KR102302580B1 - Cxcr7 수용체 조절제 - Google Patents
Cxcr7 수용체 조절제 Download PDFInfo
- Publication number
- KR102302580B1 KR102302580B1 KR1020157036801A KR20157036801A KR102302580B1 KR 102302580 B1 KR102302580 B1 KR 102302580B1 KR 1020157036801 A KR1020157036801 A KR 1020157036801A KR 20157036801 A KR20157036801 A KR 20157036801A KR 102302580 B1 KR102302580 B1 KR 102302580B1
- Authority
- KR
- South Korea
- Prior art keywords
- ethyl
- tetrahydro
- isoquinolin
- acetamide
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC(C)(**[C@@]1(*)[Rh])c2c1c(IIC(O)=O)ccc2 Chemical compound CC(C)(**[C@@]1(*)[Rh])c2c1c(IIC(O)=O)ccc2 0.000 description 7
- ZARYDSVMAKKSAR-UHFFFAOYSA-N CC(OC(C(Cl)=O)OC(C)=O)=O Chemical compound CC(OC(C(Cl)=O)OC(C)=O)=O ZARYDSVMAKKSAR-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2013054478 | 2013-05-30 | ||
| IBPCT/IB2013/054478 | 2013-05-30 | ||
| PCT/IB2014/061774 WO2014191929A1 (en) | 2013-05-30 | 2014-05-28 | Cxcr7 receptor modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20160013197A KR20160013197A (ko) | 2016-02-03 |
| KR102302580B1 true KR102302580B1 (ko) | 2021-09-15 |
Family
ID=50943357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157036801A Expired - Fee Related KR102302580B1 (ko) | 2013-05-30 | 2014-05-28 | Cxcr7 수용체 조절제 |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US9920010B2 (https=) |
| EP (1) | EP3004082B1 (https=) |
| JP (1) | JP6393749B2 (https=) |
| KR (1) | KR102302580B1 (https=) |
| CN (1) | CN105263924B (https=) |
| AR (1) | AR096490A1 (https=) |
| AU (1) | AU2014272718B2 (https=) |
| BR (1) | BR112015030095B1 (https=) |
| CA (1) | CA2912133C (https=) |
| CL (1) | CL2015003470A1 (https=) |
| CY (1) | CY1119537T1 (https=) |
| DK (1) | DK3004082T3 (https=) |
| EA (1) | EA028604B1 (https=) |
| ES (1) | ES2645470T3 (https=) |
| HR (1) | HRP20171597T1 (https=) |
| HU (1) | HUE036649T2 (https=) |
| IL (1) | IL242782B (https=) |
| LT (1) | LT3004082T (https=) |
| MA (1) | MA38679B1 (https=) |
| MX (1) | MX364104B (https=) |
| MY (1) | MY173564A (https=) |
| NO (1) | NO3004082T3 (https=) |
| PH (1) | PH12015502632A1 (https=) |
| PL (1) | PL3004082T3 (https=) |
| PT (1) | PT3004082T (https=) |
| SG (1) | SG11201509057UA (https=) |
| SI (1) | SI3004082T1 (https=) |
| TW (1) | TWI640510B (https=) |
| UA (1) | UA118562C2 (https=) |
| WO (1) | WO2014191929A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR091516A1 (es) | 2012-06-22 | 2015-02-11 | Actelion Pharmaceuticals Ltd | Derivados de 1-[m-carboxamido(hetero)aril-metil]-heterociclil-carboxamida |
| ES2732437T3 (es) | 2014-12-01 | 2019-11-22 | Idorsia Pharmaceuticals Ltd | Moduladores del receptor de CXCR7 |
| WO2017070431A1 (en) * | 2015-10-23 | 2017-04-27 | James Merritt | Use of ccr1 antagonists as a treatment for tumors of the central nervous system |
| HRP20230313T1 (hr) * | 2016-07-28 | 2023-05-12 | Idorsia Pharmaceuticals Ltd | Modulatori receptora cxcr7 piperidina |
| EA201992676A1 (ru) | 2017-05-18 | 2020-05-06 | Идорсия Фармасьютиклз Лтд | Фенильные производные в качестве модуляторов pge2 рецепторов |
| PL3625228T3 (pl) | 2017-05-18 | 2021-12-20 | Idorsia Pharmaceuticals Ltd | Pochodne pirymidyny jako modulatory receptora pge2 |
| KR102502046B1 (ko) | 2018-01-26 | 2023-02-20 | 이도르시아 파마슈티컬스 리미티드 | Cxcr7 수용체 작동제 (3s,4s)-1-시클로프로필메틸-4-｛[5-(2,4-디플루오로-페닐)-이속사졸-3-카르보닐]-아미노｝-피페리딘-3-카르복실산 (1-피리미딘-2-일-시클로프로필)-아미드의 결정질 형태 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004058705A2 (en) | 2002-12-20 | 2004-07-15 | Chemocentryx | Inhibitors of the binding of chemokines i-tac or sdf-1 to the ccxckr2 receptor |
