 102485612 B1 KR102485612 B1 KR 102485612B1 KR 1020200069596 A KR1020200069596 A KR 1020200069596A KR 20200069596 A KR20200069596 A KR 20200069596A KR 102485612 B1 KR102485612 B1 KR 102485612B1
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- South Korea
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- collagen
- concentrate
- composition
- weight
- pomegranate
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Abstract
본 발명의 콜라겐 조성물은 정제수, 콜라겐, 히알루론산, 레드비트농축액, 아세로라농축액, 타우린, 필수아미노산, L-아르기닌(L-Arginine), 복합황금추출물, 에리스리톨, 천연석류향, 효소처리스테비아, 무수구연산(Citric Acid Anhydrous), 구연산삼나트륨, 석류농축액, 세븐베리농축액을 포함한다.The collagen composition of the present invention contains purified water, collagen, hyaluronic acid, red beet concentrate, acerola concentrate, taurine, essential amino acid, L-arginine, complex golden extract, erythritol, natural pomegranate flavor, enzyme-treated stevia, anhydrous citric acid ( Citric Acid Anhydrous), trisodium citrate, pomegranate concentrate, sevenberry concentrate.
Description
본 발명은 체내로의 콜라겐 흡수 및 체내에서 콜라겐 합성을 촉진하는 조성물에 관한 것이다.The present invention relates to compositions that promote collagen uptake into the body and collagen synthesis in the body.
콜라겐(Collagen)은 경단백질 또는 교원질(膠原質)이라고도 하며 무척추동물이나 척추동물 등의 다세포동물에 널리 분포하며 양적으로도 가장 많이 발견되는 경단백질이다. 포유류에서는 전체 단백질의 약 1/3을 차지하며 동물의 결합조직을 구성하고 있는 주요한 섬유 모양의 장력이 매우 강한 경단백질로서 힘줄이나 인대에서 힘을 손실 없이 전달한다.Collagen, also known as light protein or collagen, is widely distributed in multicellular animals such as invertebrates and vertebrates, and is the most frequently found light protein in terms of quantity. In mammals, it accounts for about 1/3 of the total protein and is a major fiber-like light protein that constitutes animal connective tissue and has a very strong tensile strength. It transmits force without loss in tendons or ligaments.
콜라겐의 기본적 구조단위는 분자량 약 30만의 트로포콜라겐(母膠原質)이다. 이 분자는 3가닥의 폴리펩티드사슬이 오른쪽 꼬임의 삼중나선구조로 되어 있다. 트로포콜라겐분자는 회합하여 콜라겐 섬유(교원섬유)를 형성하는데 각 분자는 축 방향으로 1/4 씩 어긋나게 배열되어 64 ㎚ 간격의 독특한 줄무늬를 형성하면서 동물의 생장과 함께 분자 사이에 다리 걸친 구조가 생겨 불용성으로 된다. 그러나 콜라겐을 열수나 희산 또는 묽은 알칼리에서 오래 끓이면 물에 녹는 유도단백질 젤라틴으로 변한다.The basic structural unit of collagen is tropocollagen with a molecular weight of about 300,000. This molecule has a triple helix structure in which the three-stranded polypeptide chain is twisted to the right. Tropocollagen molecules associate to form collagen fibers (collagen fibers). Each molecule is arranged offset by 1/4 in the axial direction to form unique stripes at intervals of 64 nm. become insoluble. However, when collagen is boiled for a long time in hot water, dilute acid, or dilute alkali, it turns into gelatin, a induced protein that is soluble in water.
콜라겐의 주된 기능은 피부의 견고성, 조직의 저항력과 결합력, 세포접착의 지탱 등이 알려져 있다. 이러한 콜라겐은 고령화 및 자외선 조사에 의한 광노화로 인하여 피부의 두께가 얇아지고 이러한 현상은 피부의 주름 형성에 밀접한 관련이 있다고 알려져 있다.It is known that the main functions of collagen are skin firmness, tissue resistance and cohesion, and support of cell adhesion. It is known that the thickness of the skin becomes thinner due to aging and photoaging by ultraviolet irradiation, and this phenomenon is closely related to the formation of wrinkles in the skin.
소득 수준이 높아지고 노령화 사회로 접어 들면서 피부 노화에 대한 광범위한 연구가 진전되어 콜라겐의 피부에 대한 기능이 밝혀지고 있다. 그 중에서 콜라겐의 합성 촉진에 의해 콜라겐 대사가 활발해지면 진피 메트릭스의 성분이 증가되어 주름개선, 탄력증진, 피부강화 및 상처치유의 효과를 기대할 수 있다는 주장에 따라 콜라겐합성 촉진물질인 레티논산(retinoic acid), TGF(transforming growth factor), 동물유래 태반(placenta), 베투린산(betulinic acid), 클로렐라추출물 등을 피부강화용 화장료 조성물로 사용한 제품들이 많이 출시되었으나 크게 각광을 받지 못하였다.As the income level rises and we enter an aging society, extensive research on skin aging has progressed, and the function of collagen for the skin has been revealed. Among them, retinoic acid, a substance that promotes collagen synthesis, was developed according to the claim that when collagen metabolism is activated by promoting collagen synthesis, the components of the dermal matrix are increased and the effects of wrinkle improvement, elasticity enhancement, skin strengthening, and wound healing can be expected. ), TGF (transforming growth factor), animal-derived placenta, betulinic acid, and chlorella extract as skin-strengthening cosmetic compositions have been released, but have not received much attention.
또한 콜라겐을 피부 보호용 화장품 조성물로 하는 콜라겐을 배합한 제품들이 다수 판매되고 있으나, 피부 표면에 도포하는 화장품은 고분자인 콜라겐의 경피 흡수가 어려워 피부의 보습작용을 기대하기 어렵다는 지적이 있다.In addition, many products containing collagen as a cosmetic composition for skin protection are sold, but it is pointed out that cosmetics applied to the skin surface have difficulty in percutaneous absorption of collagen, a polymer, so that it is difficult to expect a moisturizing effect on the skin.
최근 들어 콜라겐 펩타이드는 건강식품, 외과용 또는 안과용 치료제 또는 화장품용 첨가제로 사용이 증가되고 있는 추세이다. 한편 이들 콜라겐 펩타이드는 식품학적, 약제학적 및 화장품학적으로 볼 때 제품의 안정성과 피부 또는 체내 흡수율이 중요시되고 있다.In recent years, collagen peptides have been increasingly used as health foods, surgical or ophthalmic treatments, or cosmetic additives. On the other hand, these collagen peptides are regarded as food, pharmaceutical, and cosmetic, and the stability of the product and the skin or body absorption rate are important.
