KR102385934B1 - 안구 질환을 치료하기 위한 abcb5(+) 줄기 세포 - Google Patents
안구 질환을 치료하기 위한 abcb5(+) 줄기 세포 Download PDFInfo
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- KR102385934B1 KR102385934B1 KR1020157025733A KR20157025733A KR102385934B1 KR 102385934 B1 KR102385934 B1 KR 102385934B1 KR 1020157025733 A KR1020157025733 A KR 1020157025733A KR 20157025733 A KR20157025733 A KR 20157025733A KR 102385934 B1 KR102385934 B1 KR 102385934B1
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts or implants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0668—Mesenchymal stem cells from other natural sources
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/02—Atmosphere, e.g. low oxygen conditions
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/602—Sox-2
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/603—Oct-3/4
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/604—Klf-4
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- Biotechnology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Botany (AREA)
- Virology (AREA)
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- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020227011673A KR102474489B1 (ko) | 2013-02-19 | 2014-02-19 | 안구 질환을 치료하기 위한 abcb5(+) 줄기 세포 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361766424P | 2013-02-19 | 2013-02-19 | |
| US61/766,424 | 2013-02-19 | ||
| PCT/US2014/017076 WO2014130518A1 (en) | 2013-02-19 | 2014-02-19 | Abcb5(+) stem cells for treating ocular disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227011673A Division KR102474489B1 (ko) | 2013-02-19 | 2014-02-19 | 안구 질환을 치료하기 위한 abcb5(+) 줄기 세포 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20160033068A KR20160033068A (ko) | 2016-03-25 |
| KR102385934B1 true KR102385934B1 (ko) | 2022-04-13 |
Family
ID=51391751
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227011673A Active KR102474489B1 (ko) | 2013-02-19 | 2014-02-19 | 안구 질환을 치료하기 위한 abcb5(+) 줄기 세포 |
| KR1020157025733A Active KR102385934B1 (ko) | 2013-02-19 | 2014-02-19 | 안구 질환을 치료하기 위한 abcb5(+) 줄기 세포 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227011673A Active KR102474489B1 (ko) | 2013-02-19 | 2014-02-19 | 안구 질환을 치료하기 위한 abcb5(+) 줄기 세포 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9801912B2 (https=) |
| EP (2) | EP2964238B1 (https=) |
| JP (2) | JP7027026B2 (https=) |
| KR (2) | KR102474489B1 (https=) |
| AU (1) | AU2014219026B2 (https=) |
| CA (1) | CA2901931C (https=) |
| DK (1) | DK2964238T3 (https=) |
| ES (1) | ES2860573T3 (https=) |
| WO (1) | WO2014130518A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1290028B1 (en) | 2000-06-05 | 2009-12-23 | The Brigham And Women's Hospital, Inc. | A GENE ENCODING A MULTIDRUG RESISTANCE HUMAN P-GLYCOPROTEIN HOMOLOGUE ON CHROMOSOME 7p15-21 AND USES THEREOF |
| HUE059011T2 (hu) | 2006-05-31 | 2022-09-28 | Childrens Medical Center | Immunmodulátorként szolgáló ABC5-pozitív mezenchimális õssejtek |
| DK2155248T3 (en) | 2007-04-12 | 2015-09-14 | Brigham & Womens Hospital | Targeting abcb5 for cancer therapy |
| US11542328B2 (en) | 2008-11-14 | 2023-01-03 | The Brigham And Women's Hospital, Inc. | Therapeutic and diagnostic methods relating to cancer stem cells |
| PT3130923T (pt) | 2008-11-14 | 2020-06-17 | Brigham & Womens Hospital Inc | Métodos terapêuticos relacionados com células estaminais |
| AU2014219026B2 (en) | 2013-02-19 | 2018-11-29 | Children's Medical Center Corporation | ABCB5(+) stem cells for treating ocular disease |
| EP4008369A1 (en) | 2013-05-10 | 2022-06-08 | Children's Medical Center Corporation | Wound healing and tissue engineering |
| EP4036228A1 (en) | 2015-11-13 | 2022-08-03 | Avellino Lab USA, Inc. | Methods for the treatment of corneal dystrophies |
| WO2019210109A1 (en) | 2018-04-25 | 2019-10-31 | Children's Medical Center Corporation | Abcb5 ligands and substrates |
| WO2020021535A1 (en) * | 2018-07-22 | 2020-01-30 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of ocular diseases |
| EP3823646A4 (en) | 2018-07-22 | 2022-06-08 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of brain diseases |
| EP3823644A4 (en) | 2018-07-22 | 2022-06-08 | Minovia Therapeutics Ltd. | MITOCHONDRIAL AUGMENTATION THERAPY OF PANCREATIC DISEASES |
