KR102090855B1 - 액체 크로마토그래피용 펌프 및 주입 밸브 - Google Patents
액체 크로마토그래피용 펌프 및 주입 밸브 Download PDFInfo
- Publication number
- KR102090855B1 KR102090855B1 KR1020157021646A KR20157021646A KR102090855B1 KR 102090855 B1 KR102090855 B1 KR 102090855B1 KR 1020157021646 A KR1020157021646 A KR 1020157021646A KR 20157021646 A KR20157021646 A KR 20157021646A KR 102090855 B1 KR102090855 B1 KR 102090855B1
- Authority
- KR
- South Korea
- Prior art keywords
- stator
- port
- channel
- communication
- barrel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000002347 injection Methods 0.000 title claims abstract description 89
- 239000007924 injection Substances 0.000 title claims abstract description 89
- 238000004811 liquid chromatography Methods 0.000 title description 2
- 238000004891 communication Methods 0.000 claims description 62
- 238000004587 chromatography analysis Methods 0.000 claims description 19
- 239000012530 fluid Substances 0.000 claims description 18
- 239000004033 plastic Substances 0.000 claims description 14
- 238000001802 infusion Methods 0.000 claims description 13
- 238000004128 high performance liquid chromatography Methods 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 8
- 238000007789 sealing Methods 0.000 claims description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 238000004458 analytical method Methods 0.000 abstract description 7
- 238000010586 diagram Methods 0.000 description 6
- 239000004696 Poly ether ether ketone Substances 0.000 description 4
- 229920002530 polyetherether ketone Polymers 0.000 description 4
- 230000002452 interceptive effect Effects 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 229910000531 Co alloy Inorganic materials 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- PRQRQKBNBXPISG-UHFFFAOYSA-N chromium cobalt molybdenum nickel Chemical compound [Cr].[Co].[Ni].[Mo] PRQRQKBNBXPISG-UHFFFAOYSA-N 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- -1 polytetrafluoroethylene Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 229910000601 superalloy Inorganic materials 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
- F04B19/006—Micropumps
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B13/00—Pumps specially modified to deliver fixed or variable measured quantities
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B7/00—Piston machines or pumps characterised by having positively-driven valving
- F04B7/0003—Piston machines or pumps characterised by having positively-driven valving the distribution member forming both the inlet and discharge distributor for one single pumping chamber
- F04B7/0007—Piston machines or pumps characterised by having positively-driven valving the distribution member forming both the inlet and discharge distributor for one single pumping chamber and having a rotating movement
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N2030/167—Injection on-column injection
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Reciprocating Pumps (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361753299P | 2013-01-16 | 2013-01-16 | |
| US61/753,299 | 2013-01-16 | ||
| PCT/US2014/011697 WO2014113480A2 (en) | 2013-01-16 | 2014-01-15 | Pump and injector for liquid chromatography |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20150118137A KR20150118137A (ko) | 2015-10-21 |
| KR102090855B1 true KR102090855B1 (ko) | 2020-03-18 |
Family
ID=51164444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157021646A Active KR102090855B1 (ko) | 2013-01-16 | 2014-01-15 | 액체 크로마토그래피용 펌프 및 주입 밸브 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9546646B2 (enExample) |
| EP (1) | EP2946188B1 (enExample) |
| JP (1) | JP6114405B2 (enExample) |
