KR102405779B1 - Functional composition containing nettle and manufacturing method thereof - Google Patents

Abstract

The present invention relates to a composition containing nettle and a method for preparing the same, and more particularly, to a cosmetic composition, a pharmaceutical composition, and a method for preparing the same, including a nettle extract and an Espenozilia extract as active ingredients, with improved antioxidant function will be.

Description

Functional composition containing nettle and manufacturing method thereof {Functional composition containing nettle and manufacturing method thereof}

The present invention relates to a composition containing nettle and a method for preparing the same, and more particularly, to a cosmetic composition, a pharmaceutical composition, and a method for preparing the same, including a nettle extract and an Espenozilia extract as active ingredients, with improved antioxidant function will be.

The human body has about 100,000 to 150,000 hairs, and each hair has a different cycle between 3 to 6 years and repeats the anagen, catagen, and telogen phases, and the average daily 50 to 100 hairs fall out normally.

Although the mechanism of hair loss is not yet known precisely, it is generally known that it is caused by an unbalanced diet, excessive drinking and smoking, drug use, lack of sleep, excessive stress, childbirth, menopausal disorders, frequent perms and dyeing, and hormonal imbalance. . The hair that grows on the human head maintains a certain cycle, but when hair loss progresses due to the above various causes, the number of hair loss increases as the hair on the crown or forehead first becomes thin and the strength begins to disappear. That is, there is a general trend that people with baldness due to hair loss due to genetic factors, acquired natural hair loss, various diseases, etc. are increasing, and bald people not only receive severe mental stress, but also put a lot of effort to treat it. It is leaning.

Among them, seborrheic hair loss is caused by seborrheic scalpitis. Abnormal increase in the amount of sebum secretion of the scalp, imbalance of microbial distribution, abnormal immune response, abnormality of neurotransmitters, etc. are presumed to be the causes, and if the inflammation of the scalp is severe, hair loss may progress temporarily. When the inflammation is relieved, the symptoms of hair loss are also restored.

Therefore, it is important to maintain the balance of oil and moisture in the skin in order to prevent or treat the seborrheic hair loss. As an organ in constant contact with the external environment, the skin prevents the intrusion of mechanically and chemically harmful substances, prevents the loss of internal moisture from the external environment that is drier than the living body, and at the same time, the stratum corneum itself retains adequate moisture. maintaining flexibility.

However, despite these functions, the balance of oil and moisture may be disturbed in the skin due to bad weather, strong UV rays, excessive use of face wash, stress and natural skin aging. Due to lack of ability, preparation for seborrheic hair loss is insufficient.

Accordingly, the present invention is to solve various drawbacks and problems caused by the prior art in consideration of the above circumstances, and to provide a cosmetic composition containing nettle and a method for manufacturing the same, maintaining the oil and moisture balance of the skin aims to make

In addition, the problems to be solved by the present invention are not limited to the problems mentioned above, and other problems not mentioned will be clearly understood by those skilled in the art from the following description.

According to one embodiment of the present invention in order to achieve the above object, there is provided a cosmetic composition for skin improvement comprising a nettle extract as an active ingredient.

Also, in the present invention, the composition may further include Espinozilia extract as an active ingredient.

Also, in the present invention, the composition may further include black bean extract as an active ingredient.

In addition, in the present invention, the composition may further include black sesame extract, sangbaekpi extract, and sewage extract as active ingredients.

Also, in the present invention, the black sesame extract is prepared by extracting 15 to 50 parts by weight of black sesame dry weight based on 100 parts by weight of nettle dry weight, and the sangbaekpi extract is sangbaekpi dry weight based on 100 parts by weight of nettle dry weight It is prepared by extracting 15 to 50 parts by weight, and the sewage extract may be prepared by extracting 15 to 30 parts by weight of sewage by dry weight based on 100 parts by weight of nettle dry weight.

In addition, in the present invention, the composition may be to further include eoseongcho extract as an active ingredient.

Also in the present invention, the eoseongcho extract may be prepared from eoseongcho containing 20% or more moisture.

According to another embodiment of the present invention, a pharmaceutical composition for preventing or treating seborrheic hair loss comprising a nettle extract as an active ingredient may be provided.

