KR102366656B1 - 플로우셀 계수기의 광학 시스템을 위한 시스템, 방법 및 장치 - Google Patents

플로우셀 계수기의 광학 시스템을 위한 시스템, 방법 및 장치 Download PDF

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KR102366656B1
KR102366656B1 KR1020167026642A KR20167026642A KR102366656B1 KR 102366656 B1 KR102366656 B1 KR 102366656B1 KR 1020167026642 A KR1020167026642 A KR 1020167026642A KR 20167026642 A KR20167026642 A KR 20167026642A KR 102366656 B1 KR102366656 B1 KR 102366656B1
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converging
light beam
flow cell
passing
optical system
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KR20160126062A (ko
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그레고리 카두착
웨슬리 스미스
마이클 워드
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라이프 테크놀로지스 코포레이션
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N2015/1438—Using two lasers in succession

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  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Measuring Cells (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
KR1020167026642A 2014-02-28 2015-01-28 플로우셀 계수기의 광학 시스템을 위한 시스템, 방법 및 장치 Active KR102366656B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461946579P 2014-02-28 2014-02-28
US61/946,579 2014-02-28
US201462041806P 2014-08-26 2014-08-26
US62/041,806 2014-08-26
PCT/US2015/013279 WO2015130423A1 (en) 2014-02-28 2015-01-28 Systems, methods, and apparatuses for optical systems in flow cytometers

Publications (2)

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KR20160126062A KR20160126062A (ko) 2016-11-01
KR102366656B1 true KR102366656B1 (ko) 2022-02-23

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US (2) US10018553B2 (https=)
EP (1) EP3111193B1 (https=)
JP (1) JP2017512301A (https=)
KR (1) KR102366656B1 (https=)
CN (2) CN106461530B (https=)
AU (1) AU2015223493A1 (https=)
MX (1) MX2016011193A (https=)
RU (1) RU2016131016A (https=)
SG (1) SG11201605084PA (https=)
WO (1) WO2015130423A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2016011193A (es) 2014-02-28 2016-12-16 Life Technologies Corp Sistemas, metodos y aparatos para sistemas opticos en citometros de flujo.
ES2778148T3 (es) * 2018-01-31 2020-08-07 Sick Engineering Gmbh Aparato de análisis para la determinación de polvo fino
KR102130100B1 (ko) * 2018-09-07 2020-07-03 주식회사 더웨이브톡 광학 검출 시스템
CN109381292A (zh) * 2018-10-09 2019-02-26 武汉博激世纪科技有限公司 激光光束耦合输出装置和耦合输出方法
US11169386B2 (en) * 2019-04-24 2021-11-09 Coherent, Inc. Beam forming with focus location adjustment
EP4062153B1 (en) * 2019-11-22 2023-08-23 ams AG Optical based particulate matter sensing
US12584902B2 (en) 2023-12-10 2026-03-24 Instrumentation Laboratory Company Acoustic separation of a test sample

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5999250A (en) 1997-03-17 1999-12-07 Tsi Corporation System for detecting fluorescing components in aerosols
US20020093641A1 (en) * 2000-08-25 2002-07-18 Ortyn William E. Measuring the velocity of small moving objects such as cells
WO2007133465A2 (en) 2006-05-12 2007-11-22 Immunivest Corporation A laser illumination system in fluorescent microscopy
US20090122311A1 (en) 2005-08-08 2009-05-14 Masahiko Kanda Flow Cytometer and Flow Cytometry