본 발명은 식품, 화장품 또는 사료 등에 사용할 수 있는 콜라겐 조성물로, 콜라겐의 체내 흡수와 체내 합성에 효과적일 뿐 아니라, 보존성 또는 안정성이 좋고, 식감이 좋은 콜라겐의 흡수 및 콜라겐의 합성을 촉진하는 조성물을 제공한다.The present invention is a collagen composition that can be used for food, cosmetics, feed, etc., and is effective for absorption and synthesis of collagen in the body, as well as a composition that promotes absorption and synthesis of collagen with good preservation or stability and good texture. to provide.
본 발명의 콜라겐 조성물은, 정제수, 콜라겐, 히알루론산, 레드비트농축액, 아세로라농축액, 타우린, 필수아미노산, L-아르기닌(L-Arginine), 복합황금추출물, 에리스리톨, 천연석류향, 효소처리스테비아, 무수구연산(Citric Acid Anhydrous), 구연산삼나트륨, 석류농축액, 세븐베리농축액을 포함한다.The collagen composition of the present invention contains purified water, collagen, hyaluronic acid, red beet concentrate, acerola concentrate, taurine, essential amino acid, L-Arginine, complex golden extract, erythritol, natural pomegranate flavor, enzyme-treated stevia, anhydrous citric acid (Citric Acid Anhydrous), trisodium citrate, pomegranate concentrate, sevenberry concentrate.
상기 콜라겐 조성물은 정제수 50 내지 52 중량부, 콜라겐 26 내지 27 중량부, 히알루론산 0.4 내지 0.5중량부, 레드비트농축액 0.6 내지 0.7 중량부, 아세로라농축액 1.18 내지 1.22 중량부, 타우린 1.6 내지 1.7 중량부, 필수아미노산 0.09 내지 0.11 중량부, L-아르기닌 0.035 내지0.039 중량부, 복합황금추출물 0.19 내지 0.21 중량부, 에리스리톨 10.8 내지 11.2 중량부, 천연석류향 0.5 내지 0.7 중량부, 효소처리스테비아 0.198 내지 0.022 중량부, 무수구연산(Citric Acid Anhydrous) 1.1 내지 1.3, 구연산삼나트륨 0.08 내지 0.12 중량부, 석류농축액 2.9 내지 3.1 중량부, 세븐베리농축액 1.9 내지 2.1 중량부를 포함할 수 있다.The collagen composition contains 50 to 52 parts by weight of purified water, 26 to 27 parts by weight of collagen, 0.4 to 0.5 parts by weight of hyaluronic acid, 0.6 to 0.7 parts by weight of red beet concentrate, 1.18 to 1.22 parts by weight of acerola concentrate, 1.6 to 1.7 parts by weight of taurine, 0.09 to 0.11 parts by weight of essential amino acids, 0.035 to 0.039 parts by weight of L-arginine, 0.19 to 0.21 parts by weight of complex golden extract, 10.8 to 11.2 parts by weight of erythritol, 0.5 to 0.7 parts by weight of natural pomegranate flavor, 0.198 to 0.022 parts by weight of enzyme-treated stevia, 1.1 to 1.3 parts by weight of anhydrous citric acid, 0.08 to 0.12 parts by weight of trisodium citrate, 2.9 to 3.1 parts by weight of pomegranate concentrate, and 1.9 to 2.1 parts by weight of sevenberry concentrate.
상기 콜라겐은, 크기가 1nm 내지 10nm로 나노화되며, 분자량이 250 Da 내지 650 Da인 콜라겐 펩타이드인 것을 특징으로 할 수 있다.The collagen may be characterized in that it is a collagen peptide having a size of 1 nm to 10 nm and a molecular weight of 250 Da to 650 Da.
상기 콜라겐은, 크기가 6nm 내지 8nm이고 평균분자량이 500 Da이고 콜라겐 펩타이드인 것을 특징으로 할 수 있다.The collagen may be characterized in that it has a size of 6 nm to 8 nm, an average molecular weight of 500 Da, and is a collagen peptide.
상기 콜라겐은 KTTKS, GHK, AHK 및 이들의 혼합물 중 어느 하나 이상일 수 있다.The collagen may be any one or more of KTTKS, GHK, AHK, and mixtures thereof.
본 발명의 콜라겐의 흡수 및 콜라겐의 합성을 촉진하는 조성물은 콜라겐의 체내 흡수와 체내 합성에 효과적일 뿐 아니라, 보존성 또는 안정성이 좋고, 식감이 좋다. 이에 따라 피부 노화를 억제하고, 피부 주름을 개선할 수 있으며, 피부의 수분 함유량을 높여 피부 보습성을 개선시킬 수 있다.The composition for promoting collagen absorption and synthesis of collagen of the present invention is not only effective for absorption and synthesis of collagen in the body, but also has good preservability or stability and good texture. Accordingly, skin aging can be inhibited, skin wrinkles can be improved, and skin moisturizing properties can be improved by increasing the moisture content of the skin.
본 발명의 조성물은 비타민, 철분, 칼륨, 섬유소질 및 베타시아닌 등이 풍부해 빈혈 예방에 효과적이고, 혈압을 낮추는 효과가 있다.The composition of the present invention is rich in vitamins, iron, potassium, fiber and beta cyanine, and is effective in preventing anemia and lowering blood pressure.
본 발명의 조성물은 아스코르빈산(ascorbic acid), 베카카로틴, 니아신, 티아민, 리보플라민, 플라노보이드 등의 각종 미네랄이 풍부하여 알레르기 비염이나 헤르페스 바이러스 감염 예방에 효과가 있다.The composition of the present invention is rich in various minerals such as ascorbic acid, beca-carotene, niacin, thiamine, riboflavin, and flavonoids, and is effective in preventing allergic rhinitis or herpes virus infection.
본 발명의 조성물은 타우린을 포함하고 있어, 혈관 내 혈소판 응집 작용뿐만 아니라 각종 혈관계 질환의 예방에 효과적이다.Since the composition of the present invention contains taurine, it is effective not only for platelet aggregation in blood vessels but also for preventing various vascular diseases.
본 발명의 조성물은 L-아르기닌을 포함하고 있어, 고혈압 및 협심증 치료, 항산화 기능, 면역조절, 상처치유에 효과가 있다The composition of the present invention contains L-arginine and is effective in treating hypertension and angina pectoris, antioxidant function, immune regulation, and wound healing.
