KR102428987B1 - 차나무의 추출물을 함유하는 조성물 - Google Patents
차나무의 추출물을 함유하는 조성물 Download PDFInfo
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- KR102428987B1 KR102428987B1 KR1020170060641A KR20170060641A KR102428987B1 KR 102428987 B1 KR102428987 B1 KR 102428987B1 KR 1020170060641 A KR1020170060641 A KR 1020170060641A KR 20170060641 A KR20170060641 A KR 20170060641A KR 102428987 B1 KR102428987 B1 KR 102428987B1
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- extract
- tea tree
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- weight
- tea
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KR1020170060641A KR102428987B1 (ko) | 2017-05-16 | 2017-05-16 | 차나무의 추출물을 함유하는 조성물 |
PCT/KR2018/005605 WO2018212588A1 (fr) | 2017-05-16 | 2018-05-16 | Composition contenant un extrait de camellia sinensis |
CN201880032982.9A CN111050783A (zh) | 2017-05-16 | 2018-05-16 | 含茶树提取物的组合物 |
MYPI2019006749A MY197901A (en) | 2017-05-16 | 2018-05-16 | Composition containing camellia sinensis extract |
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KR (1) | KR102428987B1 (fr) |
CN (1) | CN111050783A (fr) |
MY (1) | MY197901A (fr) |
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FR3116438B1 (fr) | 2020-11-23 | 2022-10-14 | Isp Investments Llc | Procede d’obtention d’extraits aqueux de feuilles de thes, compositions comprenant de tels extraits et leurs utilisations cosmetiques |
CN112545909B (zh) * | 2020-12-14 | 2022-06-21 | 湖南农业大学 | 一种茶黄素组合物及其应用 |
FR3125425A1 (fr) | 2021-07-22 | 2023-01-27 | Isp Investments Llc | Extrait de feuilles de the noir, compositions le comprenant et ses utilisations cosmetiques |
KR102462676B1 (ko) | 2021-10-05 | 2022-11-03 | 권휘 | 차종의 외피를 활용한 차 제다 방법 |
KR20230136988A (ko) | 2022-03-21 | 2023-10-04 | 영남대학교 산학협력단 | 에피갈로카테킨 갈레이트를 유효성분으로 포함하는 테트라넥틴 활성 억제용 조성물 |
KR20230170163A (ko) | 2022-06-09 | 2023-12-19 | 대한민국(농촌진흥청장) | 신품종 차나무 및 이의 육종방법 |
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JP2007060957A (ja) | 2005-08-30 | 2007-03-15 | National Agriculture & Food Research Organization | 飲料及びその製造方法 |
WO2015199169A1 (fr) | 2014-06-27 | 2015-12-30 | 国立大学法人九州大学 | Procédé d'amélioration de la fonction de la catéchine |
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ES2275463T3 (es) * | 1999-08-16 | 2007-06-16 | Dsm Ip Assets B.V. | Proceso para la produccion de galato de epigalocatequina. |
EP1157693A1 (fr) * | 2000-05-12 | 2001-11-28 | National Agricultural Research Organisation (NARO) | Utilisation de l'epigallocatechin 3-o-(3-o-methyl) gallate et/ou l'epigallocatechin 3-o-(4-o-methyl) gallate pour le traitement de l'allergie et/ou l'inflammation |
CN1951383A (zh) * | 2005-10-17 | 2007-04-25 | 美国安乃仁生命科技公司 | 稳定化含儿茶素医药及化妆品用组合物 |
KR101213200B1 (ko) * | 2009-08-24 | 2012-12-18 | 주식회사 장원 | 신품종 차나무의 육종방법 |
KR20160069738A (ko) * | 2014-12-09 | 2016-06-17 | (주)아모레퍼시픽 | 메틸화된 카테킨을 유효성분으로 함유하는 ercc8 유전자 활성화용 조성물 |
KR20160069737A (ko) * | 2014-12-09 | 2016-06-17 | (주)아모레퍼시픽 | 메틸화된 카테킨을 유효성분으로 함유하는 Sirt-1 유전자 활성화용 조성물 |
CN104820059B (zh) * | 2015-04-22 | 2016-07-06 | 湖南农业大学 | 一种快速筛选含有EGCG3"Me茶树资源的方法 |
KR101722429B1 (ko) * | 2015-04-27 | 2017-04-04 | 강원대학교산학협력단 | 메틸화카테킨을 유효성분으로 함유하는 항피부노화용 조성물 |
KR101722427B1 (ko) * | 2015-04-27 | 2017-04-04 | 강원대학교산학협력단 | 메틸화카테킨을 유효성분으로 함유하는 암세포의 성장억제용 조성물 |
-
2017
- 2017-05-16 KR KR1020170060641A patent/KR102428987B1/ko active IP Right Grant
-
2018
- 2018-05-16 CN CN201880032982.9A patent/CN111050783A/zh active Pending
- 2018-05-16 WO PCT/KR2018/005605 patent/WO2018212588A1/fr active Application Filing
- 2018-05-16 MY MYPI2019006749A patent/MY197901A/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007060957A (ja) | 2005-08-30 | 2007-03-15 | National Agriculture & Food Research Organization | 飲料及びその製造方法 |
WO2015199169A1 (fr) | 2014-06-27 | 2015-12-30 | 国立大学法人九州大学 | Procédé d'amélioration de la fonction de la catéchine |
Non-Patent Citations (1)
Title |
---|
FENG-LAN CHIU 외. J. Agric. Food Chem. 2005, Vol. 53, pp. 7035-7042* |
Also Published As
Publication number | Publication date |
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WO2018212588A1 (fr) | 2018-11-22 |
CN111050783A (zh) | 2020-04-21 |
KR20180125828A (ko) | 2018-11-26 |
MY197901A (en) | 2023-07-24 |
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