KR102240111B1 - Cosmetic composition for moisturizing skin and improving skin wrinkles containing nano collagen peptide chelate mineral - Google Patents

Abstract

The present invention relates to a skin wrinkle improvement and skin moisturizing cosmetic composition comprising a nano collagen peptide chelate mineral.

Description

Skin wrinkle improvement and skin moisturizing cosmetic composition containing nano collagen peptide chelate mineral {COSMETIC COMPOSITION FOR MOISTURIZING SKIN AND IMPROVING SKIN WRINKLES CONTAINING NANO COLLAGEN PEPTIDE CHELATE MINERAL}

The present invention relates to a cosmetic composition for improving skin wrinkles and moisturizing skin containing a nano collagen peptide chelate mineral.

In general, collagen (Collagen) is also called light protein or collagen (膠原質), widely distributed in multicellular animals such as invertebrates and vertebrates, and is most often found quantitatively.

In mammals, collagen accounts for about one-third of the total protein, and it is a light protein with very strong tension that makes up the connective tissue, and it transmits power from the tendons or ligaments without loss.

The basic structural unit of collagen is tropocollagen with a molecular weight of about 300,000. This molecule has a triple helix structure with a three-stranded polypeptide chain twisted to the right. Tropocollagen molecules associate to form collagen fibers (collagen fibers). Each molecule is arranged in a quarter of an axial direction to form a unique stripe at intervals of 64 nm, forming a bridge structure between the molecules along with the growth of animals. Becomes insoluble. However, if collagen is boiled for a long time in hot water, dilute acid, or dilute alkali, it turns into gelatin, a derived protein that dissolves in water.

Collagen Peptide is a type of fibrous protein composed of glycine, proline, hydroxyproline, glutamic acid, etc., and is a kind of fibrous protein composed of glycine, proline, hydroxyproline, glutamic acid, etc. It mainly exists in the membrane surrounding organs in the body, joint cartilage, cornea of the eye, bones and skin, and plays a very important role as a component of the dermal layer in the skin.

The main functions of collagen are known for its firmness, tissue resistance and bonding, and support for cell adhesion. These collagens are known to be closely related to the formation of wrinkles in the skin due to aging and photoaging due to UV irradiation, and thus the thickness of the skin becomes thinner.

With the rising income level and entering an aging society, extensive research on skin aging has progressed, revealing the function of collagen on the skin. Among them, retinoic acid, a substance that promotes collagen synthesis, is claimed that when collagen metabolism is activated by promoting collagen synthesis, the components of the dermal matrix increase, which can improve wrinkles, improve elasticity, strengthen skin, and heal wounds. ), TGF (transforming growth factor), animal-derived placenta, beturinic acid, and chlorella extract as cosmetic compositions for skin enhancement have been released, but have not received much attention. In addition, many products containing collagen, which use collagen as a cosmetic composition for skin protection, are being sold, but it is pointed out that cosmetics applied to the skin surface have difficulty in expecting a skin moisturizing effect because transdermal absorption of collagen, a polymer, is difficult.

In recent years, collagen peptides are increasingly used as health foods, surgical or ophthalmic therapeutics, or cosmetic additives. Meanwhile, in terms of food, pharmaceutical, and cosmetic, these collagen peptides are important for product stability and absorption in the skin and body.

Korean Registered Patent Publication No. 10-0488913 (2005.05.11)

The present invention relates to a skin wrinkle improvement and skin moisturizing composition containing nano-collagen peptide chelate minerals that can be used in cosmetics, etc., and has excellent preservation or stability of the product, and is a mineral chelated to collagen peptides as well as peptides in the skin or body. It is an object of the present invention to provide a cosmetic composition for improving skin wrinkles and moisturizing skin containing nano collagen peptide chelate minerals having excellent absorption rate of.

The present invention provides a skin wrinkle improvement and skin moisturizing cosmetic composition comprising a nano collagen peptide chelate mineral.

The nano-collagen peptide chelate mineral of the present invention has an effect of preventing aging, discoloration, and deterioration when used in food, and when used as a cosmetic, it increases the moisture content of the skin to maintain moisture and improve wrinkles.

In addition, the product is excellent in preservation or stability, and the absorption rate of not only collagen peptides but also minerals chelated to collagen peptides in the skin or body is excellent.