When the cosmetic composition and the pharmaceutical composition comprising the nettle extract according to the present invention act on the skin, it can have an effect of preventing or treating seborrheic hair loss by controlling the oil and moisture balance of the skin.

Effects of the present invention are not limited to the effects mentioned above, and other effects not mentioned will be clearly understood by those skilled in the art from the following description.

1 shows the result of confirming the IL-6 expression level when the functional composition according to the present invention is treated.

Hereinafter, the present invention will be described in detail in order to achieve the above object. Prior to this, the terms or words used in the present specification and claims should not be construed as being limited to conventional or dictionary meanings, and the inventor should properly understand the concept of the term in order to best describe his invention. It should be interpreted as meaning and concept consistent with the technical idea of the present invention based on the principle that it can be defined in Therefore, the configuration described in the embodiment described in this specification is only the most preferred embodiment of the present invention and does not represent all the technical spirit of the present invention, so at the time of the present application, various equivalents and It should be understood that there may be variations.

In the present invention, "Nettle (Urtica thunbergiana)" is a herbaceous plant of the nettle family and has stinging hairs, and the hairs on the inside of the leaves contain antibacterial and antioxidant substances. It is also known to contain magnesium, vitamin C, vitamin B, vitamin K, potassium, silica, zinc, iron, omega 3, lignan, selenium and vitamin E from the beak stem.

In the present invention, "Espinosilla (Espinosilla)" is a natural herb native to Mexico region, it is known that it contains vitamins, amino acids, beta-carotene, malic acid, citric acid, flavonoids, unsaturated fatty acids and minerals.

In the present invention, "black bean (Glycine max (L.) merr)" is known to contain vitamin E, unsaturated fatty acids, phytoestrogens and cysteine.

In the present invention, "black sesame" is a black seed of the dicotyledonous plant Sesameaceae, it is known that it contains keratin, tocopherol and vitamin E.

In the present invention, "Sangbaekpi (Mori Radicis Cortex)" is the root bark of a mulberry tree from which the bark has been removed. dried in It has a slightly characteristic odor and almost no taste.

In the present invention, "Hasuo (Polygonum multiflorum Thunberg)" is a tuberous root, a quadrangular pyramid shape or a lump, and has a length of 5 cm to 15 cm, and a diameter of 3 cm to 10 cm. The outer surface is reddish-brown to blackish-brown, somewhat uneven and uneven, with grooves and irregular wrinkle patterns, odorless, and slightly bitter and astringent in taste.

In the present invention, "Houttuynia cordata" is also called weak wheat, has a fishy smell from the leaves, has a vigorous fertility like weeds, relieves eohyeol, and is known to be good for atopy due to its excellent sterilization effect, and is mainly made into tea and edible.

In the present invention, the term "extract" refers to a liquid component obtained by immersing a target substance in a solvent and then extracting it for a certain period of time at room temperature, low temperature, or heating condition, or a solid obtained by removing the solvent from the liquid component, etc. means the result of In addition, in addition to the result, it can be comprehensively interpreted as including all of the dilutions of the results, their concentrates, their preparations, and their purified products.

In the present invention, the method for obtaining the extract is not particularly limited and various extraction methods commonly used in the technical field to which the present invention pertains may be used. For example, the solvents of purified water, methanol, ethanol, glycerin, ethyl acetate, butylene glycol, propylene glycol, dichloromethane, and hexane can be used alone or a solvent obtained by mixing two or more thereof can be used as the extraction solvent. have. Or, hot water extraction; extraction by ultra-high pressure extraction; extraction by ultrasonic extraction; separation using an ultrafiltration membrane with a constant molecular weight cut-off value; Fractions obtained through various additional purification methods, such as separation by various chromatography, are also included in the extract.

In the present invention, "skin improvement" refers to the process of treating, alleviating, alleviating skin damage caused by intrinsic factors or extrinsic factors of the skin, or its effects, etc., comprehensively, and more specifically, skin whitening, It may include one or more selected from wrinkle improvement, elasticity enhancement, skin regeneration, skin moisturizing, anti-aging, skin irritation alleviation, acne improvement, and atopic improvement effect, and for the purpose of the present invention, maintaining the oil and moisture balance of the skin can

In the present invention, "prevention" may include, without limitation, any act of blocking, suppressing or delaying the symptoms of the above-listed diseases using the pharmaceutical composition of the present invention.

