KR102474663B1 - 세포주로부터 랍도바이러스를 탐지 및 제거하는 방법 - Google Patents

세포주로부터 랍도바이러스를 탐지 및 제거하는 방법 Download PDF

Info

Publication number
KR102474663B1
KR102474663B1 KR1020167010089A KR20167010089A KR102474663B1 KR 102474663 B1 KR102474663 B1 KR 102474663B1 KR 1020167010089 A KR1020167010089 A KR 1020167010089A KR 20167010089 A KR20167010089 A KR 20167010089A KR 102474663 B1 KR102474663 B1 KR 102474663B1
Authority
KR
South Korea
Prior art keywords
rhabdovirus
rna
seq
sample
delete delete
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020167010089A
Other languages
English (en)
Korean (ko)
Other versions
KR20160062049A (ko
Inventor
조엘 헤인즈
Original Assignee
다케다 백신즈 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 다케다 백신즈 인코포레이티드 filed Critical 다케다 백신즈 인코포레이티드
Priority to KR1020217038994A priority Critical patent/KR102649950B1/ko
Publication of KR20160062049A publication Critical patent/KR20160062049A/ko
Application granted granted Critical
Publication of KR102474663B1 publication Critical patent/KR102474663B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/205—Rhabdoviridae, e.g. rabies virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C12N7/045—Pseudoviral particles; Non infectious pseudovirions, e.g. genetically engineered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20051—Methods of production or purification of viral material
    • C12N2760/20052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020167010089A 2013-10-03 2014-10-03 세포주로부터 랍도바이러스를 탐지 및 제거하는 방법 Active KR102474663B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020217038994A KR102649950B1 (ko) 2013-10-03 2014-10-03 세포주로부터 랍도바이러스를 탐지 및 제거하는 방법

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361886438P 2013-10-03 2013-10-03
US61/886,438 2013-10-03
PCT/US2014/059060 WO2015051255A1 (en) 2013-10-03 2014-10-03 Methods of detection and removal of rhabdoviruses from cell lines

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020217038994A Division KR102649950B1 (ko) 2013-10-03 2014-10-03 세포주로부터 랍도바이러스를 탐지 및 제거하는 방법

Publications (2)

Publication Number Publication Date
KR20160062049A KR20160062049A (ko) 2016-06-01
KR102474663B1 true KR102474663B1 (ko) 2022-12-07

Family

ID=52779185

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020167010089A Active KR102474663B1 (ko) 2013-10-03 2014-10-03 세포주로부터 랍도바이러스를 탐지 및 제거하는 방법
KR1020217038994A Active KR102649950B1 (ko) 2013-10-03 2014-10-03 세포주로부터 랍도바이러스를 탐지 및 제거하는 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020217038994A Active KR102649950B1 (ko) 2013-10-03 2014-10-03 세포주로부터 랍도바이러스를 탐지 및 제거하는 방법

Country Status (9)

