KR20100054772A - 비타민나무 추출물 및 이의 분획물 - Google Patents
비타민나무 추출물 및 이의 분획물 Download PDFInfo
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- KR20100054772A KR20100054772A KR1020100031410A KR20100031410A KR20100054772A KR 20100054772 A KR20100054772 A KR 20100054772A KR 1020100031410 A KR1020100031410 A KR 1020100031410A KR 20100031410 A KR20100031410 A KR 20100031410A KR 20100054772 A KR20100054772 A KR 20100054772A
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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Abstract
Description
a: 뿌리; 및,
b: 줄기.
도 2는 산자나무 추출물 및 이의 분획물의 α-글루코시다아제 활성을 나타낸 도이다:
a: 뿌리; 및,
b: 줄기.
추출물 및 이의 분획물 | RC50 1 ) (㎍/㎖) | |
뿌리 | 줄기 | |
MeOH 추출물 | 5 ± 0.5 | 2.7 ± 0.5 |
물 추출물 | 10.9 ± 0.43 | 4.1 ± 0.24 |
EtOH 추출물 | 4.3 ± 0.56 | 2.6 ± 0.32 |
Hexane 분획물 | 3 ± 1.0 | 3.2 ± 0.23 |
EtOAc 분획물 | 1.5 ± 0.29 | 1 ± 0.35 |
BuOH 분획물 | 2.5 ± 0.58 | 1.4 ± 0.2 |
수용성 분획물 | 9.5 ± 0.2 | 3.3 ± 0.2 |
BHT | 34 ± 0.58 | |
BHA | 14 ± 0.5 | |
α-토코페롤 | 12 ± 1.15 |
농도 (ppm) |
SOD 유사 활성1 ) | ||||||||
MeOH 추출물 | 물 추출물 | EtOH 추출물 | Hexane 분획물 | EtOAc 분획물 | BuOH 분획물 | 수용성 분획물 | 아스코르브산 | ||
뿌리 | 100 | 3.4± 0.1 | 1.5± 0.2 | 4.4± 0.4 | 7.3± 0.2 | 2.9± 0.3 | 1.1± 0.3 | 0.5± 0.3 | 32.5± 0.5 |
1,000 | 12.8± 1 | 10.8± 1.2 | 21.4± 1.8 | 65.7± 0.12 | 25.7± 1.4 | 11.7± 0.4 | 11.3± 2.0 | 68.5± 0.5 | |
5,000 | 44.3± 2.0 | 20.1± 1.0 | 66.1± 2.2 | 92.4± 0.3 | 67.9± 2.0 | 41.1± 2.0 | 24.1± 1.5 | <99.0 | |
10,000 | 66.6± 0.1 | 30.1± 0.5 | 75.2± 0.2 | 95.1± 0.1 | 80.4± 2.0 | 58.7± 2.0 | 33.7± 2.0 | <99.0줄기 | |
줄기 | 100 | 2.1± 0.4 | 1.6± 0.3 | 2.3± 0.5 | 9.1± 1.4 | 2.2± 0.5 | 8.0± 0.5 | 2.6± 0.4 | 32.5± 0.5 |
1,000 | 25.4± 1.5 | 20.1± 1.4 | 28.3± 0.5 | 73.4± 1.0 | 31.4± 1.5 | 21.3± 2.0 | 21.8± 0.4 | 68.5± 0.5 | |
5,000 | 69.8± 1.4 | 35.7± 0.5 | 53.5± 0.7 | 92.9± 0.2. | 54.0± 0.3 | 58.5± 0.5 | 39.7± 1.7 | <99.0 | |
10,000 | 72.6± 1.4 | 45.3± 1.2 | 58.6± 1.0 | 94.6± 0.3 | 58.0± 2.0 | 61.2± 0.5 | 48.5± 1.2 | <99.0 |
