KR102356433B1 - 치환된 아미노퓨린 화합물, 이의 조성물, 및 그것에 의한 치료 방법 - Google Patents

치환된 아미노퓨린 화합물, 이의 조성물, 및 그것에 의한 치료 방법 Download PDF

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KR102356433B1
KR102356433B1 KR1020187028514A KR20187028514A KR102356433B1 KR 102356433 B1 KR102356433 B1 KR 102356433B1 KR 1020187028514 A KR1020187028514 A KR 1020187028514A KR 20187028514 A KR20187028514 A KR 20187028514A KR 102356433 B1 KR102356433 B1 KR 102356433B1
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cancer
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aminopurine
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KR20180126497A (ko
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존 에프. 보이랜
고든 엘. 브레이
엘렌 필바로프
로버트 허바드
데이비드 미코론
헤더 레이먼
타오 쉬
탐 엠. 트란
토시야 쯔지
릴리 엘. 웡
쉬찬 쉬
단 쥬
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시그날 파마소티칼 엘엘씨
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020187028514A 2016-04-01 2017-03-31 치환된 아미노퓨린 화합물, 이의 조성물, 및 그것에 의한 치료 방법 Active KR102356433B1 (ko)

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US201662317412P 2016-04-01 2016-04-01
US62/317,412 2016-04-01
PCT/US2017/025252 WO2017173206A1 (en) 2016-04-01 2017-03-31 Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith

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KR20180126497A KR20180126497A (ko) 2018-11-27
KR102356433B1 true KR102356433B1 (ko) 2022-01-27

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US (1) US10576085B2 (https=)
EP (1) EP3436018A4 (https=)
JP (1) JP7014731B2 (https=)
KR (1) KR102356433B1 (https=)
CN (1) CN109069512B (https=)
AU (1) AU2017241837B2 (https=)
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CA (1) CA3018986A1 (https=)
CL (1) CL2018002787A1 (https=)
EA (1) EA039392B1 (https=)
IL (1) IL262007B2 (https=)
MX (1) MX379513B (https=)
NZ (1) NZ746554A (https=)
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CN110753682B (zh) 2017-05-22 2023-06-30 杨森制药公司 作为登革热病毒复制抑制剂的经取代的吲哚啉衍生物
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SI3773589T1 (sl) 2018-04-03 2024-03-29 Blueprint Medicines Corporation Inhibitor RET za uporabo pri zdravljenju raka, ki ima RET spremembo
WO2020033838A2 (en) * 2018-08-10 2020-02-13 Blueprint Medicines Corporation Treatment of egfr-mutant cancer
HUE070525T2 (hu) * 2019-04-16 2025-06-28 Vivace Therapeutics Inc Biciklusos vegyületek
US12122787B2 (en) 2019-09-20 2024-10-22 Shanghai Jemincare Pharmaceuticals Co., Ltd Fused pyridone compound, and preparation method therefor and use thereof
CN115279368B (zh) * 2019-11-20 2024-05-24 维瓦斯治疗公司 杂芳基化合物
JP2023527412A (ja) 2020-05-29 2023-06-28 ブループリント メディシンズ コーポレイション プラルセチニブの固体形態
TW202202498A (zh) * 2020-07-01 2022-01-16 大陸商四川海思科製藥有限公司 一種並環雜環衍生物及其在醫藥上的應用
KR102664454B1 (ko) * 2021-08-03 2024-05-09 한국생명공학연구원 젬시타빈에 대한 민감성 향상을 위한 신규 표적 및 이의 활용
CN114681456A (zh) * 2022-02-23 2022-07-01 中山大学附属第六医院 Plx3397在结直肠癌的治疗中的用途
EP4703725A1 (en) 2024-08-29 2026-03-04 Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus Modulators of the mitotic cell cycle in cancer cells and uses thereof for the treatment of cancer

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BR112018070163A2 (pt) 2019-01-29
US10576085B2 (en) 2020-03-03
IL262007B2 (en) 2023-04-01
MX2018011992A (es) 2019-01-24
AU2017241837A1 (en) 2018-10-25
KR20180126497A (ko) 2018-11-27
CN109069512B (zh) 2022-06-14
CL2018002787A1 (es) 2019-01-18
CN109069512A (zh) 2018-12-21
IL262007B (en) 2022-12-01
MX379513B (es) 2025-03-11
SG11201808388QA (en) 2018-10-30
EP3436018A4 (en) 2019-11-13
CA3018986A1 (en) 2017-10-05
EA039392B1 (ru) 2022-01-21
JP7014731B2 (ja) 2022-02-01
IL262007A (en) 2018-10-31
EP3436018A1 (en) 2019-02-06
US20170281633A1 (en) 2017-10-05
JP2019510066A (ja) 2019-04-11
WO2017173206A1 (en) 2017-10-05
EA201892229A1 (ru) 2019-03-29
NZ746554A (en) 2023-03-31
AU2017241837B2 (en) 2021-07-22
SG10202009589UA (en) 2020-10-29

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