KR102307279B1 - 배양에서 바이러스 수율을 증가시키기 위한 inos 억제제의 용도 - Google Patents

배양에서 바이러스 수율을 증가시키기 위한 inos 억제제의 용도 Download PDF

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KR102307279B1
KR102307279B1 KR1020157021175A KR20157021175A KR102307279B1 KR 102307279 B1 KR102307279 B1 KR 102307279B1 KR 1020157021175 A KR1020157021175 A KR 1020157021175A KR 20157021175 A KR20157021175 A KR 20157021175A KR 102307279 B1 KR102307279 B1 KR 102307279B1
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hsv
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virus
cells
aav
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KR20150103275A (ko
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피터 피챈
제프리 아르딘저
아브라함 스카리아
사무엘 와즈워쓰
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젠자임 코포레이션
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/245Herpetoviridae, e.g. herpes simplex virus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641Use of virus, viral particle or viral elements as a vector
    • C12N2710/16643Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16651Methods of production or purification of viral material
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
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  • Genetics & Genomics (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Wood Science & Technology (AREA)
  • Virology (AREA)
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  • Microbiology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020157021175A 2013-01-08 2014-01-07 배양에서 바이러스 수율을 증가시키기 위한 inos 억제제의 용도 Active KR102307279B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361750175P 2013-01-08 2013-01-08
US61/750,175 2013-01-08
PCT/US2014/010553 WO2014110053A1 (en) 2013-01-08 2014-01-07 Use of inos inhibitors to increase viral yield in culture

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KR20150103275A KR20150103275A (ko) 2015-09-09
KR102307279B1 true KR102307279B1 (ko) 2021-09-29

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KR1020157021175A Active KR102307279B1 (ko) 2013-01-08 2014-01-07 배양에서 바이러스 수율을 증가시키기 위한 inos 억제제의 용도

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US (2) US11299715B2 (enExample)
EP (3) EP2943567B1 (enExample)
JP (2) JP6534933B2 (enExample)
KR (1) KR102307279B1 (enExample)
CN (1) CN105008523B (enExample)
AR (1) AR094389A1 (enExample)
AU (1) AU2014205604B2 (enExample)
BR (2) BR122020002822B1 (enExample)
CA (1) CA2897444A1 (enExample)
DK (1) DK2943567T3 (enExample)
ES (1) ES2651763T3 (enExample)
HK (1) HK1249544A1 (enExample)
HU (1) HUE037482T2 (enExample)
IL (1) IL239824B (enExample)
MX (2) MX378877B (enExample)
NO (1) NO3050055T3 (enExample)
RU (1) RU2676733C2 (enExample)
SG (3) SG10201806715TA (enExample)
TW (1) TWI608102B (enExample)
WO (1) WO2014110053A1 (enExample)

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SG11201703148TA (en) 2014-11-05 2017-05-30 Voyager Therapeutics Inc Aadc polynucleotides for the treatment of parkinson's disease
US10597660B2 (en) 2014-11-14 2020-03-24 Voyager Therapeutics, Inc. Compositions and methods of treating amyotrophic lateral sclerosis (ALS)
MX2017006217A (es) 2014-11-14 2018-05-02 Voyager Therapeutics Inc Polinucleotidos moduladores.
HK1245326A1 (zh) 2014-12-12 2018-08-24 Voyager Therapeutics, Inc. 用於生产scaav的组合物和方法
EP4159867A1 (en) 2016-03-28 2023-04-05 Ultragenyx Pharmaceutical Inc. Methods of heat inactivation of adenovirus
KR20240056729A (ko) 2016-05-18 2024-04-30 보이저 테라퓨틱스, 인크. 조절성 폴리뉴클레오티드
EP3526321B1 (en) 2016-10-14 2024-11-27 Ultragenyx Pharmaceutical Inc. Use of tonicifying agents to enhance recombinant adeno-associated virus yield
EP3601581B1 (en) 2017-03-22 2025-04-30 Ultragenyx Pharmaceutical Inc. CELL CULTURE METHODS INVOLVING HDAC INHIBITORS OR REP PROTEINS
JP7218303B2 (ja) 2017-05-09 2023-02-06 ウルトラジェニックス ファーマシューティカル インコーポレイテッド トランスフェクション試薬を生成するための拡大可能な方法
JOP20190269A1 (ar) 2017-06-15 2019-11-20 Voyager Therapeutics Inc بولي نوكليوتيدات aadc لعلاج مرض باركنسون
EP3794126A1 (en) 2018-05-15 2021-03-24 Voyager Therapeutics, Inc. Compositions and methods for the treatment of parkinson's disease
CN110835622B (zh) * 2018-08-16 2021-04-27 上海药明生物技术有限公司 用于调节哺乳动物细胞乳酸代谢的培养基及其应用
AU2019346655B2 (en) 2018-09-28 2025-03-13 Voyager Therapeutics, Inc. Frataxin expression constructs having engineered promoters and methods of use thereof
WO2021188449A1 (en) 2020-03-16 2021-09-23 Ultragenyx Pharmaceutical Inc. Methods for enhancing recombinant adeno-associated virus yield
JPWO2023157976A1 (enExample) * 2022-02-21 2023-08-24

