KR102165113B1 - Ａ2ａ 길항제 성질을 갖는 헤테로비시클로-치환된-[1,2,4]트리아졸로[1,5-ｃ]퀴나졸린-5-아민 화합물 - Google Patents
Ａ2ａ 길항제 성질을 갖는 헤테로비시클로-치환된-[1,2,4]트리아졸로[1,5-ｃ]퀴나졸린-5-아민 화합물 Download PDFInfo
- Publication number
- KR102165113B1 KR102165113B1 KR1020157020147A KR20157020147A KR102165113B1 KR 102165113 B1 KR102165113 B1 KR 102165113B1 KR 1020157020147 A KR1020157020147 A KR 1020157020147A KR 20157020147 A KR20157020147 A KR 20157020147A KR 102165113 B1 KR102165113 B1 KR 102165113B1
- Authority
- KR
- South Korea
- Prior art keywords
- triazolo
- amine
- methoxy
- quinazolin
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 C=*1SC1c1cnc[o]1 Chemical compound C=*1SC1c1cnc[o]1 0.000 description 6
- UBQKCCHYAOITMY-UHFFFAOYSA-N O=C1NC=CC=C1 Chemical compound O=C1NC=CC=C1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N C1CCCCC1 Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- SJMNQXLXIIXDDS-UHFFFAOYSA-N C1NCc2c1cccn2 Chemical compound C1NCc2c1cccn2 SJMNQXLXIIXDDS-UHFFFAOYSA-N 0.000 description 1
- KKBXSSJOMUKAON-UHFFFAOYSA-N CCOC(CC(NNc(c1ccc2)nc(N)nc1c2OC)=O)=O Chemical compound CCOC(CC(NNc(c1ccc2)nc(N)nc1c2OC)=O)=O KKBXSSJOMUKAON-UHFFFAOYSA-N 0.000 description 1
- CFOHRCNONSEVOJ-MRVPVSSYSA-N CC[C@@H]1CC=CCC1 Chemical compound CC[C@@H]1CC=CCC1 CFOHRCNONSEVOJ-MRVPVSSYSA-N 0.000 description 1
- RTMAFJOMBKRXCH-SECBINFHSA-N CC[C@]1(C)CC=CCC1 Chemical compound CC[C@]1(C)CC=CCC1 RTMAFJOMBKRXCH-SECBINFHSA-N 0.000 description 1
- DKTFRTHXQMXJFX-UHFFFAOYSA-N COCc1c2nc(N)[n]3nc(CN(C4)Cc5c4cccn5)nc3c2ccc1 Chemical compound COCc1c2nc(N)[n]3nc(CN(C4)Cc5c4cccn5)nc3c2ccc1 DKTFRTHXQMXJFX-UHFFFAOYSA-N 0.000 description 1
- YZGRUUWJCIUCAO-UHFFFAOYSA-N COCc1cccc2c1nc(N)[n]1nc(CCl)nc21 Chemical compound COCc1cccc2c1nc(N)[n]1nc(CCl)nc21 YZGRUUWJCIUCAO-UHFFFAOYSA-N 0.000 description 1
- XNDHOWKKQLGUGN-UHFFFAOYSA-N COc1c2nc(N)[n]3nc(CC(N4Cc5ncccc5C4)=O)nc3c2ccc1 Chemical compound COc1c2nc(N)[n]3nc(CC(N4Cc5ncccc5C4)=O)nc3c2ccc1 XNDHOWKKQLGUGN-UHFFFAOYSA-N 0.000 description 1
- FPRXKWBZQHJDPC-UHFFFAOYSA-N COc1c2nc(N)[n]3nc(CC(O)=O)nc3c2ccc1 Chemical compound COc1c2nc(N)[n]3nc(CC(O)=O)nc3c2ccc1 FPRXKWBZQHJDPC-UHFFFAOYSA-N 0.000 description 1
- ZJQDAQQPAJWURN-UHFFFAOYSA-N COc1c2nc(N)[n]3nc(CN4Cc5ncccc5CC4)nc3c2ccc1 Chemical compound COc1c2nc(N)[n]3nc(CN4Cc5ncccc5CC4)nc3c2ccc1 ZJQDAQQPAJWURN-UHFFFAOYSA-N 0.000 description 1
- DZNPOCHJCGTGCP-UHFFFAOYSA-N COc1cccc(c(Cl)n2)c1nc2Cl Chemical compound COc1cccc(c(Cl)n2)c1nc2Cl DZNPOCHJCGTGCP-UHFFFAOYSA-N 0.000 description 1
