KR102474663B1 - 세포주로부터 랍도바이러스를 탐지 및 제거하는 방법 - Google Patents

세포주로부터 랍도바이러스를 탐지 및 제거하는 방법 Download PDF

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KR102474663B1
KR102474663B1 KR1020167010089A KR20167010089A KR102474663B1 KR 102474663 B1 KR102474663 B1 KR 102474663B1 KR 1020167010089 A KR1020167010089 A KR 1020167010089A KR 20167010089 A KR20167010089 A KR 20167010089A KR 102474663 B1 KR102474663 B1 KR 102474663B1
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rhabdovirus
rna
seq
sample
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KR20160062049A (ko
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조엘 헤인즈
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다케다 백신즈 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
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    • A—HUMAN NECESSITIES
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    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/20011—Rhabdoviridae
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    • C12Q2600/00—Oligonucleotides characterized by their use
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KR1020167010089A 2013-10-03 2014-10-03 세포주로부터 랍도바이러스를 탐지 및 제거하는 방법 Active KR102474663B1 (ko)

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KR1020217038994A KR102649950B1 (ko) 2013-10-03 2014-10-03 세포주로부터 랍도바이러스를 탐지 및 제거하는 방법

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US201361886438P 2013-10-03 2013-10-03
US61/886,438 2013-10-03
PCT/US2014/059060 WO2015051255A1 (en) 2013-10-03 2014-10-03 Methods of detection and removal of rhabdoviruses from cell lines

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KR102474663B1 true KR102474663B1 (ko) 2022-12-07

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KR1020217038994A Active KR102649950B1 (ko) 2013-10-03 2014-10-03 세포주로부터 랍도바이러스를 탐지 및 제거하는 방법

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US (5) US10501500B2 (enExample)
EP (1) EP3052631B1 (enExample)
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CN (1) CN106103720A (enExample)
AU (3) AU2014329403B2 (enExample)
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Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012103541A2 (en) * 2011-01-28 2012-08-02 Schlumberger Canada Limited Pipe damage interpretation system
KR102474663B1 (ko) 2013-10-03 2022-12-07 다케다 백신즈 인코포레이티드 세포주로부터 랍도바이러스를 탐지 및 제거하는 방법
EP3245306A4 (en) * 2015-01-16 2018-09-05 Takeda Vaccines, Inc. Detection of particle-contained reverse transcriptase activity
CN113156135B (zh) 2015-03-05 2025-01-07 勃林格殷格翰动物保健美国有限公司 用于杆状病毒表达的亚单位抗原的标记系统及其用途
CN104962580B (zh) * 2015-06-30 2018-04-27 浙江大学 一种重组植物弹状病毒载体及其构建方法
IL258996B2 (en) 2015-11-01 2023-03-01 Glycobac Llc Virus-free cell lines and methods for obtaining them
CN109182277B (zh) * 2018-09-07 2021-05-07 中国水产科学研究院长江水产研究所 一种黄鳝弹状病毒CrERV及RT-PCR检测引物及应用
US20210341620A1 (en) 2018-12-02 2021-11-04 Gentex Corporation SYSTEMS, DEVICES AND METHODS FOR MICRO-VIBRATION DATA EXTRACTION USING A TIME OF FLIGHT (ToF) IMAGING DEVICE
JP2023513135A (ja) 2020-02-06 2023-03-30 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー 抗ラブドウイルス抗体を検出するのに有用なポリペプチド
WO2021163079A1 (en) * 2020-02-10 2021-08-19 Biomarin Pharmaceutical Inc. Virus-free cell cultures
CN114686599A (zh) * 2020-12-30 2022-07-01 北京五加和基因科技有限公司 宿主昆虫细胞dna残留含量定量检测方法及试剂盒
WO2022246323A1 (en) 2021-05-21 2022-11-24 Takeda Vaccines, Inc. Solid composition, freeze-drying method and glass vial
CN115491377B (zh) * 2021-06-18 2025-09-16 北京三诺佳邑生物技术有限责任公司 一种诱导rna干扰和降低并清除细胞中病毒污染的核苷酸序列及应用
CN116731953A (zh) * 2022-03-01 2023-09-12 成都威斯克生物医药有限公司 弹状病毒阴性草地贪夜蛾昆虫细胞株及其筛选、鉴定和应用
CN118547114A (zh) * 2024-05-29 2024-08-27 长春生物制品研究所有限责任公司 一种用于Sf弹状病毒荧光定量检测的引物、探针、试剂盒及方法
CN120700212A (zh) * 2025-08-27 2025-09-26 北京昭衍生物技术有限公司 一种用于检测弹状病毒的qPCR引物探针组合物、试剂盒及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102605106B (zh) * 2012-03-29 2013-09-04 浙江省检验检疫科学技术研究院 蚕微孢子虫、核型多角体病毒和浓核病毒的三重荧光pcr检测方法及试剂盒和引物、探针

