KR102420323B1 - 아미노에스터 유도체 - Google Patents

아미노에스터 유도체 Download PDF

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Publication number
KR102420323B1
KR102420323B1 KR1020167032346A KR20167032346A KR102420323B1 KR 102420323 B1 KR102420323 B1 KR 102420323B1 KR 1020167032346 A KR1020167032346 A KR 1020167032346A KR 20167032346 A KR20167032346 A KR 20167032346A KR 102420323 B1 KR102420323 B1 KR 102420323B1
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KR
South Korea
Prior art keywords
ethyl
methyl
phenyl
ium
oxido
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Expired - Fee Related
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KR1020167032346A
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English (en)
Korean (ko)
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KR20170015294A (ko
Inventor
엘리사베타 아르마니
가브리엘 아마리
카르멜리다 카팔디
웨슬리 블랙커비
이안 린니
에르베 반 드 포엘
찰스 베이커-글렌
나이미샤 트리베디
Original Assignee
키에시 파르마슈티시 엣스. 피. 에이.
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Publication of KR20170015294A publication Critical patent/KR20170015294A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)
KR1020167032346A 2014-06-05 2015-06-03 아미노에스터 유도체 Expired - Fee Related KR102420323B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14171266.1 2014-06-05
EP14171266 2014-06-05
PCT/EP2015/062417 WO2015185649A1 (en) 2014-06-05 2015-06-03 Aminoester derivatives

Publications (2)

Publication Number Publication Date
KR20170015294A KR20170015294A (ko) 2017-02-08
KR102420323B1 true KR102420323B1 (ko) 2022-07-13

Family

ID=50884281

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020167032346A Expired - Fee Related KR102420323B1 (ko) 2014-06-05 2015-06-03 아미노에스터 유도체

Country Status (32)

Country Link
US (2) US9763924B2 (https=)
EP (1) EP3152201B1 (https=)
JP (1) JP2017516824A (https=)
KR (1) KR102420323B1 (https=)
CN (1) CN106459020B (https=)
AR (1) AR100732A1 (https=)
AU (1) AU2015270539B2 (https=)
BR (1) BR112016026725B1 (https=)
CA (1) CA2953198C (https=)
CL (1) CL2016003117A1 (https=)
CY (1) CY1120698T1 (https=)
DK (1) DK3152201T3 (https=)
EA (1) EA032761B1 (https=)
ES (1) ES2688826T3 (https=)
GE (2) GEAP201814338A (https=)
HR (1) HRP20181967T1 (https=)
HU (1) HUE042119T2 (https=)
IL (1) IL249325B (https=)
LT (1) LT3152201T (https=)
MA (1) MA39947B1 (https=)
MX (1) MX377669B (https=)
PE (1) PE20161557A1 (https=)
PH (1) PH12016502221A1 (https=)
PL (1) PL3152201T3 (https=)
PT (1) PT3152201T (https=)
RS (1) RS57787B1 (https=)
SG (1) SG11201610132RA (https=)
SI (1) SI3152201T1 (https=)
TN (1) TN2016000546A1 (https=)
TW (1) TW201625600A (https=)
WO (1) WO2015185649A1 (https=)
ZA (1) ZA201608331B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016177849A1 (en) 2015-05-07 2016-11-10 Chiesi Farmaceutici S.P.A. Aminoester derivatives
AR104829A1 (es) * 2015-06-01 2017-08-16 Chiesi Farm Spa Derivados de aminoésteres
AR104822A1 (es) * 2015-06-01 2017-08-16 Chiesi Farm Spa Derivado de aminoésteres
CN106866474B (zh) * 2017-02-16 2018-12-28 陕西师范大学 一种手性α-芳基甘氨酸酯衍生物的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009018909A2 (en) 2007-08-08 2009-02-12 Chiesi Farmaceutici S.P.A. Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors
US20090203657A1 (en) 2008-02-06 2009-08-13 Glaxo Group Limited Dual Pharmacophores - PDE4-Muscarinic Antagonistics
WO2010089107A1 (en) 2009-02-06 2010-08-12 Chiesi Farmaceutici S.P.A. Benzoic acid (1-phenyl-2-pyridin-4-yl) ethyl esters as phosphodiesterase inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1213245A1 (zh) 2012-12-05 2016-06-30 奇斯药制品公司 作为pde4抑制剂的苯乙基吡啶衍生物
HK1212988A1 (zh) 2012-12-05 2016-07-22 奇斯药制品公司 作为pde-4抑制剂的苯基乙基吡啶衍生物
WO2014086852A1 (en) 2012-12-05 2014-06-12 Chiesi Farmaceutici S.P.A. Phenylethylpyridine derivatives as pde4-inhibitors
RU2016121852A (ru) 2013-12-05 2017-12-07 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Производные бензгидрила для лечения респираторных заболеваний
US9133185B2 (en) 2013-12-05 2015-09-15 Chiesi Farmaceutici S.P.A Heteroaryl derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009018909A2 (en) 2007-08-08 2009-02-12 Chiesi Farmaceutici S.P.A. Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors
US20090203657A1 (en) 2008-02-06 2009-08-13 Glaxo Group Limited Dual Pharmacophores - PDE4-Muscarinic Antagonistics
WO2010089107A1 (en) 2009-02-06 2010-08-12 Chiesi Farmaceutici S.P.A. Benzoic acid (1-phenyl-2-pyridin-4-yl) ethyl esters as phosphodiesterase inhibitors

