JP6755976B2 - 治療薬の網膜下送達のための進入ブレブを形成する器具および方法 - Google Patents

治療薬の網膜下送達のための進入ブレブを形成する器具および方法 Download PDF

Info

Publication number
JP6755976B2
JP6755976B2 JP2018565696A JP2018565696A JP6755976B2 JP 6755976 B2 JP6755976 B2 JP 6755976B2 JP 2018565696 A JP2018565696 A JP 2018565696A JP 2018565696 A JP2018565696 A JP 2018565696A JP 6755976 B2 JP6755976 B2 JP 6755976B2
Authority
JP
Japan
Prior art keywords
needle
fluid
cannula
flexible
injector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018565696A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019517888A (ja
JP2019517888A5 (enExample
Inventor
プライス・ダニエル・ダブリュ
オーベルキルヒャー・ブレンダン・ジェイ
プレンジャー・ダニエル・ジェイ
キング・ジェフリー
マイヤー・トーマス・イー
コー・ベンジャミン・エル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orbit Biomedical Ltd
Original Assignee
Orbit Biomedical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orbit Biomedical Ltd filed Critical Orbit Biomedical Ltd
Publication of JP2019517888A publication Critical patent/JP2019517888A/ja
Publication of JP2019517888A5 publication Critical patent/JP2019517888A5/ja
Application granted granted Critical
Publication of JP6755976B2 publication Critical patent/JP6755976B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/00736Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/34Trocars; Puncturing needles
    • A61B17/3403Needle locating or guiding means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008Introducing ophthalmic products into the ocular cavity or retaining products therein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/42Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
    • A61M5/427Locating point where body is to be pierced, e.g. vein location means using ultrasonic waves, injection site templates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/34Trocars; Puncturing needles
    • A61B17/3403Needle locating or guiding means
    • A61B2017/3405Needle locating or guiding means using mechanical guide means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00Anatomical parts of the body
    • A61M2210/06Head
    • A61M2210/0612Eyes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2018565696A 2016-06-17 2017-06-14 治療薬の網膜下送達のための進入ブレブを形成する器具および方法 Active JP6755976B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662351611P 2016-06-17 2016-06-17
US62/351,611 2016-06-17
US15/609,386 US10646374B2 (en) 2016-06-17 2017-05-31 Apparatus and method to form entry bleb for subretinal delivery of therapeutic agent
US15/609,386 2017-05-31
PCT/US2017/037361 WO2017218610A1 (en) 2016-06-17 2017-06-14 Apparatus and method to form entry bleb for subretinal delivery of therapeutic agent

Publications (3)

Publication Number Publication Date
JP2019517888A JP2019517888A (ja) 2019-06-27
JP2019517888A5 JP2019517888A5 (enExample) 2020-07-02
JP6755976B2 true JP6755976B2 (ja) 2020-09-16

Family

ID=60661489

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018565696A Active JP6755976B2 (ja) 2016-06-17 2017-06-14 治療薬の網膜下送達のための進入ブレブを形成する器具および方法

Country Status (12)