이하, 본 발명의 일부 실시 예들을 예시적인 도면을 통해 상세하게 설명한다. 각 도면의 구성요소들에 참조부호를 부가함에 있어서, 동일한 구성요소들에 대해서는 비록 다른 도면상에 표시되더라도 가능한 한 동일한 부호를 가지도록 하고 있음에 유의해야 한다.Hereinafter, some embodiments of the present invention will be described in detail through exemplary drawings. In adding reference numerals to components of each drawing, it should be noted that the same components have the same numerals as much as possible even if they are displayed on different drawings.
그리고 본 발명의 실시 예를 설명함에 있어, 관련된 공지 구성 또는 기능에 대한 구체적인 설명이 본 발명의 실시 예에 대한 이해를 방해한다고 판단되는 경우에는 그 상세한 설명은 생략한다. And, in describing the embodiments of the present invention, if it is determined that a detailed description of a related known configuration or function interferes with understanding of the embodiment of the present invention, the detailed description will be omitted.
또한, 본 발명의 실시 예의 구성 요소를 설명하는 데 있어서, 제 1, 제 2, A, B, (a), (b) 등의 용어를 사용할 수 있다. 이러한 용어는 그 구성 요소를 다른 구성 요소와 구별하기 위한 것일 뿐, 그 용어에 의해 해당 구성 요소의 본질이나 차례 또는 순서 등이 한정되지 않는다.Also, terms such as first, second, A, B, (a), and (b) may be used to describe components of an embodiment of the present invention. These terms are only used to distinguish the component from other components, and the nature, order, or order of the corresponding component is not limited by the term.
이하에서는 본 발명의 실시 예에 따른 콜라겐의 흡수 및 콜라겐의 합성을 촉진하는 조성물(이하, '콜라겐 조성물'이라고 함.)을 설명한다.Hereinafter, a composition for promoting absorption of collagen and synthesis of collagen (hereinafter, referred to as 'collagen composition') according to an embodiment of the present invention will be described.
본 발명의 콜라겐 조성물은 정제수, 콜라겐, 히알루론산, 레드비트농축액, 아세로라농축액, 타우린, 필수아미노산, L-아르기닌(L-Arginine), 복합황금추출물, 에리스리톨, 천연석류향, 효소처리스테비아, 무수구연산(Citric Acid Anhydrous), 구연산삼나트륨, 석류농축액, 세븐베리농축액을 포함할 수 있다.The collagen composition of the present invention contains purified water, collagen, hyaluronic acid, red beet concentrate, acerola concentrate, taurine, essential amino acid, L-arginine, complex golden extract, erythritol, natural pomegranate flavor, enzyme-treated stevia, anhydrous citric acid ( Citric Acid Anhydrous), trisodium citrate, pomegranate concentrate, and sevenberry concentrate.
구체적으로 본 발명의 콜라겐 조성물은, 정제수 50 내지 52 중량부, 콜라겐 26 내지 27 중량부, 히알루론산 0.4 내지 0.5중량부, 레드비트농축액 0.6 내지 0.7 중량부, 아세로라농축액 1.18 내지 1.22 중량부, 타우린 1.6 내지 1.7 중량부, 필수아미노산 0.09 내지 0.11 중량부, L-아르기닌 0.035 내지0.039 중량부, 복합황금추출물 0.19 내지 0.21 중량부, 에리스리톨 10.8 내지 11.2 중량부, 천연석류향 0.5 내지 0.7 중량부, 효소처리스테비아 0.198 내지 0.022 중량부, 무수구연산(Citric Acid Anhydrous) 1.1 내지 1.3, 구연산삼나트륨 0.08 내지 0.12 중량부, 석류농축액 2.9 내지 3.1 중량부, 세븐베리농축액 1.9 내지 2.1 중량부를 포함할 수 있다.Specifically, the collagen composition of the present invention contains 50 to 52 parts by weight of purified water, 26 to 27 parts by weight of collagen, 0.4 to 0.5 parts by weight of hyaluronic acid, 0.6 to 0.7 parts by weight of red beet concentrate, 1.18 to 1.22 parts by weight of acerola concentrate, and 1.6 parts by weight of taurine. to 1.7 parts by weight, essential amino acids 0.09 to 0.11 parts by weight, L-arginine 0.035 to 0.039 parts by weight, complex golden extract 0.19 to 0.21 parts by weight, erythritol 10.8 to 11.2 parts by weight, natural pomegranate flavor 0.5 to 0.7 parts by weight, enzyme-treated stevia 0.198 to 0.022 parts by weight, 1.1 to 1.3 parts by weight of anhydrous citric acid, 0.08 to 0.12 parts by weight of trisodium citrate, 2.9 to 3.1 parts by weight of pomegranate concentrate, and 1.9 to 2.1 parts by weight of sevenberry concentrate.
상기 정제수는 물에 함유되어 있는 용해된 이온, 고체입자, 미생물, 유기물 및 용해된 기체류 등의 모든 불순물을 제거한 물을 의미한다.The purified water refers to water from which all impurities such as dissolved ions, solid particles, microorganisms, organic substances, and dissolved gases contained in water are removed.
상기 콜라겐은 우피, 돈피 등의 동물성 콜라겐과, 과실류, 채소류, 종자류, 견과류, 버섯류 등의 식물성 콜라겐과 해조류, 어류, 어류비늘, 어피 등의 해양성 콜라겐으로 이루어진 군에서 선택된 어느 하나 이상일 수 있다.The collagen may be at least one selected from the group consisting of animal collagen such as cow skin and pork skin, vegetable collagen such as fruits, vegetables, seeds, nuts, and mushrooms, and marine collagen such as seaweed, fish, fish scales, and fish skin.
상기 콜라겐은, 크기가 1nm 내지 10nm로 나노화되며, 분자량이 250 Da 내지 650 Da인 콜라겐 펩타이드일 수 있다.The collagen may be a collagen peptide having a size of 1 nm to 10 nm and a molecular weight of 250 Da to 650 Da.
바람직하게 상기 콜라겐은 평균분자량이 500 Da이고, 크기가 6nm 내지 8nm인 콜라겐 펩타이드일 수 있다.Preferably, the collagen may be a collagen peptide having an average molecular weight of 500 Da and a size of 6 nm to 8 nm.
상기 콜라겐은 KTTKS, GHK, AHK 및 이들의 혼합물 중 어느 하나 이상일 수 있다. The collagen may be any one or more of KTTKS, GHK, AHK, and mixtures thereof.
상기 히알루론산은 글루쿠론산과 N-아세틸 글루코사민의 이당중합체이고, 상기 콜라겐 조성물에서 겔을 형성하고 세균 침입을 방지할 수 있다.The hyaluronic acid is a disaccharide polymer of glucuronic acid and N-acetyl glucosamine, and can form a gel in the collagen composition and prevent bacterial invasion.
