KR102227429B1 - 치료제 전달을 위한 진입 수포를 형성하는 장치 및 방법 - Google Patents

치료제 전달을 위한 진입 수포를 형성하는 장치 및 방법 Download PDF

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KR102227429B1
KR102227429B1 KR1020197001537A KR20197001537A KR102227429B1 KR 102227429 B1 KR102227429 B1 KR 102227429B1 KR 1020197001537 A KR1020197001537 A KR 1020197001537A KR 20197001537 A KR20197001537 A KR 20197001537A KR 102227429 B1 KR102227429 B1 KR 102227429B1
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needle
control module
cannula
fluid
flexible
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KR20190022646A (ko
Inventor
다니엘 더블유. 프라이스
제이. 오버키르히어 브렌단
다니엘 제이. 프랜저
제프리 킹
토마스 이. 메이어
벤자민 엘. 코
Original Assignee
자이로스코프 테라퓨틱스 리미티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/00736—Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3403—Needle locating or guiding means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
    • A61M5/427—Locating point where body is to be pierced, e.g. vein location means using ultrasonic waves, injection site templates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3403—Needle locating or guiding means
    • A61B2017/3405—Needle locating or guiding means using mechanical guide means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0612—Eyes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020197001537A 2016-06-17 2017-06-14 치료제 전달을 위한 진입 수포를 형성하는 장치 및 방법 Active KR102227429B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662351611P 2016-06-17 2016-06-17
US62/351,611 2016-06-17
US15/609,386 US10646374B2 (en) 2016-06-17 2017-05-31 Apparatus and method to form entry bleb for subretinal delivery of therapeutic agent
US15/609,386 2017-05-31
PCT/US2017/037361 WO2017218610A1 (en) 2016-06-17 2017-06-14 Apparatus and method to form entry bleb for subretinal delivery of therapeutic agent

Publications (2)

Publication Number Publication Date
KR20190022646A KR20190022646A (ko) 2019-03-06
KR102227429B1 true KR102227429B1 (ko) 2021-03-15

Family

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KR1020197001537A Active KR102227429B1 (ko) 2016-06-17 2017-06-14 치료제 전달을 위한 진입 수포를 형성하는 장치 및 방법

Country Status (11)