Country Link
US (1) US10646374B2 (enExample)
EP (1) EP3471670B8 (enExample)
JP (1) JP6755976B2 (enExample)
KR (1) KR102227429B1 (enExample)
CN (1) CN109310518B (enExample)
AU (1) AU2017285139B2 (enExample)
CA (1) CA3026284A1 (enExample)
IL (1) IL263599B2 (enExample)
RU (1) RU2742971C2 (enExample)
SA (1) SA518400661B1 (enExample)
SG (1) SG11201810521WA (enExample)
WO (1) WO2017218610A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10624785B2 (en) 2016-01-30 2020-04-21 Carl Zeiss Meditec Cataract Technology Inc. Devices and methods for ocular surgery
US10806629B2 (en) 2016-06-17 2020-10-20 Gyroscope Therapeutics Limited Injection device for subretinal delivery of therapeutic agent
US11000410B2 (en) 2016-06-17 2021-05-11 Gyroscope Therapeutics Limited Guide apparatus for tangential entry into suprachoroidal space
US11076984B2 (en) 2017-03-13 2021-08-03 Gyroscope Therapeutics Limited Method of performing subretinal drainage and agent delivery
EP4052685B1 (en) 2017-05-04 2025-07-02 Carl Zeiss Meditec Cataract Technology Inc. Devices for ocular surgery
WO2019236615A1 (en) 2018-06-05 2019-12-12 Carl Zeiss Meditec Cataract Technology Inc. Ophthalmic microsurgical tools, systems, and methods of use
CN113710209B (zh) 2019-02-01 2024-06-25 卡尔蔡司白内障医疗技术公司 具有集成抽吸泵的眼科切割器械
WO2020163262A1 (en) * 2019-02-08 2020-08-13 Mcilrath Patrick Needle sensor assembly and method of use of same
US11759355B1 (en) * 2019-02-26 2023-09-19 Gyroscope Therapeutics Limited Method of delivering leading blebs and agent to subretinal space
WO2020236593A1 (en) 2019-05-17 2020-11-26 Carl Zeiss Meditec Cataract Technology Inc. Ophthalmic cutting instruments having integrated aspiration pump
AU2020288110B2 (en) 2019-06-07 2024-11-21 Carl Zeiss Meditec Cataract Technology Inc. Multi-stage trigger for ophthalmology cutting tool
US11738154B2 (en) * 2019-09-11 2023-08-29 Altaviz, Llc Micro-volume injectors with dose guidance and methods for use
US11771834B2 (en) 2019-10-11 2023-10-03 Gyroscope Therapeutics Limited Dose clip assembly for syringe
IT202000009049A1 (it) * 2020-04-27 2021-10-27 Marco Codenotti Dispositivo per chirurugia vitreo-retinica
DE102020115346A1 (de) 2020-06-09 2021-12-09 Carl Zeiss Meditec Ag Kontrollierte Injektion zwischen zwei Gewebeschichten des menschlichen Auges
WO2022136913A1 (en) 2020-12-22 2022-06-30 Gyroscope Therapeutics Limited Ocular cannula guide
US12214160B2 (en) * 2021-01-25 2025-02-04 Alcon Inc. Method and apparatus for subretinal injection
CN112842686A (zh) * 2021-02-05 2021-05-28 中国人民解放军陆军特色医学中心 老年性黄斑变性治疗用微针装置
WO2023053003A1 (en) * 2021-09-30 2023-04-06 Alcon Inc. Apparatus for subretinal injection
NL2032219B1 (en) 2022-06-20 2024-01-08 Crea Ip B V Injector device
AU2023308426A1 (en) 2022-07-11 2025-01-23 Genentech, Inc. Transvitreal subretinal injector
JP2025527930A (ja) * 2022-09-06 2025-08-22 ジェネンテック, インコーポレイテッド 二重湾曲針を介した治療剤の網膜下投与のための装置
CN120513071A (zh) 2023-01-13 2025-08-19 基因泰克公司 用于注射器的剂量对接座
CN116509627B (zh) * 2023-04-23 2025-07-25 哈尔滨工业大学 一种耳科手术机器人内耳注射采样执行器
WO2025072590A1 (en) 2023-09-29 2025-04-03 Genentech, Inc. Ocular cannula guide, applicator, and marking instrument
WO2025207699A1 (en) 2024-03-27 2025-10-02 Genentech, Inc. Torque ring for subretinal injection device

