KR102162213B1 - 이미지 형성 세포 계수기 - Google Patents

이미지 형성 세포 계수기 Download PDF

Info

Publication number
KR102162213B1
KR102162213B1 KR1020157036826A KR20157036826A KR102162213B1 KR 102162213 B1 KR102162213 B1 KR 102162213B1 KR 1020157036826 A KR1020157036826 A KR 1020157036826A KR 20157036826 A KR20157036826 A KR 20157036826A KR 102162213 B1 KR102162213 B1 KR 102162213B1
Authority
KR
South Korea
Prior art keywords
delete delete
light
sample
image
light source
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020157036826A
Other languages
English (en)
Korean (ko)
Other versions
KR20160047432A (ko
Inventor
마틴 그렌스브제르그
요한 홀름
소렌 크제룰프
한센 프란스 에즈너 라븐
Original Assignee
세모메테크 에이/에스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 세모메테크 에이/에스 filed Critical 세모메테크 에이/에스
Publication of KR20160047432A publication Critical patent/KR20160047432A/ko
Application granted granted Critical
Publication of KR102162213B1 publication Critical patent/KR102162213B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0227—Investigating particle size or size distribution by optical means using imaging; using holography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N2015/1438—Using two lasers in succession
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N2015/144—Imaging characterised by its optical setup
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1493—Particle size
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1493—Particle size
    • G01N2015/1495—Deformation of particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G01N2201/06113—Coherent sources; lasers
    • G01N2201/0612—Laser diodes
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10056—Microscopic image
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10064—Fluorescence image
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Theoretical Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Medical Informatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Quality & Reliability (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Multimedia (AREA)
  • Signal Processing (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Microscoopes, Condenser (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
KR1020157036826A 2013-05-28 2014-05-28 이미지 형성 세포 계수기 Active KR102162213B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201370291 2013-05-28
DKPA201370291 2013-05-28
PCT/DK2014/050151 WO2014191003A1 (en) 2013-05-28 2014-05-28 Image forming cytometer

Publications (2)

Publication Number Publication Date
KR20160047432A KR20160047432A (ko) 2016-05-02
KR102162213B1 true KR102162213B1 (ko) 2020-10-07

Family

ID=51022214

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020157036826A Active KR102162213B1 (ko) 2013-05-28 2014-05-28 이미지 형성 세포 계수기

Country Status (9)