Country Link
US (1) US10646374B2 (enExample)
EP (1) EP3471670B8 (enExample)
JP (1) JP6755976B2 (enExample)
KR (1) KR102227429B1 (enExample)
CN (1) CN109310518B (enExample)
AU (1) AU2017285139B2 (enExample)
IL (1) IL263599B2 (enExample)
RU (1) RU2742971C2 (enExample)
SA (1) SA518400661B1 (enExample)
SG (1) SG11201810521WA (enExample)
WO (1) WO2017218610A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10624785B2 (en) 2016-01-30 2020-04-21 Carl Zeiss Meditec Cataract Technology Inc. Devices and methods for ocular surgery
US10806629B2 (en) 2016-06-17 2020-10-20 Gyroscope Therapeutics Limited Injection device for subretinal delivery of therapeutic agent
US11000410B2 (en) 2016-06-17 2021-05-11 Gyroscope Therapeutics Limited Guide apparatus for tangential entry into suprachoroidal space
US11076984B2 (en) 2017-03-13 2021-08-03 Gyroscope Therapeutics Limited Method of performing subretinal drainage and agent delivery
EP3618784B1 (en) 2017-05-04 2022-03-02 Carl Zeiss Meditec Cataract Technology Inc. Devices for ocular surgery
CN112702982B (zh) 2018-06-05 2023-12-19 卡尔蔡司白内障医疗技术公司 眼科显微手术工具、系统和使用方法
WO2020160434A1 (en) 2019-02-01 2020-08-06 Carl Zeiss Meditec Cataract Technology Inc. Ophthalmic cutting instruments having integrated aspiration pump
CN113453738B (zh) * 2019-02-08 2023-11-21 追踪注射器有限责任公司 针传感器组件及其使用方法
US11759355B1 (en) * 2019-02-26 2023-09-19 Gyroscope Therapeutics Limited Method of delivering leading blebs and agent to subretinal space
CA3140788A1 (en) 2019-05-17 2020-11-26 Carl Zeiss Meditec Cataract Technology Inc. Ophthalmic cutting instruments having integrated aspiration pump
KR102931503B1 (ko) 2019-06-07 2026-02-27 칼 짜이스 메디텍 캐터랙트 테크놀로지 인크. 눈의 수정체 낭 내부로부터 렌즈 조직을 제거하기 위한 의료 디바이스
CN114945397B (zh) * 2019-09-11 2025-02-25 阿尔塔维兹有限责任公司 具有剂量指导的微体积注射器和使用方法
AU2020362958B2 (en) 2019-10-11 2026-07-09 Genentech, Inc. Dose clip assembly for syringe
IT202000009049A1 (it) * 2020-04-27 2021-10-27 Marco Codenotti Dispositivo per chirurugia vitreo-retinica
DE102020115346A1 (de) 2020-06-09 2021-12-09 Carl Zeiss Meditec Ag Kontrollierte Injektion zwischen zwei Gewebeschichten des menschlichen Auges
WO2022136913A1 (en) 2020-12-22 2022-06-30 Gyroscope Therapeutics Limited Ocular cannula guide
EP4281025B1 (en) * 2021-01-25 2026-02-18 Alcon Inc. Apparatus for subretinal injection
AU2022356475A1 (en) * 2021-09-30 2024-02-22 Alcon Inc. Apparatus for subretinal injection
NL2032219B1 (en) 2022-06-20 2024-01-08 Crea Ip B V Injector device
KR20250052375A (ko) 2022-07-11 2025-04-18 제넨테크, 인크. 유리체 통과 망막하 주입기
AU2023336875A1 (en) 2022-09-06 2025-03-20 Genentech, Inc. Apparatus for subretinal administration of therapeutic agent via dual-curved needle
IL322034A (en) 2023-01-13 2025-09-01 Genentech Inc Syringe dosing station
CN116509627B (zh) * 2023-04-23 2025-07-25 哈尔滨工业大学 一种耳科手术机器人内耳注射采样执行器
TW202529711A (zh) 2023-09-29 2025-08-01 美商建南德克公司 眼插管導引器、施用器及標記器械
TW202602405A (zh) 2024-03-27 2026-01-16 美商建南德克公司 用於視網膜下注射裝置的扭矩環

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5709661A (en) 1992-04-14 1998-01-20 Endo Sonics Europe B.V. Electronic catheter displacement sensor
US6171276B1 (en) 1997-08-06 2001-01-09 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
WO2015094507A1 (en) 2013-12-18 2015-06-25 Alcon Research, Ltd. Systems and methods for subretinal delivery of therapeutic agents
WO2016023116A1 (en) 2014-08-12 2016-02-18 Patrick Gooi Device, delivery system, and method for ocular therapy
WO2016040631A1 (en) 2014-09-11 2016-03-17 Ethicon Endo-Surgery, Inc. Method and apparatus for sensing position between layers of an eye