| JP7586811B2 (ja) | 2018-07-22 | 2024-11-19 | ミノヴィア セラピューティクス リミテッド | 腎臓疾患のミトコンドリア増強療法 |
| AU2019311859B2 (en) * | 2018-07-22 | 2025-12-18 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy for primary mitochondrial diseases |
| KR20210145178A (ko) * | 2019-04-01 | 2021-12-01 | 스템사이트 오와이 | Abcg2-양성 각막 주변부 줄기 세포를 수득 또는 유지하는 방법 |
| WO2021092564A1 (en) * | 2019-11-07 | 2021-05-14 | Massachusetts Eye And Ear Infirmary | Cultivated autologous limbal epithelial cell (calec) transplantation |
| EP3842079A1 (en) * | 2019-12-24 | 2021-06-30 | Universiteit Antwerpen | Ophthalmological device for the treatment of lscd and substrate for use in same |
| US20230148432A1 (en) * | 2020-03-30 | 2023-05-11 | Children's Medical Center Corporation | Use of stem cells for treatment of excessive inflammation |
| BR112022019609A2 (pt) | 2020-03-31 | 2022-11-29 | Minovia Therapeutics Ltd | Células geneticamente modificadas enriquecidas com mitocôndrias e usos das mesmas |
| US20240335562A1 (en) * | 2021-08-04 | 2024-10-10 | Alpine Biotherapeutics Corporation | Sustainable ocular cell-mediated intraocular delivery of cellular therapeutics for treatment of ocular diseases or disorders |
| KR20230129828A (ko) | 2022-03-02 | 2023-09-11 | 포항공과대학교 산학협력단 | 안구 후방 질환 또는 손상의 예방 또는 치료용 조성물 |
| KR102913194B1 (ko) | 2022-03-03 | 2026-01-19 | 서울대학교병원 | 안구건조증 또는 마이봄샘 기능장애의 예방, 개선, 또는 치료용 조성물 |
| CN115074368B (zh) * | 2022-06-09 | 2023-08-08 | 澳门科技大学 | 一种耐药型类风湿性关节炎动物模型的构建及其应用 |
| WO2025090565A1 (en) * | 2023-10-23 | 2025-05-01 | The Children's Medical Center Corporation | Abcb5-targeted stem cell reprogramming and anti-aging strategies |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080003206A1 (en) * | 2006-05-31 | 2008-01-03 | The Brigham And Women's Hospital, Inc. | ABCB5 positive mesenchymal stem cells as immunomodulators |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5434075A (en) | 1992-03-20 | 1995-07-18 | Board Of Trustees Of The University Of Illinois | Monoclonal antibody to a human MDR1 multidrug resistance gene product, and uses |
| US5837258A (en) | 1991-08-30 | 1998-11-17 | University Of South Florida | Induction of tissue, bone or cartilage formation using connective tissue growth factor |
| US6231881B1 (en) | 1992-02-24 | 2001-05-15 | Anton-Lewis Usala | Medium and matrix for long-term proliferation of cells |
| US5906934A (en) | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
| ATE439849T1 (de) | 1996-04-19 | 2009-09-15 | Osiris Therapeutics Inc | Die wiederherstellung und verstärkung von knochen mittels mesenchymalen stammzellen |
| US6152142A (en) | 1997-02-28 | 2000-11-28 | Tseng; Scheffer C. G. | Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries |
| DE19722075C1 (de) | 1997-05-27 | 1998-10-01 | Wilhelm Dr Med Fleischmann | Vorrichtung zur Applikation von Wirkstoffen an einer Wundoberfläche |
| AU749675B2 (en) | 1998-03-13 | 2002-07-04 | Mesoblast International Sarl | Uses for human non-autologous mesenchymal stem cells |
| US6368636B1 (en) | 1998-03-18 | 2002-04-09 | Osiris Therapeutics, Inc. | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
| PT1066060E (pt) | 1998-04-03 | 2003-12-31 | Osiris Therapeutics Inc | Celulas estaminais mesenquimais como imunossupressores |
| AU4221399A (en) | 1998-05-29 | 1999-12-13 | Osiris Therapeutics, Inc. | Human cd45+ and/or fibroblast + mesenchymal stem cells |
| PL366290A1 (en) | 1999-11-29 | 2005-01-24 | Hill-Rom Services, Inc. | Wound treatment apparatus |
| EP1290028B1 (en) | 2000-06-05 | 2009-12-23 | The Brigham And Women's Hospital, Inc. | A GENE ENCODING A MULTIDRUG RESISTANCE HUMAN P-GLYCOPROTEIN HOMOLOGUE ON CHROMOSOME 7p15-21 AND USES THEREOF |
| AU2002211389A1 (en) | 2000-10-03 | 2002-04-15 | California Institute Of Technology | Microfluidic devices and methods of use |
| US6695824B2 (en) | 2001-04-16 | 2004-02-24 | The United States Of America As Represented By The Secretary Of The Army | Wound dressing system |
| US6905678B2 (en) | 2001-07-07 | 2005-06-14 | Crucell Holland B.V. | Gene delivery vectors with cell type specificity for mesenchymal stem cells |
