EA032067B1 - Совместное введение стероидов и золедроновой кислоты для профилактики и лечения остеоартрита - Google Patents
Совместное введение стероидов и золедроновой кислоты для профилактики и лечения остеоартрита Download PDFInfo
- Publication number
- EA032067B1 EA032067B1 EA201591638A EA201591638A EA032067B1 EA 032067 B1 EA032067 B1 EA 032067B1 EA 201591638 A EA201591638 A EA 201591638A EA 201591638 A EA201591638 A EA 201591638A EA 032067 B1 EA032067 B1 EA 032067B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- steroid
- zoledronic acid
- osteoarthritis
- pharmaceutically acceptable
- acceptable salt
- Prior art date
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- 229960004276 zoledronic acid Drugs 0.000 title claims abstract description 76
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 title claims abstract description 76
- 201000008482 osteoarthritis Diseases 0.000 title claims abstract description 75
- 150000003431 steroids Chemical class 0.000 title claims abstract description 68
- 238000011260 co-administration Methods 0.000 title abstract description 9
- 238000004519 manufacturing process Methods 0.000 claims abstract description 8
- 150000003839 salts Chemical class 0.000 claims description 40
- 238000000034 method Methods 0.000 claims description 32
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- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims description 20
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- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
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Landscapes
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| PCT/US2014/022169 WO2014138712A1 (en) | 2013-03-08 | 2014-03-07 | Co-administration of steroids and zoledronic acid to prevent and treat osteoarthritis |
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| EP (1) | EP2964209B1 (enExample) |
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| WO2017155233A1 (ko) | 2016-03-09 | 2017-09-14 | 주식회사 바이오펩 | 염증성 질환의 예방 또는 치료용 펩타이드 및 이의 용도 |
| US10913772B2 (en) | 2016-03-09 | 2021-02-09 | Kine Sciences Co., Ltd. | Peptide for preventing or treating inflammatory diseases and use thereof |
| US10913771B2 (en) | 2016-03-09 | 2021-02-09 | Kine Sciences Co., Ltd. | Peptide for preventing or treating inflammatory diseases and use thereof |
| WO2017155234A1 (ko) | 2016-03-09 | 2017-09-14 | 주식회사 바이오펩 | 염증성 질환의 예방 또는 치료용 펩타이드 및 이의 용도 |
| KR101897122B1 (ko) | 2016-03-09 | 2018-09-10 | 주식회사 바이오펩 | 염증성 질환의 예방 또는 치료용 펩타이드 및 이의 용도 |
| JP7127616B2 (ja) | 2019-06-04 | 2022-08-30 | 横河電機株式会社 | 情報処理装置、アラーム管理システム、及びアラーム管理方法 |
| WO2021163432A1 (en) * | 2020-02-12 | 2021-08-19 | Levolta Pharmaceuticals, Inc. | Co-administration of prednisolone/methyl prednisolone and zoledronic acid to treat and prevent osteoarthritis |
| CN114028571B (zh) * | 2021-11-18 | 2023-04-28 | 中国医学科学院基础医学研究所 | 含氮双膦酸盐联合糖皮质激素在预防或治疗病毒性肺炎中的应用 |
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| US20040063670A1 (en) * | 2000-11-29 | 2004-04-01 | Alyson Fox | Use of bisphosphonates for pain treatment |
| US20110263537A1 (en) * | 2010-04-26 | 2011-10-27 | Ketan Desai | Co-administration of steroids and zoledronic acid to prevent and treat side effects from zoledronic acid infusion |
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| JP5240925B2 (ja) * | 2005-05-25 | 2013-07-17 | カロシン ファーマ， インコーポレイテッド | 変形性関節症を処置するための方法および組成物 |
| US20070048372A1 (en) * | 2005-08-18 | 2007-03-01 | Srz Properties, Inc. | Method for treating non-inflammatory osteoarthritic pain |
| MX2009001248A (es) * | 2006-08-03 | 2009-02-11 | Nitec Pharma Ag | Tratamiento con glucocorticoide de liberacion prolongada de enfermedad reumatoide. |
| WO2010071866A2 (en) * | 2008-12-19 | 2010-06-24 | Nuon Therapeutics, Inc. | Combination therapy for arthritis with tranilast |
| JP5648174B2 (ja) * | 2009-05-04 | 2015-01-07 | ヌボ リサーチ インコーポレイテッド | 神経腫、神経絞扼、および他の状態と関連する疼痛を処置する方法 |
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| WO2014138712A1 (en) | 2014-09-12 |
| MX377447B (es) | 2025-03-10 |
| BR112015021503B1 (pt) | 2022-09-06 |
| MX2015011671A (es) | 2016-05-12 |
| KR102253394B1 (ko) | 2021-05-20 |
| ES2904365T3 (es) | 2022-04-04 |
| JP2016510765A (ja) | 2016-04-11 |
| US20140256681A1 (en) | 2014-09-11 |
| AU2014225373B2 (en) | 2018-07-05 |
| CA2941346A1 (en) | 2014-09-12 |
| AU2014225373A1 (en) | 2015-10-22 |
| EP2964209B1 (en) | 2021-10-27 |
| US9012432B2 (en) | 2015-04-21 |
| CN105324113A (zh) | 2016-02-10 |
| BR112015021503A2 (pt) | 2018-05-15 |
| JP6839491B2 (ja) | 2021-03-17 |
| EP2964209A1 (en) | 2016-01-13 |
| EP2964209A4 (en) | 2016-08-03 |
| JP2019104762A (ja) | 2019-06-27 |
| CA2941346C (en) | 2020-03-10 |
| CN105324113B (zh) | 2018-07-03 |
| KR20150125001A (ko) | 2015-11-06 |
| EA201591638A1 (ru) | 2016-02-29 |
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