KR102066292B1 - 박테리아용 폴리시스트론 발현 시스템 - Google Patents
박테리아용 폴리시스트론 발현 시스템 Download PDFInfo
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- KR102066292B1 KR102066292B1 KR1020137033153A KR20137033153A KR102066292B1 KR 102066292 B1 KR102066292 B1 KR 102066292B1 KR 1020137033153 A KR1020137033153 A KR 1020137033153A KR 20137033153 A KR20137033153 A KR 20137033153A KR 102066292 B1 KR102066292 B1 KR 102066292B1
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11168495.7 | 2011-06-01 | ||
| EP11168495 | 2011-06-01 | ||
| EP11173588.2 | 2011-07-12 | ||
| EP11173588 | 2011-07-12 | ||
| PCT/EP2012/060431 WO2012164083A1 (en) | 2011-06-01 | 2012-06-01 | Polycistronic expression system for bacteria |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20140027405A KR20140027405A (ko) | 2014-03-06 |
| KR102066292B1 true KR102066292B1 (ko) | 2020-01-14 |
Family
ID=46354175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137033153A Expired - Fee Related KR102066292B1 (ko) | 2011-06-01 | 2012-06-01 | 박테리아용 폴리시스트론 발현 시스템 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9920324B2 (enExample) |
| EP (2) | EP2714912B1 (enExample) |
| JP (3) | JP6175428B2 (enExample) |
| KR (1) | KR102066292B1 (enExample) |
| CN (2) | CN103562390B (enExample) |
| AU (2) | AU2012264589B2 (enExample) |
| BR (1) | BR112013030824A8 (enExample) |
| CA (2) | CA2837634C (enExample) |
| DK (1) | DK2714912T3 (enExample) |
| ES (1) | ES2676877T3 (enExample) |
| HU (1) | HUE039577T2 (enExample) |
| RU (2) | RU2644346C2 (enExample) |
| WO (1) | WO2012164083A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6175428B2 (ja) | 2011-06-01 | 2017-08-02 | イントレクソン・アクトバイオテイクス・エヌブイIntrexon Actobiotics NV | 細菌のポリシストロン性発現系 |
| US9593339B1 (en) * | 2013-02-14 | 2017-03-14 | David Gordon Bermudes | Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment |
| EP3034610A1 (en) * | 2013-08-13 | 2016-06-22 | The Kitasato Institute | Novel terpenoid compound and method for producing same |
| CA2969100C (en) * | 2014-12-03 | 2023-03-21 | Anaeropharma Science, Inc. | Coexpression plasmid |
| JP6581208B2 (ja) | 2014-12-23 | 2019-09-25 | イリヤ ファーマ エービー | 創傷治癒の方法 |
| AU2016261279B2 (en) | 2015-05-10 | 2020-12-10 | Ventana Medical Systems, Inc. | Compositions and methods for simultaneous inactivation of alkaline phosphatase and peroxidase enzymes during automated multiplex tissue staining assays |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| RU2760997C2 (ru) | 2016-01-14 | 2021-12-02 | Интрексон Актобиотикс Н.В. | Композиции и способы для лечения диабета 1 типа |
| JP7016865B2 (ja) | 2016-09-02 | 2022-03-03 | イントレクソン・アクトバイオテイクス・エヌブイ | Il-10およびインスリンを安定的に発現する遺伝子改変された細菌 |
| RU2021135949A (ru) | 2016-09-13 | 2022-04-14 | Интрексон Актобиотикс Н.В. | Мукоадгезивный микроорганизм |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| GB201906775D0 (en) * | 2019-05-14 | 2019-06-26 | Res & Innovation Uk | Synthetic genome |
| WO2021059240A1 (en) | 2019-09-27 | 2021-04-01 | Intrexon Actobiotics Nv D/B/A Precigen Actobio | Treatment of celiac disease |
| WO2024003873A1 (en) | 2022-06-30 | 2024-01-04 | Intrexon Actobiotics Nv D/B/A Precigen Actobio | Single variable domain antibodies against tumor necrosis factor-alpha |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001062944A2 (en) * | 2000-02-24 | 2001-08-30 | Siga Pharmaceuticals, Inc. | Intergenic and intragenic integration sites for foreign gene expression in recombinant s. gordonii strains |
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| JPS58116498A (ja) | 1981-12-28 | 1983-07-11 | Takeda Chem Ind Ltd | Il‐2をコードする新規伝令rnaの製造法 |
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| US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
| US4752585A (en) | 1985-12-17 | 1988-06-21 | Cetus Corporation | Oxidation-resistant muteins |
| JPH01196296A (ja) * | 1988-01-29 | 1989-08-08 | Toray Ind Inc | 動物細胞用発現ベクター |
| US4919918A (en) | 1988-03-14 | 1990-04-24 | Spectrum Consumer Products Co., Inc. | Non-alcoholic mouthwash |
| US5972685A (en) | 1988-07-21 | 1999-10-26 | Iowa State University Research Foundation, Inc. | Oral administration of coprostanol producing microorganisms to humans to decrease plasma cholesterol concentration |
| GB9006400D0 (en) | 1990-03-22 | 1990-05-23 | Ciba Geigy Ag | Bacterial vectors |
| CA2104104A1 (en) | 1991-02-14 | 1992-09-03 | Daniel K. Podolsky | Intestinal trefoil proteins |
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| US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
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