KR102428569B1 - 방사성 핵종 표지 화합물 및 이것을 함유하는 이미징제 - Google Patents

방사성 핵종 표지 화합물 및 이것을 함유하는 이미징제 Download PDF

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KR102428569B1
KR102428569B1 KR1020207023105A KR20207023105A KR102428569B1 KR 102428569 B1 KR102428569 B1 KR 102428569B1 KR 1020207023105 A KR1020207023105 A KR 1020207023105A KR 20207023105 A KR20207023105 A KR 20207023105A KR 102428569 B1 KR102428569 B1 KR 102428569B1
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tau
radionuclide
amyloid
imaging
compound
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KR20200109335A (ko
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빈 지
마코토 히구치
테츠야 스하라
춘-젠 첸
오스케 후지모토
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상하이 차트웰 메디컬 사이언스 앤 테크놀로지 컴퍼니 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020207023105A 2018-01-12 2019-01-11 방사성 핵종 표지 화합물 및 이것을 함유하는 이미징제 Active KR102428569B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2018-003564 2018-01-12
JP2018003564A JP6831802B2 (ja) 2018-01-12 2018-01-12 放射性核種標識化合物及びこれを含有するイメージング剤
PCT/IB2019/000060 WO2019138296A2 (ja) 2018-01-12 2019-01-11 放射性核種標識化合物及びこれを含有するイメージング剤

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KR20200109335A KR20200109335A (ko) 2020-09-22
KR102428569B1 true KR102428569B1 (ko) 2022-08-03

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JP (1) JP6831802B2 (https=)
KR (1) KR102428569B1 (https=)
CN (1) CN111556868B (https=)
TW (1) TWI818946B (https=)
WO (1) WO2019138296A2 (https=)

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Publication number Priority date Publication date Assignee Title
CA3190550A1 (en) * 2020-08-25 2022-03-03 Makoto Higuchi Novel compound, .alpha.-synuclein aggregate binder, and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009007348A (ja) * 2007-05-30 2009-01-15 Fujifilm Ri Pharma Co Ltd アミロイドの凝集及び／又は沈着に起因する疾患のイメージング薬及び治療薬

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
CA2444214A1 (en) * 2001-04-23 2002-10-31 The Trustees Of The University Of Pennsylvania Amyloid plaque aggregation inhibitors and diagnostic imaging agents
CA2500358A1 (en) * 2003-08-13 2005-02-24 Bf Research Institute, Inc. Probes for diseases in which amyloid accumulates, agents for staining amyloid, drugs for treatment and prophylaxis of diseases with accumulated amyloid, and probes for diagnosis of neurofibrillary tangles and agents for staining neurofibrillary tangles
WO2005016384A1 (ja) * 2003-08-13 2005-02-24 Bf Research Institute, Inc. アミロイド蓄積性疾患のプローブ、アミロイド染色剤、アミロイド蓄積性疾患の治療および予防薬、ならびに神経原線維変化の診断プローブおよび染色剤
WO2007063946A1 (ja) * 2005-11-30 2007-06-07 Fujifilm Ri Pharma Co., Ltd. アミロイドの凝集及び／又は沈着に起因する疾患の診断薬及び治療薬
CN101466711A (zh) * 2006-05-19 2009-06-24 日本医事物理股份有限公司 对淀粉状蛋白具有亲和性的新化合物
WO2008078424A1 (ja) * 2006-12-25 2008-07-03 Tohoku University ベンゾキサゾール誘導体
AU2009260519A1 (en) * 2008-05-30 2009-12-23 Merck Sharp & Dohme Corp. Novel substituted azabenzoxazoles
AU2012259929B2 (en) * 2011-05-20 2016-08-04 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
CA2839199C (en) * 2011-06-24 2018-11-06 Nihon Medi-Physics Co., Ltd. Novel compound with amyloid affinity
DK2767532T3 (en) * 2012-12-21 2016-09-12 Nat Inst For Quantum And Radiological Science And Tech New connection for reproduction of tau protein heavy in the brain.
CN105229009B (zh) * 2013-05-23 2017-09-29 豪夫迈·罗氏有限公司 作为成像剂的2‑苯基咪唑并[1,2‑a]嘧啶

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009007348A (ja) * 2007-05-30 2009-01-15 Fujifilm Ri Pharma Co Ltd アミロイドの凝集及び／又は沈着に起因する疾患のイメージング薬及び治療薬

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Publication number Publication date
CN111556868A (zh) 2020-08-18
WO2019138296A2 (ja) 2019-07-18
WO2019138296A3 (ja) 2019-10-03
KR20200109335A (ko) 2020-09-22
TW201929909A (zh) 2019-08-01
JP6831802B2 (ja) 2021-02-17
JP2019123675A (ja) 2019-07-25
TWI818946B (zh) 2023-10-21
CN111556868B (zh) 2023-03-28

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