In the present invention, "treatment" may include without limitation any action in which the symptoms of the above-listed diseases are improved or beneficially changed using the pharmaceutical composition of the present invention.

In the present invention, the "pharmaceutical composition" may be characterized in the form of capsules, tablets, granules, injections, ointments, powders or beverages, and the pharmaceutical composition may be characterized in that it is intended for humans. The pharmaceutical composition is not limited thereto, but may be formulated in the form of oral dosage forms such as powders, granules, capsules, tablets, aqueous suspensions, external preparations, suppositories, and sterile injection solutions, respectively, according to conventional methods. .

The pharmaceutical composition of the present invention may include a pharmaceutically acceptable carrier. Pharmaceutically acceptable carriers may include binders, lubricants, disintegrants, excipients, solubilizers, dispersants, stabilizers, suspending agents, dyes, fragrances, etc. for oral administration, and in the case of injections, buffers, preservatives, pain-freezing agents A topical agent, solubilizer, isotonic agent, stabilizer, etc. can be mixed and used, and in the case of topical administration, a base, excipient, lubricant, preservative, etc. can be used. The dosage form of the pharmaceutical composition of the present invention can be prepared in various ways by mixing with a pharmaceutically acceptable carrier as described above. For example, in the case of oral administration, it can be prepared in the form of tablets, troches, capsules, elixirs, suspensions, syrups, wafers, etc., and in the case of injections, it can be prepared in the form of unit dose ampoules or multiple doses. have. In addition, it can be formulated as a solution, suspension, tablet, capsule, sustained release formulation, and the like.

Meanwhile, examples of suitable carriers, excipients and diluents for formulation include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, malditol, starch, acacia gum, alginate, gelatin, calcium phosphate, calcium silicate, Cellulose, methyl cellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate or mineral oil may be used. In addition, it may further include a filler, an anti-agglomeration agent, a lubricant, a wetting agent, a flavoring agent, an emulsifier, a preservative, and the like.

The pharmaceutical composition of the present invention depends on several factors including the activity of the specific compound used, age, weight, general health, sex, formula, administration time, administration route, excretion rate, drug formulation, and the severity of the specific disease to be prevented or treated. The dosage of the pharmaceutical composition may vary depending on the patient's condition, weight, disease severity, drug form, administration route and period, but may be appropriately selected by those skilled in the art, and 0.0001 mg/kg per day to 50 mg/kg or 0.001 mg/kg to 50 mg/kg. Administration may be administered once a day, or may be administered in several divided doses. The above dosage does not limit the scope of the present invention in any way. The pharmaceutical composition according to the present invention may be formulated as pills, dragees, capsules, solutions, gels, syrups, slurries, and suspensions.

In the present invention, the external preparation may be formulated containing a cosmetically or dermatologically acceptable medium or base. These are all formulations suitable for topical application, for example, solutions, gels, solids, kneaded dry products, emulsions obtained by dispersing an oily phase in an aqueous phase, suspensions, microemulsions, microcapsules, microgranules or ionic (liposomes) and non It may be in the form of an ionic vesicle dispersant, or it may be provided in the form of a cream, skin, lotion, powder, ointment, spray or concealer stick. It may also be used in the form of a foam or in the form of an aerosol composition further containing a compressed propellant. These compositions can be prepared according to conventional methods in the art.

In addition, the external preparation is a fatty substance, an organic solvent, a solubilizer, a thickener, a gelling agent, an emollient, an antioxidant, a suspending agent, a stabilizer, a foaming agent, a fragrance, a surfactant, water, an ionic or non-ionic emulsifier cosmetology, such as fillers, sequestering agents, chelating agents, preservatives, vitamins, blocking agents, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic actives, lipid vesicles or any other ingredient commonly used in cosmetics; or It may contain adjuvants commonly used in the field of dermatology. The adjuvant may be introduced in an amount generally used in the field of cosmetology or dermatology.

In addition, the external preparation may contain a skin absorption promoting material to increase the effect. In addition, the external preparation may contain, other than the extract, other ingredients that can preferably give a synergistic effect to the effect within a range that does not impair the purpose of the present invention.

