KR102253394B1 - 골관절염의 예방 및 치료를 위한 스테로이드류 및 졸레드론산의 공투여 - Google Patents
골관절염의 예방 및 치료를 위한 스테로이드류 및 졸레드론산의 공투여 Download PDFInfo
- Publication number
- KR102253394B1 KR102253394B1 KR1020157027348A KR20157027348A KR102253394B1 KR 102253394 B1 KR102253394 B1 KR 102253394B1 KR 1020157027348 A KR1020157027348 A KR 1020157027348A KR 20157027348 A KR20157027348 A KR 20157027348A KR 102253394 B1 KR102253394 B1 KR 102253394B1
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- KR
- South Korea
- Prior art keywords
- pharmaceutically acceptable
- prednisolone
- acceptable salt
- zoledronic acid
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 title claims abstract description 67
- 201000008482 osteoarthritis Diseases 0.000 title claims abstract description 59
- 229960004276 zoledronic acid Drugs 0.000 title claims abstract description 58
- 150000003431 steroids Chemical class 0.000 title abstract description 33
- 238000011260 co-administration Methods 0.000 title abstract description 9
- -1 hydroxy, amino Chemical group 0.000 claims description 27
- 150000003839 salts Chemical class 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 24
- 238000011282 treatment Methods 0.000 claims description 21
- 125000000217 alkyl group Chemical group 0.000 claims description 19
- 229960005205 prednisolone Drugs 0.000 claims description 16
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 15
- 238000001990 intravenous administration Methods 0.000 claims description 14
- 150000001875 compounds Chemical class 0.000 claims description 13
- 238000002347 injection Methods 0.000 claims description 13
- 239000007924 injection Substances 0.000 claims description 13
- FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 claims description 11
- 229910052736 halogen Inorganic materials 0.000 claims description 11
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- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims description 9
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 5
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- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 claims description 5
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US13/791,685 US9012432B2 (en) | 2013-03-08 | 2013-03-08 | Co-administration of steroids and zoledronic acid to prevent and treat osteoarthritis |
| US13/791,685 | 2013-03-08 | ||
| PCT/US2014/022169 WO2014138712A1 (en) | 2013-03-08 | 2014-03-07 | Co-administration of steroids and zoledronic acid to prevent and treat osteoarthritis |
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| KR20150125001A KR20150125001A (ko) | 2015-11-06 |
| KR102253394B1 true KR102253394B1 (ko) | 2021-05-20 |
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| WO2017155233A1 (ko) | 2016-03-09 | 2017-09-14 | 주식회사 바이오펩 | 염증성 질환의 예방 또는 치료용 펩타이드 및 이의 용도 |
| US10913772B2 (en) | 2016-03-09 | 2021-02-09 | Kine Sciences Co., Ltd. | Peptide for preventing or treating inflammatory diseases and use thereof |
| US10913771B2 (en) | 2016-03-09 | 2021-02-09 | Kine Sciences Co., Ltd. | Peptide for preventing or treating inflammatory diseases and use thereof |
| WO2017155234A1 (ko) | 2016-03-09 | 2017-09-14 | 주식회사 바이오펩 | 염증성 질환의 예방 또는 치료용 펩타이드 및 이의 용도 |
| KR101897122B1 (ko) | 2016-03-09 | 2018-09-10 | 주식회사 바이오펩 | 염증성 질환의 예방 또는 치료용 펩타이드 및 이의 용도 |