Hereinafter, the present invention will be described in more detail to aid understanding of the present invention. At this time, terms or words used in the present specification and claims should not be construed as being limited to a conventional or dictionary meaning, and the inventor appropriately defines the concept of the term in order to describe his own invention in the best way. It should be interpreted as a meaning and concept consistent with the technical idea of the present invention based on the principle that it can be done.

The present invention relates to a skin wrinkle improvement and skin moisturizing composition containing nano-collagen peptide chelate minerals that can be used in cosmetics, etc., and has excellent preservation or stability of the product, and is a mineral chelated to collagen peptides as well as peptides in the skin or body. It is an object of the present invention to provide a cosmetic composition for improving skin wrinkles and moisturizing skin containing nano collagen peptide chelate minerals having excellent absorption rate of.

Specifically, the cosmetic composition for improving skin wrinkles and moisturizing the skin of the present invention includes a nano collagen peptide chelate mineral.

The skin wrinkle improvement and skin moisturizing cosmetic composition may contain 0.01 to 30 parts by weight of the nano collagen peptide chelate mineral, and 0.01 to 30 parts by weight of fish collagen.

In addition, the skin wrinkle improvement and skin moisturizing cosmetic composition may further include 0.01 to 30 parts by weight of the nano-collagen peptide chelate mineral, and 0.01 to 30 parts by weight of phyto-collagen.

The skin wrinkle improvement and skin moisturizing cosmetic composition may further include 0.01 to 10 parts by weight of panthenol.

The skin wrinkle improvement and skin moisturizing cosmetic composition may further include 0.01 to 20 parts by weight of butylene glycol.

The skin wrinkle improvement and skin moisturizing cosmetic composition may further include 0.04 to 2 parts by weight of adenosine.

Collagen, also called light protein or collagen, is widely distributed in multicellular animals such as invertebrates and vertebrates, and is the most quantitatively found light protein. It is mainly present in the cornea, bones, and skin, and especially plays a very important role as a component of the dermal layer in the skin. The main functions of collagen are known for its firmness, tissue resistance and bonding, and support for cell adhesion.

Collagen can be largely divided into animal collagen such as beef skin and pork skin, vegetable collagen such as fruits, vegetables, seeds, nuts, mushrooms, and marine collagen such as seaweed, fish, fish scale, and fish skin, and the nano collagen peptide chelate mineral (Mineral The collagen used in the preparation of Chelate Collagen Peptide) is characterized in that it is at least one selected from the group consisting of animal collagen, vegetable collagen, and marine collagen.

Collagen is commonly referred to as collagen. Collagen is a fibrous protein found in most animals, especially mammals, and occupies most of all connective tissues in the body, such as skin and cartilage. Collagen has a triple helix structure in which three polypeptide chains are twisted, and the average molecular weight of collagen is 300,000 Da (Dalton, Dalton), which has a large molecular weight.

In the present invention, in order to increase the skin absorption rate of the nano-collagen peptide chelate mineral, the preparation of the chelate collagen peptide is first 1) hydrolyzed by adding an enzyme to collagen to form a collagen peptide (hereinafter referred to as'collagen nano-ization step'). .

Accordingly, the average molecular weight of the collagen peptide of the present invention is 200 Da to 600 Da, more specifically 300 Da to 400 Da, and its size is 0.1 nm to 10 nm, more specifically 1 nm to 5 nm. Bar, due to its small molecular weight and small size, it shows the effect of being quickly absorbed into the skin.

The enzyme used in the collagen nano-ization step is a proteolytic enzyme, characterized in that it contains at least one selected from the group consisting of collagenase, trypsin, papain, pepsin, and alcalase, and decomposes collagen into collagen peptides. The hydrolysis reaction is characterized in that it is carried out at 50° C. to 70° C., more specifically 50° C. to 60° C. for 2 to 24 hours.

When the hydrolysis reaction occurs under the above range of temperature and time conditions, it is possible to obtain a collagen peptide having an appropriate molecular weight and size with a high absorption rate in the body.

After the collagen nano-ization step, the nano-collagen peptide chelate mineral is 2) formed by adding a mineral to the collagen peptide (hereinafter, also referred to as a'collagen peptide chelation step').

In the collagen peptide chelation step of the present invention, the terminal group of the amino acid is made from NH ²⁺ to NH ³⁺ to form a covalent bond, while ionic bonds in the form of adding minerals instead of H ions of the COOH group are performed to stabilize. In addition, the mineral is characterized in that 1 to 20 parts by weight relative to 100 parts by weight of the collagen peptide, and within the above range, nano-collagen peptide chelate minerals can be obtained with high purity without unreacted minerals.

