KR102289168B1 - 고형 조직으로부터 세포를 생착시키는 방법 - Google Patents

고형 조직으로부터 세포를 생착시키는 방법 Download PDF

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KR102289168B1
KR102289168B1 KR1020197033328A KR20197033328A KR102289168B1 KR 102289168 B1 KR102289168 B1 KR 102289168B1 KR 1020197033328 A KR1020197033328 A KR 1020197033328A KR 20197033328 A KR20197033328 A KR 20197033328A KR 102289168 B1 KR102289168 B1 KR 102289168B1
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cells
liver
mixture
cell
cmha
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KR1020197033328A
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KR20190128754A (ko
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레이첼 터너
데이비드 거버
오스왈도 로소야
롤라 엠. 레이드
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유니버시티 오브 노스캐롤라이나 앳 채플 힐
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Priority to KR1020217024885A priority Critical patent/KR102493613B1/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/734—Alginic acid
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/42—Respiratory system, e.g. lungs, bronchi or lung cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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    • A—HUMAN NECESSITIES
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    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
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    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/28—Materials or treatment for tissue regeneration for liver reconstruction
    • C—CHEMISTRY; METALLURGY
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    • C12N2537/10—Cross-linking
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Molecular Biology (AREA)
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KR1020197033328A 2010-05-07 2011-05-06 고형 조직으로부터 세포를 생착시키는 방법 KR102289168B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020217024885A KR102493613B1 (ko) 2010-05-07 2011-05-06 고형 조직으로부터 세포를 생착시키는 방법

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33244110P 2010-05-07 2010-05-07
US61/332,441 2010-05-07
PCT/US2011/035498 WO2011140428A1 (fr) 2010-05-07 2011-05-06 Procédé de greffage de cellules à partir de tissus solides
KR1020127032025A KR20130108996A (ko) 2010-05-07 2011-05-06 고형 조직으로부터 세포를 접목시키는 방법

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KR1020127032025A Division KR20130108996A (ko) 2010-05-07 2011-05-06 고형 조직으로부터 세포를 접목시키는 방법

Related Child Applications (1)

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KR1020217024885A Division KR102493613B1 (ko) 2010-05-07 2011-05-06 고형 조직으로부터 세포를 생착시키는 방법

Publications (2)

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KR20190128754A KR20190128754A (ko) 2019-11-18
KR102289168B1 true KR102289168B1 (ko) 2021-08-11

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Family Applications (4)

Application Number Title Priority Date Filing Date
KR1020217024885A KR102493613B1 (ko) 2010-05-07 2011-05-06 고형 조직으로부터 세포를 생착시키는 방법
KR1020197033328A KR102289168B1 (ko) 2010-05-07 2011-05-06 고형 조직으로부터 세포를 생착시키는 방법
KR1020127032025A KR20130108996A (ko) 2010-05-07 2011-05-06 고형 조직으로부터 세포를 접목시키는 방법
KR1020197002829A KR102230864B1 (ko) 2010-05-07 2011-05-06 고형 조직으로부터 세포를 생착시키는 방법

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KR1020217024885A KR102493613B1 (ko) 2010-05-07 2011-05-06 고형 조직으로부터 세포를 생착시키는 방법

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Application Number Title Priority Date Filing Date
KR1020127032025A KR20130108996A (ko) 2010-05-07 2011-05-06 고형 조직으로부터 세포를 접목시키는 방법
KR1020197002829A KR102230864B1 (ko) 2010-05-07 2011-05-06 고형 조직으로부터 세포를 생착시키는 방법

Country Status (18)

Country Link
US (1) US20110274666A1 (fr)
EP (1) EP2566567A4 (fr)
JP (4) JP6177687B2 (fr)
KR (4) KR102493613B1 (fr)
CN (2) CN102985130A (fr)
AR (1) AR081906A1 (fr)
AU (1) AU2011247984B2 (fr)
BR (1) BR112012028265B1 (fr)
CA (2) CA3146949A1 (fr)
CL (1) CL2012003085A1 (fr)
CR (1) CR20120603A (fr)
IL (3) IL222857A (fr)
MX (3) MX359678B (fr)
NZ (2) NZ630598A (fr)
RU (1) RU2736955C2 (fr)
SG (2) SG10201503582YA (fr)
TW (3) TW201202424A (fr)
WO (1) WO2011140428A1 (fr)

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WO2013010045A1 (fr) 2011-07-12 2013-01-17 Biotime Inc. Nouveaux procédés et formulations pour thérapie cellulaire orthopédique
US8961617B2 (en) * 2012-03-08 2015-02-24 Liventa Bioscience, Inc. Amnion and chorion constructs and uses thereof in abdominal surgery
US9533013B2 (en) 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
EP2886644A1 (fr) * 2013-12-20 2015-06-24 Kallistem Procédé de mise en oeuvre de spermatogenèse in vitro et dispositif associé
US10765705B2 (en) 2014-11-24 2020-09-08 Prime Merger Sub, Llc Visco-supplement compositions, and methods of use thereof
WO2016118950A1 (fr) * 2015-01-23 2016-07-28 Everon Biosciences, Inc. Induction de la sénescence cellulaire pour thérapies tissulaires
CN106148266A (zh) * 2015-04-20 2016-11-23 烟台赛泽生物技术有限公司 一种免疫细胞用培养基及该培养基的添加剂
JP2016209303A (ja) * 2015-05-08 2016-12-15 レジエンス株式会社 肝組織を再生するための製剤
US20170369849A1 (en) * 2016-05-11 2017-12-28 The University Of North Carolina At Chapel Hill Compositions and methods for bioengineered tissues
EP3520746A4 (fr) 2016-09-30 2020-05-06 Taipei Veterans General Hospital Agent antigel pour protéger un tissu biologique pendant un traitement par congélation et son procédé de préparation
JP2020516257A (ja) * 2017-04-06 2020-06-11 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｎｏｒｔｈ Ｃａｒｏｌｉｎａ Ａｔ Ｃｈａｐｅｌ Ｈｉｌｌ 凍結保存方法
JP7539832B2 (ja) * 2017-06-12 2024-08-26 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 細胞生着のためのパッチグラフト組成物
JP2020050625A (ja) 2018-09-27 2020-04-02 株式会社北里コーポレーション 卵巣組織の移植方法および卵胞活性化方法
JP7350505B2 (ja) * 2019-02-15 2023-09-26 イビデン株式会社 生体試料を含む固化体
JPWO2023042875A1 (fr) * 2021-09-16 2023-03-23
JP7440987B2 (ja) * 2021-12-28 2024-02-29 株式会社ポル・メド・テック 移植材料の製造方法、及び移植材料
WO2024043306A1 (fr) * 2022-08-24 2024-02-29 株式会社ヴィータ Composition pour marquage fluorescent, sonde fluorescente, agent d'injection, remplissage de seringue, appareil médical, matériau de fibre médicale, procédé de production de composition pour marquage fluorescent, et procédé de production de matériau fibreux médical

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WO2008156667A1 (fr) * 2007-06-15 2008-12-24 University Of North Carolina At Chapel Hill Signaux paracrines provenant de cellules nourricières mésenchymateuses et régulation de l'expansion et de la différenciation de cellules souches utilisant ces signaux

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