상기 레드비트농축액은 증발 공정을 통해 레드비트의 수분함량을 70% 내지 80%, 바람직하게는 76% 감소시킨 농축액이다.The red beet concentrate is a concentrate in which the moisture content of red beets is reduced by 70% to 80%, preferably 76%, through an evaporation process.
비타민과 철분이 풍부한 레드비트에 의해, 상기 콜라겐 조성물은 빈혈 예방에 효과가 있다. 또한 레드비트의 뿌리에는 당분, 비타민 A, 칼륨, 철, 섬유소질 및 베타시아닌이 풍부해 상기 콜라겐 조성물은 혈압을 낮추는 효과도 있다.With red beets rich in vitamins and iron, the collagen composition is effective in preventing anemia. In addition, since the root of red beet is rich in sugar, vitamin A, potassium, iron, fiber and betacyanin, the collagen composition has an effect of lowering blood pressure.
상기 아세로라농축액은 증발 공정을 통해 아세로라의 수분함량을 76% 내지 86%, 바람직하게는 82% 감소시킨 농축액을 의미한다The acerola concentrate refers to a concentrate in which the water content of acerola is reduced by 76% to 86%, preferably by 82%, through an evaporation process.
아세로라는 비타민 C, 아스코르빈산(ascorbic acid), 베카카로틴 함량이 높으며, 니아신, 티아민, 리보플라민, 플라노보이드, 칼륨 등의 각종 미네랄이 풍부하다. 이에 상기 콜라겐 조성물은 면역 증강 및 노화 방지 효과뿐 아니라, 알레르기 비염이나 헤르페스 바이러스 감염 예방에도 효과가 있다.Acerola is high in vitamin C, ascorbic acid, and beca-carotene, and is rich in various minerals such as niacin, thiamine, riboflavin, flavonoids, and potassium. Accordingly, the collagen composition is effective not only in enhancing immunity and preventing aging, but also in preventing allergic rhinitis or herpes virus infection.
상기 타우린은 뇌의 교감 신경에 대해 억제 작용을 나타내어 혈압의 안정화 및 뇌졸중의 예방에 도움을 주고, 심장의 저칼슘 상태에서 심근의 수축력이 저하할 때 수축력을 증가시키고, 역으로 고칼슘의 경우 수축력을 감소시켜 부정맥이나 심부전에 효과가 있다. 또한, 타우린은 동맥경화, 협심증, 심근경색 등을 유발하는 저밀도 지단백질(LDL) 콜레스테롤의 생성을 억제하고, 혈관 조직에 침투되어 있는 콜레스테롤을 분해시키는 고밀도 비단백질(HDL) 콜레스테롤의 양을 증가시켜, 혈관 내 혈소판 응집 작용뿐만 아니라 각종 혈관계 질환의 예방에 효과가 있다.The taurine exhibits an inhibitory action on the sympathetic nerve of the brain to help stabilize blood pressure and prevent stroke, increase the contractile force when the contractile force of the myocardium decreases in the low calcium state of the heart, and conversely increase the contractile force in the case of high calcium. It is effective in reducing arrhythmia or heart failure. In addition, taurine inhibits the production of low-density lipoprotein (LDL) cholesterol, which causes arteriosclerosis, angina pectoris, and myocardial infarction, and increases the amount of high-density non-protein (HDL) cholesterol that decomposes cholesterol penetrating into vascular tissue, It is effective in preventing various vascular diseases as well as platelet aggregation in blood vessels.
상기 타우린은 에틸렌 옥사이드(ethylene oxide)와 아황산수소 소듐(sodium bisulfite)사이의 반응으로 2-하이드록시에테인설폰산(2-hydroxyethanesulfonic acid, isethionic acid)을 만든 후, 가암모니아 분해 반응(aminolysis)을 통해서 타우린을 합성하거나, 아지리딘(aziridine)과 아황산 (sulfurous acid)과의 반응으로 합성하거나, 브로모에테인설폰산 염과 암모니아의 반응으로도 합성할 수도 있다. The taurine is obtained through aminolysis after making 2-hydroxyethanesulfonic acid (isethionic acid) by a reaction between ethylene oxide and sodium bisulfite. Taurine can also be synthesized, synthesized by the reaction of aziridine and sulfurous acid, or synthesized by the reaction of bromoethanesulfonic acid salt and ammonia.
상기 필수아미노산은 아이소류신(isoleucine), 류신(leucine), 라이신(lysine), 메티오닌(methionine), 페닐알라닌(phenylalanine), 트레오닌(threonine), 트립토판(tryptophan), 발린(valine)를 포함하는 것으로, 체내에서 합성되지 않거나 합성되더라도 그 양이 매우 적어 생리기능을 달성하기에 충분하지 않아서 반드시 음식에서 섭취해야만 하는 아미노산이다.The essential amino acids include isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine. It is an amino acid that is not synthesized or synthesized in a very small amount and is not sufficient to achieve physiological functions, so it must be obtained from food.
상기 L-아르기닌(C6H14N4O2)은 염기성이 강한 아미노산으로 수용액은 알칼리성을 되고, 비필수 아미노산이지만 요소합성반응에서 중요한 역할을 하며 오르니틴회로에 관여한다. 이러한 L-아르기닌 고혈압 및 협심증 치료, 항산화 기능, 면역조절, 상처치유에 효과가 있다.The L-arginine (C6H14N4O2) is a highly basic amino acid, and an aqueous solution becomes alkaline, and although it is a non-essential amino acid, it plays an important role in the urea synthesis reaction and is involved in the ornithine cycle. This L-arginine is effective in treating hypertension and angina pectoris, antioxidant function, immune regulation, and wound healing.
상기 복합황금추출물은 보전제로 쓰이며, 황금농축액 36.8%, 감초농축액 27.2%, 대추농축액 10%, 황기농축액 7.2%, 텍스트린10%, 젖산 2%, 글리세린 6.8%를 포함한다.The complex golden extract is used as a preservative, and includes 36.8% of golden concentrate, 27.2% of licorice concentrate, 10% of jujube concentrate, 7.2% of astragalus concentrate, 10% of dextrin, 2% of lactic acid, and 6.8% of glycerin.
상기 에리스리톨(erythritol)은 효모인 Moniliella pollinis 또는 Trichosporonoides megachilensis 등의 발효액을 여과, 정제, 결정화, 세척, 및 건조 공정을 통해 제조될 수 있다.The erythritol may be prepared by filtering, purifying, crystallizing, washing, and drying a fermentation broth of yeasts such as Moniliella pollinis or Trichosporonoides megachilensis.