In the present invention, "individual" refers to an individual in need of improvement, prevention or treatment of skin disease or seborrheic hair loss, and may include both mammals and non-mammals. Here, examples of such mammals include humans, non-human primates such as chimpanzees, other apes or monkey species; livestock animals such as cattle, horses, sheep, goats, pigs; domestic animals such as rabbits, dogs or cats; laboratory animals such as rodents such as rats, mice or guinea pigs, but are not limited thereto. In addition, examples of the non-mammal in the present invention may include, but are not limited to, birds or fish.

In the present invention, "administration" refers to the process of introducing the active ingredient of the present invention to an individual by any suitable method, and the administration method in the treatment method of the present invention is administered through various routes, such as oral or parenteral. can be

For the purposes of the present invention, a specific pharmaceutically effective amount for a target subject includes the type and extent of the reaction to be achieved, the specific composition comprising the active ingredient, including whether other agents are used in some cases, the age of the patient, Body weight, general health status, sex and diet, administration time, administration route and secretion rate of a composition containing the active ingredient, treatment period, various factors including drugs used or used together with a specific composition and well-known in the pharmaceutical field It is preferable to apply differently depending on similar factors.

According to one embodiment of the present invention, there is provided a cosmetic composition for improving skin comprising a nettle extract as an active ingredient.

In the present invention, the composition may further include Espinozilia extract as an active ingredient.

In the present invention, the composition may further include black bean extract as an active ingredient.

In the present invention, the black bean extract may be prepared by extracting 10 parts by weight to 60 parts by weight of black beans dry weight based on 100 parts by weight of the nettle dry weight extracted for the preparation of the nettle extract, preferably the extracted It may be prepared by extracting 45 parts by weight to 55 parts by weight of black beans dry weight based on 100 parts by weight of nettle dry weight.

In the present invention, the composition may further include black sesame extract, sangbaekpi extract and sorghum extract as active ingredients.

In the present invention, the black sesame extract, the sangbaekpi extract and the sewage extract may be extracted under ultrasonic irradiation. The ultrasonic irradiation may be carried out at a temperature of room temperature, 10 ℃ to 30 ℃, 10 ℃ to 40 ℃ or 37 ℃ to 40 ℃, for 10 minutes to 6 hours, 10 minutes to 1 hour, or 45 minutes to 55 minutes may be performed.

In the present invention, the black sesame extract may be prepared by extracting 15 to 50 parts by weight of black sesame dry weight based on 100 parts by weight of nettle dry weight extracted for the preparation of the nettle extract, and extracted nettle dry weight Preferably, it may be prepared by extracting 25 to 35 parts by weight of black sesame by dry weight based on 100 parts by weight.

In the present invention, the extract may be prepared by extracting 15 parts by weight to 50 parts by weight of the dry weight of the sagebrush with respect to 100 parts by weight of the dry weight of the nettle extracted for the preparation of the nettle extract, preferably the extracted nettle dried It may be prepared by extracting 15 to 25 parts by weight of dry weight of sangbaek skin with respect to 100 parts by weight.

In the present invention, the sewage extract may be prepared by extracting 15 to 30 parts by weight of sewage dry weight based on 100 parts by weight of the nettle dry weight extracted for the preparation of the nettle extract, preferably the extracted nettle dried It may be prepared by extracting 19 parts by weight to 22 parts by weight of sewage dry weight based on 100 parts by weight.

In the present invention, the composition may further include eoseongcho extract as an active ingredient, preferably, the eoseongcho extract may be collected in October.

In the present invention, the eoseongcho extract may be a hot water extraction. The hot water extraction may be carried out at a temperature of 110 ° C. to 190 ° C., 115 ° C. to 135 ° C. or 175 ° C. to 185 ° C., and is performed for 10 minutes to 6 hours, 10 minutes to 1 hour, or 10 minutes to 40 minutes. it could be

In the present invention, the eoseongcho extract may be prepared from eoseongcho containing 20% or more moisture. When the moisture of the eoseongcho is less than 20%, the activity of the active ingredient may fall.

According to another embodiment of the present invention, a cosmetic comprising the cosmetic composition for improving skin according to the present invention may be provided.

In the present invention, the cosmetics may be any one or more selected from lotions, emulsions, serums, essences, eye creams, nourishing creams and night creams.

In the present invention, the omitted descriptions may be interpreted similarly to the description of the cosmetic composition described above.