| KR (1) | KR102090855B1 (enExample) |
| CN (1) | CN104956199B (enExample) |
| AU (1) | AU2014207605B2 (enExample) |
| CA (1) | CA2894177C (enExample) |
| ES (1) | ES2744351T3 (enExample) |
| WO (1) | WO2014113480A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008006266B4 (de) | 2008-01-25 | 2011-06-09 | Dionex Softron Gmbh | Probengeber für die Flüssigkeitschromatographie, insbesondere für die Hochleistungsflüssigkeitschromatographie |
| US9539524B2 (en) | 2013-01-16 | 2017-01-10 | Valco Instruments Company, L.P. | Pump and injector for liquid chromatography |
| CN107003287B (zh) * | 2014-12-15 | 2020-06-05 | 通用电气健康护理生物科学股份公司 | 旋转阀和系统 |
| DE202016100451U1 (de) | 2015-06-25 | 2016-02-16 | Dionex Softron Gmbh | Probengeber für die Flüssigkeitschromatographie, insbesondere für die Hochleistungsflüssigkeitschromatographie |
| DE102016101658B4 (de) | 2016-01-29 | 2018-04-05 | Dionex Softron Gmbh | Probenvorkompressionsventil für die Flüssigkeitschromatographie, insbesondere für die Hochleistungsflüssigkeitschromatographie |
| US11119076B2 (en) | 2018-02-26 | 2021-09-14 | Valco Instruments Company, L.P. | System and valve for liquid chromatography |
| US11002262B2 (en) | 2018-02-26 | 2021-05-11 | Valco Instruments Company, L.P. | Pump for liquid chromatography with pressure sensor |
| US11041581B2 (en) | 2018-02-26 | 2021-06-22 | Valco Instruments Company, L.P. | Zero dead volume fitting assembly |
| US11067473B2 (en) * | 2019-06-07 | 2021-07-20 | Packaging Technologies & Inspection, LLC | System and method for high voltage leak detection |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003202332A (ja) | 2002-01-08 | 2003-07-18 | Shimadzu Corp | 高速液体クロマトグラフ |
| US20060191581A1 (en) | 2003-04-03 | 2006-08-31 | Cueni Hansjorg E | Rotating valve |
| JP2007121164A (ja) | 2005-10-28 | 2007-05-17 | Shimadzu Corp | 流路切換バルブ及びそれを用いた高速液体クロマトグラフ |
| US20090145205A1 (en) | 2007-12-10 | 2009-06-11 | Hermann Hochgraeber | Autosampler for high-performance liquid chromatography |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4300393A (en) * | 1979-12-14 | 1981-11-17 | Stearns Stanley D | Sample introduction apparatus for gas chromatographic analysis using packed or capillary bore open tubular columns and method of testing |
| US4444066A (en) * | 1981-06-29 | 1984-04-24 | Beckman Instruments, Inc. | High pressure sample injector valve |
| US4506558A (en) * | 1983-03-03 | 1985-03-26 | Rheodyne Incorporated | Injector with minimal flow-interrupt transient |
| JPS61134668A (ja) * | 1984-12-06 | 1986-06-21 | Toyo Soda Mfg Co Ltd | 液注入装置 |
| JPS61118640A (ja) * | 1984-11-15 | 1986-06-05 | Toyo Soda Mfg Co Ltd | 液注入装置 |
| US4926702A (en) * | 1987-09-18 | 1990-05-22 | Beckman Instruments, Inc. | Sample presence detector for automatic sample injector |
| NL8802810A (nl) * | 1988-11-15 | 1990-06-01 | Eurotool Bv | Inspuitmondstuk voor toepassing bij een spuitgiet-inrichting. |
| US4957085A (en) * | 1989-02-16 | 1990-09-18 | Anatoly Sverdlin | Fuel injection system for internal combustion engines |
| US5920006A (en) * | 1997-06-16 | 1999-07-06 | Digichrom, Inc. | Liquid chromatographic pump and valve assembly |
| US5948448A (en) * | 1997-11-18 | 1999-09-07 | Eurotool, Inc. | Apparatus for controlling plastic melt flow in injection molding machines |
| US6155123A (en) * | 1998-04-17 | 2000-12-05 | Rheodyne, L.P. | Multivalving sample injection system |
| ES2188493T3 (es) * | 2000-12-11 | 2003-07-01 | Gilson Inc | Bomba de alta presion y bajo volumen. |
| US6382035B1 (en) * | 2001-04-02 | 2002-05-07 | Rheodyne, Lp | Multi-valving sample injection apparatus |
| CN100422731C (zh) * | 2005-06-27 | 2008-10-01 | 浙江大学 | 微流控芯片负压进样和分离的装置 |