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5024947A (en) 1987-07-24 1991-06-18 Cetus Corporation Serum free media for the growth on insect cells and expression of products thereby
US5457189A (en) * 1989-12-04 1995-10-10 Isis Pharmaceuticals Antisense oligonucleotide inhibition of papillomavirus
US5646262A (en) * 1994-07-28 1997-07-08 Georgetown University Antisense oligonucleotides against hepatitis B viral replication
US6103526A (en) 1998-10-08 2000-08-15 Protein Sciences Corporation Spodoptera frugiperda single cell suspension cell line in serum-free media, methods of producing and using
SI1561756T1 (sl) * 2002-09-11 2016-02-29 Chugai Seiyaku Kabushiki Kaisha Postopek čiščenja proteinov
JP2005168485A (ja) * 2003-11-20 2005-06-30 Tsutomu Suzuki ｓｉＲＮＡの設計方法
ES2618885T3 (es) 2006-09-29 2017-06-22 Takeda Vaccines, Inc. Formulaciones de vacuna para norovirus
KR20170001720A (ko) 2007-03-14 2017-01-04 다케다 백신즈 인코포레이티드 바이러스 유사 입자 정제
CA2728575A1 (en) * 2007-06-29 2009-01-08 Boston Biomedical, Inc. Enabling the use of long dsrna for gene targeting in mammalian and other selected animal cells
KR20100083150A (ko) 2007-09-18 2010-07-21 리고사이트 파머슈티컬즈 인코퍼레이티드 노로바이러스에 대한 보호면역반응을 제공하는 방법
AU2009279456B2 (en) 2008-08-08 2015-02-05 Takeda Vaccines, Inc. Virus-like particles comprising composite capsid amino acid sequences for enhanced cross reactivity
EP2346901A1 (en) * 2008-10-20 2011-07-27 Abbott Laboratories Antibodies that bind to il-18 and methods of purifying the same
US9056896B2 (en) * 2009-03-27 2015-06-16 Asahi Kasei Medical Co., Ltd. Method for removing viruses from high concentration monoclonal antibody solution
WO2012083363A1 (en) * 2010-12-22 2012-06-28 Murdoch Childrens Research Institute A method of treatment
HK1199202A1 (en) 2011-07-11 2015-06-26 武田疫苗股份有限公司 Parenteral norovirus vaccine formulations
JOP20130186B1 (ar) 2012-06-22 2021-08-17 Takeda Vaccines Montana Inc تنقية الجزيئات الشبيهة بالفيروسات
KR102474663B1 (ko) 2013-10-03 2022-12-07 다케다 백신즈 인코포레이티드 세포주로부터 랍도바이러스를 탐지 및 제거하는 방법
IL258996B2 (en) 2015-11-01 2023-03-01 Glycobac Llc Virus-free cell lines and methods for obtaining them
CN114807009A (zh) 2022-03-28 2022-07-29 成都纳微金生物技术有限公司 一种不依赖血清的无弹状病毒污染的sf9细胞株、筛选方法及应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102605106B (zh) * 2012-03-29 2013-09-04 浙江省检验检疫科学技术研究院 蚕微孢子虫、核型多角体病毒和浓核病毒的三重荧光pcr检测方法及试剂盒和引物、探针

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US12006341B2 (en) 2024-06-11
US11286282B2 (en) 2022-03-29
EP3052631A1 (en) 2016-08-10
CN106103720A (zh) 2016-11-09
US20160244487A1 (en) 2016-08-25
WO2015051255A1 (en) 2015-04-09
US10501500B2 (en) 2019-12-10
JP2023126495A (ja) 2023-09-07
US12479891B2 (en) 2025-11-25
US20200190146A1 (en) 2020-06-18
JP2020036613A (ja) 2020-03-12
KR20210154988A (ko) 2021-12-21
SG10202107054TA (en) 2021-08-30
AU2014329403A1 (en) 2016-05-05
KR20160062049A (ko) 2016-06-01
EP3052631B1 (en) 2019-08-07
AU2022259826B2 (en) 2025-01-02
JP2023024506A (ja) 2023-02-16
US20230303633A1 (en) 2023-09-28
AU2020294216A1 (en) 2021-01-28
JP2022009010A (ja) 2022-01-14
JP2024050747A (ja) 2024-04-10
JP7191175B2 (ja) 2022-12-16
KR102649950B1 (ko) 2024-03-22
US20250109172A1 (en) 2025-04-03
SG10201802772YA (en) 2018-05-30
JP2016533172A (ja) 2016-10-27
US20220213150A1 (en) 2022-07-07
AU2020294216B2 (en) 2022-11-24
CA2926225A1 (en) 2015-04-09
SG11201602585XA (en) 2016-05-30
AU2022259826A1 (en) 2023-01-19
AU2014329403B2 (en) 2020-10-08
US12018052B2 (en) 2024-06-25
EP3052631A4 (en) 2017-06-14

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