According to another embodiment of the present invention, a pharmaceutical composition for preventing or treating seborrheic hair loss comprising a nettle extract as an active ingredient may be provided.

In the present invention, the omitted descriptions may be interpreted similarly to the description of the cosmetic composition described above.

According to another embodiment of the present invention, it relates to a method for preventing or treating seborrheic alopecia, comprising administering to a target subject in a pharmaceutically effective amount the pharmaceutical composition for preventing or treating seborrheic alopecia according to the present invention. .

In the present invention, the remaining descriptions omitted may be interpreted similarly to the description of the cosmetic composition and the pharmaceutical composition described above.

Hereinafter, the present invention will be described in more detail through examples of the present invention, but it is obvious that the present invention is not limited by the following examples.

Preparation Example 1. Extract Preparation (1)

The nettle extract, black soybean extract, black sesame extract, sagebrush extract, and sewage extract used in the preparation examples of the present invention were prepared by ultrasonic extraction. Specifically, the same weight (2 kg) of each dried product of black sesame, sangbaekpi, and sewage was prepared, administered to the prepared 50% ethanol aqueous solution, and extracted at a temperature of 38° C. for 50 minutes.

In addition, the Eoseongcho extract used in the preparation of the present invention was prepared by hot water extraction. Specifically, eoseongcho harvested in October and containing moisture was extracted for 20 minutes under a pressurized condition of 120 ℃.

In addition, the Espinozilia extract used in the preparation of the present invention was purchased commercially.

Preparation Example 2. Extract Preparation (2)

Echo extract used in Comparative Example of the present invention was prepared using ultrasonic extraction. Specifically, eoseongcho containing moisture was prepared, administered to the prepared 50% ethanol aqueous solution, and then extracted at a temperature of 38 ℃ for 50 minutes.

Preparation Example 3. Extract Preparation (3)

The dried fishwort extract used in the comparative example of the invention was prepared using ultrasonic extraction. Specifically, dried eoseongcho of less than 5% moisture was prepared, administered to the prepared 50% ethanol aqueous solution, and extracted for 50 minutes at a temperature of 38 ℃.

Preparation Example 4. Preparation of functional composition (1)

In order to prepare the functional composition according to the present invention, the components and ratios (%) shown in Table 1 below were taken out from the entire solution of each extract extracted at the same dry weight and mixed.

Raw material name Preparation Example 1 Preparation 2 Preparation 3 Preparation 4 Preparation 5 nettle 10.00 10.00 10.00 10.00 10.00 black beans 0.00 5.00 5.00 5.00 5.00 black sesame 0.00 0.00 0.00 3.00 3.00 sangbaekpi 0.00 0.00 0.00 2.00 2.00 Ha Soo Oh 0.00 0.00 0.00 2.00 2.00 Eoseongcho unadded unadded unadded unadded adding Espenocilia adding unadded adding adding adding

Preparation Example 5. Preparation of functional composition (2)

In addition, in order to prepare the functional composition according to the present invention, each extract is mixed according to the components and ratios of Preparation Example 5, but in the case of Eoseongcho extract, the functional composition of Preparation Example 6 is prepared using the extract prepared in Preparation Example 2 did

Preparation Example 6. Preparation of functional composition (3)

In addition, in order to prepare the functional composition according to the present invention, each extract is mixed according to the components and ratios of Preparation Example 5, but in the case of Eoseongcho extract, the functional composition of Preparation Example 7 is prepared using the extract prepared in Preparation Example 3 did

Evaluation Example 1. Confirmation of hair loss improvement effect

In order to confirm the hair loss improvement effect of the functional composition according to the composition of the extract, an animal experiment was performed on the functional composition of Preparation Examples 1 to 5. Specifically, six male C57BL/6 mice were prepared from 42 to 49 days of age, and hairs on the back were removed. Next, each mouse was assigned to the functional composition of Preparation Examples 1 to 5, and applied once a day, 100 μl, for 30 days, and physiological saline was applied to the control group. The effect of improving hair loss was measured by measuring the area (B) in which new hair was grown with respect to the area (A) in which the hair was removed using an image analyzer, and the result of calculating the ratio (100 x A/B) is shown in Table 2 below. .

division Preparation Example 1 Preparation 2 Preparation 3 Preparation 4 Preparation 5 control Area ratio (%) 40.26 50.30 51.78 62.92 71.89 15.95

As shown in Table 2, when the composition of Preparation Examples 1 to 5 containing the nettle extract was administered as an external preparation, it was confirmed that there was a wool effect, in particular, nettle extract, black bean extract, black sesame extract, sagebrush extract, and sewage. When the compositions of Preparation Examples 4 to 5 containing the extract were administered as external preparations, it was confirmed that the wool effect was very excellent.

