KR102221141B1 - Cosmetic composition for improving acne - Google Patents

Abstract

The present invention relates to a cosmetic composition for improving acne-prone skin, and more specifically, includes a Salix alba bark extract, an Echinacea purpurea extract, and an Ananas comosus extract as active ingredients. The present invention has advantages of effectively inhibiting the growth of acne bacteria and skin flora, strengthening skin immunity, effectively alleviating acne by softening hyperkeratinized hair follicles, and causing little skin irritation by using natural substances.

Description

Cosmetic composition for improving acne skin {Cosmetic composition for improving acne}

The present invention relates to a cosmetic composition for improving acne skin, and more specifically, to a cosmetic composition for improving acne skin comprising willow bark extract, echinacea extract and pineapple extract as active ingredients.

Acne (Acne vulgaris) is a chronic inflammatory disease that acts on the pilosebaceous follicle of the skin. Acne is caused by the complex action of various factors. It is known as the main cause of occurrence, such as hyperkeratinization of hair follicles, formation of colonies of acne bacteria, excessive sebum production, and inflammation due to immune response. In addition, genetic factors, environment, eating habits, Stress, wrong skin care, or the use of inappropriate products are also factors.

Excessive sebum and hyperkeratinized hair follicles clog the pores due to the condition of the skin, hormone secretion, and harmful external environment, and the anaerobic acne bacteria proliferate excessively in the clogged pores, resulting in inflammation resulting in acne. Will develop. Here, when the skin is damaged due to external harmful environment, excessive contact or friction, and proliferation of various harmful bacteria and fungi, the inflammation worsens and progresses to an uncontrollable state.

Conventionally, such acne treatment includes topical formulation application therapy and oral drug administration therapy.

For topical application therapy, antibacterial agents such as azelaic acid and salicylic acid are used for antibacterial action against propionibacterium acnes, which is known as the causative agent of acne, or benzoylperoxide for dissolving comedones. (benzoyl peroxide) is used as an external ointment type. However, azelaic acid is difficult to formulate, and salicylic acid is classified as a preservative in Korea and has a problem that it cannot contain more than 0.5% in the formulation, so its effect is insignificant. In addition, there is a problem that benzoyl peroxide is a raw material that cannot be used as a cosmetic raw material in Korea.

Oral drug therapy uses retinoids and corticosteroids for the purpose of suppressing the function of the sebaceous glands and the destruction of the hair follicle wall. These formulations, when taken in excessive amounts, have side effects such as skin rash and dry skin, and may cause allergies depending on the individual.

Therefore, recently, a method for improving acne skin using natural products has been proposed.

Such conventional techniques include a cosmetic composition for improving acne using the extract of Japanese oak tree of Korean Patent No. 10-1827771 as an active ingredient, and a cosmetic composition for improving acne using the Vietnamese ginseng extract of Korean Patent No. 10-1789875.

However, this cosmetic composition simply has an antibacterial action against acne bacteria, and since acne is caused by various causes as described above, there is a problem that it is not possible to reliably improve acne by using such an extract alone.

Therefore, the present invention has come to develop a cosmetic composition for improving acne skin based on a relatively safe natural product extract that effectively responds to various causes of acne.

KR 10-1827771 B1 KR 10-1789875 B1

Accordingly, an object of the present invention is to effectively cope with various acne etiologies by combining willow bark extract with excellent antibacterial effect, echinacea extract with excellent antioxidant and skin immunity enhancing effect, and pineapple extract with excellent softening effect of hyperkeratinized hair follicles. It is to provide a cosmetic composition for improving acne skin that treats and improves acne.

Another object of the present invention is to provide a cosmetic composition for improving acne skin based on a safe natural extract.

The cosmetic composition for improving acne skin of the present invention for achieving the above object is characterized in that it contains willow bark extract, echinacea extract and pineapple extract as active ingredients.

It characterized in that it comprises 0.01 to 90% by weight of the willow bark extract, 0.01 to 90% by weight of the echinacea extract, and 0.01 to 90% by weight of the pineapple extract, based on the total amount of the cosmetic composition.

The willow bark extract and echinacea extract are an extract using water, an organic solvent or a mixed solvent thereof, the pineapple extract is an extract by compression, and the organic solvent is selected from the group consisting of alcohols having 1 to 5 carbon atoms. It is characterized by more than one type.