- DLFIXPTUMHDGCB-UHFFFAOYSA-N CS(OCCF)(=O)=O Chemical compound CS(OCCF)(=O)=O DLFIXPTUMHDGCB-UHFFFAOYSA-N 0.000 description 1
- WTZFMKSUEPBREG-UHFFFAOYSA-N Cc(c1n2)cccc1c(NNC(CO)=O)nc2Cl Chemical compound Cc(c1n2)cccc1c(NNC(CO)=O)nc2Cl WTZFMKSUEPBREG-UHFFFAOYSA-N 0.000 description 1
- VCPJOOVRGLLBPO-UHFFFAOYSA-N Cc(cccc12)c1nc(NCc(ccc(OC)c1)c1OC)nc2NNC(CO)=O Chemical compound Cc(cccc12)c1nc(NCc(ccc(OC)c1)c1OC)nc2NNC(CO)=O VCPJOOVRGLLBPO-UHFFFAOYSA-N 0.000 description 1
- XCIWNFKPROTKHB-UHFFFAOYSA-N Cc(cccc1c(Cl)n2)c1nc2Cl Chemical compound Cc(cccc1c(Cl)n2)c1nc2Cl XCIWNFKPROTKHB-UHFFFAOYSA-N 0.000 description 1
- IMFJPXDDHSOHKV-UHFFFAOYSA-N Cc1c2nc(N)[n]3nc(CN4Cc5ncccc5C4)nc3c2ccc1 Chemical compound Cc1c2nc(N)[n]3nc(CN4Cc5ncccc5C4)nc3c2ccc1 IMFJPXDDHSOHKV-UHFFFAOYSA-N 0.000 description 1
- HRRBZXKLAVTZHN-UHFFFAOYSA-N Cc1c2nc(NCc(ccc(OC)c3)c3OC)[n]3nc(CCl)nc3c2ccc1 Chemical compound Cc1c2nc(NCc(ccc(OC)c3)c3OC)[n]3nc(CCl)nc3c2ccc1 HRRBZXKLAVTZHN-UHFFFAOYSA-N 0.000 description 1
- URLJCVGMSXAGAX-UHFFFAOYSA-N Nc([n]1nc(CN2Cc3ncccc3CC2)nc1c1ccc2)nc1c2OCCF Chemical compound Nc([n]1nc(CN2Cc3ncccc3CC2)nc1c1ccc2)nc1c2OCCF URLJCVGMSXAGAX-UHFFFAOYSA-N 0.000 description 1
- RQOCQLWOWIEFHU-UHFFFAOYSA-N Nc1nc(c(O)ccc2)c2c2nc(CN3Cc4ncccc4CC3)n[n]12 Chemical compound Nc1nc(c(O)ccc2)c2c2nc(CN3Cc4ncccc4CC3)n[n]12 RQOCQLWOWIEFHU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2012/087865 | 2012-12-28 | ||
| PCT/CN2012/087865 WO2014101120A1 (en) | 2012-12-28 | 2012-12-28 | Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties |
| CNPCT/CN2013/076853 | 2013-06-06 | ||
| PCT/CN2013/076853 WO2014101373A1 (en) | 2012-12-28 | 2013-06-06 | Heterobicyclo-substituted-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds for treatment of central nervous system disorder |
| PCT/US2013/076781 WO2014105666A1 (en) | 2012-12-28 | 2013-12-20 | Heterobicyclo-substituted-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20150100879A KR20150100879A (ko) | 2015-09-02 |
| KR102165113B1 true KR102165113B1 (ko) | 2020-10-13 |
Family
ID=51019745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157020147A Expired - Fee Related KR102165113B1 (ko) | 2012-12-28 | 2013-12-20 | Ａ2ａ 길항제 성질을 갖는 헤테로비시클로-치환된-[1,2,4]트리아졸로[1,5-ｃ]퀴나졸린-5-아민 화합물 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9708347B2 (https=) |
| EP (1) | EP2945632B1 (https=) |
| JP (1) | JP6306049B2 (https=) |
| KR (1) | KR102165113B1 (https=) |
| AU (1) | AU2013370977B2 (https=) |
| BR (1) | BR112015015468B8 (https=) |
| CA (1) | CA2896056C (https=) |