추출물 및 이의 분획물 | MIC1 ) (㎍/㎖) | |||||||
세균 | 진균 | |||||||
Gram (+) Gram (-) | ||||||||
B.s. 1) | S.a. 1) | E.c. 1) | S.t. 1) | K.p. 1) | P.j. 1) | C.a. 1) | ||
뿌리 | MeOH 추출물 | 1000 | 500 | 500 | 1000 | 1000 | 125 | 125 |
물 추출물 | 500 | 1000 | 500 | 500 | 1000 | 125 | 125 | |
EtOH 추출물 | 500 | 250 | 250 | 500 | 1000 | 125 | 125 | |
Hexane 분획물 | 1000 | 1000 | 500 | 1000 | 1000 | 125 | 125 | |
EtOAc 분획물 | 500 | 250 | 250 | 500 | 1000 | 125 | 125 | |
BuOH 분획물 | 500 | 125 | 500 | 500 | 1000 | 125 | 125 | |
수용성 분획물 | 500 | 1000 | 500 | 500 | 1000 | 125 | 125 | |
줄기 | MeOH 추출물 | 500 | 250 | 500 | 1000 | 1000 | 125 | 62 |
물 추출물 | 500 | 500 | 500 | 500 | 500 | 125 | 125 | |
EtOH 추출물 | 500 | 250 | 250 | 500 | 1000 | 125 | 62 | |
Hexane 분획물 | 1000 | 250 | 500 | 500 | 1000 | 62 | 62 | |
EtOAc 분획물 | 1000 | 125 | 250 | 500 | 1000 | 62 | 62 | |
BuOH 분획물 | 125 | 500 | 500 | 500 | 500 | 125 | 125 | |
수용성 분획물 | 500 | 500 | 500 | 500 | 500 | 125 | 125 | |
(+)-카테킨 | 1000< | 1000< | 1000< | 1000< | 1000< | 500 | 500 | |
Ketoconazol | - | - | - | - | - | 250 | 250 | |
Mycostantin | - | - | - | - | - | 500 | 500 | |
테트라시클린 | 8 | 8 | 8 | 8 | 8 | - | - |
원료 | 함량(중량부) |
산자나무 추출물 또는 분획물 | 10.00 |
1,3-부틸렌글리콜 | 1.00 |
디소듐이디티에이 | 0.05 |
알란토인 | 0.10 |
디포타슘글리시리제이트 | 0.05 |
시트릭애씨드 | 0.01 |
소듐시트레이트 | 0.02 |
글리세레스-26 | 1.00 |
알부틴 | 2.00 |
하이드로제네이티드캐스터오일 | 1.00 |
에탄올 | 30.00 |
보존제 | 미량 |
착색제 | 미량 |
착향제 | 미량 |
정제수 | 잔량 |
원료 | 함량(중량부) |
산자나무 추출물 또는 분획물 | 10.0 |
1,3-부틸렌 글리콜 | 7.0 |
글리세린 | 1.0 |
D-판테놀 | 0.1 |
식물 추출물 | 3.2 |
마그네슘알루미늄실리케이트 | 0.3 |
PEG-40 스테아레이트 | 1.2 |
스테아릭애씨드 | 2.0 |
폴리소르베이트 60 | 1.5 |
친유형글리세릴스테아레이트 | 2.0 |
소르비탄세스퀴올리에이트 | 1.5 |
세테아릴알코올 | 3.0 |
미네랄오일 | 4.0 |
스쿠알란 | 3.8 |
카르릴릭/카프릭트리글리세라이드 | 2.8 |
식물성 오일 | 1.8 |
디메치콘 | 0.4 |
디포타슘글리시리제이트 | 미량 |
알란토인 | 미량 |
소듐 히아루로네이트 | 미량 |
토코페릴아세테이트 | 적량 |
트리에탄올아민 | 적량 |
보존제 | 적량 |
착향제 | 적량 |
정제수 | 잔량 |
Claims (10)
- 산자나무 잎, 뿌리 또는 줄기 추출물 또는 그의 유기 용매 분획물을 유효성분으로 포함하는 항산화제.