Country Link
US (5) US10501500B2 (enExample)
EP (1) EP3052631B1 (enExample)
JP (6) JP2016533172A (enExample)
KR (2) KR102474663B1 (enExample)
CN (1) CN106103720A (enExample)
AU (3) AU2014329403B2 (enExample)
CA (1) CA2926225A1 (enExample)
SG (3) SG11201602585XA (enExample)
WO (1) WO2015051255A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201391095A1 (ru) * 2011-01-28 2013-12-30 Шлюмбергер Текнолоджи Б.В. Система интерпретации повреждения труб
AU2014329403B2 (en) 2013-10-03 2020-10-08 Takeda Vaccines, Inc. Methods of detection and removal of rhabdoviruses from cell lines
US10920288B2 (en) 2015-01-16 2021-02-16 Takeda Vaccines, Inc. Detection of particle-contained reverse transcriptase activity
MX380411B (es) 2015-03-05 2025-03-12 Boehringer Ingelheim Animal Health Usa Inc Sistema de marcadores, en particular para antigenos subunitarios expresados por baculovirus.
CN104962580B (zh) * 2015-06-30 2018-04-27 浙江大学 一种重组植物弹状病毒载体及其构建方法
KR20250121616A (ko) * 2015-11-01 2025-08-12 글리코백, 엘엘씨 바이러스 비함유 세포주 및 이를 획득하기 위한 방법
CN109182277B (zh) * 2018-09-07 2021-05-07 中国水产科学研究院长江水产研究所 一种黄鳝弹状病毒CrERV及RT-PCR检测引物及应用
EP4600699A3 (en) 2018-12-02 2025-10-22 Gentex Corporation Systems, devices and methods for microvibration data extraction using a time of flight (tof) imaging device
US11858962B2 (en) 2020-02-06 2024-01-02 Boehringer Ingelheim Vetmedica Gmbh Polypeptides useful for detecting anti-rhabdovirus antibodies
US20230075854A1 (en) * 2020-02-10 2023-03-09 Biomarin Pharmaceutical Inc. Virus-free cell cultures
CN114686599A (zh) * 2020-12-30 2022-07-01 北京五加和基因科技有限公司 宿主昆虫细胞dna残留含量定量检测方法及试剂盒
EP4340874A1 (en) 2021-05-21 2024-03-27 Takeda Vaccines, Inc. Solid composition, freeze-drying method and glass vial
CN115491377B (zh) * 2021-06-18 2025-09-16 北京三诺佳邑生物技术有限责任公司 一种诱导rna干扰和降低并清除细胞中病毒污染的核苷酸序列及应用
CN116731953A (zh) * 2022-03-01 2023-09-12 成都威斯克生物医药有限公司 弹状病毒阴性草地贪夜蛾昆虫细胞株及其筛选、鉴定和应用
CN118547114A (zh) * 2024-05-29 2024-08-27 长春生物制品研究所有限责任公司 一种用于Sf弹状病毒荧光定量检测的引物、探针、试剂盒及方法
CN120700212A (zh) * 2025-08-27 2025-09-26 北京昭衍生物技术有限公司 一种用于检测弹状病毒的qPCR引物探针组合物、试剂盒及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102605106B (zh) * 2012-03-29 2013-09-04 浙江省检验检疫科学技术研究院 蚕微孢子虫、核型多角体病毒和浓核病毒的三重荧光pcr检测方法及试剂盒和引物、探针

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5024947A (en) * 1987-07-24 1991-06-18 Cetus Corporation Serum free media for the growth on insect cells and expression of products thereby
US5457189A (en) * 1989-12-04 1995-10-10 Isis Pharmaceuticals Antisense oligonucleotide inhibition of papillomavirus
US5646262A (en) * 1994-07-28 1997-07-08 Georgetown University Antisense oligonucleotides against hepatitis B viral replication
US6103526A (en) 1998-10-08 2000-08-15 Protein Sciences Corporation Spodoptera frugiperda single cell suspension cell line in serum-free media, methods of producing and using
ES2626268T3 (es) * 2002-09-11 2017-07-24 Chugai Seiyaku Kabushiki Kaisha Método de purificación de proteínas
JP2005168485A (ja) * 2003-11-20 2005-06-30 Tsutomu Suzuki ｓｉＲＮＡの設計方法
ES2577833T3 (es) 2006-09-29 2016-07-19 Takeda Vaccines, Inc. Formulaciones de vacuna para norovirus
HUE028605T2 (en) 2007-03-14 2016-12-28 Takeda Vaccines Inc Cleaning virus-like particles
EP2173901A4 (en) * 2007-06-29 2011-12-14 Boston Biomedical Inc DNA MODULATION INDUCED BY MICRO-RNA BACTERIA
SG10201601660YA (en) 2007-09-18 2016-04-28 Takeda Vaccines Inc Method of conferring a protective immune response to norovirus
KR101793161B1 (ko) 2008-08-08 2017-11-03 다케다 백신즈 인코포레이티드 강화된 교차 반응성을 가진 복합체 캡시드 아미노산 서열들을 포함하는 바이러스-유사 입자들
EP2346901A1 (en) * 2008-10-20 2011-07-27 Abbott Laboratories Antibodies that bind to il-18 and methods of purifying the same
JP5755136B2 (ja) * 2009-03-27 2015-07-29 旭化成メディカル株式会社 高濃度モノクローナル抗体溶液中のウイルス除去方法
WO2012083363A1 (en) * 2010-12-22 2012-06-28 Murdoch Childrens Research Institute A method of treatment
EP3299030B1 (en) 2011-07-11 2022-06-08 Takeda Vaccines, Inc. Parenteral norovirus vaccine formulations
JOP20130186B1 (ar) 2012-06-22 2021-08-17 Takeda Vaccines Montana Inc تنقية الجزيئات الشبيهة بالفيروسات
AU2014329403B2 (en) 2013-10-03 2020-10-08 Takeda Vaccines, Inc. Methods of detection and removal of rhabdoviruses from cell lines
KR20250121616A (ko) 2015-11-01 2025-08-12 글리코백, 엘엘씨 바이러스 비함유 세포주 및 이를 획득하기 위한 방법
CN114807009A (zh) 2022-03-28 2022-07-29 成都纳微金生物技术有限公司 一种不依赖血清的无弹状病毒污染的sf9细胞株、筛选方法及应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102605106B (zh) * 2012-03-29 2013-09-04 浙江省检验检疫科学技术研究院 蚕微孢子虫、核型多角体病毒和浓核病毒的三重荧光pcr检测方法及试剂盒和引物、探针