이러한 에리스리톨은 백색의 결정성분말로서 냄새가 없고, 물에 잘 녹고, 내열성이 뛰어나고 흡습성도 낮아서 결정을 쉽게 형성하는 장점이 있다. 에리스리톨의 감미도는 설탕의 70% 내지 80% 정도이며 청량한 감미를 가지고 있다. 또한 에리스리톨은 다른 감미료와 달리 체내에서 에너지원으로 이용되지 않고 대부분 배출되므로 낮은 체내 흡수율을 갖는 효과가 있다. Erythritol is a white crystalline powder that has no odor, dissolves well in water, has excellent heat resistance and low hygroscopicity, so it has the advantage of easily forming crystals. The sweetness of erythritol is about 70% to 80% of sugar and has a refreshing sweetness. In addition, unlike other sweeteners, erythritol is not used as an energy source in the body and is mostly excreted, so it has an effect of having a low absorption rate in the body.
상기 효소처리스테비아(Enzymatically Modified Stevia Glucosyl Stevia)는 스테비아추출물에 α-Glucosyltransferase(α-글루코실 전이효소) 등을 작용시켜 생성된, α-글루코실스테비오시드, α-글루코실리바우디오시드 A를 정제하여 얻은 것으로서 감미의 주성분은 α-글루코실스테비오시드이다The Enzymatically Modified Stevia Glucosyl Stevia is purified of α-glucosyl stevioside and α-glucosylbaudioside A, which are produced by the action of α-Glucosyltransferase (α-glucosyl transferase) on stevia extract. The main component of sweetness is α-glucosylstevioside.
상기 석류농축액은 증발 공정을 통해 석류의 수분함량을 72% 내지 88%, 바람직하게는 80% 감소시킨 농축액이다.The pomegranate concentrate is a concentrate obtained by reducing the water content of pomegranate by 72% to 88%, preferably 80%, through an evaporation process.
석류는 포도당과 과당이 40%, 새콤한 맛을 내는 시트르산이 1.5% 를 차지하고, B1, B2, 나이아신 등의 수용성 비타민도 포함한다. 그리고 석류의 껍질에는 타닌, 종자에는 갱년기 장애에 좋은 천연식물성 에스트로겐을 포함한다. 석류의 열매와 껍질 모두 고혈압과, 동맥경화 예방에 좋으며, 부인병과 부스럼에 효과가 있다.Pomegranate contains 40% glucose and fructose, 1.5% citric acid, which gives a sour taste, and also contains water-soluble vitamins such as B1, B2, and niacin. And pomegranate skin contains tannin, and seeds contain natural plant estrogen that is good for menopausal disorders. Both the fruit and peel of the pomegranate are good for preventing high blood pressure and arteriosclerosis, and are effective for women's diseases and swelling.
상기 무수구연산(Anhydrous citric acid)은 유기산으로서 자연에서는 감귤 또는 레몬에서 추출될 수 있고, 감미, 방향, 살균의 효과가 있다.Anhydrous citric acid is an organic acid that can be extracted from citrus or lemon in nature, and has effects of sweetness, aroma, and sterilization.
상기 구연산삼나트륨(Trisodium Citrate)은, 무색 투명한 결정 또는 흰색의 결정성 가루로서 냄새가 없고 청량한 짠맛과 쓴맛이 있다. 그리고 상기 구연산삼나트륨은 콜라겐 조성물의 pH를 조절할 수 있다.The trisodium citrate (Trisodium Citrate) is a colorless transparent crystal or a white crystalline powder that has no odor and has a refreshing salty and bitter taste. And the trisodium citrate can adjust the pH of the collagen composition.
상기 세븐베리농축액은, 블루베리, 크랜베리, 스트로베리, 라즈베리, 아사이베리, 블랙베리 및 블랙커런트의 농축혼합물을 의미한다.The seven berry concentrate refers to a concentrated mixture of blueberries, cranberries, strawberries, raspberries, acai berries, blackberries and black currants.
실시예 1_ 제1콜라겐 조성물의 제조Example 1_ Preparation of the first collagen composition
정제수 538.0198g, 콜라겐 280.8351g, 히알루론산 4.6859g, 레드비트농축액 7.0235g, 아세로라농축액 12.6360g, 타우린 17.5535g, 필수아미노산 1.0530g, L-아르기닌(L-Arginine) 0.3896g, 복합황금추출물 2.1060g, 에리스리톨 115.8300g, 천연석류향 6.3180g, 효소처리스테비아 0.2106g, 무수구연산(Citric Acid Anhydrous) 12.6360g, 구연산삼나트륨 1.0530g, 석류농축액 31.5900g, 세븐베리농축액 21.0600g가 혼합된 1053g의 제1콜라겐 조성물의 제조하였다.Purified Water 538.0198g, Collagen 280.8351g, Hyaluronic Acid 4.6859g, Red Beet Concentrate 7.0235g, Acerola Concentrate 12.6360g, Taurine 17.5535g, Essential Amino Acid 1.0530g, L-Arginine 0.3896g, Complex Golden Extract 2.1060g 115.8300g of erythritol, 6.3180g of natural pomegranate flavor, 0.2106g of enzyme-treated stevia, 12.6360g of citric acid anhydrous, 1.0530g of trisodium citrate, 31.5900g of pomegranate concentrate, 21.0600g of sevenberry concentrate 1053g of a first collagen composition mixed with of was made.
여기서 콜라겐은 어류콜라겐으로 평균분자량이 500 Da이고, 크기가 6nm 내지 8nm인 콜라겐 펩타이드를 사용하였다.Here, the collagen was fish collagen, and collagen peptides having an average molecular weight of 500 Da and a size of 6 nm to 8 nm were used.
비교예 1_ 제2콜라겐 조성물의 제조Comparative Example 1_ Preparation of the second collagen composition
정제수 538.0198g, 콜라겐 280.8351g, 천연석류향 6.3180g, 에리스리톨 115.8300g, 석류농축액 31.5900g 가 혼합된 972.5929의 제2콜라겐 조성물의 제조하였다.A second collagen composition of 972.5929 was prepared by mixing 538.0198 g of purified water, 280.8351 g of collagen, 6.3180 g of natural pomegranate flavor, 115.8300 g of erythritol, and 31.5900 g of pomegranate concentrate.
여기서 콜라겐은 어류콜라겐으로 평균분자량이 500 Da이고, 크기가 6nm 내지 8nm인 콜라겐 펩타이드를 사용하였다.Here, the collagen was fish collagen, and collagen peptides having an average molecular weight of 500 Da and a size of 6 nm to 8 nm were used.