It characterized in that it further comprises 0.01 to 10% by weight of leather tree extract as an active ingredient.

The cosmetic composition is characterized in that it is formulated in any one of solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, lotions, packs and essences.

According to the cosmetic composition for improving acne skin of the present invention, it effectively inhibits the growth of acne and skin flora, strengthens skin immunity, and softens hyperkeratinized hair follicles to effectively improve acne, while based on natural substances. The advantage is that there is little skin irritation.

1 is a photograph of the effect of inhibiting the growth of Staphylococcus epidermidis according to Test Example 1 of the present invention.
Figure 2 is a photograph of the effect of inhibiting the growth of Cutibacterium acnes bacteria according to Test Example 1 of the present invention.
3 is a graph showing the results of improving acne according to Test Example 3 of the present invention.
4 and 5 are photographs showing before and after the use of lotion by a test subject according to Test Example 3 of the present invention.

Hereinafter, the present invention will be described in detail.

Conventional cosmetic compositions for improving acne skin have only simple antibacterial and anti-inflammatory effects, and have a problem in that they cannot effectively improve acne due to poor response to various acne etiologies.

In order to solve this problem, the present invention is a willow bark extract having excellent antibacterial effect and excellent anti-acne bacteria inhibitory effect, and an echinacea extract that protects the skin from external harmful environments such as oxidizing substances with excellent antioxidant and skin immunity enhancing effects, and It is characterized in that it can effectively improve acne in response to various acne etiologies by compounding a pineapple extract that softens hyperkeratinized hair follicles.

Hereinafter, the present invention will be described in more detail.

The present invention is characterized in that it comprises a willow bark extract, echinacea extract and pineapple extract as active ingredients.

Willow ( Salix alba) has been mainly used for fever and pain relief in Asia and Europe for centuries. Salicin, the main active ingredient of willow bark extract, is structurally similar to salicylic acid, an active metabolite of aspirin that has antipyretic, analgesic, and anti-inflammatory properties. Salicylic acid is a representative beta-hydroxy acid (BHA), which is effective for exfoliating skin, and is reported to be effective for antibacterial and anti-inflammatory. Therefore, the willow bark extract is excellent in inhibiting acne bacteria, as well as helping to remove dead skin cells.

Echinacea ( Echinacea purpurea) has long been used as a traditional folk medicine for various diseases by Native Americans in North America, and 9 types of Echinacea plants are known, of which 3 species ( Echinacea angustifolia, Echinacea pallida, Echinacea purpurea ). It is mainly used for medicinal purposes. The echinacea extract has been reported to have antioxidant, antibacterial, antiviral, antifungal, and anti-inflammatory effects. The immune function of echinacea extract has been reported to affect the metabolism of granulocytes, lymphocytes, monocytes and macrophages.According to the reported research results, echinacea extracts contain Nitric Oxide and Il-1, Il-6 , Il-8, Il-12, and promotes the secretion of cytokines such as TNF-α and increases the activity of macrophages (macrophages) has been reported to help strengthen immunity. The main active ingredient of echinacea extract is a derivative of Caffeic Acid, a polyphenol, and contains ingredients such as Caftaric acid, Chlorogenic acid, Cynarin, Echinacoside, and Cichoric acid. Therefore, the echinacea extract effectively protects the skin from external harmful environments such as oxidizing substances through strong antioxidant and immune functions.

Pineapple ( Ananas comosus ) fruit and stem extracts contain a large amount of a proteolytic enzyme called bromelain. Bromelain is reported to have various medicinal effects through protein decomposition effects, such as reducing swelling and redness, healing of burns and wounds, insect bites, sports injury, sinusitis through mucus decomposition, and promotion of digestion. It is reported as giving. Therefore, the pineapple extract softens hyperkeratinized hair follicles of acne skin through the protein decomposition effect, helps in keratin management by decomposing old keratin, and reduces swelling and redness to solve various skin problems other than acne.

That is, the present invention does not simply inhibit the activity of acne bacteria, but inhibits the activity of acne bacteria through the combination of the above-described willow bark extract, echinacea extract, and pineapple extract, keratin removal, hyperkeratinized hair follicle softening, immune action It has a back, and it significantly improves acne skin through the interaction of each extract.

