KR102169940B1 - 암, 바이러스성 감염 및 폐질환의 치료를 위한 인돌의 새로운 유도체 - Google Patents

암, 바이러스성 감염 및 폐질환의 치료를 위한 인돌의 새로운 유도체 Download PDF

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KR102169940B1
KR102169940B1 KR1020157018178A KR20157018178A KR102169940B1 KR 102169940 B1 KR102169940 B1 KR 102169940B1 KR 1020157018178 A KR1020157018178 A KR 1020157018178A KR 20157018178 A KR20157018178 A KR 20157018178A KR 102169940 B1 KR102169940 B1 KR 102169940B1
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indol
acrylonitrile
bromo
pyridin
chloro
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KR20150092301A (ko
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세실 보우케레트
캐서린 귈로우
줄리안 루로
줄리 리볼리아
데니스 카니아토
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상뜨르 나쇼날 드 라 러쉐르쉬 샹띠피끄
바이오키네시스
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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  • Chemical & Material Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Virology (AREA)
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  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020157018178A 2012-12-07 2013-12-06 암, 바이러스성 감염 및 폐질환의 치료를 위한 인돌의 새로운 유도체 Active KR102169940B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261734451P 2012-12-07 2012-12-07
EP12306536.9 2012-12-07
US61/734,451 2012-12-07
EP12306536 2012-12-07
EP13157372.7 2013-03-01
EP13157372 2013-03-01
PCT/EP2013/075776 WO2014086964A1 (en) 2012-12-07 2013-12-06 New derivatives of indole for the treatment of cancer, viral infections and lung diseases

Publications (2)

Publication Number Publication Date
KR20150092301A KR20150092301A (ko) 2015-08-12
KR102169940B1 true KR102169940B1 (ko) 2020-10-26

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US (3) US9643923B2 (enExample)
EP (1) EP2928864B1 (enExample)
JP (1) JP6250062B2 (enExample)
KR (1) KR102169940B1 (enExample)
CN (2) CN104854088B (enExample)
CA (1) CA2891900C (enExample)
IL (1) IL238722B (enExample)
PL (1) PL2928864T3 (enExample)
WO (1) WO2014086964A1 (enExample)

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CN104854088B (zh) 2012-12-07 2018-02-16 生物控制术公司 用于治疗癌症、病毒感染和肺病的新型吲哚衍生物
KR102532912B1 (ko) * 2016-10-24 2023-05-15 다이어큐레이트 자궁 내막증 치료용 인돌의 신규 유도체
WO2020227337A1 (en) * 2019-05-07 2020-11-12 Bristol-Myers Squibb Company Prodrug compounds
KR20250029903A (ko) 2022-06-27 2025-03-05 이벡스타 바이오 암 치료를 위한 n-치환 인돌 유도체 및 접합체
WO2024121072A1 (en) 2022-12-05 2024-06-13 Centre National De La Recherche Scientifique Derivatives of indole for the treatment of cancer and infections
JP2025539491A (ja) 2022-12-16 2025-12-05 イヴクスタ・バイオ （ｚ）－３－（２－（５－ブロモ－１ｈ－インドール－３－イル）－２－シアノビニル）－４－メトキシベンゾニトリルを調製する方法

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CN104854088B (zh) 2012-12-07 2018-02-16 生物控制术公司 用于治疗癌症、病毒感染和肺病的新型吲哚衍生物
KR102532912B1 (ko) 2016-10-24 2023-05-15 다이어큐레이트 자궁 내막증 치료용 인돌의 신규 유도체

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CN104854088B (zh) 2018-02-16
PL2928864T3 (pl) 2020-06-15
WO2014086964A1 (en) 2014-06-12
EP2928864B1 (en) 2020-01-15
CA2891900C (en) 2021-07-06
CN108341799B (zh) 2022-01-25
US20170233342A1 (en) 2017-08-17
EP2928864A1 (en) 2015-10-14
US20190169124A1 (en) 2019-06-06
CN104854088A (zh) 2015-08-19
JP2016501254A (ja) 2016-01-18
HK1210607A1 (en) 2016-04-29
CA2891900A1 (en) 2014-06-12
IL238722B (en) 2018-10-31
US20150307450A1 (en) 2015-10-29
US9643923B2 (en) 2017-05-09
KR20150092301A (ko) 2015-08-12
US10851054B2 (en) 2020-12-01
CN108341799A (zh) 2018-07-31
US10189782B2 (en) 2019-01-29
IL238722A0 (en) 2015-06-30
JP6250062B2 (ja) 2017-12-20

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