The chelate refers to a bond when a ligand having a plurality of coordination groups coordinating with a metal ion in one molecule is coordinarily bonded with a metal, or a complex formed by the bond. In the present invention, a pair of non-shared electrons that do not participate in the covalent bond of the amino group bonded to the alpha carbon of the amino acid forms a complete coordination bond with the mineral to form a nano-collagen peptide chelate mineral.

The present invention can improve the preservation or stability of a product through chelation of such collagen peptides and minerals, and can exhibit an effect of improving the absorption rate of minerals together with collagen peptides in the skin.

Thereafter, the nanocollagen peptide chelate mineral of the present invention may be prepared through one or more steps selected from the group consisting of a purification step, a sterilization step, and a drying step.

High purity nano-collagen peptide chelate mineral can be prepared through the purification step. The purification step may be performed by filtering and separating a high molecular weight or large-sized collagen peptide that has not been hydrolyzed to an appropriate molecular weight and size by a collagen nano-ization step, unreacted enzymes and minerals, and by-products.

In addition, in the sterilization step, microorganisms harmful to the human body may be removed through physical or chemical treatment of the nano-collagen peptide chelate mineral. It can be added to heat-resistant appliances (glassware, ceramics, some metal products, etc.) and heated at 70°C to 90°C for 1 hour and 5 hours to dry heat sterilization of harmful microorganisms and bacteria.

In addition, in the drying step, the nanocollagen peptide chelate mineral may be dried using a dryer.

The nano-collagen peptide chelate mineral prepared through the above-described steps is represented by the following formula (1).

[Formula 1]

(R represents a side chain that determines the type of amino acid, and M is at least one selected from the group consisting of Ca, Cu, Zn, Fe, Se, Cr, Mg, Mn, and Co.)

The nano-collagen peptide chelate mineral of the present invention can be quickly absorbed into the skin together with the chelated mineral within 1 hour, more specifically 30 minutes.When applied for a long period of time, compared to other collagen products, the skin moisturizing, elasticity, and It can show an excellent effect in improving wrinkles.

Fish Collagen is a low-molecular collagen mainly extracted from fish such as pollock, skate, and salmon, fish scales, and fish skin. Fish from which fish collagen is extracted is not limited, and any fish that can extract fish collagen can be used.

Phyto collagen is an amino acid complex extracted from vegetable proteins such as fruits, vegetables, seeds, nuts, and mushrooms, and is characterized by being composed of amino acids with a high content of oxyproline among the amino acid components contained in plants. Phyto collagen is mainly included in the cosmetic composition and is absorbed into the skin, thereby improving skin elasticity and exhibiting excellent skin moisturizing effect.

Panthenol is an alcohol derivative of pantothenic acid. When absorbed into the skin, it is oxidized to become pantothenic acid. These panthenols are known to have effects such as collagen formation, skin regeneration, oil suppression, and inflammation suppression in the body.

Butylene glycol is a component made from a substance derived from fatty acids extracted by fermentation of sugar cane. It attracts moisture and has a moisturizing effect.

Adenosine is the nucleotide of adenine and D-ribose. It is a component such as ribonucleic acid (RNA) or ATP, which penetrates into the skin and has the effect of improving skin wrinkles and skin troubles.

Hereinafter, embodiments of the present invention will be described in detail so that those of ordinary skill in the art can easily implement the present invention. However, the present invention may be implemented in various different forms and is not limited to the embodiments described herein.

Example 1

The marine collagen of fish skin and jellyfish was washed with purified water to remove impurities, and 4 liters of purified water were added to 1 kg of raw materials and pulverized to 50 μm with a chopper. Thereafter, the deodorized raw material was passed through ozone into a 0.5% solution of citric acid, and 0.5 w% of pepsin protease was added and hydrolyzed at 55° C. for 24 hours to have a molecular weight of 300 Da to 400 Da and a size of 1 nm to 5 nm. A collagen peptide was obtained.

For the preparation of the nano-collagen peptide chelate mineral, ferric sulfate was added in an amount of 1 to 20 parts by weight based on 100 weight of collagen peptide, and a chelating reaction was carried out while enzymatic hydrolysis at 55°C. It was dried using a spray dryer to prepare a chelate complex powder of Fe-collagen peptide.

