KR102070566B1 - 크로마토그래피 방법 - Google Patents

크로마토그래피 방법 Download PDF

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KR102070566B1
KR102070566B1 KR1020147032736A KR20147032736A KR102070566B1 KR 102070566 B1 KR102070566 B1 KR 102070566B1 KR 1020147032736 A KR1020147032736 A KR 1020147032736A KR 20147032736 A KR20147032736 A KR 20147032736A KR 102070566 B1 KR102070566 B1 KR 102070566B1
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separation unit
column
sample
chromatography
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Korean (ko)
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KR20150005996A (ko
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로마스 스쿠다스
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메르크 파텐트 게엠베하
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/468—Flow patterns using more than one column involving switching between different column configurations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/44—Flow patterns using recycling of the fraction to be distributed

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sustainable Development (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Peptides Or Proteins (AREA)
KR1020147032736A 2012-04-23 2013-03-26 크로마토그래피 방법 Active KR102070566B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12002828.7A EP2656892A1 (en) 2012-04-23 2012-04-23 Chromatography method
EP12002828.7 2012-04-23
US201261666453P 2012-06-29 2012-06-29
US61/666,453 2012-06-29
PCT/EP2013/000910 WO2013159858A1 (en) 2012-04-23 2013-03-26 Chromatography method

Publications (2)

Publication Number Publication Date
KR20150005996A KR20150005996A (ko) 2015-01-15
KR102070566B1 true KR102070566B1 (ko) 2020-01-29

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KR1020147032736A Active KR102070566B1 (ko) 2012-04-23 2013-03-26 크로마토그래피 방법

Country Status (6)

Country Link
US (1) US9149738B2 (enExample)
EP (2) EP2656892A1 (enExample)
JP (1) JP2015520667A (enExample)
KR (1) KR102070566B1 (enExample)
ES (1) ES2855182T3 (enExample)
WO (1) WO2013159858A1 (enExample)

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US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
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CN107793469B (zh) * 2017-10-16 2021-07-30 上海药明生物技术有限公司 一种去除宿主细胞蛋白含量的亲和纯化工艺
GB201806752D0 (en) * 2018-04-25 2018-06-06 Ge Healthcare Bioprocess R&D Ab Method in bioprocess system
GB201810772D0 (en) 2018-06-29 2018-08-15 Ge Healthcare Bio Sciences Ab Method in bioprocess purification system
TWI853823B (zh) * 2018-07-02 2024-09-01 美商里珍納龍藥品有限公司 自混合物製備多肽之系統及方法
JP7527273B2 (ja) * 2018-08-17 2024-08-02 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 多量体タンパク質の量および純度を決定するための方法およびクロマトグラフィーシステム
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US10981950B2 (en) * 2019-01-31 2021-04-20 Joanna Pezzini Therapeutic protein flow kit for a continuous purification system
TWI870412B (zh) * 2019-06-05 2025-01-21 美商建南德克公司 過載層析管柱之再生方法
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US20130280788A1 (en) 2013-10-24
ES2855182T3 (es) 2021-09-23
WO2013159858A1 (en) 2013-10-31
EP2841176A1 (en) 2015-03-04
KR20150005996A (ko) 2015-01-15
EP2656892A1 (en) 2013-10-30
JP2015520667A (ja) 2015-07-23
EP2841176B1 (en) 2020-12-23
US9149738B2 (en) 2015-10-06

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