| US7517395B2 (en) * | 2005-12-01 | 2009-04-14 | Agilent Technologies, Inc. | Seal having low friction non-stick surface layer |
| JP5270582B2 (ja) * | 2007-02-22 | 2013-08-21 | ジーイー・ヘルスケア・バイオ−サイエンシズ・アーベー | 試料注入用回転弁 |
| JP2009276110A (ja) * | 2008-05-13 | 2009-11-26 | Tosoh Corp | クロマトグラフ分析装置用試料注入システム |
| DE102009004828B4 (de) * | 2009-01-13 | 2010-12-09 | Lts Lohmann Therapie-Systeme Ag | Injektor mit verdrängbarem Stopfenteil |
| US7955071B1 (en) * | 2009-11-30 | 2011-06-07 | Dme Company Llc | Apparatus for injection molding |
| US8047836B2 (en) * | 2010-04-06 | 2011-11-01 | Mold Hotrunner Solutions Inc. | Nozzle valve gate apparatus with wiper seal |
| JP5646902B2 (ja) * | 2010-07-26 | 2014-12-24 | アークレイ株式会社 | 液体クロマトグラフィ装置およびインジェクションバルブ |
| DE102011000104B4 (de) | 2011-01-12 | 2013-02-07 | Dionex Softron Gmbh | Hochdruck-Schaltventil für die Hochleistungsflüssigkeitschromatographie |
| US20130340609A1 (en) * | 2011-03-10 | 2013-12-26 | Waters Technologies Corporation | Pump head outlet port |
| US9488277B2 (en) * | 2011-03-10 | 2016-11-08 | Waters Technologies Corporation | Seal assemblies for reciprocating and rotary applications |
-
2014
- 2014-01-15 ES ES14740712T patent/ES2744351T3/es active Active
- 2014-01-15 AU AU2014207605A patent/AU2014207605B2/en not_active Ceased
- 2014-01-15 EP EP14740712.6A patent/EP2946188B1/en active Active
- 2014-01-15 CA CA2894177A patent/CA2894177C/en active Active
- 2014-01-15 WO PCT/US2014/011697 patent/WO2014113480A2/en not_active Ceased
- 2014-01-15 JP JP2015552680A patent/JP6114405B2/ja active Active
- 2014-01-15 KR KR1020157021646A patent/KR102090855B1/ko active Active
- 2014-01-15 CN CN201480005085.0A patent/CN104956199B/zh not_active Expired - Fee Related
- 2014-01-15 US US14/156,197 patent/US9546646B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003202332A (ja) | 2002-01-08 | 2003-07-18 | Shimadzu Corp | 高速液体クロマトグラフ |
| US20060191581A1 (en) | 2003-04-03 | 2006-08-31 | Cueni Hansjorg E | Rotating valve |
| JP2007121164A (ja) | 2005-10-28 | 2007-05-17 | Shimadzu Corp | 流路切換バルブ及びそれを用いた高速液体クロマトグラフ |
| US20090145205A1 (en) | 2007-12-10 | 2009-06-11 | Hermann Hochgraeber | Autosampler for high-performance liquid chromatography |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2894177C (en) | 2019-04-30 |
| WO2014113480A3 (en) | 2014-10-23 |
| KR20150118137A (ko) | 2015-10-21 |
| CA2894177A1 (en) | 2014-07-24 |
| AU2014207605B2 (en) | 2016-12-22 |
| CN104956199A (zh) | 2015-09-30 |
| AU2014207605A1 (en) | 2015-05-21 |
| WO2014113480A2 (en) | 2014-07-24 |
| CN104956199B (zh) | 2018-08-21 |
| JP2016507048A (ja) | 2016-03-07 |
| EP2946188A2 (en) | 2015-11-25 |
| US9546646B2 (en) | 2017-01-17 |
| EP2946188B1 (en) | 2019-08-21 |
| US20140197247A1 (en) | 2014-07-17 |
| JP6114405B2 (ja) | 2017-04-12 |
| EP2946188A4 (en) | 2016-09-07 |
| ES2744351T3 (es) | 2020-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20150811 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20180717 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20190918 Patent event code: PE09021S01D |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 20191224 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
Comment text: Registration of Establishment Patent event date: 20200312 Patent event code: PR07011E01D |
|
| PR1002 | Payment of registration fee |
Payment date: 20200312 End annual number: 3 Start annual number: 1 |
|
| PG1601 | Publication of registration | ||
| PR1001 | Payment of annual fee |
Payment date: 20230130 Start annual number: 4 End annual number: 4 |
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| PR1001 | Payment of annual fee |
Payment date: 20240826 Start annual number: 5 End annual number: 5 |