In the present invention, the method of preparing the willow bark extract, echinacea extract, and pineapple extract may be obtained by extracting and separating from nature using a method for extracting and separating known in the art. I never do that. In addition, each of the extracts may be in a liquid state, but it is natural that one prepared in a powder state may be used through an additional process such as concentration under reduced pressure, freeze drying or spray drying after extraction.

As the extraction method, any one of a hot water extraction method, a cold needle extraction method, a reflux cooling extraction method, a solvent extraction method, a steam distillation method, an ultrasonic extraction method, an elution method, a compression method, etc. may be selected and used, but is not limited thereto. That is, there is no limitation to the method for preparing the extract of the present invention, and any known method may be used.

At this time, for the effective improvement of the acne skin, the willow bark extract and the echinacea extract are applied with an extract using water, an organic solvent or a mixed solvent thereof, and the pineapple extract is applied with an extract by compression. It is desirable, but it is not necessarily limiting. In this case, the organic solvent is one or more selected from the group consisting of alcohols having 1 to 5 carbon atoms.

In addition, the willow bark extract, echinacea extract and pineapple extract, based on the total amount of the cosmetic composition, 0.01 to 90% by weight of the willow bark extract, 0.01 to 90% by weight of the echinacea extract, and 0.01 to 90% by weight of the pineapple extract % Can be included as an active ingredient, and if each extract is less than 0.01% by weight, its efficacy is insignificant, and if it exceeds 90% by weight, the content of other ingredients is relatively reduced, resulting in good efficacy in improving acne skin, formulation stability, etc. Because it can't.

On the other hand, the cosmetic composition of the present invention may further include a leather tree extract as an active ingredient. The leather tree (Ailanthus altissima) is a deciduous tree of the family Simarou ba ceae, and is also called a weight tree. It contains phenolic substances such as 4,5-trimethoxyphenol, p-comeric acid, vanillin and vanillic acid, merosine, tannin propbafen, and alantone. It is a known fact that these extracts of leather wood exhibit excellent antioxidant effects to enhance skin immunity. In addition, when the extract of the leather tree is combined with the willow bark extract, echinacea extract, and pineapple extract of the present invention, it shows a further improved acne skin improvement effect due to the interaction. In particular, it is more effective in relieving early acne.

The leather tree extract is obtained from the leaves of the leather tree, and a specific method thereof may be extracted and used in the same manner as the willow bark extract or echinacea extract described above.

The leather tree extract may be included in an amount of 0.01 to 10% by weight, based on the total amount of the cosmetic composition, but is not necessarily limited thereto.

On the other hand, the cosmetic composition of the present invention may include, without limitation, ingredients that are generally allowed in addition to the active ingredients, such as diluents, excipients, buffers, dispersants, surfactants, colorants, flavors or sweeteners. can do.

In addition, the cosmetic composition may further add functional cosmetic ingredients, moisturizers, and other additives that impart cosmetic functionality to the skin, and may further include one or more cosmetically acceptable carriers formulated in general skin cosmetics. . As such carrier components, animal oil, vegetable oil, wax, paraffin, silicone, lactose, silica, talc, water, ethanol, benzyl alcohol, glycerol aliphatic ester, aliphatic alcohol sulfate, etc. can be used, but the type is not limited. Is of course.

In addition, the cosmetic composition according to the present invention may have any one formulation selected from the group consisting of solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, lotions, packs, and essences, and is limited thereto. It does not become.

Hereinafter, the present invention will be described in more detail through the following test examples.

(Example 1)

Preparation of complex solution

Washed and dried willow bark was cut into pieces of 1 cm or less in width and length, and then added to 20 times the volume of distilled water and extracted with hot water at 90-100° C. for 4 hours. After extraction, it was filtered through a filter net, and filtered through Whatman No. 2 filter paper to prepare an extract.

Echinacea outposts (flowers, leaves, stems, roots) were collected, washed with running water, dried, minced, put in 50 times the volume of distilled water, and extracted with hot water at 90 to 100°C for 4 hours. After extraction, it was filtered through a filter net, and filtered through Whatman No. 2 filter paper to prepare an extract. The prepared extract was lyophilized and dissolved in distilled water of 10 times the weight of the initial Echinacea.

The outer skin of the pineapple fruit was peeled and extracted by pressing. After extraction, it was filtered through Whatman No. 2 filter paper to prepare an extract.

And the willow bark extract, echinacea extract, and pineapple extract were mixed in a weight ratio of 6:3:1 to prepare a complex solution.