실험예 1_ 혈중 히드록시프롤린 펩타이드 측정Experimental Example 1_ Measurement of Hydroxyproline Peptide in Blood
체중이 55kg 내지 70kg인 40대 여성, 20명을 무작위로 10 명씩, 제A그룹과 제B그룹으로 나누어 제A그룹은 실시예 1의 제1콜라겐 조성물을 10분동안 100g 섭취하고, 제B그룹은 비교예 1의 제2콜라겐 조성물을 100g을 섭취하여, 100분후 제A그룹과 제B그룹의 평균 혈중 히드록시프롤린 펩타이드를 측정하였다. 결과는 아래의 표 1과 같다.20 women in their 40s with a body weight of 55 kg to 70 kg were randomly divided into groups A and B, and group A consumed 100 g of the first collagen composition of Example 1 for 10 minutes, group B 100 g of the second collagen composition of Comparative Example 1 was ingested, and 100 minutes later, average blood hydroxyproline peptides of groups A and B were measured. The results are shown in Table 1 below.
실시예 1의 제1콜라겐 조성물의 체내 흡수율이 비교예 1의 제2콜라겐 조성물의 체내 흡수율 보다 2.02배 높은 것으로 확인되었다.It was confirmed that the absorption rate in the body of the first collagen composition of Example 1 was 2.02 times higher than the absorption rate in the body of the second collagen composition of Comparative Example 1.
실험예 2_ 피부 보습 측정Experimental Example 2_ Skin Moisture Measurement
체중이 55kg 내지 70kg인 40대 여성, 20명을 무작위로 10 명씩, 제A그룹과 제B그룹으로 나누어 제A그룹은 실시예 1의 제1콜라겐 조성물 30g씩 30일 섭취를 하였고, 제B그룹은 비교예 1의 제2콜라겐 조성물을 30g씩 30일 섭취를 하였다. 섭취 전과 30일 동안 섭취 한 후의 피부 수분 측정을 통해 증가한 보습력을 %의 평균을 확인하였다. 피부 수분 측정은 피부수분측정기(my-808s, 스칼라 주식회사 Made in Japan)를 이용하였다. 결과는 아래의 표 2와 같다.20 women in their 40s with a body weight of 55 kg to 70 kg were randomly divided into groups A and B, 10 each at random, and group A consumed 30 g of the first collagen composition of Example 1 for 30 days, and group B 30 g of the second collagen composition of Comparative Example 1 was ingested for 30 days. The increased moisturizing power through skin moisture measurement before intake and after intake for 30 days was confirmed as the average of %. Skin moisture was measured using a skin moisture meter (my-808s, Scala Co., Ltd. Made in Japan). The results are shown in Table 2 below.
실시예 1의 제1콜라겐 조성물의 피부보습효과가 비교예 1의 제2콜라겐 조성물의 피부보습효과보다 21% 높은 것을 확인하였다.It was confirmed that the skin moisturizing effect of the first collagen composition of Example 1 was 21% higher than that of the second collagen composition of Comparative Example 1.
실험예 3_ 피부 탄력 측정Experimental Example 3_ skin elasticity measurement
체중이 55kg 내지 70kg인 40대 여성, 20명을 무작위로 10 명씩, 제A그룹과 제B그룹으로 나누어 제A그룹은 실시예 1의 제1콜라겐 조성물 30g씩 30일 섭취를 하였고, 제B그룹은 비교예 1의 제2콜라겐 조성물을 30g씩 30일 섭취를 하였다. 섭취 전과 30일 동안 섭취 한 후의 피부 탄력 측정을 통해 증가한 탄력을 %의 평균을 확인하였다. 피부 탄력 측정은 피부탄력측정기(cutometer; SEM474, Courage+Khazaka electronic GmbH Germany)를 이용하였다. 결과는 아래의 표 3과 같다.20 women in their 40s with a body weight of 55 kg to 70 kg were randomly divided into groups A and B, 10 each at random, and group A consumed 30 g of the first collagen composition of Example 1 for 30 days, and group B 30 g of the second collagen composition of Comparative Example 1 was ingested for 30 days. Through skin elasticity measurement before intake and after intake for 30 days, the average increase in elasticity was confirmed. Skin elasticity was measured using a cutometer (SEM474, Courage+Khazaka electronic GmbH Germany). The results are shown in Table 3 below.
실시예 1의 제1콜라겐 조성물의 피부탄력효과가 비교예 1의 제2콜라겐 조성물의 피부탄력효과보다 27.9% 높은 것을 확인하였다.It was confirmed that the skin elasticity effect of the first collagen composition of Example 1 was 27.9% higher than that of the second collagen composition of Comparative Example 1.
실험예 2 및 실험예 3의 결과는, 실시예 1의 제1콜라겐 조성물에 포함된 레드비트에 풍부한 규소(Si), 철분(Fe), 구리(Cu) 등의 미네랄이 콜라겐의 합성에 중요한 콜라겐 부스터(Collagen Booster)로 작용하여, 피부의 콜라겐을 증가시킨것에 기인한 것이다.The results of Experimental Example 2 and Experimental Example 3 show that minerals such as silicon (Si), iron (Fe), and copper (Cu), which are abundant in red beet contained in the first collagen composition of Example 1, are important for the synthesis of collagen. It works as a collagen booster and is due to the increase in collagen in the skin.
실험예 4_식품의 보관Experimental Example 4_ storage of food
실시예 1의 제1콜라겐 조성물과 비교예 1의 제2콜라겐 조성물을 이용하여 백설기, 두부, 식빵, 가래떡, 우무을 대상으로 변화 확인하였다. 식품의 변화를 확인하기 위해 실시예 1의 제1콜라겐 조성물과 비교예 1의 제2콜라겐 조성물을 각각 조라 과정의 재료 또는 조리한 음식에 1.2 내지 2.3 중량% 섞거나 뿌려 실온에서 24 시간 경과한 후, 굳는 정도, 변색 등을 육안관찰과 관능검사를 통하여 비교하였다. 결과는 아래의 표 4와 같고, A는 매우 양호, B는 양호, C는 보통, D는 불량, F는 매우 불량을 의미한다.Using the first collagen composition of Example 1 and the second collagen composition of Comparative Example 1, changes were confirmed in Baekseolgi, tofu, bread, rice cake, and agar. In order to confirm the change in food, 1.2 to 2.3% by weight of the first collagen composition of Example 1 and the second collagen composition of Comparative Example 1 were mixed or sprinkled on the ingredients of the cooking process or cooked food, respectively, after 24 hours at room temperature. , degree of hardening, discoloration, etc. were compared through visual observation and sensory tests. The results are shown in Table 4 below, where A is very good, B is good, C is normal, D is bad, and F is very bad.
