KR102186851B1 - 세균성 질병 치료용 피리미딘 유도체 - Google Patents
세균성 질병 치료용 피리미딘 유도체 Download PDFInfo
- Publication number
- KR102186851B1 KR102186851B1 KR1020147029515A KR20147029515A KR102186851B1 KR 102186851 B1 KR102186851 B1 KR 102186851B1 KR 1020147029515 A KR1020147029515 A KR 1020147029515A KR 20147029515 A KR20147029515 A KR 20147029515A KR 102186851 B1 KR102186851 B1 KR 102186851B1
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- compound
- formula
- halo
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 ***CC*(CI)c(nc(*)nc1)c1-c1ccc(*)c(*)c1* Chemical compound ***CC*(CI)c(nc(*)nc1)c1-c1ccc(*)c(*)c1* 0.000 description 3
- BBRHGWWHGWUOHB-UHFFFAOYSA-N CC(C)(C)CN(CC1)CCC1c1nc(-c2ccncc2)ncc1-c1cc(OC)ccc1 Chemical compound CC(C)(C)CN(CC1)CCC1c1nc(-c2ccncc2)ncc1-c1cc(OC)ccc1 BBRHGWWHGWUOHB-UHFFFAOYSA-N 0.000 description 2
- ISNVUTLYXMSBNS-UHFFFAOYSA-N COc1cccc(-c2cnc(-c3ccncc3)nc2C2CCNCC2)c1 Chemical compound COc1cccc(-c2cnc(-c3ccncc3)nc2C2CCNCC2)c1 ISNVUTLYXMSBNS-UHFFFAOYSA-N 0.000 description 2
- RCZNRJVVXOOAHG-ONEGZZNKSA-N CCOC(/C(/Br)=C\Br)=O Chemical compound CCOC(/C(/Br)=C\Br)=O RCZNRJVVXOOAHG-ONEGZZNKSA-N 0.000 description 1
- RCGWINPQRISTLP-UHFFFAOYSA-N COc1cccc(-c2cnc(-c3ccncc3)nc2C2CCN(CC#C)CC2)c1 Chemical compound COc1cccc(-c2cnc(-c3ccncc3)nc2C2CCN(CC#C)CC2)c1 RCGWINPQRISTLP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12166140.9 | 2012-04-30 | ||
| EP12166140 | 2012-04-30 | ||
| PCT/EP2013/058980 WO2013164337A1 (en) | 2012-04-30 | 2013-04-30 | New compounds and new use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20150003749A KR20150003749A (ko) | 2015-01-09 |
| KR102186851B1 true KR102186851B1 (ko) | 2020-12-07 |
Family
ID=48430690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020147029515A Expired - Fee Related KR102186851B1 (ko) | 2012-04-30 | 2013-04-30 | 세균성 질병 치료용 피리미딘 유도체 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9725432B2 (enExample) |
| EP (1) | EP2938599B1 (enExample) |
| JP (2) | JP6349303B2 (enExample) |
| KR (1) | KR102186851B1 (enExample) |
| CN (1) | CN104487425B (enExample) |
| AR (1) | AR090880A1 (enExample) |
| AU (1) | AU2013255843B2 (enExample) |
| BR (1) | BR112014026776B1 (enExample) |
| CA (1) | CA2868930C (enExample) |
| EA (1) | EA030899B1 (enExample) |
| ES (1) | ES2676189T3 (enExample) |
| IN (1) | IN2014MN02363A (enExample) |
| MX (1) | MX358189B (enExample) |
| NZ (2) | NZ700507A (enExample) |
| TW (1) | TWI598099B (enExample) |
| WO (1) | WO2013164337A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR090880A1 (es) * | 2012-04-30 | 2014-12-10 | Janssen R & D Ireland | Derivados de pirimidina |
| WO2019121352A1 (en) * | 2017-12-20 | 2019-06-27 | Basf Se | Herbicidal pyrimidine compounds |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6887870B1 (en) | 1999-10-12 | 2005-05-03 | Bristol-Myers Squibb Company | Heterocyclic sodium/proton exchange inhibitors and method |
| WO2011073378A1 (en) | 2009-12-18 | 2011-06-23 | Basilea Pharmaceutica Ag | Tricyclic antibiotics |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003077656A1 (en) | 2002-03-15 | 2003-09-25 | Ciba Specialty Chemicals Holding Inc. | 4-aminopyrimidines and their use for the antimicrobial treatment of surfaces |
| DE102004003493A1 (de) | 2004-01-23 | 2005-08-11 | Bayer Cropscience Ag | 5-Phenylpyrimidine |