| US8034904B2 (en) | 2002-06-14 | 2011-10-11 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| US20050186672A1 (en) | 2004-01-27 | 2005-08-25 | Reliance Life Sciences Pvt. Ltd. | Tissue system with undifferentiated stem cells derived from corneal limbus |
| WO2006103685A2 (en) | 2005-03-28 | 2006-10-05 | Vision Research Foundation | A method for cultivating cells derived from corneal limbal tissue and cells deived from corneal limbal tissue |
| IL296832A (en) | 2005-10-18 | 2022-11-01 | Nat Jewish Health | Process of preparing red blood cells using conditionally immortalized long-term hematopoietic stem cells and erythropoietin |
| GB0610778D0 (en) | 2006-05-31 | 2006-07-12 | Het Nl Kanker I | Phosphatidylinositol phospahte and apoptosis |
| DK2155248T3 (en) | 2007-04-12 | 2015-09-14 | Brigham & Womens Hospital | Targeting abcb5 for cancer therapy |
| US9011840B2 (en) | 2008-03-14 | 2015-04-21 | The Board Of Trustees Of The University Of Illinois | Activated mesenchymal stem cells for wound healing and impaired tissue regeneration |
| PT3130923T (pt) | 2008-11-14 | 2020-06-17 | Brigham & Womens Hospital Inc | Métodos terapêuticos relacionados com células estaminais |
| WO2010065711A1 (en) | 2008-12-04 | 2010-06-10 | Adimab, Inc. | An abcb5 epitope and antibodies thereto for the treatment of cancer |
| GB0908927D0 (en) * | 2009-05-22 | 2009-07-01 | Univ Reading The | Synthetic graft |
| US20140309738A1 (en) | 2011-06-01 | 2014-10-16 | The Board Of Trustees Of The University Of Illinois | Membrane-Scaffold Composites for Tissue Engineering Applications |
| AU2014219026B2 (en) * | 2013-02-19 | 2018-11-29 | Children's Medical Center Corporation | ABCB5(+) stem cells for treating ocular disease |
| EP4008369A1 (en) | 2013-05-10 | 2022-06-08 | Children's Medical Center Corporation | Wound healing and tissue engineering |
| WO2016179576A1 (en) | 2015-05-07 | 2016-11-10 | Bioxcel Corporation | Novel immunomodulatory therapeutic strategies targeting tumors in cancer |
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2014
- 2014-02-19 AU AU2014219026A patent/AU2014219026B2/en active Active
- 2014-02-19 DK DK14754427.4T patent/DK2964238T3/da active
- 2014-02-19 KR KR1020227011673A patent/KR102474489B1/ko active Active
- 2014-02-19 ES ES14754427T patent/ES2860573T3/es active Active
- 2014-02-19 JP JP2015558916A patent/JP7027026B2/ja active Active
- 2014-02-19 KR KR1020157025733A patent/KR102385934B1/ko active Active
- 2014-02-19 EP EP14754427.4A patent/EP2964238B1/en active Active
- 2014-02-19 EP EP21150996.3A patent/EP3865573A1/en active Pending
- 2014-02-19 US US14/768,885 patent/US9801912B2/en active Active
- 2014-02-19 WO PCT/US2014/017076 patent/WO2014130518A1/en not_active Ceased
- 2014-02-19 CA CA2901931A patent/CA2901931C/en active Active
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2017
- 2017-10-30 US US15/796,920 patent/US11129854B2/en active Active
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2019
- 2019-02-28 JP JP2019036040A patent/JP2019189600A/ja active Pending
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2021
- 2021-09-27 US US17/486,855 patent/US20220118024A1/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080003206A1 (en) * | 2006-05-31 | 2008-01-03 | The Brigham And Women's Hospital, Inc. | ABCB5 positive mesenchymal stem cells as immunomodulators |
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| US20150374756A1 (en) | 2015-12-31 |
| JP2019189600A (ja) | 2019-10-31 |
| US9801912B2 (en) | 2017-10-31 |
| US20220118024A1 (en) | 2022-04-21 |
| US20180064762A1 (en) | 2018-03-08 |
| AU2014219026A1 (en) | 2015-09-17 |
| EP3865573A1 (en) | 2021-08-18 |
| KR20220048048A (ko) | 2022-04-19 |
| US11129854B2 (en) | 2021-09-28 |
| JP2016510727A (ja) | 2016-04-11 |
| EP2964238A1 (en) | 2016-01-13 |
| DK2964238T3 (da) | 2021-03-22 |
| ES2860573T3 (es) | 2021-10-05 |
| JP7027026B2 (ja) | 2022-03-01 |
| AU2014219026B2 (en) | 2018-11-29 |
| EP2964238B1 (en) | 2021-01-13 |
| KR102474489B1 (ko) | 2022-12-06 |
| CA2901931C (en) | 2023-03-07 |
| WO2014130518A1 (en) | 2014-08-28 |
| KR20160033068A (ko) | 2016-03-25 |
| EP2964238A4 (en) | 2016-09-07 |
| CA2901931A1 (en) | 2014-08-28 |
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