KR102126318B1 - 돌연변이된 시스타티오닌 감마 신타제를 이용한 o-포스포-l-호모세린 및 메탄티올로부터 l-메티오닌의 제조 방법 - Google Patents

돌연변이된 시스타티오닌 감마 신타제를 이용한 o-포스포-l-호모세린 및 메탄티올로부터 l-메티오닌의 제조 방법 Download PDF

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KR102126318B1
KR102126318B1 KR1020157009704A KR20157009704A KR102126318B1 KR 102126318 B1 KR102126318 B1 KR 102126318B1 KR 1020157009704 A KR1020157009704 A KR 1020157009704A KR 20157009704 A KR20157009704 A KR 20157009704A KR 102126318 B1 KR102126318 B1 KR 102126318B1
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KR20150076159A (ko
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뮈리엘 메르캄므
도미니끄 루이스
카린 자일라흐동
도미니끄 토마스
필립 마리에르
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아디쎄오 프랑스 에스에이에스
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P11/00—Preparation of sulfur-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/01—Methyltransferases (2.1.1)
    • C12Y201/01013—Methionine synthase (2.1.1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01048—Cystathionine gamma-synthase (2.5.1.48)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
KR1020157009704A 2012-10-26 2013-10-25 돌연변이된 시스타티오닌 감마 신타제를 이용한 o-포스포-l-호모세린 및 메탄티올로부터 l-메티오닌의 제조 방법 Active KR102126318B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12190150.8 2012-10-26
EP12190150 2012-10-26
PCT/EP2013/072380 WO2014064244A2 (en) 2012-10-26 2013-10-25 Means and methods for the enzymatic production of l-methionine from o-phospho-l-homoserine and methanethiol

Publications (2)

Publication Number Publication Date
KR20150076159A KR20150076159A (ko) 2015-07-06
KR102126318B1 true KR102126318B1 (ko) 2020-06-25

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KR1020157009704A Active KR102126318B1 (ko) 2012-10-26 2013-10-25 돌연변이된 시스타티오닌 감마 신타제를 이용한 o-포스포-l-호모세린 및 메탄티올로부터 l-메티오닌의 제조 방법

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US (1) US9803225B2 (enExample)
EP (1) EP2912185A2 (enExample)
JP (1) JP6438402B2 (enExample)
KR (1) KR102126318B1 (enExample)
CN (1) CN104755625B (enExample)
BR (1) BR112015007212B1 (enExample)
IN (1) IN2015DN02439A (enExample)
MY (1) MY176164A (enExample)
RU (1) RU2650859C2 (enExample)
WO (1) WO2014064244A2 (enExample)

Families Citing this family (9)

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US10382927B2 (en) * 2015-08-20 2019-08-13 Samsung Electronics Co., Ltd. Method of text input for wearable devices
EP3330380A1 (en) * 2016-12-05 2018-06-06 Evonik Degussa GmbH Process for producing l-methionine from methional
US11162122B2 (en) 2017-07-11 2021-11-02 Adisseo France S.A.S. Methionine-producing yeast
KR102025867B1 (ko) * 2017-07-13 2019-09-27 씨제이제일제당 주식회사 인산을 발효액 또는 발효 폐액으로부터 회수 및 재사용하는 방법
EP3875590A4 (en) * 2018-10-30 2023-02-15 Green Earth Institute Co., Ltd. PROCESS FOR THE PRODUCTION OF AN ORGANIC COMPOUND AND CORYNEFORM BACTERIUM
US20220315965A1 (en) * 2019-06-25 2022-10-06 Zymergen Inc. Engineered biosynthetic pathways for production of cystathionine by fermentation
KR102744891B1 (ko) 2022-03-24 2024-12-19 씨제이제일제당 주식회사 인산을 발효액 또는 발효 폐액으로부터 회수 및 재사용하는 방법
JP2026508194A (ja) * 2023-03-01 2026-03-10 フーナン リアー バイオテック カンパニー リミテッド Ｌ－メチオニンをｌ－ホモセリンから直接調製するプロセス
CN117165549B (zh) * 2023-08-30 2026-08-11 天津科技大学 一种胱硫醚-γ-合酶突变体及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011031285A1 (en) 2009-09-08 2011-03-17 Shai Ufaz Improving essential amino acid content in algae and cyanobacteria for animal feed

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Publication number Priority date Publication date Assignee Title
EP0630406A1 (en) * 1992-02-20 1994-12-28 Genencor International, Inc. Biosynthesis of methionine using a reduced source of sulfur
EP1846547A2 (en) * 2005-02-07 2007-10-24 Metabolic Explorer Microorganisms comprising enzymes expressed with low gamma-elimination activity
KR20080036608A (ko) * 2005-07-18 2008-04-28 바스프 에스이 메티오닌 생산 재조합 미생물

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011031285A1 (en) 2009-09-08 2011-03-17 Shai Ufaz Improving essential amino acid content in algae and cyanobacteria for animal feed

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Journal of Biological Chemistry, Vol. 277, pp. 36380-36386 (2002.)
Nucleic Acid Research, Vol. 24, pp. 2627-2631 (1996.)
Plant Physiology, Vol. 128, pp. 454-462 (2002.)

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Publication number Publication date
KR20150076159A (ko) 2015-07-06
WO2014064244A3 (en) 2014-08-14
US9803225B2 (en) 2017-10-31
BR112015007212A2 (pt) 2018-01-30
JP2015533280A (ja) 2015-11-24
JP6438402B2 (ja) 2018-12-12
US20150275247A1 (en) 2015-10-01
RU2650859C2 (ru) 2018-04-17
IN2015DN02439A (enExample) 2015-09-04
MY176164A (en) 2020-07-24
CN104755625B (zh) 2020-02-07
CN104755625A (zh) 2015-07-01
WO2014064244A2 (en) 2014-05-01
RU2015119400A (ru) 2016-12-20
BR112015007212B1 (pt) 2022-07-05
EP2912185A2 (en) 2015-09-02

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