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9702872D0 (sv) * 1997-08-06 1997-08-06 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
US6368315B1 (en) 1999-06-23 2002-04-09 Durect Corporation Composite drug delivery catheter
AU2003213075A1 (en) 2002-02-14 2003-09-04 Henry J. Kaplan Subretinal implantation device and surgical cannulas for use therewith
US7328064B2 (en) * 2002-07-04 2008-02-05 Inovio As Electroporation device and injection apparatus
CA2689424A1 (en) 2002-09-29 2004-04-08 Surmodics, Inc. Methods for treatment and/or prevention of retinal disease
ES2569780T3 (es) 2003-06-27 2016-05-12 DePuy Synthes Products, Inc. Células posparto derivadas de tejido placentario y métodos de preparación y uso de las mismas
EP2248494B1 (en) 2004-01-23 2013-06-05 iScience Interventional Corporation Composite ophthalmic microcannula
US20080058704A1 (en) 2004-04-29 2008-03-06 Michael Hee Apparatus and Method for Ocular Treatment
US20060257835A1 (en) * 2005-05-13 2006-11-16 Wallaker Daniel M Endoscopy simulation system
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
US8425473B2 (en) 2009-01-23 2013-04-23 Iscience Interventional Corporation Subretinal access device
WO2010132751A1 (en) 2009-05-15 2010-11-18 Iscience Interventional Corporation Methods and apparatus for sub-retinal catheterization
WO2012051575A2 (en) 2010-10-15 2012-04-19 Iscience Interventional Corporation Device for ocular access
CA2882184C (en) 2012-08-27 2021-09-07 Clearside Biomedical, Inc. Apparatus and methods for drug delivery using microneedles
AU2013342275B2 (en) 2012-11-08 2017-11-09 Clearside Biomedical, Inc. Methods and devices for the treatment of ocular diseases in human subjects
JP6548229B2 (ja) 2014-02-12 2019-07-24 オービット・バイオメディカル・リミテッドＯｒｂｉｔ Ｂｉｏｍｅｄｉｃａｌ Ｌｉｍｉｔｅｄ 治療薬の脈絡膜上投与のための方法及び装置
US9925088B2 (en) 2014-06-06 2018-03-27 Janssen Biotech, Inc. Sub-retinal tangential needle catheter guide and introducer
US9949874B2 (en) 2014-06-06 2018-04-24 Janssen Biotech, Inc. Therapeutic agent delivery device with convergent lumen
BR112016029864A2 (pt) 2014-06-17 2017-08-22 Clearside Biomedical Inc métodos e dispositivos para tratamento de desordens oculares posteriores.
WO2015196085A2 (en) 2014-06-20 2015-12-23 Clearside Biomedical, Inc. Variable diameter cannula and methods for controlling insertion depth for medicament delivery
US10064752B2 (en) 2014-09-11 2018-09-04 Orbit Biomedical Limited Motorized suprachoroidal injection of therapeutic agent
US10219936B2 (en) 2014-09-11 2019-03-05 Orbit Biomedical Limited Therapeutic agent delivery device with advanceable cannula and needle
US10258502B2 (en) 2014-09-18 2019-04-16 Orbit Biomedical Limited Therapeutic agent delivery device
GB201516066D0 (en) 2015-09-10 2015-10-28 Young & Co Llp D Treatment of retinitis pigmentosa
US10478553B2 (en) 2016-03-09 2019-11-19 Orbit Biomedical Limited Apparatus for subretinal administration of therapeutic agent via a curved needle
US11000410B2 (en) 2016-06-17 2021-05-11 Gyroscope Therapeutics Limited Guide apparatus for tangential entry into suprachoroidal space
US10806629B2 (en) 2016-06-17 2020-10-20 Gyroscope Therapeutics Limited Injection device for subretinal delivery of therapeutic agent

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5709661A (en) 1992-04-14 1998-01-20 Endo Sonics Europe B.V. Electronic catheter displacement sensor
US6171276B1 (en) 1997-08-06 2001-01-09 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
WO2015094507A1 (en) 2013-12-18 2015-06-25 Alcon Research, Ltd. Systems and methods for subretinal delivery of therapeutic agents
WO2016023116A1 (en) 2014-08-12 2016-02-18 Patrick Gooi Device, delivery system, and method for ocular therapy
WO2016040631A1 (en) 2014-09-11 2016-03-17 Ethicon Endo-Surgery, Inc. Method and apparatus for sensing position between layers of an eye

Also Published As

Publication number Publication date
IL263599B (en) 2022-10-01
EP3471670A1 (en) 2019-04-24
CN109310518A (zh) 2019-02-05
US20170360607A1 (en) 2017-12-21
SA518400661B1 (ar) 2022-09-19
RU2742971C2 (ru) 2021-02-12
WO2017218610A1 (en) 2017-12-21
IL263599B2 (en) 2023-02-01
RU2019101083A3 (enExample) 2020-08-27
CA3026284A1 (en) 2017-12-21
JP6755976B2 (ja) 2020-09-16
AU2017285139A1 (en) 2018-12-20
EP3471670B8 (en) 2020-11-11
EP3471670B1 (en) 2020-10-14
US10646374B2 (en) 2020-05-12
JP2019517888A (ja) 2019-06-27
AU2017285139B2 (en) 2020-12-24
CN109310518B (zh) 2021-08-17
IL263599A (en) 2019-01-31
SG11201810521WA (en) 2018-12-28
BR112018075965A2 (pt) 2019-04-02
RU2019101083A (ru) 2020-07-17
KR20190022646A (ko) 2019-03-06

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