| CY (1) | CY1120258T1 (https=) |
| DK (1) | DK2945632T3 (https=) |
| ES (1) | ES2667477T3 (https=) |
| HR (1) | HRP20180678T1 (https=) |
| HU (1) | HUE037950T2 (https=) |
| LT (1) | LT2945632T (https=) |
| ME (1) | ME03034B (https=) |
| MX (1) | MX370017B (https=) |
| NO (1) | NO2945632T3 (https=) |
| PL (1) | PL2945632T3 (https=) |
| PT (1) | PT2945632T (https=) |
| RS (1) | RS57162B1 (https=) |
| RU (2) | RU2018136104A (https=) |
| SI (1) | SI2945632T1 (https=) |
| WO (3) | WO2014101120A1 (https=) |
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| EP3253390B1 (en) | 2015-02-06 | 2022-04-13 | Merck Sharp & Dohme Corp. | Aminoquinazoline compounds as a2a antagonist |
| WO2016200717A1 (en) * | 2015-06-11 | 2016-12-15 | Merck Sharp & Dohme Corp. | Aminopyrazine compounds with a2a antagonist properties |
| WO2017008205A1 (en) | 2015-07-10 | 2017-01-19 | Merck Sharp & Dohme Corp. | Substituted aminoquinazoline compounds as a2a antagonist |
| HK1257102A1 (zh) | 2015-08-21 | 2019-10-11 | Portola Pharmaceuticals, Inc. | 苯基哌嗪前蛋白转化酶枯草杆菌蛋白酶/kexin9型(pcsk9)调节剂及其应用 |
| EP3337564A4 (en) * | 2015-08-21 | 2019-01-23 | Portola Pharmaceuticals, Inc. | COMPOSITION AND METHOD FOR THE USE OF TETRAHYDROISOCHINOLINE SMALL MOLECULES FOR THE BINDING AND MODULATION OF PCSK9 PROTEIN ACTIVITY |
| EP3337497B1 (en) | 2015-08-21 | 2023-07-12 | SRX Cardio, LLC | Composition and methods of use of novel phenylalanine small organic compounds to directly modulate pcsk9 protein activity |
| WO2017107089A1 (en) | 2015-12-23 | 2017-06-29 | Merck Sharp & Dohme Corp. | 3- (1h-pyrazol-4-yl) pyridineallosteric modulators of the m4 muscarinic acetylcholine receptor |
| TW201726675A (zh) | 2015-12-23 | 2017-08-01 | 默沙東藥廠 | M4毒蕈鹼乙醯膽鹼受體之異位調節劑6,7-二氫-5h-吡咯并[3,4-b]吡啶-5-酮 |
| WO2017107087A1 (en) * | 2015-12-23 | 2017-06-29 | Merck Sharp & Dohme Corp. | 6, 7-dihydro-5h-pyrrolo [3, 4-b] pyridin-5-oneallosteric modulators of the m4 muscarinic acetylcholine receptor |
| WO2017147328A1 (en) | 2016-02-23 | 2017-08-31 | Portola Pharmaceuticals, Inc. | Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9) |
| WO2018112843A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor |
| WO2018112842A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor |
| WO2018130184A1 (zh) | 2017-01-13 | 2018-07-19 | 江苏恒瑞医药股份有限公司 | 1,2,4-三嗪-3-胺类衍生物、其制备方法及其在医药上的应用 |
| US11365196B2 (en) | 2017-02-27 | 2022-06-21 | Betta Pharmaceuticals Co., Ltd. | FGFR inhibitor and application thereof |