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04142530A (ja) * 1990-10-04 1992-05-15 Seiko Epson Corp 投写型液晶表示装置
JPH0734012B2 (ja) * 1991-02-27 1995-04-12 東亜医用電子株式会社 フローイメージサイトメータ
JPH0561129A (ja) * 1991-08-29 1993-03-12 Tamron Co Ltd 投射型表示装置
JP3260469B2 (ja) * 1992-04-01 2002-02-25 シスメックス株式会社 粒子分析装置
EP0774112B1 (en) 1994-08-01 2002-07-03 Abbott Laboratories Pseudo telecentric optical design for flow cytometric blood cell analyzer
JPH08292395A (ja) * 1995-04-20 1996-11-05 Fuji Photo Optical Co Ltd 液晶プロジェクタ
JPH10228665A (ja) * 1997-02-12 1998-08-25 Hitachi Ltd 光ディスク装置及びそれに用いる光ヘッド
US6975400B2 (en) 1999-01-25 2005-12-13 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US7050380B2 (en) * 2000-04-18 2006-05-23 Ricoh Company, Ltd. Optical element, optical pickup unit, and optical disk drive unit
WO2002031182A2 (en) * 2000-10-12 2002-04-18 Amnis Corporation Method and apparatus for reading reporter labeled beads
US7061614B2 (en) * 2001-10-16 2006-06-13 Therma-Wave, Inc. Measurement system with separate optimized beam paths
JP2005518562A (ja) * 2002-02-19 2005-06-23 ユナキス・バルツェルス・アクチェンゲゼルシャフト 狭帯域光源を用いて画像を投影するためのシステム
ATE514939T1 (de) 2005-02-09 2011-07-15 S3I Llc Verfahren und system für die erkennung, klassifizierung und identifizierung von partikeln
FR2884920B1 (fr) * 2005-04-21 2007-08-10 Horiba Abx Sa Sa Dispositif et procede d'analyse multiparametrique d'elements microscopiques
US7411734B2 (en) * 2005-11-10 2008-08-12 3M Innovative Properties Company Color-splitting optical element and an optical system utilizing the color-splitting optical element
JP2008039539A (ja) 2006-08-04 2008-02-21 Shimadzu Corp 光散乱検出装置
JP2008089540A (ja) * 2006-10-05 2008-04-17 Furukawa Electric Co Ltd:The 光計測方法および光計測装置
JP5259305B2 (ja) * 2007-10-03 2013-08-07 シスメックス株式会社 細胞分析装置及び細胞分析方法
US8432541B2 (en) * 2007-12-17 2013-04-30 Accuri Cytometers, Inc. Optical system for a flow cytometer with an interrogation zone
JP4365439B2 (ja) * 2008-03-04 2009-11-18 三井造船株式会社 蛍光検出方法及び蛍光検出装置
JP4600573B2 (ja) * 2008-05-29 2010-12-15 ソニー株式会社 光学的測定装置、並びに光検出器の波長校正方法及び光学的測定方法
JP5633138B2 (ja) * 2008-12-24 2014-12-03 セイコーエプソン株式会社 照明装置およびプロジェクター
US8376551B2 (en) * 2010-02-25 2013-02-19 Corning Incorporated Illumination system for laser projection
AT510765B1 (de) 2010-12-15 2012-09-15 Wolfgang Dipl Ing Vogl Vorrichtung zur photometrischen bzw. spektrometrischen untersuchung einer flüssigen probe
CN102175587A (zh) * 2010-12-31 2011-09-07 深圳市美思康电子有限公司 用于血液细胞分析、流式细胞分析、体液分析的激光系统
US9168568B2 (en) * 2012-08-01 2015-10-27 Owl biomedical, Inc. Particle manipulation system with cytometric confirmation
US9523857B2 (en) 2013-03-14 2016-12-20 Abbott Laboratories Beam shaping optics of flow cytometer systems and methods related thereto
JP5925746B2 (ja) * 2013-10-18 2016-05-25 増田　麻言 レーザ光投射装置および投影装置
US9360164B2 (en) * 2013-12-12 2016-06-07 Owl biomedical, Inc. Particle manipulation system with stay-wet algorithm
US9638988B2 (en) * 2013-12-12 2017-05-02 Corning Incorporated Light multiplexer with color combining element
US9726593B2 (en) 2014-02-28 2017-08-08 Life Technologies Corporation Systems, methods, and apparatuses for optical systems in flow cytometers
MX2016011193A (es) 2014-02-28 2016-12-16 Life Technologies Corp Sistemas, metodos y aparatos para sistemas opticos en citometros de flujo.
EP3163287B1 (en) * 2015-10-30 2022-03-23 Sysmex Corporation Cell information obtaining method and cell information obtaining apparatus
JP2017146552A (ja) * 2016-02-19 2017-08-24 セイコーエプソン株式会社 照明装置及びプロジェクター

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5999250A (en) 1997-03-17 1999-12-07 Tsi Corporation System for detecting fluorescing components in aerosols
US20020093641A1 (en) * 2000-08-25 2002-07-18 Ortyn William E. Measuring the velocity of small moving objects such as cells
US20090122311A1 (en) 2005-08-08 2009-05-14 Masahiko Kanda Flow Cytometer and Flow Cytometry
WO2007133465A2 (en) 2006-05-12 2007-11-22 Immunivest Corporation A laser illumination system in fluorescent microscopy

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RU2016131016A3 (https=) 2018-03-29
EP3111193A1 (en) 2017-01-04
EP3111193B1 (en) 2020-02-26
US10473578B2 (en) 2019-11-12
WO2015130423A1 (en) 2015-09-03
US20180067037A1 (en) 2018-03-08
US20190033199A1 (en) 2019-01-31
JP2017512301A (ja) 2017-05-18
RU2016131016A (ru) 2018-03-29
CN204649590U (zh) 2015-09-16
CN106461530B (zh) 2020-12-18
KR20160126062A (ko) 2016-11-01
MX2016011193A (es) 2016-12-16
SG11201605084PA (en) 2016-09-29
AU2015223493A1 (en) 2016-10-27
US10018553B2 (en) 2018-07-10
CN106461530A (zh) 2017-02-22

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