Country Link
US (2) US10458896B2 (enExample)
EP (2) EP4027132A1 (enExample)
JP (1) JP6717741B2 (enExample)
KR (1) KR102162213B1 (enExample)
CN (2) CN105579828B (enExample)
AU (1) AU2014273560B2 (enExample)
CA (1) CA2913667A1 (enExample)
DK (1) DK3004838T3 (enExample)
WO (1) WO2014191003A1 (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170186262A1 (en) * 2014-02-14 2017-06-29 Rotas Italia SRL Product authentication method
CA2977481C (en) 2015-02-24 2021-02-02 The University Of Tokyo Dynamic high-speed high-sensitivity imaging device and imaging method
CN104990907B (zh) * 2015-07-01 2018-05-08 上海睿钰生物科技有限公司 自动多通道类流式图像荧光分析系统
WO2017036483A1 (en) * 2015-08-28 2017-03-09 Chemometec A/S Continuous image cytometer
EP3372985B1 (en) 2015-10-28 2025-06-25 The University Of Tokyo Analysis device
JP6571210B2 (ja) * 2016-01-27 2019-09-04 株式会社日立ハイテクノロジーズ 観察装置
US11035795B2 (en) 2016-02-18 2021-06-15 Optofluidics, Inc. Methods for identification of particles in a fluid sample
EP3427024A4 (en) * 2016-02-18 2019-11-06 Optofluidics, Inc. SYSTEM AND METHOD FOR CHARACTERIZING PARTICLES IN A LIQUID SAMPLE
DE102016211038A1 (de) * 2016-06-21 2017-12-21 Cytena Gmbh Vorrichtung und Verfahren zum Detektieren von Zellen oder Partikeln in einem Fluidbehälter
SG11201908847TA (en) 2017-03-31 2019-10-30 Life Technologies Corp Apparatuses, systems and methods for imaging flow cytometry
CN107389535A (zh) * 2017-07-18 2017-11-24 深圳小孚医疗科技有限公司 一种显微成像照明系统的照明方法
GB201711886D0 (en) 2017-07-24 2017-09-06 Univ College Cardiff Consultants Ltd Analysing nano - objects
WO2019031048A1 (ja) * 2017-08-08 2019-02-14 ソニー株式会社 情報処理装置、情報処理方法及びプログラム
JP6413006B1 (ja) * 2017-11-28 2018-10-24 リオン株式会社 パーティクルカウンタ
EP3743712B8 (en) * 2018-01-26 2023-07-19 Molecular Devices (Austria) GmbH System and method for intensity stabilization for quantitative fluorescence imaging
MA52114A (fr) 2018-02-28 2021-01-06 Juno Therapeutics Inc Procédés de détection de particules présentes dans une composition cellulaire
WO2019202005A1 (en) 2018-04-17 2019-10-24 Chemometec A/S Depicting of objects
LU100777B1 (de) * 2018-04-23 2019-10-23 Cytena Gmbh Verfahren zum Untersuchen einer Flüssigkeit, die wenigstens eine Zelle und/oder wenigstens ein Partikel enthält
WO2019241443A1 (en) 2018-06-13 2019-12-19 Thinkcyte Inc. Methods and systems for cytometry
US20200158628A1 (en) * 2018-10-22 2020-05-21 Bioelectronica Corporation Multiplexed assay systems and methods
JP2020094925A (ja) * 2018-12-13 2020-06-18 住友電気工業株式会社 品質評価方法
CN109709025B (zh) * 2019-02-12 2021-07-16 军事科学院系统工程研究院卫勤保障技术研究所 一种多模成像光学系统
CN110487686B (zh) * 2019-09-03 2022-09-02 中国工程物理研究院流体物理研究所 一种空气气溶胶单粒子多模态光谱诊断装置及诊断方法
CN110609026B (zh) * 2019-10-31 2020-11-03 福州大学 激光功率反馈控制的上转换荧光成像装置及其成像方法
EP4083603A4 (en) 2019-12-27 2024-04-03 ThinkCyte, Inc. FLOW CYTOMETER PERFORMANCE EVALUATION METHODS AND STANDARD PARTICLE SUSPENSION
EP3851834B1 (en) * 2020-01-16 2024-06-05 Roche Diagnostics GmbH Device for thermocycling biological samples, monitoring instrument comprising the same, and method for thermocycling biological samples using such device
US11806955B2 (en) 2020-02-26 2023-11-07 Depuy Ireland Unlimited Company Method for testing additively manufactured orthopaedic prosthetic components
WO2021200911A1 (ja) 2020-04-01 2021-10-07 シンクサイト株式会社 フローサイトメーター
WO2021200960A1 (ja) 2020-04-01 2021-10-07 シンクサイト株式会社 観察装置
FR3109159B1 (fr) * 2020-04-09 2023-06-23 Interscience Procédé de traitement d’images appliqué aux compteurs de colonies en microbiologie
KR102286722B1 (ko) * 2020-04-14 2021-08-06 주식회사 톱텍 자동 세포 계수 장치 및 그를 이용한 세포 계수 방법
CN111598058A (zh) * 2020-06-24 2020-08-28 无锡市科德科技有限公司 一种基于单一光源的明场和暗场定向反射光源总成
EP4200658A1 (en) * 2020-08-20 2023-06-28 Maytronics Ltd. Multi-region optical filters and systems and methods using same
KR102505687B1 (ko) * 2020-11-30 2023-03-03 디투이모션(주) 혈구계산기를 이용한 반자동 세포 계수 방법
US20240069315A1 (en) * 2021-01-06 2024-02-29 Scopgenx Private Limited A compact portable multimodal microscopy
US20240233089A1 (en) * 2021-07-29 2024-07-11 Shimadzu Corporation Image processing method and image processing apparatus
JPWO2023053679A1 (enExample) * 2021-09-30 2023-04-06
CN114088606B (zh) * 2021-10-23 2023-05-09 广州市艾贝泰生物科技有限公司 细胞分析装置
KR102645654B1 (ko) * 2021-12-22 2024-03-13 (주)얼라인드제네틱스 고효율 다중 스펙트럼 검출을 위한 라인 공초점 세포 계수기
EP4605909A1 (en) * 2022-10-17 2025-08-27 Becton, Dickinson and Company Methods for classifying particles using images based on filtered layers and machine learning models and systems for same
CN116660126A (zh) * 2023-04-06 2023-08-29 北京寻因生物科技有限公司 一种细胞计数仪及其计数方法
JP7393836B1 (ja) * 2023-04-25 2023-12-07 株式会社写真化学 菌体観察装置
WO2025117820A1 (en) * 2023-11-30 2025-06-05 Cellanome, Inc. Objective lens assembly
CN117348225A (zh) * 2023-12-04 2024-01-05 成都丹诺迪医疗科技有限公司 显微装置