| US20070078135A1 (en) * | 2005-04-18 | 2007-04-05 | Neurogen Corporation | Substituted heteroaryl CB1 antagonists |
| KR101595506B1 (ko) * | 2008-02-01 | 2016-02-18 | 오키드 리서치 레버라토리즈 리미티드 | 신규한 헤테로사이클 |
| MX2012005759A (es) | 2009-11-18 | 2012-10-03 | Fab Pharma S A S | Acrilamidas heterociclicas novedosas y su uso como farmacos. |
| WO2011060976A1 (en) * | 2009-11-20 | 2011-05-26 | Universite De Liege | Tryptamine-derived compounds as antibacterial agents |
| AR090880A1 (es) * | 2012-04-30 | 2014-12-10 | Janssen R & D Ireland | Derivados de pirimidina |
-
2013
- 2013-04-29 AR ARP130101454A patent/AR090880A1/es active IP Right Grant
- 2013-04-29 TW TW102115187A patent/TWI598099B/zh not_active IP Right Cessation
- 2013-04-30 IN IN2363MUN2014 patent/IN2014MN02363A/en unknown
- 2013-04-30 KR KR1020147029515A patent/KR102186851B1/ko not_active Expired - Fee Related
- 2013-04-30 EP EP13722329.3A patent/EP2938599B1/en active Active
- 2013-04-30 WO PCT/EP2013/058980 patent/WO2013164337A1/en not_active Ceased
- 2013-04-30 CA CA2868930A patent/CA2868930C/en active Active
- 2013-04-30 JP JP2015509418A patent/JP6349303B2/ja active Active
- 2013-04-30 EA EA201491992A patent/EA030899B1/ru not_active IP Right Cessation
- 2013-04-30 ES ES13722329.3T patent/ES2676189T3/es active Active
- 2013-04-30 NZ NZ700507A patent/NZ700507A/en not_active IP Right Cessation
- 2013-04-30 AU AU2013255843A patent/AU2013255843B2/en not_active Ceased
- 2013-04-30 CN CN201380022591.6A patent/CN104487425B/zh active Active
- 2013-04-30 MX MX2014013165A patent/MX358189B/es active IP Right Grant
- 2013-04-30 US US14/397,501 patent/US9725432B2/en active Active
- 2013-04-30 BR BR112014026776-6A patent/BR112014026776B1/pt not_active IP Right Cessation
- 2013-04-30 NZ NZ724424A patent/NZ724424A/en not_active IP Right Cessation
-
2017
- 2017-08-04 US US15/668,773 patent/US10221157B2/en active Active
-
2018
- 2018-03-20 JP JP2018052573A patent/JP6622839B2/ja active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6887870B1 (en) | 1999-10-12 | 2005-05-03 | Bristol-Myers Squibb Company | Heterocyclic sodium/proton exchange inhibitors and method |
| WO2011073378A1 (en) | 2009-12-18 | 2011-06-23 | Basilea Pharmaceutica Ag | Tricyclic antibiotics |
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St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
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| PN2301 | Change of applicant |
St.27 status event code: A-3-3-R10-R13-asn-PN2301 St.27 status event code: A-3-3-R10-R11-asn-PN2301 |
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| R17-X000 | Change to representative recorded |
St.27 status event code: A-3-3-R10-R17-oth-X000 |
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| PA0201 | Request for examination |
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| R18-X000 | Changes to party contact information recorded |
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| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
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| P11-X000 | Amendment of application requested |
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| P13-X000 | Application amended |
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| E701 | Decision to grant or registration of patent right | ||
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