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5709661A (en) * 1992-04-14 1998-01-20 Endo Sonics Europe B.V. Electronic catheter displacement sensor
US6171276B1 (en) * 1997-08-06 2001-01-09 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
SE9702872D0 (sv) * 1997-08-06 1997-08-06 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
US6368315B1 (en) 1999-06-23 2002-04-09 Durect Corporation Composite drug delivery catheter
GB2399020B (en) 2002-02-14 2005-01-12 Photogenesis Inc Subretinal implantation device and surgical cannulas for use therewith
US7328064B2 (en) * 2002-07-04 2008-02-05 Inovio As Electroporation device and injection apparatus
US20050143363A1 (en) 2002-09-29 2005-06-30 Innorx, Inc. Method for subretinal administration of therapeutics including steroids; method for localizing pharmacodynamic action at the choroid of the retina; and related methods for treatment and/or prevention of retinal diseases
CA2530421C (en) 2003-06-27 2015-04-21 Ethicon, Incorporated Repair and regeneration of ocular tissue using postpartum-derived cells
DE10168535T1 (de) 2004-01-23 2011-03-17 Iscience Interventional Corp., Menlo Park Zusammengesetzte Ophthalmische Mikrokanuele
US20080058704A1 (en) 2004-04-29 2008-03-06 Michael Hee Apparatus and Method for Ocular Treatment
US20060257835A1 (en) * 2005-05-13 2006-11-16 Wallaker Daniel M Endoscopy simulation system
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
US8425473B2 (en) 2009-01-23 2013-04-23 Iscience Interventional Corporation Subretinal access device
KR20120018353A (ko) 2009-05-15 2012-03-02 아이싸이언스 인터벤셔날 코포레이션 망막하 카테터 삽입을 위한 장치 및 방법
BR112013009205A2 (pt) 2010-10-15 2016-07-26 Iscience Interventional Corp dispositivo para colocação na esclera de um olho, método para acessar o espaço supracoroidal de um olho, para acessar o espaço subretinal de um olho e para colocar um orifício dentro de um trato escleral em um olho.
CA2882184C (en) 2012-08-27 2021-09-07 Clearside Biomedical, Inc. Apparatus and methods for drug delivery using microneedles
CA3240136A1 (en) 2012-11-08 2014-05-15 Clearside Biomedical, Inc. Methods and devices for the treatment of ocular diseases in human subjects
US10010447B2 (en) 2013-12-18 2018-07-03 Novartis Ag Systems and methods for subretinal delivery of therapeutic agents
CN106687078B (zh) 2014-02-12 2019-10-25 轨道生物医学有限公司 用于治疗剂的脉络膜上施用的方法和设备
US9925088B2 (en) 2014-06-06 2018-03-27 Janssen Biotech, Inc. Sub-retinal tangential needle catheter guide and introducer
US9949874B2 (en) 2014-06-06 2018-04-24 Janssen Biotech, Inc. Therapeutic agent delivery device with convergent lumen
EP3157463A4 (en) 2014-06-17 2018-02-21 Clearside Biomedical, Inc. Methods and devices for treating posterior ocular disorders
RU2710491C2 (ru) 2014-06-20 2019-12-26 Клиасайд Байомедикал, Инк. Устройство для инъекции лекарственного средства в глазную ткань и способ инъекции лекарственного средства в глазную ткань
CA2956273A1 (en) * 2014-08-12 2016-02-18 Patrick Gooi Device, delivery system, and method for ocular therapy
US10322028B2 (en) 2014-09-11 2019-06-18 Orbit Biomedical Limited Method and apparatus for sensing position between layers of an eye
US10219936B2 (en) 2014-09-11 2019-03-05 Orbit Biomedical Limited Therapeutic agent delivery device with advanceable cannula and needle
US10064752B2 (en) 2014-09-11 2018-09-04 Orbit Biomedical Limited Motorized suprachoroidal injection of therapeutic agent
US10258502B2 (en) 2014-09-18 2019-04-16 Orbit Biomedical Limited Therapeutic agent delivery device
GB201516066D0 (en) 2015-09-10 2015-10-28 Young & Co Llp D Treatment of retinitis pigmentosa
US10478553B2 (en) 2016-03-09 2019-11-19 Orbit Biomedical Limited Apparatus for subretinal administration of therapeutic agent via a curved needle
US10806629B2 (en) 2016-06-17 2020-10-20 Gyroscope Therapeutics Limited Injection device for subretinal delivery of therapeutic agent
US11000410B2 (en) 2016-06-17 2021-05-11 Gyroscope Therapeutics Limited Guide apparatus for tangential entry into suprachoroidal space

Also Published As

Publication number Publication date
JP2019517888A (ja) 2019-06-27
US10646374B2 (en) 2020-05-12
CN109310518A (zh) 2019-02-05
CN109310518B (zh) 2021-08-17
RU2742971C2 (ru) 2021-02-12
IL263599B (en) 2022-10-01
CA3026284A1 (en) 2017-12-21
US20170360607A1 (en) 2017-12-21
KR20190022646A (ko) 2019-03-06
KR102227429B1 (ko) 2021-03-15
EP3471670B1 (en) 2020-10-14
AU2017285139B2 (en) 2020-12-24
SG11201810521WA (en) 2018-12-28
RU2019101083A (ru) 2020-07-17
EP3471670A1 (en) 2019-04-24
BR112018075965A2 (pt) 2019-04-02
IL263599A (en) 2019-01-31
EP3471670B8 (en) 2020-11-11
SA518400661B1 (ar) 2022-09-19
AU2017285139A1 (en) 2018-12-20
RU2019101083A3 (enExample) 2020-08-27
WO2017218610A1 (en) 2017-12-21
IL263599B2 (en) 2023-02-01

Similar Documents

Publication Publication Date Title
JP6755976B2 (ja) 治療薬の網膜下送達のための進入ブレブを形成する器具および方法
JP7770988B2 (ja) 治療薬の網膜下送達のための注入装置
US11554042B2 (en) Method and apparatus for subretinal administration of therapeutic agent
JP6828059B2 (ja) 上脈絡膜腔内への接線方向の進入のためのガイド器具
JP2023169335A (ja) 湾曲した針を介する治療剤の網膜下投与のための装置
US10064752B2 (en) Motorized suprachoroidal injection of therapeutic agent
BR112018075965B1 (pt) Aparelho para formar entrada de bolha (bleb) para distribuição sub- retinal de agente terapêutico

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200518

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20200518

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20200518

A975 Report on accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A971005

Effective date: 20200717

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20200728

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20200826

R150 Certificate of patent or registration of utility model

Ref document number: 6755976

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R360 Written notification for declining of transfer of rights

Free format text: JAPANESE INTERMEDIATE CODE: R360

R360 Written notification for declining of transfer of rights

Free format text: JAPANESE INTERMEDIATE CODE: R360

R371 Transfer withdrawn

Free format text: JAPANESE INTERMEDIATE CODE: R371

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250