표 4에서 확인할 수 있듯이, 실시예 1의 제1콜라겐 조성물은 비교예 1의 제2콜라겐 조성물 보다 식품의 보관성 개선시킴을 알 수 있다. As can be seen from Table 4, it can be seen that the first collagen composition of Example 1 improves storage stability of food compared to the second collagen composition of Comparative Example 1.
비교예 2_제3콜라겐 조성물의 제조Comparative Example 2_Manufacture of Third Collagen Composition
정제수 538.0198g, 콜라겐 280.8351g, 히알루론산 4.6859g, 레드비트농축액 4.0235g, 아세로라농축액 6.6360g, 타우린 17.5535g, 필수아미노산 1.0530g, L-아르기닌(L-Arginine) 0.3896g, 복합황금추출물 2.1060g, 에리스리톨 115.8300g, 천연석류향 6.3180g, 효소처리스테비아 0.2106g, 무수구연산(Citric Acid Anhydrous) 12.6360g, 구연산삼나트륨 1.0530g, 석류농축액 31.5900g, 세븐베리농축액 21.0600g가 혼합된 1044g의 제3콜라겐 조성물의 제조하였다.Purified Water 538.0198g, Collagen 280.8351g, Hyaluronic Acid 4.6859g, Red Beet Concentrate 4.0235g, Acerola Concentrate 6.6360g, Taurine 17.5535g, Essential Amino Acid 1.0530g, L-Arginine 0.3896g, Complex Golden Extract 2.1060g 1044g of third collagen composition mixed with erythritol 115.8300g, natural pomegranate flavor 6.3180g, enzyme-treated stevia 0.2106g, citric acid anhydrous 12.6360g, trisodium citrate 1.0530g, pomegranate concentrate 31.5900g, sevenberry concentrate 21.0600g of was made.
비교예 3_제4콜라겐 조성물의 제조Comparative Example 3_Manufacture of the 4th Collagen Composition
정제수 538.0198g, 콜라겐 280.8351g, 히알루론산 4.6859g, 레드비트농축액 7.0235g, 아세로라농축액 12.6360g, 타우린 17.5535g, 필수아미노산 1.0530g, L-아르기닌(L-Arginine) 0.3896g, 복합황금추출물 2.1060g, 에리스리톨 110.8300g, 천연석류향 6.3180g, 효소처리스테비아 0.2106g, 무수구연산(Citric Acid Anhydrous) 12.6360g, 구연산삼나트륨 1.0530g, 석류농축액 31.5900g, 세븐베리농축액 21.0600g가 혼합된 1049g의 제4콜라겐 조성물의 제조하였다.Purified Water 538.0198g, Collagen 280.8351g, Hyaluronic Acid 4.6859g, Red Beet Concentrate 7.0235g, Acerola Concentrate 12.6360g, Taurine 17.5535g, Essential Amino Acid 1.0530g, L-Arginine 0.3896g, Complex Golden Extract 2.1060g Erythritol 110.8300g, Natural Pomegranate Flavor 6.3180g, Enzyme-Processed Stevia 0.2106g, Citric Acid Anhydrous 12.6360g, Trisodium Citrate 1.0530g, Pomegranate Concentrate 31.5900g, Sevenberry Concentrate 21.0600g Mixed 1049g Fourth Collagen Composition of was made.
비교예 4_제5콜라겐 조성물의 제조Comparative Example 4_Manufacture of Fifth Collagen Composition
정제수 538.0198g, 콜라겐 280.8351g, 히알루론산 4.6859g, 레드비트농축액 7.0235g, 아세로라농축액 12.6360g, 타우린 17.5535g, 필수아미노산 1.0530g, L-아르기닌(L-Arginine) 0.3896g, 복합황금추출물 2.1060g, 에리스리톨 120.8300g, 천연석류향 6.3180g, 효소처리스테비아 0.2106g, 무수구연산(Citric Acid Anhydrous) 12.6360g, 구연산삼나트륨 1.0530g, 석류농축액 31.5900g, 세븐베리농축액 21.0600g가 혼합된 1058g의 제5콜라겐 조성물의 제조하였다.Purified Water 538.0198g, Collagen 280.8351g, Hyaluronic Acid 4.6859g, Red Beet Concentrate 7.0235g, Acerola Concentrate 12.6360g, Taurine 17.5535g, Essential Amino Acid 1.0530g, L-Arginine 0.3896g, Complex Golden Extract 2.1060g 120.8300g of erythritol, 6.3180g of natural pomegranate flavor, 0.2106g of enzyme-treated stevia, 12.6360g of citric acid anhydrous, 1.0530g of trisodium citrate, 31.5900g of pomegranate concentrate, 21.0600g of seven berry concentrate 1058g of the fifth collagen composition of was made.
비교예 5_제6콜라겐 조성물의 제조Comparative Example 5_Manufacture of sixth collagen composition
정제수 538.0198g, 콜라겐 280.8351g, 히알루론산 4.6859g, 레드비트농축액 7.0235g, 아세로라농축액 12.6360g, 타우린 17.5535g, 필수아미노산 1.0530g, L-아르기닌(L-Arginine) 0.3896g, 복합황금추출물 2.1060g, 에리스리톨 115.8300g, 천연석류향 6.3180g, 효소처리스테비아 0.2106g, 무수구연산(Citric Acid Anhydrous) 12.6360g, 구연산삼나트륨 1.0530g, 석류농축액 21.5900g, 세븐베리농축액 16.0600g가 혼합된 1038g의 제6콜라겐 조성물의 제조하였다.Purified Water 538.0198g, Collagen 280.8351g, Hyaluronic Acid 4.6859g, Red Beet Concentrate 7.0235g, Acerola Concentrate 12.6360g, Taurine 17.5535g, Essential Amino Acid 1.0530g, L-Arginine 0.3896g, Complex Golden Extract 2.1060g Erythritol 115.8300g, Natural Pomegranate Flavor 6.3180g, Enzyme Treated Stevia 0.2106g, Citric Acid Anhydrous 12.6360g, Trisodium Citrate 1.0530g, Pomegranate Concentrate 21.5900g, Sevenberry Concentrate 16.0600g Mixed 1038g Sixth Collagen Composition of was made.