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WO1992001070A1 (en) 1990-07-09 1992-01-23 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce High efficiency packaging of mutant adeno-associated virus using amber suppressions
US5173414A (en) 1990-10-30 1992-12-22 Applied Immune Sciences, Inc. Production of recombinant adeno-associated virus vectors
RU2012335C1 (ru) 1991-07-04 1994-05-15 Уфимский научно-исследовательский институт глазных болезней Ингибитор вируса простого герпеса
DK0648271T3 (da) 1991-08-20 2003-07-21 Us Gov Health & Human Serv Adenovirusmedieret overførsel af gener til mave-/tarmkanal
DE69332501T3 (de) 1992-07-31 2009-03-26 The President And Fellows Of Harvard College, Cambridge Herpesvirus impfstoffe
US7223411B1 (en) 1992-07-31 2007-05-29 Dana-Farber Cancer Institute Herpesvirus replication defective mutants
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CN100348718C (zh) * 2005-10-18 2007-11-14 中国人民解放军军事医学科学院生物工程研究所 一种支持hek293细胞贴附培养的无动物来源成分无血清培养基
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Publication number Publication date
MX378877B (es) 2025-03-10
CA2897444A1 (en) 2014-07-17
MX2015008861A (es) 2016-04-13
CN105008523B (zh) 2020-03-27
BR112015016328A2 (enExample) 2017-09-05
HK1214840A1 (en) 2016-08-05
HK1249544A1 (en) 2018-11-02
AU2014205604A1 (en) 2015-08-13
US20150353899A1 (en) 2015-12-10
CN105008523A (zh) 2015-10-28
RU2015133205A (ru) 2017-02-14
TWI608102B (zh) 2017-12-11
AU2014205604B2 (en) 2020-01-02
EP2943567B1 (en) 2017-09-13
BR112015016328B1 (pt) 2023-04-18
RU2676733C2 (ru) 2019-01-10
KR20150103275A (ko) 2015-09-09
EP3521420A1 (en) 2019-08-07
DK2943567T3 (en) 2018-01-02
IL239824B (en) 2019-03-31
TW201446965A (zh) 2014-12-16
NO3050055T3 (enExample) 2018-02-10
AR094389A1 (es) 2015-07-29
JP2016504913A (ja) 2016-02-18
RU2018144779A3 (enExample) 2022-03-02
WO2014110053A1 (en) 2014-07-17
SG11201505333PA (en) 2015-08-28
JP2019187420A (ja) 2019-10-31
EP3266866A1 (en) 2018-01-10
US20220340883A1 (en) 2022-10-27
SG10201913130PA (en) 2020-03-30
JP6837094B2 (ja) 2021-03-03
ES2651763T3 (es) 2018-01-29
BR122020002822B1 (pt) 2023-04-18
HUE037482T2 (hu) 2018-08-28
SG10201806715TA (en) 2018-09-27
IL239824A0 (en) 2015-08-31
MX360470B (es) 2018-11-05
US11299715B2 (en) 2022-04-12
EP2943567A1 (en) 2015-11-18
JP6534933B2 (ja) 2019-06-26
EP3266866B1 (en) 2019-03-06
RU2018144779A (ru) 2019-01-29

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