(Comparative Examples 1 to 3)

In the same manner as in Example 1, willow bark extract (Comparative Example 1), Echinacea extract (Comparative Example 2), and pineapple extract (Comparative Example 3) were prepared, respectively.

(Test Example 1)

Antibacterial efficacy evaluation

In order to evaluate the antimicrobial efficacy of Example 1 according to the present invention, the degree of inhibition of growth of the bacteria was confirmed using a liquid medium dilution method. The bacteria used in the experiment were Staphylococcus epidermidis (KCTC 1917), an epidermal flora, and Cutibacterium acnes (KCTC 3314), an acne-causing bacteria, from the Korea Research Institute of Bioscience and Biotechnology Biological Resource Center.

As a specific test method, the aerobic bacteria Staphylococcus epidermidis was inoculated into a sterilized Brain Heart Infusion (BHI) medium, cultured for 16 hours in a shaking incubator at 36°C, and then serially diluted and added to the medium in equal amounts. The bacteria were inoculated. After inoculation of bacteria, culture was performed for 16 hours, and the degree of inhibition of growth was confirmed.

Cutibacterium acnes, acne bacteria, is inoculated in sterilized Brain Heart Infusion (BHI) medium and incubated for 48 hours in a constant temperature incubator at 36℃ under anaerobic conditions using a gas pack that creates an anaerobic environment, and then the sample is serially diluted. Then, the same amount was added to the medium and the bacteria were inoculated. After inoculation of the bacteria, they were cultured for 48 hours in anaerobic conditions, and the degree of inhibition of growth was confirmed.

At this time, the samples of Example 1 and Comparative Examples 1 to 3 were filtered once more with a 0.2 μm syringe filter and used.

And the results are shown in Table 1 and FIGS. 1 and 2 below. 1 is a photograph of the growth inhibition effect of Example 1 against Staphylococcus epidermidis by, FIG. 2 is a photograph of the growth inhibition effect of Example 1 against Cutibacterium acnes bacteria, 1 is a control group in which Example 1 is not mixed, and 2 is A test group treated with a 20-fold dilution solution of Example 1, 3 is a test group treated with a 5-fold dilution of Example 1, and 4 is a photograph of a test group treated with the stock solution of Example 1.

Antibacterial efficacy evaluation result according to Test Example 1 division Staphylococcus epidermidis
Inhibitory efficacy Cutibacterium acnes
Inhibitory efficacy Comparative Example 1 (willow bark extract) +++ +++ Comparative Example 2 (Echinacea extract) + + Comparative Example 3 (pineapple extract) + + Example 1 (composite solution) ++ ++ Inhibitory efficacy evaluation criteria:-no effect,
+ Effective in undiluted solution,
++ Effective in 1/5 diluent,
+++ Effective in 1/20 diluted solution.

As shown in Table 1, as a result of the antibacterial efficacy evaluation, Comparative Example 1 showed the effect of inhibiting the growth of skin flora and acne bacteria from a 20-fold diluted solution, and Example 1 inhibited the growth of skin flora and acne bacteria from a 5-fold dilution. Efficacy was shown, and it was confirmed that Comparative Examples 2 and 3 showed the effect of inhibiting the growth of skin flora and acne bacteria only in the undiluted solution.

(Example 2)

Manufacturing lotion for acne improvement

A lotion for improving acne was prepared in the content ratio of Table 2 and Table 3 below. Sample #1 of Table 2 is a composition of a lotion sample for evaluating the efficacy of improving acne, and Sample #2 of Table 3 is a composition of a lotion sample containing a high concentration of extract for skin irritation test. At this time, the willow bark extract, echinacea extract, and pineapple extract were prepared in the same manner as in Example 1, but filtered through Whatman No. 2 filter paper, and then filtered once more with a 0.45 μm filter.