| AU2018233367B2 (en) | 2017-03-16 | 2021-08-12 | Jiangsu Hengrui Medicine Co., Ltd. | Heteroaryl[4,3-c]pyrimidine-5-amine derivative, preparation method therefor, and medical uses thereof |
| JP6836693B2 (ja) * | 2017-09-28 | 2021-03-03 | シーストーン・ファーマスーティカルズ・（スージョウ）・カンパニー・リミテッドＣｓｔｏｎｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ （Ｓｕｚｈｏｕ） Ｃｏ．， Ｌｔｄ． | Ａ２ａ受容体アンタゴニストとしての縮合環誘導体 |
| US11498923B2 (en) | 2017-12-13 | 2022-11-15 | Merck Sharp & Dohme Llc | Substituted imidazo[1,2-c]quinazolines as A2A antagonists |
| WO2019154294A1 (zh) | 2018-02-06 | 2019-08-15 | 江苏恒瑞医药股份有限公司 | 吡唑并[1,5-a][1,3,5]三嗪-2-胺类衍生物、其制备方法及其在医药上的应用 |
| AU2019383948A1 (en) | 2018-11-20 | 2021-05-20 | Merck Sharp & Dohme Llc | Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use |
| US12414952B2 (en) | 2018-11-20 | 2025-09-16 | Merck Sharp & Dohme Llc | Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use |
| AU2019388872A1 (en) | 2018-11-30 | 2021-05-27 | Merck Sharp & Dohme Llc | 7-, 8-, and 10-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use |
| WO2020112700A1 (en) | 2018-11-30 | 2020-06-04 | Merck Sharp & Dohme Corp. | 9-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use |
| MX2021008094A (es) | 2019-01-11 | 2021-09-21 | Omeros Corp | Metodos y composiciones para el tratamiento del cancer. |
| AR117844A1 (es) | 2019-01-22 | 2021-09-01 | Merck Patent Gmbh | Derivados de tiazolopiridina como antagonistas del receptor de adenosina |
| WO2020196946A1 (ko) | 2019-03-26 | 2020-10-01 | 노벨파마 주식회사 | 지속형 지방산 결합 GnRH 유도체 및 이를 포함하는 약제학적 조성물 |
| HRP20241159T1 (hr) | 2020-02-07 | 2024-12-06 | Gasherbrum Bio, Inc. | Heterociklički agonisti za glp-1 |
| WO2022020550A1 (en) * | 2020-07-24 | 2022-01-27 | Merck Sharp & Dohme Corp. | Adenosine a2a and a2b receptor dual antagonists for immuno-oncology |
| WO2022020552A1 (en) * | 2020-07-24 | 2022-01-27 | Merck Sharp & Dohme Corp. | Adenosine a2a and a2b receptor dual antagonists for immuno-oncology |
| CN116368140A (zh) | 2020-09-10 | 2023-06-30 | 加舒布鲁姆生物公司 | 杂环glp-1激动剂 |
| CN112159411A (zh) * | 2020-10-15 | 2021-01-01 | 南京工业大学 | 一种三氟甲基取代嘧啶并[1,3]二氮杂*化合物及其制备方法 |
| US12115154B2 (en) | 2020-12-16 | 2024-10-15 | Srx Cardio, Llc | Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) |
| JP2025512384A (ja) | 2022-04-13 | 2025-04-17 | ギリアード サイエンシーズ， インコーポレイテッド | Ｔｒｏｐ－２発現がんを治療するための併用療法 |
| CN120957993A (zh) | 2023-02-16 | 2025-11-14 | 加舒布鲁姆生物公司 | 杂环glp-1激动剂 |
| WO2025137640A1 (en) | 2023-12-22 | 2025-06-26 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
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