KR102257154B1 - Pd-1 결합 단백질을 사용하는 면역 질환의 치료 방법 - Google Patents

Pd-1 결합 단백질을 사용하는 면역 질환의 치료 방법 Download PDF

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KR102257154B1
KR102257154B1 KR1020197007885A KR20197007885A KR102257154B1 KR 102257154 B1 KR102257154 B1 KR 102257154B1 KR 1020197007885 A KR1020197007885 A KR 1020197007885A KR 20197007885 A KR20197007885 A KR 20197007885A KR 102257154 B1 KR102257154 B1 KR 102257154B1
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antibody
amino acid
acid sequence
antigen
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헨리 에이치. 찬
은 미 허
롤리 카트리
모니카 리웅
가스 이. 링하임
피터 에이치. 쉐퍼
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셀진 코포레이션
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07ORGANIC CHEMISTRY
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P37/08Antiallergic agents
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    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71Decreased effector function due to an Fc-modification
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Immunology (AREA)
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  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020197007885A 2016-09-19 2017-09-18 Pd-1 결합 단백질을 사용하는 면역 질환의 치료 방법 Active KR102257154B1 (ko)

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US201662396736P 2016-09-19 2016-09-19
US62/396,736 2016-09-19
PCT/US2017/052021 WO2018053405A1 (en) 2016-09-19 2017-09-18 Methods of treating immune disorders using pd-1 binding proteins

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KR20190069399A KR20190069399A (ko) 2019-06-19
KR102257154B1 true KR102257154B1 (ko) 2021-05-28

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US (2) US10751414B2 (enExample)
EP (1) EP3515944A4 (enExample)
JP (1) JP2019531284A (enExample)
KR (1) KR102257154B1 (enExample)
CN (1) CN109952317A (enExample)
AU (1) AU2017329024A1 (enExample)
BR (1) BR112019004733A2 (enExample)
CA (1) CA3036701A1 (enExample)
CL (1) CL2019000622A1 (enExample)
EA (1) EA201990747A1 (enExample)
IL (1) IL265197A (enExample)
MX (1) MX2019002867A (enExample)
SG (1) SG11201901950TA (enExample)
WO (1) WO2018053405A1 (enExample)

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