Composition of lotion (#1) Ingredient name Content (% by weight) Purified water 84 Willow bark extract 3 Echinacea extract 3 Pineapple extract 1.5 1,3-Butylene Glycol 5 glycerin 1.5 1,2-Hexanediol 2 Sum 100

Composition of lotion (#2) Ingredient name Content (% by weight) Purified water 16.5 Willow bark extract 30 Echinacea extract 30 Pineapple extract 15 1,3-Butylene Glycol 5 glycerin 1.2 1,2-Hexanediol 2 Sum 100

(Test Example 2)

Skin irritation test

In order to evaluate the skin irritation of the sample, a single skin patch test using Example 2 (#2) was conducted. The subjects were 10 males and 10 females each, aged 15 to 35 years, with no skin disease or wound on the test site, and the patch site was the skin inside the upper arm. After wiping the patch area with 70% alcohol and drying it, a nonwoven fabric impregnated with the sample was attached and placed in a closed condition for 4 hours. Skin irritation was evaluated 30 minutes after removal of the nonwoven fabric and 24 hours after removal. The skin irritation determination score system was shown in Table 4 below, and the evaluation results were shown in Table 5 below.

Skin irritation judgment score score Criteria 0 Show no signs of inflammation; Healthy and normal skin 0.5 Glossy or barely noticeable erythema on the exterior of the area One Slight erythema 2 Moderate erythema, accompanied by barely noticeable edema at the edges
Possibility, possibility of papules 3 Moderate erythema with edema throughout 4 Intensive erythema with intensity edema, accompanied by small blisters, or
Does not accompany 5 Response of intensity that spreads beyond the patch area

Skin irritation test result score 0 0.5 One 2 3 4 5 Number of subjects (persons) 30 minutes later 18 2 0 0 0 0 0 After 24 hours 20 0 0 0 0 0 0

As can be seen in Table 5, as a result of the skin irritation test, the skin irritation level did not exceed 0.5 in all 20 subjects 30 minutes after removal of the nonwoven fabric, and the average skin irritation level was measured as 0.05. In addition, the skin irritation level after 24 hours was 0 for all 20 subjects. Therefore, it was confirmed that this sample had little skin irritation.

(Test Example 3)

Acne improvement efficacy evaluation

In order to evaluate the effect of improving acne, the sample (#1) of Example 2 was used to evaluate the effect of improving acne. The subjects were 10 men and women aged 15 to 35 years old with acne symptoms. As for the method of use, the facial area such as cheeks and forehead was used twice a day after cleansing in the morning and in the evening, and the body parts such as upper arm, back, and chest were used once a day after washing up in the evening. Acne improvement evaluation was evaluated through the primary visual inspection, the criterion was as shown in Table 6 below. In addition, the acne improvement effect was evaluated according to the acne degree evaluation criteria (Investigator's Global Acne Severity Assessment) of Table 7 below. And the results are shown in Table 8 and Figure 3 below.

Acne improvement criteria Judgment score Criteria +++ 3 Acne grade 2 or higher improvement ++ 2 Acne Grade 1 Improvement + One There is no change in acne grade, but slightly improved ± 0 No change in acne severity - -One No change in acne grade, but slightly worse - -2 Acne Grade 1 worsening --- -3 Acne Grade 2 or higher worsening

Acne severity evaluation criteria (Investigator's Global Acne Severity Assessment) ranking Contents 0 No acne No inflammatory or non-inflammatory wounds. One Ieast Few non-inflammatory wounds and one or more small inflammatory wounds present. 2 orderliness Severe than grade 1. There are several non-inflammatory wounds and several or more inflammatory wounds. 3 usually Severe than grade 2. There are many non-inflammatory wounds and there may be several inflammatory wounds. One or more small nodular wounds present. 4 Severe Severe than grade 3. There are multiple non-inflammatory and inflammatory wounds and several nodular wounds may be present. 5 Very severe There are severe inflammatory, non-inflammatory wounds and multiple crystalline wounds.

Acne improvement efficacy evaluation result Subject
Serial Number Score by period of use 1 week 2 weeks 3 weeks 4 weeks #01 + ++ ++ ++ #02 + ++ ++ ++ #03 ++ ++ ++ +++ #04 ++ +++ +++ +++ #05 ++ ++ +++ +++ #06 + ++ ++ ++ #07 + + ++ ++ #08 ++ +++ +++ +++ #09 ± ++ +++ +++ #10 ± ++ ++ ++ Average score 1.2 2.1 2.4 2.5

As shown in Table 8 and FIG. 3, the acne improvement evaluation result showed 1.2 points after 1 week of use, 2.1 points after 2 weeks, 2.4 points after 3 weeks, and 2.5 points after 4 weeks. Therefore, after 2 weeks of use, the acne grade was improved by more than 1 step, and after 4 weeks, it was evaluated that there is an effect of improving acne between the acne grade 1 and 2 stages.

