JP6250062B2 - がん、ウイルス感染症、及び肺疾患の処置のためのインドールの新規誘導体 - Google Patents

がん、ウイルス感染症、及び肺疾患の処置のためのインドールの新規誘導体 Download PDF

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JP6250062B2
JP6250062B2 JP2015546026A JP2015546026A JP6250062B2 JP 6250062 B2 JP6250062 B2 JP 6250062B2 JP 2015546026 A JP2015546026 A JP 2015546026A JP 2015546026 A JP2015546026 A JP 2015546026A JP 6250062 B2 JP6250062 B2 JP 6250062B2
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indol
acrylonitrile
bromo
pyridin
chloro
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JP2016501254A5 (enExample
JP2016501254A (ja
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セシール・ブージェレ
カトリーヌ・ギユー
ジュリアン・ルロー
ジュリー・リヴォリエ
ドニ・カルニアート
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Centre National de la Recherche Scientifique
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
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    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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  • Chemical & Material Sciences (AREA)
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  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015546026A 2012-12-07 2013-12-06 がん、ウイルス感染症、及び肺疾患の処置のためのインドールの新規誘導体 Active JP6250062B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261734451P 2012-12-07 2012-12-07
US61/734,451 2012-12-07
EP12306536.9 2012-12-07
EP12306536 2012-12-07
EP13157372 2013-03-01
EP13157372.7 2013-03-01
PCT/EP2013/075776 WO2014086964A1 (en) 2012-12-07 2013-12-06 New derivatives of indole for the treatment of cancer, viral infections and lung diseases

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JP2016501254A JP2016501254A (ja) 2016-01-18
JP2016501254A5 JP2016501254A5 (enExample) 2017-11-16
JP6250062B2 true JP6250062B2 (ja) 2017-12-20

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JP2015546026A Active JP6250062B2 (ja) 2012-12-07 2013-12-06 がん、ウイルス感染症、及び肺疾患の処置のためのインドールの新規誘導体

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US (3) US9643923B2 (enExample)
EP (1) EP2928864B1 (enExample)
JP (1) JP6250062B2 (enExample)
KR (1) KR102169940B1 (enExample)
CN (2) CN108341799B (enExample)
CA (1) CA2891900C (enExample)
IL (1) IL238722B (enExample)
PL (1) PL2928864T3 (enExample)
WO (1) WO2014086964A1 (enExample)

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EP2928864B1 (en) 2012-12-07 2020-01-15 Biokinesis New derivatives of indole for the treatment of cancer, viral infections and lung diseases
JP7130180B2 (ja) * 2016-10-24 2022-09-05 ディアキュレイト 子宮内膜症の処置のためのインドールの新規誘導体
US20220213099A1 (en) * 2019-05-07 2022-07-07 Bristol-Myers Squibb Company Prodrug compounds
WO2024003002A1 (en) 2022-06-27 2024-01-04 Diaccurate N-substituted indole derivatives and conjugates for the treatment of cancer
US20260199308A1 (en) 2022-12-05 2026-07-16 Centre National De La Recherche Scientifique Derivatives of indole for the treatment of cancer
JP2025539491A (ja) 2022-12-16 2025-12-05 イヴクスタ・バイオ （ｚ）－３－（２－（５－ブロモ－１ｈ－インドール－３－イル）－２－シアノビニル）－４－メトキシベンゾニトリルを調製する方法

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JP2002500190A (ja) 1998-01-08 2002-01-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 海洋海綿から誘導されるキネシンモーターモジュレーター
JP2000336075A (ja) * 1999-05-26 2000-12-05 Sankyo Co Ltd アクリロニトリル誘導体
US6890933B1 (en) 2000-02-24 2005-05-10 President And Fellows Of Harvard College Kinesin inhibitors
US6335342B1 (en) * 2000-06-19 2002-01-01 Pharmacia & Upjohn S.P.A. Azaindole derivatives, process for their preparation, and their use as antitumor agents
US7361764B2 (en) 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
CN101027302B (zh) * 2004-07-27 2011-05-11 Sgx药物公司 吡咯并吡啶激酶调节剂
EP2266562A1 (en) * 2009-06-23 2010-12-29 Centre National de la Recherche Scientifique Use of derivatives of indoles for the treatment of cancer
WO2012009097A1 (en) 2010-06-17 2012-01-19 Cytokinetics, Inc. Methods of treating lung disease
EP2455456A1 (en) 2010-11-22 2012-05-23 Institut Curie Use of kinesin inhibitors in HIV infection treatment and a method for screening them
EP2928864B1 (en) 2012-12-07 2020-01-15 Biokinesis New derivatives of indole for the treatment of cancer, viral infections and lung diseases
JP7130180B2 (ja) 2016-10-24 2022-09-05 ディアキュレイト 子宮内膜症の処置のためのインドールの新規誘導体

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US20190169124A1 (en) 2019-06-06
CN108341799B (zh) 2022-01-25
US10189782B2 (en) 2019-01-29
CA2891900C (en) 2021-07-06
US20150307450A1 (en) 2015-10-29
IL238722B (en) 2018-10-31
EP2928864B1 (en) 2020-01-15
CN104854088B (zh) 2018-02-16
WO2014086964A1 (en) 2014-06-12
JP2016501254A (ja) 2016-01-18
HK1210607A1 (en) 2016-04-29
CN108341799A (zh) 2018-07-31
IL238722A0 (en) 2015-06-30
KR102169940B1 (ko) 2020-10-26
US10851054B2 (en) 2020-12-01
US9643923B2 (en) 2017-05-09
PL2928864T3 (pl) 2020-06-15
CN104854088A (zh) 2015-08-19
KR20150092301A (ko) 2015-08-12
US20170233342A1 (en) 2017-08-17
EP2928864A1 (en) 2015-10-14
CA2891900A1 (en) 2014-06-12

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