Evaluation Example 2. Confirmation of inflammatory relief effect

In order to confirm the anti-inflammatory effect of the functional composition according to the presence or absence of Ewoongcho containing and processing method, an experiment was performed on the functional composition of Preparation Examples 4 to 7. Specifically, in a 96-well plate, RAW264.7 cells were prepared in an amount of 5×10 ⁴ per well and treated with LPS 1 μg/mL. Next, the functional compositions of Preparation Examples 4 to 7 were treated in different wells by 50 μg/mL, and in the positive control group, only the RAW264.7 cells were treated with LPS and not treated with the functional composition, and in the control group, the RAW264.7 cells were not treated. Cells were not treated with both LPS and functional compositions. The inflammation relief effect was determined by measuring the IL-6 expression level of the experimental group, the control group and the positive control group treated with the functional composition, and calculating the relative value (fold change) of the IL-6 expression level with respect to the IL-6 expression level of the control group. is shown in FIG. 1 .

As shown in Figure 1, when the functional composition of Preparation Examples 5 to 7 was treated, the IL-6 expression level decreased compared to the case of the positive control group or when the functional composition of Preparation Example 4 was treated, thereby confirming the effect of reducing inflammation, In particular, it was confirmed that, as in Preparation Example 5, when eoseongcho containing water was extracted with hot water, the effect of reducing inflammation was remarkable compared to the case where it was not.

The description of the present invention described above is for illustration, and those of ordinary skill in the art to which the present invention pertains can understand that it can be easily modified into other specific forms without changing the technical spirit or essential features of the present invention. will be. Therefore, it should be understood that the embodiments described above are illustrative in all respects and not restrictive. For example, each component described as a single type may be implemented in a dispersed form, and likewise components described as dispersed may be implemented in a combined form.

The scope of the present invention is indicated by the claims, and all changes or modifications derived from the meaning and scope of the claims and their equivalents should be construed as being included in the scope of the present invention.

Claims (8)

Contains nettle extract as an active ingredient,
It further contains black bean extract as an active ingredient,
It further contains black sesame extract, sagebrush extract and sorghum extract as active ingredients,
The black sesame extract is prepared by extracting 15 to 50 parts by weight of black sesame dry weight based on 100 parts by weight of nettle dry weight,
The sangbaek skin extract is prepared by extracting 15 to 50 parts by weight of sangbaek hull dry weight based on 100 parts by weight of nettle dry weight,
The sewage extract is prepared by extracting 15 to 30 parts by weight of sewage by dry weight based on 100 parts by weight of nettle dry weight,
It will further include eoseongcho extract as an active ingredient,
The eoseongcho extract is to be prepared from eoseongcho containing 20% or more moisture,
It is intended to relieve inflammation and reduce sebum secretion,
A cosmetic composition for improving skin.
The method of claim 1,
The composition which further comprises Espinozilia extract as an active ingredient.
delete delete delete delete delete Contains nettle extract as an active ingredient,
It further contains black bean extract as an active ingredient,
It further contains black sesame extract, sagebrush extract and sorghum extract as active ingredients,
The black sesame extract is prepared by extracting 15 to 50 parts by weight of black sesame dry weight based on 100 parts by weight of nettle dry weight,
The sangbaek skin extract is prepared by extracting 15 to 50 parts by weight of sangbaek hull dry weight based on 100 parts by weight of nettle dry weight,
The sewage extract is prepared by extracting 15 to 30 parts by weight of sewage by dry weight based on 100 parts by weight of nettle dry weight,
It will further include eoseongcho extract as an active ingredient,
The eoseongcho extract is to be prepared from eoseongcho containing 20% or more moisture,
It is intended to relieve inflammation and reduce sebum secretion,
A pharmaceutical composition for preventing or treating seborrheic hair loss.

Images