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070190661A1 (en) 2003-12-22 2007-08-16 Gudermann Frank T Method and device for recording microscopic images
JP2008533440A (ja) * 2005-02-01 2008-08-21 アムニス コーポレイション イメージングフローサイトメータを使用した血液及び細胞の分析
US20090208072A1 (en) 2008-02-18 2009-08-20 Visiongate, Inc. 3d imaging of live cells with ultraviolet radiation
US20100079762A1 (en) * 2008-09-30 2010-04-01 Sysmex Corporation Sample analyzer, and a method for analyzing a sample
WO2011088014A2 (en) * 2010-01-12 2011-07-21 Nexcelom Bioscience Llc Systems and methods for counting cells and biomolecules

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4786165A (en) * 1986-07-10 1988-11-22 Toa Medical Electronics Co., Ltd. Flow cytometry and apparatus therefor
DE3714830A1 (de) * 1987-05-05 1988-11-17 Leitz Ernst Gmbh Kombinierte hellfeld-dunkelfeld- auflichtbeleuchtungseinrichtung
JP3084296B2 (ja) * 1991-02-27 2000-09-04 シスメックス株式会社 フローイメージサイトメータ
US6180415B1 (en) * 1997-02-20 2001-01-30 The Regents Of The University Of California Plasmon resonant particles, methods and apparatus
ATE398185T1 (de) 1997-05-05 2008-07-15 Chemometec As Verfahren und system zur bestimmung von somazellen in milch
US6731100B1 (en) 1997-05-05 2004-05-04 Chemometec A/S Method and a system for determination of somatic cells in milk
US6707555B1 (en) 1998-10-15 2004-03-16 Sysmex Corporation Optical information measuring apparatus
HK1039805A1 (zh) 1998-11-05 2002-05-10 Chemometec A/S 颗粒评价方法以及用於该方法的系统和装置
DE19923822A1 (de) * 1999-05-19 2000-11-23 Zeiss Carl Jena Gmbh Scannende Anordnung, vorzugsweise zur Erfassung von Fluoreszenzlicht
US7738945B2 (en) * 2002-04-19 2010-06-15 University Of Washington Method and apparatus for pseudo-projection formation for optical tomography
GB0227649D0 (en) * 2002-11-27 2003-01-08 Medical Res Council Uses of optical projection tomography methods and apparatus
DE10239548A1 (de) * 2002-08-23 2004-03-04 Leica Microsystems Semiconductor Gmbh Vorrichtung und Verfahren zur Inspektion eines Objekts
DE10239955B3 (de) * 2002-08-26 2004-05-13 Carl Zeiss Smt Ag Mikroskop mit Hell- und Dunkelfeldbeleuchtung
JP4598766B2 (ja) * 2003-04-29 2010-12-15 エス３アイ， エル エル シィ 生物学的微粒子及び非生物学的微粒子を検出し且つ分類するためのマルチスペクトル光学方法及びシステム
JP4698992B2 (ja) * 2004-09-14 2011-06-08 浜松ホトニクス株式会社 試料計測装置及び計測方法
US7660045B2 (en) * 2004-11-24 2010-02-09 Takashi Yoshimine Object lens and condenser
JP2007033381A (ja) * 2005-07-29 2007-02-08 Tokyo Seimitsu Co Ltd 光学式検査装置及びその照明方法
WO2007057016A1 (en) 2005-11-16 2007-05-24 Chemometec A/S Determination of chemical or physical properties of sample or component of a sample
JP4723362B2 (ja) 2005-11-29 2011-07-13 株式会社日立ハイテクノロジーズ 光学式検査装置及びその方法
JP5028014B2 (ja) * 2006-02-08 2012-09-19 株式会社日立ハイテクノロジーズ パターン検査方法及びその装置
JP2008002932A (ja) * 2006-06-22 2008-01-10 Tokyo Seimitsu Co Ltd 試料撮像装置及び試料の照明方法
US7700928B2 (en) * 2007-01-25 2010-04-20 Etaluma, Inc. Apparatus and method for interleaving detection of fluorescence and luminescence
CN101622522A (zh) * 2007-01-26 2010-01-06 贝克顿·迪金森公司 用于细胞计数和分析的方法、系统和组合物
EP2156138A1 (en) 2007-04-18 2010-02-24 ChemoMetec A/S Interferometer actuator
CN101216601B (zh) * 2007-12-29 2010-12-15 中国科学院西安光学精密机械研究所 使用锥镜实现暗场显微及荧光显微的方法及装置
JP2009237486A (ja) * 2008-03-28 2009-10-15 Kawasaki Heavy Ind Ltd ズーム位相差観察装置および位相差観察用照明装置
US20100189338A1 (en) * 2008-04-09 2010-07-29 Nexcelom Bioscience Systems and methods for counting cells and biomolecules
WO2010045949A2 (en) 2008-10-21 2010-04-29 Chemometec A/S A method and apparatus for analysis of a particle
DE102009004920B4 (de) * 2009-01-16 2018-10-11 Schaeffler Technologies AG & Co. KG Kombiniertes Radial-Axialwälzlager
WO2010088585A1 (en) * 2009-01-30 2010-08-05 Trustees Of Boston University Chemical/biological sensor employing scattered chromatic components in nano-patterned aperiodic surfaces
US20120195024A1 (en) 2009-10-14 2012-08-02 Sharp Kabushiki Kaisha Flexible circuit board connection structure and display device
CN104330346B (zh) 2009-12-04 2017-04-12 生命技术公司 用于声学流式细胞计量术的方法
EP2348301B1 (en) * 2010-01-08 2013-08-21 Sysmex Corporation Sample analyzer
WO2012096153A1 (ja) * 2011-01-12 2012-07-19 株式会社ニコン 顕微鏡システム
US8681215B2 (en) * 2011-04-29 2014-03-25 ProteinSimple Method and particle analyzer for determining a broad particle size distribution
JP6076801B2 (ja) * 2013-03-29 2017-02-08 シスメックス株式会社 血球分析装置および血球分析方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070190661A1 (en) 2003-12-22 2007-08-16 Gudermann Frank T Method and device for recording microscopic images
JP2008533440A (ja) * 2005-02-01 2008-08-21 アムニス コーポレイション イメージングフローサイトメータを使用した血液及び細胞の分析
JP4982385B2 (ja) 2005-02-01 2012-07-25 アムニス コーポレイション イメージングフローサイトメータを使用した血液及び細胞の分析
US20090208072A1 (en) 2008-02-18 2009-08-20 Visiongate, Inc. 3d imaging of live cells with ultraviolet radiation
US20100079762A1 (en) * 2008-09-30 2010-04-01 Sysmex Corporation Sample analyzer, and a method for analyzing a sample
WO2011088014A2 (en) * 2010-01-12 2011-07-21 Nexcelom Bioscience Llc Systems and methods for counting cells and biomolecules