- 제 1항에 있어서, 추출물은 물, 알콜 또는 이들의 혼합물로 추출한 것을 특징으로 하는 항산화제.
- 제 1항에 있어서, 유기 용매 분획물은 산자나무 잎, 뿌리 또는 줄기 추출물을 물에 녹인 후 헥산, 에틸 아세테이트, 부탄올을 순차적으로 이용하여 분획한 헥산 분획물, 에틸 아세테이트 분획물, 부탄올 분획물 및 물 분획물 중 어느 하나인 것을 특징으로 하는 항산화제.
- 산자나무 잎, 뿌리 또는 줄기 추출물 또는 그의 유기 용매 분획물을 유효성분으로 포함하는 활성 산소가 과량으로 축적되어 발병하는 질환의 예방 및 치료용 약학적 조성물.
- 제 4항에 있어서, 활성 산소가 과량으로 축적되어 발병되는 질환은 간장 질환, 뇌졸중, 심근경색, 당뇨병성 혈관장애, 고지혈증, 급성염증, 류마티스, 암으로 이루어진 군으로부터 선택된 어느 하나인 것을 특징으로 하는 약학적 조성물.
- 제 4항에 있어서, 추출물은 물, 알콜 또는 이들의 혼합물로 추출한 것을 특징으로 하는 약학적 조성물.
- 제 4항에 있어서, 유기 용매 추출물은 산자나무 잎, 뿌리 또는 줄기 추출물을 물에 녹인 후 헥산, 에틸 아세테이트, 부탄올을 순차적으로 이용하여 분획한 헥산 분획물, 에틸 아세테이트 분획물, 부탄올 분획물 및 물 분획물 중 어느 하나인 것을 특징으로 하는 약학적 조성물.
- 산자나무 잎, 뿌리 또는 줄기 추출물 또는 그의 유기 용매 분획물을 유효성분으로 포함하는 노화방지용 조성물.
- 제 8항에 있어서, 추출물은 물, 알콜 또는 이들의 혼합물로 추출한 것을 특징으로 하는 노화방지용 조성물.
- 제 8항에 있어서, 유기 용매 추출물은 산자나무 잎, 뿌리 또는 줄기 추출물을 물에 녹인 후 헥산, 에틸 아세테이트, 부탄올을 순차적으로 이용하여 분획한 헥산 분획물, 에틸 아세테이트 분획물, 부탄올 분획물 및 물 분획물 중 어느 하나인 것을 특징으로 하는 노화방지용 조성물.
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KR20150025545A (ko) * | 2013-08-29 | 2015-03-11 | 신 훈 강 | 비타민나무 과즙을 포함하는 식품 조성물 |
WO2016076531A1 (ko) * | 2014-11-11 | 2016-05-19 | 주식회사 아미코스메틱 | 비타민 10가지 성분을 함유한 피부 개선용 조성물 |
WO2022071692A1 (ko) * | 2020-09-29 | 2022-04-07 | 한국식품연구원 | 비타민나무 잎 추출물을 유효성분으로 함유하는 당뇨합병증의 개선, 예방 또는 치료용 조성물 |
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Cited By (3)
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KR20150025545A (ko) * | 2013-08-29 | 2015-03-11 | 신 훈 강 | 비타민나무 과즙을 포함하는 식품 조성물 |
WO2016076531A1 (ko) * | 2014-11-11 | 2016-05-19 | 주식회사 아미코스메틱 | 비타민 10가지 성분을 함유한 피부 개선용 조성물 |
WO2022071692A1 (ko) * | 2020-09-29 | 2022-04-07 | 한국식품연구원 | 비타민나무 잎 추출물을 유효성분으로 함유하는 당뇨합병증의 개선, 예방 또는 치료용 조성물 |
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