Also Published As

Publication number Publication date
JP2023024506A (ja) 2023-02-16
CN106103720A (zh) 2016-11-09
SG10201802772YA (en) 2018-05-30
US12018052B2 (en) 2024-06-25
JP2020036613A (ja) 2020-03-12
US12006341B2 (en) 2024-06-11
CA2926225A1 (en) 2015-04-09
AU2022259826B2 (en) 2025-01-02
AU2014329403B2 (en) 2020-10-08
AU2020294216A1 (en) 2021-01-28
KR102649950B1 (ko) 2024-03-22
US20250109172A1 (en) 2025-04-03
EP3052631A4 (en) 2017-06-14
US20220213150A1 (en) 2022-07-07
WO2015051255A1 (en) 2015-04-09
SG10202107054TA (en) 2021-08-30
US11286282B2 (en) 2022-03-29
KR20160062049A (ko) 2016-06-01
US10501500B2 (en) 2019-12-10
EP3052631B1 (en) 2019-08-07
KR20210154988A (ko) 2021-12-21
EP3052631A1 (en) 2016-08-10
SG11201602585XA (en) 2016-05-30
JP2016533172A (ja) 2016-10-27
US12479891B2 (en) 2025-11-25
US20230303633A1 (en) 2023-09-28
AU2020294216B2 (en) 2022-11-24
AU2022259826A1 (en) 2023-01-19
US20200190146A1 (en) 2020-06-18
JP7191175B2 (ja) 2022-12-16
JP2023126495A (ja) 2023-09-07
JP2022009010A (ja) 2022-01-14
AU2014329403A1 (en) 2016-05-05
JP2024050747A (ja) 2024-04-10
US20160244487A1 (en) 2016-08-25

Similar Documents

Publication Publication Date Title
AU2020294216B2 (en) Methods of detection and removal of rhabdoviruses from cell lines
WO2022245888A1 (en) Seasonal flu rna vaccines and methods of use
RU2519210C2 (ru) Вакцины, содержащие генетические варианты парвовируса собак
Luo et al. Amino acid mutation in position 349 of glycoprotein affect the pathogenicity of rabies virus
US20100196420A1 (en) Immunogenic compositions, vaccines and diagnostics based on canine distemper viruses circulating in north american dogs
Makovitzki et al. Evaluation of a downstream process for the recovery and concentration of a Cell-Culture-Derived rVSV-Spike COVID-19 vaccine candidate
KR20230041686A (ko) 아넬로바이러스를 확인 및 특징화하는 방법 및 이의 용도
EP3121268B1 (en) Methods for purification of a virus produced in vitro and clearance assay for the virus
US7794928B2 (en) Norovirus detection, methods and compositions therefor
HK1227433A1 (en) Methods of detection and removal of rhabdoviruses from cell lines
HK1227433B (en) Methods of detection and removal of rhabdoviruses from cell lines
EP2331117B1 (en) Vaccines containing canine parvovirus genetic variants
CN120700002A (zh) 携带polyUC的重组寨卡病毒及其应用
EP4466014A1 (en) A live attenuated sars-cov-2 and a vaccine made thereof
HK1231118B (en) Methods for purification of a virus produced in vitro and clearance assay for the virus

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

A201 Request for examination
AMND Amendment
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

D13-X000 Search requested

St.27 status event code: A-1-2-D10-D13-srh-X000

D14-X000 Search report completed

St.27 status event code: A-1-2-D10-D14-srh-X000

AMND Amendment
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

AMND Amendment
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E601 Decision to refuse application
PE0601 Decision on rejection of patent

St.27 status event code: N-2-6-B10-B15-exm-PE0601

X091 Application refused [patent]
A107 Divisional application of patent
AMND Amendment
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A18-div-PA0104

St.27 status event code: A-0-1-A10-A16-div-PA0104

PX0901 Re-examination

St.27 status event code: A-2-3-E10-E12-rex-PX0901

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

AMND Amendment
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PX0701 Decision of registration after re-examination

St.27 status event code: A-3-4-F10-F13-rex-PX0701

X701 Decision to grant (after re-examination)
GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-OTH-PR1001 (AS PROVIDED BY THE NATIONAL OFFICE)

Year of fee payment: 4