| JP7127616B2 (ja) | 2019-06-04 | 2022-08-30 | 横河電機株式会社 | 情報処理装置、アラーム管理システム、及びアラーム管理方法 |
| WO2021163432A1 (en) * | 2020-02-12 | 2021-08-19 | Levolta Pharmaceuticals, Inc. | Co-administration of prednisolone/methyl prednisolone and zoledronic acid to treat and prevent osteoarthritis |
| CN114028571B (zh) * | 2021-11-18 | 2023-04-28 | 中国医学科学院基础医学研究所 | 含氮双膦酸盐联合糖皮质激素在预防或治疗病毒性肺炎中的应用 |
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| EP0275821B1 (de) | 1986-11-21 | 1992-02-26 | Ciba-Geigy Ag | Neue substituierte Alkandiphosphonsäuren |
| US7018647B1 (en) * | 1999-12-27 | 2006-03-28 | Teikoku Seiyaku Co., Ltd | Patches for external use |
| GB0029111D0 (en) | 2000-11-29 | 2001-01-10 | Novartis Ag | Organic compounds |
| CA2449934A1 (en) * | 2001-06-08 | 2002-12-19 | Ortho-Mcneil Pharmaceutical, Inc. | Treating pain by targeting hyperpolarization-activated, cyclic nucleotide-gated channels |
| WO2003086415A1 (en) * | 2002-04-05 | 2003-10-23 | Merck & Co., Inc. | Method for inhibiting bone resorption with an alendronate and vitamin d formulation |
| MXPA06003063A (es) * | 2003-09-19 | 2006-05-31 | Pfizer Prod Inc | Composiciones farmaceuticas y metodos que comprenden combinaciones de derivados de 2-alquiliden-19-nor-vitamina- d y un bisfosfonato. |
| EP1758653A2 (en) * | 2004-06-17 | 2007-03-07 | Osteologix A/S | Treatments comprising strontium for rheumatic and arthritic diseases and pain |
| JP5240925B2 (ja) * | 2005-05-25 | 2013-07-17 | カロシン ファーマ， インコーポレイテッド | 変形性関節症を処置するための方法および組成物 |
| US20070048372A1 (en) * | 2005-08-18 | 2007-03-01 | Srz Properties, Inc. | Method for treating non-inflammatory osteoarthritic pain |
| MX2009001248A (es) * | 2006-08-03 | 2009-02-11 | Nitec Pharma Ag | Tratamiento con glucocorticoide de liberacion prolongada de enfermedad reumatoide. |
| WO2010071866A2 (en) * | 2008-12-19 | 2010-06-24 | Nuon Therapeutics, Inc. | Combination therapy for arthritis with tranilast |
| JP5648174B2 (ja) * | 2009-05-04 | 2015-01-07 | ヌボ リサーチ インコーポレイテッド | 神経腫、神経絞扼、および他の状態と関連する疼痛を処置する方法 |
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Patent Citations (1)
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| US20110263537A1 (en) * | 2010-04-26 | 2011-10-27 | Ketan Desai | Co-administration of steroids and zoledronic acid to prevent and treat side effects from zoledronic acid infusion |
Also Published As
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|---|---|
| WO2014138712A1 (en) | 2014-09-12 |
| MX377447B (es) | 2025-03-10 |
| BR112015021503B1 (pt) | 2022-09-06 |
| MX2015011671A (es) | 2016-05-12 |
| ES2904365T3 (es) | 2022-04-04 |
| JP2016510765A (ja) | 2016-04-11 |
| US20140256681A1 (en) | 2014-09-11 |
| AU2014225373B2 (en) | 2018-07-05 |
| CA2941346A1 (en) | 2014-09-12 |
| AU2014225373A1 (en) | 2015-10-22 |
| EP2964209B1 (en) | 2021-10-27 |
| US9012432B2 (en) | 2015-04-21 |
| CN105324113A (zh) | 2016-02-10 |
| BR112015021503A2 (pt) | 2018-05-15 |
| JP6839491B2 (ja) | 2021-03-17 |
| EP2964209A1 (en) | 2016-01-13 |
| EP2964209A4 (en) | 2016-08-03 |
| JP2019104762A (ja) | 2019-06-27 |
| CA2941346C (en) | 2020-03-10 |
| CN105324113B (zh) | 2018-07-03 |
| EA032067B1 (ru) | 2019-04-30 |
| KR20150125001A (ko) | 2015-11-06 |
| EA201591638A1 (ru) | 2016-02-29 |
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