Also Published As

Publication number Publication date
SG11201610132RA (en) 2017-01-27
EP3152201A1 (en) 2017-04-12
IL249325A0 (en) 2017-02-28
US20150352091A1 (en) 2015-12-10
WO2015185649A1 (en) 2015-12-10
BR112016026725B1 (pt) 2024-02-27
CN106459020B (zh) 2019-06-18
EA201692227A1 (ru) 2017-05-31
EP3152201B1 (en) 2018-08-29
AU2015270539B2 (en) 2018-11-08
HRP20181967T1 (hr) 2019-02-08
KR20170015294A (ko) 2017-02-08
BR112016026725A2 (pt) 2017-08-15
CY1120698T1 (el) 2019-12-11
CA2953198A1 (en) 2015-12-10
BR112016026725A8 (pt) 2021-06-29
ZA201608331B (en) 2018-05-30
WO2015185649A9 (en) 2017-01-05
US20170340616A1 (en) 2017-11-30
JP2017516824A (ja) 2017-06-22
PT3152201T (pt) 2018-10-26
EA032761B1 (ru) 2019-07-31
TN2016000546A1 (en) 2018-04-04
GEAP201814338A (en) 2018-07-25
PE20161557A1 (es) 2017-02-07
DK3152201T3 (en) 2018-11-19
LT3152201T (lt) 2018-10-10
MX2016015958A (es) 2017-04-10
CN106459020A (zh) 2017-02-22
IL249325B (en) 2018-12-31
MA39947A (fr) 2017-04-12
AR100732A1 (es) 2016-10-26
PL3152201T3 (pl) 2019-02-28
MX377669B (es) 2025-03-11
MA39947B1 (fr) 2018-10-31
AU2015270539A1 (en) 2016-12-22
US10117860B2 (en) 2018-11-06
GEP20186922B (en) 2018-11-12
US9763924B2 (en) 2017-09-19
CL2016003117A1 (es) 2017-06-23
TW201625600A (zh) 2016-07-16
CA2953198C (en) 2023-06-13
ES2688826T3 (es) 2018-11-07
RS57787B1 (sr) 2018-12-31
PH12016502221A1 (en) 2017-02-06
HUE042119T2 (hu) 2019-06-28
SI3152201T1 (sl) 2018-10-30

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