Comparative Example 1

In Example 1, a collagen peptide powder was prepared in the same manner as in Example 1, except that ferric sulfate was not added.

Experimental Example 1

Using the collagen peptides of Example 1 and Comparative Example 1, a cream as shown in Table 1 was prepared and tested to see if there is improvement in skin moisturization and skin wrinkles.

Furtherance Composition ratio (% by weight) Example 1 Comparative Example 1 Collagen peptide 5% 5% Phyto Collagen 2.5% 2.5% Fish collagen 2.5% 2.5% Panthenol One% One% Butylene Clycol 10% 10% Adenosine 0.04% 0.04% Purified water 78.96% 78.96%

(In Table 1, phyto-collagen and fish collagen were hydrolyzed to use those having a molecular weight of 300 Da to 400 Da and a size of 1 nm to 5 nm.)

1-1) Measurement of skin moisture content

In order to determine the moisturizing effect of the skin, the skin moisture content was measured using a measuring device (IMPEDANCE METER, SKICON-200 IBS JAPAN). About 1 ml of a sample was applied, the remaining liquid was removed after 30 minutes, and the electrical conductivity of the skin was measured every elapsed time, and the results are shown in Table 2 below.

division
(Unit: Ω) 0
(sec) 30
(sec) 60
(sec) 150
(sec) 240
(sec) 330
(sec) 420
(sec) 510
(sec) Example 1 140 1600 650 420 340 320 310 300 Comparative Example 1 130 1100 270 140 130 125 120 110 Purified water 80 800 180 120 115 110 80 60

As shown in Table 2, the moisturizing properties were high in the order of Example 1> Comparative Example 1> purified water. Through this, it was found that the nourishing cream to which the chelate complex of Fe-collagen peptide of Example 1 was added has excellent moisturizing properties.

1-2) Wrinkle improvement experiment

30 women in their 50s were randomly divided into a first group and a second group, and in the first group, the cream of Example 1 was applied to the eye area twice every morning/evening for 2 months, and the second group was a comparative example. The results of examining whether the wrinkles around the eyes are improved by applying the cream of 1 to the eye area twice every morning/evening for 2 months are shown in Table 3 below.

No improvement Slightly improved Medium improvement Significant improvement Group 1 0 One 3 11 Group 2 0 4 5 6

The second group to which the cream of Comparative Example 1 was applied also showed some improvement in wrinkles around the eyes, but in the first group to which the cream of Example 1 was applied, a significant improvement was observed in 11 people. Through this, it was confirmed that the cream of Example 1 was excellent in improving wrinkles.

The above description of the present invention is for illustrative purposes only, and those of ordinary skill in the art to which the present invention pertains will be able to understand that other specific forms can be easily modified without changing the technical spirit or essential features of the present invention will be. Therefore, it should be understood that the embodiments described above are illustrative in all respects and are not limiting.

Claims (6)

Contains nano collagen peptide chelate mineral 5%, phyto collagen 2.5%, fish collagen 2.5%, panthenol 1%, butylene glycol 10%, adenosine 0.04%, and purified water 78.96%,
The nano collagen peptide chelate mineral,
A nano-ized collagen peptide having a molecular weight of 300 Da to 400 Da and a size of 1 nm to 5 nm,
Including minerals added to the nano-ized collagen peptide,
The mineral is characterized in that 1 to 20 parts by weight relative to 100 parts by weight of the nano-ized collagen peptide,
The nano-collagen peptide chelate mineral is stabilized by ionic bonding in the form of adding minerals instead of H ions of COOH group to improve skin wrinkles and skin moisturizing cosmetic composition represented by the following formula (1).
[Formula 1]

In Formula 1, R represents a side chain that determines the type of amino acid, and M (mineral) is at least one selected from the group consisting of Ca, Cu, Zn, Fe, Se, Cr, Mg, Mn, and Co.
The method according to claim 1,
The fish collagen is a skin wrinkle improvement and skin moisturizing cosmetic composition, characterized in that the low-molecular collagen extracted from any one or more of fish, fish scales, fish skin.
The method according to claim 1,
The phyto collagen is extracted from any one or more vegetable proteins among fruits, vegetables, seeds, nuts, and mushrooms, and is an amino acid complex containing hydroxyproline. A cosmetic composition for improving skin wrinkles and moisturizing skin.
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