비교예 6_제7콜라겐 조성물의 제조Comparative Example 6_Manufacture of seventh collagen composition
정제수 538.0198g, 콜라겐 280.8351g, 히알루론산 4.6859g, 레드비트농축액 7.0235g, 아세로라농축액 12.6360g, 타우린 17.5535g, 필수아미노산 1.0530g, L-아르기닌(L-Arginine) 0.3896g, 복합황금추출물 1.1060g, 에리스리톨 115.8300g, 천연석류향 5.3180g, 효소처리스테비아 0.2106g, 무수구연산(Citric Acid Anhydrous) 12.6360g, 구연산삼나트륨 1.0530g, 석류농축액 31.5900g, 세븐베리농축액 21.0600g가 혼합된 1053g의 제7콜라겐 조성물의 제조하였다.Purified Water 538.0198g, Collagen 280.8351g, Hyaluronic Acid 4.6859g, Red Beet Concentrate 7.0235g, Acerola Concentrate 12.6360g, Taurine 17.5535g, Essential Amino Acid 1.0530g, L-Arginine 0.3896g, Complex Golden Extract 1.1060g 115.8300g of erythritol, 5.3180g of natural pomegranate flavor, 0.2106g of enzyme-treated stevia, 12.6360g of citric acid anhydrous, 1.0530g of trisodium citrate, 31.5900g of pomegranate concentrate, 21.0600g of sevenberry concentrate 1053g of the 7th collagen composition of was made.
실험예 5_콜라겐의 식감Experimental Example 5_ texture of collagen
관능검사는 훈련된 관능검사 요원 20명에 의해, 단맛, 쓴맛, 신맛, 비린 맛, 향 등을 종합적으로 평가되었으며, 점수는 값이 작은 것부터 큰 것의 순서로 1점부터 5점까지이다. 결과는 아래의 표 5와 같다.The sensory test was comprehensively evaluated for sweetness, bitterness, sourness, fishy taste, aroma, etc. by 20 trained sensory testers, and the scores ranged from 1 to 5 in order from small to large. The results are shown in Table 5 below.
비교예 2의 제3콜라겐 조성물 내지 비교예 6의 제7콜라겐 조성물은 단맛, 신맛, 비린 맛, 향 등이 부적절하여, 비교예 1의 제1콜라겐 조성물 보다 먹기가 불편하고, 식감이 떨어지는 것이 확인되었다.It was confirmed that the third collagen composition of Comparative Example 2 to the seventh collagen composition of Comparative Example 6 had inappropriate sweetness, acidity, fishy taste, aroma, etc., and were uncomfortable to eat and had a poor texture compared to the first collagen composition of Comparative Example 1. It became.
이상에서, 본 발명의 실시 예를 구성하는 모든 구성 요소들이 하나로 결합하거나 결합하여 동작하는 것으로 설명되었다고 해서, 본 발명이 반드시 이러한 실시 예에 한정되는 것은 아니다. 즉, 본 발명의 목적 범위 안에서라면, 그 모든 구성 요소들이 하나 이상으로 선택적으로 결합하여 동작할 수도 있다.In the above, even though all the components constituting the embodiment of the present invention have been described as being combined or operated as one, the present invention is not necessarily limited to these embodiments. That is, within the scope of the object of the present invention, all of the components may be selectively combined with one or more to operate.
또한, 이상에서 기재된 기술적이거나 과학적인 용어를 포함한 모든 용어들은, 다르게 정의되지 않는 한, 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자에 의해 일반적으로 이해되는 것과 동일한 의미가 있다. 사전에 정의된 용어와 같이 일반적으로 사용되는 용어들은 관련 기술의 문맥상의 의미와 일치하는 것으로 해석되어야 하며, 본 발명에서 명백하게 정의하지 않는 한, 이상적이거나 과도하게 형식적인 의미로 해석되지 않는다.In addition, all terms including technical or scientific terms described above have the same meaning as commonly understood by one of ordinary skill in the art to which the present invention belongs, unless otherwise defined. Commonly used terms, such as terms defined in a dictionary, should be interpreted as being consistent with the contextual meaning of the related art, and unless explicitly defined in the present invention, they are not interpreted in an ideal or excessively formal meaning.
그리고 이상의 설명은 본 발명의 기술 사상을 예시적으로 설명한 것에 불과한 것으로서, 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자라면 본 발명의 본질적인 특성에서 벗어나지 않는 범위에서 다양한 수정 및 변형이 가능할 것이다. 따라서, 본 발명에 개시된 실시 예들은 본 발명의 기술 사상을 한정하기 위한 것이 아니라 설명하기 위한 것이고, 이러한 실시 예에 의하여 본 발명의 기술 사상의 범위가 한정되는 것은 아니다. 본 발명의 보호 범위는 아래의 청구범위에 의하여 해석되어야 하며, 그와 동등한 범위 내에 있는 모든 기술 사상은 본 발명의 권리범위에 포함되는 것으로 해석되어야 할 것이다.In addition, the above description is merely an example of the technical idea of the present invention, and various modifications and variations can be made to those skilled in the art without departing from the essential characteristics of the present invention. Therefore, the embodiments disclosed in the present invention are not intended to limit the technical idea of the present invention, but to explain, and the scope of the technical idea of the present invention is not limited by these embodiments. The protection scope of the present invention should be construed according to the claims below, and all technical ideas within the equivalent range should be construed as being included in the scope of the present invention.
Claims (5)
Purified Water 538.0198g, Collagen 280.8351g, Hyaluronic Acid 4.6859g, Red Beet Concentrate 7.0235g, Acerola Concentrate 12.63g, Taurine 17.5535g, Essential Amino Acid 1.053g, L-Arginine 0.3896g, Complex Golden Extract 2.106g, 115.83 g of erythritol, 6.318 g of natural pomegranate flavor, 0.2106 g of enzyme-treated stevia, 12.636 g of anhydrous citric acid, 1.053 g of trisodium citrate, 31.59 g of pomegranate concentrate, and 21.06 g of sevenberry concentrate. Collagen composition for food.
상기 콜라겐은,
크기가 1nm 내지 10nm로 나노화되며, 분자량이 250 Da 내지 650 Da인 콜라겐 펩타이드인 것을 특징으로 하는 식품용 콜라겐 조성물.
The method of claim 1,
The collagen is
A collagen composition for food, characterized in that it is a collagen peptide having a size of 1 nm to 10 nm and a molecular weight of 250 Da to 650 Da.
상기 콜라겐은,
크기가 6nm 내지 8nm이고 평균분자량이 500 Da이고 콜라겐 펩타이드인 것을 특징으로 하는 식품용 콜라겐 조성물.The method of claim 1,
The collagen is
A collagen composition for food, characterized in that the size is 6 nm to 8 nm, the average molecular weight is 500 Da, and the collagen peptide.
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JP2005255527A (en) | 2004-03-09 | 2005-09-22 | Matsuura Yakugyo Kk | Composition for in vivo collagen synthesis promotor |
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앱솔루트 콜라겐 8.0* |
어린콜라겐 이너씰* |
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