Also Published As

Publication number Publication date
WO2014191003A1 (en) 2014-12-04
JP2016529876A (ja) 2016-09-29
US20160103058A1 (en) 2016-04-14
CN111220529A (zh) 2020-06-02
EP3004838A1 (en) 2016-04-13
US10458896B2 (en) 2019-10-29
KR20160047432A (ko) 2016-05-02
US10921234B2 (en) 2021-02-16
EP4027132A1 (en) 2022-07-13
EP3004838B1 (en) 2022-03-16
AU2014273560A1 (en) 2015-12-03
JP6717741B2 (ja) 2020-07-08
US20190323944A1 (en) 2019-10-24
CN105579828B (zh) 2020-02-14
CA2913667A1 (en) 2014-12-04
DK3004838T3 (da) 2022-06-20
CN105579828A (zh) 2016-05-11
AU2014273560B2 (en) 2018-07-19

Similar Documents

Publication Publication Date Title
KR102162213B1 (ko) 이미지 형성 세포 계수기
JP7464685B2 (ja) フローサイトメトリーを撮像するための装置、システム、および方法
US10345303B2 (en) Image analysis and measurement of biological samples
JP2016529876A5 (enExample)
US12422347B2 (en) Depicting of objects
US20200379227A1 (en) Method For Analyzing Fluorescent Particles in an Immunoassay
EP3227740B1 (en) Image cytometer
US9891160B1 (en) Oil-immersion enhanced imaging flow cytometer
WO2017036483A1 (en) Continuous image cytometer
US20250341712A1 (en) Apparatuses, systems and methods for solid immersion meniscus lenses
CN113302538B (zh) 利用吸收滤光器进行相衬成像的角度可变照明
US20230341328A1 (en) Device, method and use for optically determining at least one property of a sample positioned on a sample stage
JP4054876B2 (ja) 単一粒子光散乱法による微粒子構造解析装置
WO2024243019A1 (en) Methods and systems for imaging particles

Legal Events

Date Code Title Description
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

P22-X000 Classification modified

St.27 status event code: A-2-2-P10-P22-nap-X000

A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

D13-X000 Search requested

St.27 status event code: A-1-2-D10-D13-srh-X000

D14-X000 Search report completed

St.27 status event code: A-1-2-D10-D14-srh-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6