KR102033964B1 - 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법 - Google Patents

가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법 Download PDF

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Publication number
KR102033964B1
KR102033964B1 KR1020180007310A KR20180007310A KR102033964B1 KR 102033964 B1 KR102033964 B1 KR 102033964B1 KR 1020180007310 A KR1020180007310 A KR 1020180007310A KR 20180007310 A KR20180007310 A KR 20180007310A KR 102033964 B1 KR102033964 B1 KR 102033964B1
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KR
South Korea
Prior art keywords
formula
gadoteridol
represented
lithium
reaction
Prior art date
Application number
KR1020180007310A
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English (en)
Korean (ko)
Other versions
KR20190088792A (ko
Inventor
이재용
이종수
강병규
이병우
이상오
윤대명
방제훈
손기영
Original Assignee
주식회사 엔지켐생명과학
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Priority to KR1020180007310A priority Critical patent/KR102033964B1/ko
Priority to PCT/KR2019/000483 priority patent/WO2019143073A1/ko
Priority to JP2020539756A priority patent/JP7032550B2/ja
Publication of KR20190088792A publication Critical patent/KR20190088792A/ko
Application granted granted Critical
Publication of KR102033964B1 publication Critical patent/KR102033964B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020180007310A 2018-01-19 2018-01-19 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법 KR102033964B1 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1020180007310A KR102033964B1 (ko) 2018-01-19 2018-01-19 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법
PCT/KR2019/000483 WO2019143073A1 (ko) 2018-01-19 2019-01-11 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법
JP2020539756A JP7032550B2 (ja) 2018-01-19 2019-01-11 ガドテリドール中間体及びこれを利用したガドテリドール製造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020180007310A KR102033964B1 (ko) 2018-01-19 2018-01-19 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법

Publications (2)

Publication Number Publication Date
KR20190088792A KR20190088792A (ko) 2019-07-29
KR102033964B1 true KR102033964B1 (ko) 2019-10-18

Family

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Family Applications (1)

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KR1020180007310A KR102033964B1 (ko) 2018-01-19 2018-01-19 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법

Country Status (3)

Country Link
JP (1) JP7032550B2 (ja)
KR (1) KR102033964B1 (ja)
WO (1) WO2019143073A1 (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114249701A (zh) * 2022-01-04 2022-03-29 海南普利制药股份有限公司 一种钆特醇化合物的晶型及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100269081B1 (ko) * 1992-06-04 2000-10-16 에바-마리아 시마-메이어, 얼설라 멜져, 마거, 하르트만 N-베타-히드록시알킬-트리-n-카르복시알킬-1,4,7,10-테트라아자시클로도데칸및n-베타-히드록시알킬-트리-n-카르복시알킬-1,4,8,11-테트라아자시클로테트라데칸유도체및그들의금속착화합물의제조방법
JP2002508755A (ja) * 1997-06-02 2002-03-19 シェリング アクチェンゲゼルシャフト モノ−及び１、７−ビス−ｎ−ヒドロキシアルキル−シクレン並びにそのリチウム塩錯体の製造
JP3471836B2 (ja) * 1991-12-06 2003-12-02 シエーリング アクチエンゲゼルシヤフト モノ−ｎ−置換されたテトラアザシクロドデカン誘導体および−テトラデカン誘導体の製造方法、ならびに診断および治療用の金属錯体の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4237943C2 (de) * 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
JPH09268131A (ja) * 1996-01-31 1997-10-14 Nihon Medi Physics Co Ltd 高濃度核磁気共鳴造影剤
DE10064467C2 (de) * 2000-12-15 2002-10-31 Schering Ag Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung
CN106543094A (zh) 2016-11-04 2017-03-29 嘉实（湖南）医药科技有限公司 高纯度钆布醇的制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3471836B2 (ja) * 1991-12-06 2003-12-02 シエーリング アクチエンゲゼルシヤフト モノ−ｎ−置換されたテトラアザシクロドデカン誘導体および−テトラデカン誘導体の製造方法、ならびに診断および治療用の金属錯体の製造方法
KR100269081B1 (ko) * 1992-06-04 2000-10-16 에바-마리아 시마-메이어, 얼설라 멜져, 마거, 하르트만 N-베타-히드록시알킬-트리-n-카르복시알킬-1,4,7,10-테트라아자시클로도데칸및n-베타-히드록시알킬-트리-n-카르복시알킬-1,4,8,11-테트라아자시클로테트라데칸유도체및그들의금속착화합물의제조방법
JP2002508755A (ja) * 1997-06-02 2002-03-19 シェリング アクチェンゲゼルシャフト モノ−及び１、７−ビス−ｎ−ヒドロキシアルキル−シクレン並びにそのリチウム塩錯体の製造

Also Published As

Publication number Publication date
JP7032550B2 (ja) 2022-03-08
JP2021511322A (ja) 2021-05-06
WO2019143073A1 (ko) 2019-07-25
KR20190088792A (ko) 2019-07-29

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