| WO2007059108A2 (en) | 2005-11-10 | 2007-05-24 | Chemocentryx, Inc. | Substituted quinolones and methods of use |
| WO2013190508A2 (en) | 2012-06-22 | 2013-12-27 | Actelion Pharmaceuticals Ltd | 1-[m-carboxamido(hetero)aryl-methyl]-heterocyclyl-carboxamide derivatives |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3896170A (en) | 1969-02-26 | 1975-07-22 | American Home Prod | Intermediates for the preparation of 1,3-dihydro-2h-1, -benzodiazepin-2-ones |
| IL137720A0 (en) | 1998-02-18 | 2001-10-31 | Neurosearch As | Compounds and their use as positive ampa receptor modulators |
| GB9816984D0 (en) * | 1998-08-05 | 1998-09-30 | Smithkline Beecham Plc | Novel compounds |
| WO2002046164A1 (en) | 2000-12-07 | 2002-06-13 | Astrazeneca Ab | Therapeutic compounds |
| US20100331298A1 (en) | 2007-12-10 | 2010-12-30 | Cytopathfinder, Inc. | Carboxamide Compounds and Their Use |
| ES2732437T3 (es) | 2014-12-01 | 2019-11-22 | Idorsia Pharmaceuticals Ltd | Moduladores del receptor de CXCR7 |
-
2014
- 2014-05-28 EA EA201501163A patent/EA028604B1/ru not_active IP Right Cessation
- 2014-05-28 CA CA2912133A patent/CA2912133C/en active Active
- 2014-05-28 PL PL14730591T patent/PL3004082T3/pl unknown
- 2014-05-28 HU HUE14730591A patent/HUE036649T2/hu unknown
- 2014-05-28 SG SG11201509057UA patent/SG11201509057UA/en unknown
- 2014-05-28 EP EP14730591.6A patent/EP3004082B1/en active Active
- 2014-05-28 JP JP2016516287A patent/JP6393749B2/ja not_active Expired - Fee Related
- 2014-05-28 MA MA38679A patent/MA38679B1/fr unknown
- 2014-05-28 HR HRP20171597TT patent/HRP20171597T1/hr unknown
- 2014-05-28 CN CN201480030766.2A patent/CN105263924B/zh not_active Expired - Fee Related
- 2014-05-28 SI SI201430415T patent/SI3004082T1/sl unknown
- 2014-05-28 US US14/892,959 patent/US9920010B2/en not_active Expired - Fee Related
- 2014-05-28 KR KR1020157036801A patent/KR102302580B1/ko not_active Expired - Fee Related
- 2014-05-28 MY MYPI2015704311A patent/MY173564A/en unknown
- 2014-05-28 NO NO14730591A patent/NO3004082T3/no unknown
- 2014-05-28 LT LTEP14730591.6T patent/LT3004082T/lt unknown
- 2014-05-28 PT PT147305916T patent/PT3004082T/pt unknown
- 2014-05-28 DK DK14730591.6T patent/DK3004082T3/en active
- 2014-05-28 AU AU2014272718A patent/AU2014272718B2/en not_active Ceased
- 2014-05-28 WO PCT/IB2014/061774 patent/WO2014191929A1/en not_active Ceased
- 2014-05-28 BR BR112015030095-2A patent/BR112015030095B1/pt not_active IP Right Cessation
- 2014-05-28 ES ES14730591.6T patent/ES2645470T3/es active Active
- 2014-05-28 MX MX2015016429A patent/MX364104B/es active IP Right Grant
- 2014-05-28 UA UAA201512741A patent/UA118562C2/uk unknown
- 2014-05-29 TW TW103118884A patent/TWI640510B/zh not_active IP Right Cessation
- 2014-05-29 AR ARP140102121A patent/AR096490A1/es active IP Right Grant
-
2015
- 2015-11-25 IL IL242782A patent/IL242782B/en active IP Right Grant
- 2015-11-26 PH PH12015502632A patent/PH12015502632A1/en unknown
- 2015-11-27 CL CL2015003470A patent/CL2015003470A1/es unknown
-
2017
- 2017-11-02 CY CY20171101149T patent/CY1119537T1/el unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004058705A2 (en) | 2002-12-20 | 2004-07-15 | Chemocentryx | Inhibitors of the binding of chemokines i-tac or sdf-1 to the ccxckr2 receptor |
| WO2007059108A2 (en) | 2005-11-10 | 2007-05-24 | Chemocentryx, Inc. | Substituted quinolones and methods of use |
| WO2013190508A2 (en) | 2012-06-22 | 2013-12-27 | Actelion Pharmaceuticals Ltd | 1-[m-carboxamido(hetero)aryl-methyl]-heterocyclyl-carboxamide derivatives |
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