In addition, FIG. 4 is a picture of a comparison of efficacy before and after using a lotion for acne improvement for acne on the forehead of a test subject (#05), where A is a picture before use, B is a picture after 2 weeks of use, and FIG. 05) is a picture of the comparison of efficacy before and after the use of acne-improving lotion for acne on the back of (05). A is before and B is after 2 weeks of use. As shown in FIGS. 4 and 5, it was confirmed with the naked eye that acne was remarkably improved by the use of a skin lotion for improving acne.

(Examples 3 to 7)

A lotion for improving acne was prepared in the content ratio of Table 9 below. At this time, willow bark extract, echinacea extract, and pineapple extract were prepared in the same manner as in Example 2. At this time, the leather tree extract was extracted with hot water at 90-100° C. for 4 hours after collecting the leaves of the leather tree, washing with running water, drying, cutting, and putting it in 50 times the volume of distilled water. After extraction, it was filtered through a filter net, filtered through Whatman No. 2 filter paper, and filtered once more with a 0.45 μm filter to prepare.

Composition of lotion (% by weight) Ingredient name Example 3 Example 4 Example 5 Example 6 Example 7 Purified water to 100 to 100 to 100 to 100 to 100 Willow bark extract 90 0.01 0.01 5 5 Echinacea extract 0.01 90 0.01 5 5 Pineapple extract 0.01 0.01 90 2 2 Leather tree extract - - - - One 1,3-Butylene Glycol 5 5 5 5 5 glycerin One One One One One 1,2-Hexanediol 2 2 2 2 2

(Comparative Examples 4 to 6)

In addition, Comparative Examples 4 to 6 were also prepared as shown in Table 10 below.

Composition of lotion (% by weight) Ingredient name Comparative Example 4 Comparative Example 5 Comparative Example 6 Purified water to 100 to 100 to 100 Willow bark extract 12 - - Echinacea extract - 12 - Pineapple extract - - 12 1,3-Butylene Glycol 5 5 5 glycerin One One One 1,2-Hexanediol 2 2 2

(Test Example 4)

Acne improvement efficacy evaluation

In the same manner as in Test Example 3, the acne improvement efficacy of Examples 3 to 7 and Comparative Examples 4 to 6 was evaluated. The subjects were 80 males and females aged 15 to 35 years old (10 subjects for each sample) with acne symptoms. And the results are shown in Table 11 below.

Acne improvement efficacy evaluation result (average score) division Score by period of use 1 week 2 weeks 3 weeks 4 weeks Example 3 1.2 2.0 2.3 2.4 Example 4 1.1 2.0 2.2 2.3 Example 5 1.0 1.5 1.7 1.8 Example 6 1.2 2.1 2.4 2.5 Example 7 1.8 2.2 2.7 2.8 Comparative Example 4 0.8 1.0 1.0 1.0 Comparative Example 5 0.7 0.9 0.9 0.9 Comparative Example 6 0.1 0.0 0.0 0.0

As shown in Table 11, Examples 3 to 7 were all excellent in acne improvement efficacy, but Comparative Examples 4 and 5 had some efficacy at week 1, but no further efficacy appeared even if the use period was extended, and comparison It was confirmed that Example 6 had no acne improvement effect. In addition, Example 7 was confirmed to be excellent in the initial acne improvement effect.

As the specific parts of the present invention have been described in detail above, it is clear that these specific techniques are only preferred embodiments for those of ordinary skill in the art, and the scope of the present invention is not limited thereto. Therefore, it will be said that the practical scope of the present invention is defined by the appended claims and their equivalents.

Claims (5)

Based on the total amount of cosmetic composition,
Willow bark extract 0.01 to 90% by weight, echinacea extract 0.01 to 90% by weight, pineapple extract 0.01 to 90% by weight and leather tree extract 0.01 to 10% by weight as active ingredients,
The willow bark extract, the echinacea extract and the leather tree extract,
It is an extract using water, an organic solvent or a mixed solvent thereof,
The pineapple extract is an extract by compression,
The organic solvent is a cosmetic composition for improving acne skin, characterized in that at least one selected from the group consisting of alcohols having 1 to 5 carbon atoms.
delete delete delete The method of claim 1,
The cosmetic composition,
A cosmetic composition for improving acne skin, characterized in that formulated in any one of a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, lotion, pack, and essence.

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