KR102013086B1 - 알파-2b 아드레날린성 수용체 효현제로 조절 t 세포를 활성화시키는 방법 - Google Patents
알파-2b 아드레날린성 수용체 효현제로 조절 t 세포를 활성화시키는 방법 Download PDFInfo
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US37412410P | 2010-08-16 | 2010-08-16 | |
US61/374,124 | 2010-08-16 | ||
PCT/US2011/047426 WO2012024161A1 (en) | 2010-08-16 | 2011-08-11 | Method of activating regulatory t cells with alpha-2b adrenergic receptor agonists |
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KR1020137006669A Division KR101847669B1 (ko) | 2010-08-16 | 2011-08-11 | 알파-2b 아드레날린성 수용체 효현제로 조절 t 세포를 활성화시키는 방법 |
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KR1020197023782A Division KR20190097323A (ko) | 2010-08-16 | 2011-08-11 | 알파-2b 아드레날린성 수용체 효현제로 조절 t 세포를 활성화시키는 방법 |
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KR20180040710A KR20180040710A (ko) | 2018-04-20 |
KR102013086B1 true KR102013086B1 (ko) | 2019-08-21 |
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KR1020187009383A KR102013086B1 (ko) | 2010-08-16 | 2011-08-11 | 알파-2b 아드레날린성 수용체 효현제로 조절 t 세포를 활성화시키는 방법 |
KR1020137006669A KR101847669B1 (ko) | 2010-08-16 | 2011-08-11 | 알파-2b 아드레날린성 수용체 효현제로 조절 t 세포를 활성화시키는 방법 |
KR1020197023782A KR20190097323A (ko) | 2010-08-16 | 2011-08-11 | 알파-2b 아드레날린성 수용체 효현제로 조절 t 세포를 활성화시키는 방법 |
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KR1020137006669A KR101847669B1 (ko) | 2010-08-16 | 2011-08-11 | 알파-2b 아드레날린성 수용체 효현제로 조절 t 세포를 활성화시키는 방법 |
KR1020197023782A KR20190097323A (ko) | 2010-08-16 | 2011-08-11 | 알파-2b 아드레날린성 수용체 효현제로 조절 t 세포를 활성화시키는 방법 |
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US (5) | US8575207B2 (ru) |
EP (2) | EP3332782A1 (ru) |
JP (3) | JP5938407B2 (ru) |
KR (3) | KR102013086B1 (ru) |
CN (3) | CN108272797B (ru) |
AU (1) | AU2011292296B2 (ru) |
BR (1) | BR112013003590A2 (ru) |
CA (1) | CA2808307C (ru) |
DK (1) | DK2605771T3 (ru) |
ES (1) | ES2676194T3 (ru) |
HK (2) | HK1256823A1 (ru) |
HU (1) | HUE038366T2 (ru) |
PL (1) | PL2605771T3 (ru) |
PT (1) | PT2605771T (ru) |
RU (2) | RU2016134989A (ru) |
SI (1) | SI2605771T1 (ru) |
TR (1) | TR201809456T4 (ru) |
WO (1) | WO2012024161A1 (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011014332A1 (en) * | 2009-07-30 | 2011-02-03 | Allergan, Inc. | Selective alpha 2b/2c agonists |
PT2605771T (pt) | 2010-08-16 | 2018-07-09 | Allergan Inc | Método de ativação de células t reguladoras com agonistas dos recetores adrenérgicos alfa-2b |
US20150313896A1 (en) * | 2013-07-26 | 2015-11-05 | Galderma Research & Development | Method for treating cell proliferation disorders |
RU2691412C2 (ru) * | 2015-02-24 | 2019-06-13 | Дзе Боард Оф Трастис Оф Дзе Юниверсити Оф Иллинойс | Способы и композиции для лечения болезни сухого глаза и других глазных заболеваний |
US9877964B2 (en) | 2015-02-24 | 2018-01-30 | Ocugen, Inc. | Methods and compositions for treating dry eye disease and other eye disorders |
US20180250369A1 (en) * | 2015-09-11 | 2018-09-06 | Ventria Bioscience, Inc. | Lactoferrin compositions and methods for modulation of t cell subtypes and treatment of autoimmune diseases |
WO2017062491A1 (en) * | 2015-10-05 | 2017-04-13 | Jing-Feng Huang | Therapeutic compositions for the treatment of dry eye and related ocular surface diseases |
EP3445372A4 (en) * | 2016-04-22 | 2020-03-25 | Viking Therapeutics, Inc. | USE OF BETA-AGONISTS OF THYROID HORMONES |
JP2020523406A (ja) | 2017-05-19 | 2020-08-06 | オクジェン アイエヌシー. | 眼科用組成物および使用方法 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002036162A2 (en) | 2000-11-01 | 2002-05-10 | Allergan, Inc. | Compositions for treatment of ocular neovascularization and neural injury |
WO2002076950A2 (en) | 2001-03-21 | 2002-10-03 | Allergan, Inc. | Imidiazole derivatives and their use as agonists selective at alpha 2b or 2b/2c adrenergic receptors |
WO2003099289A2 (en) | 2002-05-21 | 2003-12-04 | Allergan, Inc. | Compositions and their uses for alleviating pain |
WO2009020578A1 (en) | 2007-08-06 | 2009-02-12 | Schering Corporation | Alpha2c adrenoreceptor agonists |
WO2009052075A2 (en) | 2007-10-18 | 2009-04-23 | Allergan, Inc. | Method of treating motor disorders with alpha-2b adrenergic receptor agonists |
US20090306398A1 (en) | 2008-06-09 | 2009-12-10 | Allergan, Inc. | Methods of treating alpha adrenergic mediated conditions |
US20090306161A1 (en) | 2008-06-09 | 2009-12-10 | Allergan, Inc. | Methods of treating alpha adrenergic mediated conditions |
WO2011014332A1 (en) | 2009-07-30 | 2011-02-03 | Allergan, Inc. | Selective alpha 2b/2c agonists |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
DE2835423A1 (de) | 1978-08-12 | 1980-03-06 | Hoechst Ag | Beton- und moertelzusatzmittel und dessen verwendung |
US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
US6329369B1 (en) | 1997-12-04 | 2001-12-11 | Allergan Sales, Inc. | Methods of treating pain and other conditions |
US6040292A (en) * | 1999-06-04 | 2000-03-21 | Celtrix Pharmaceuticals, Inc. | Methods for treating diabetes |
US6313172B1 (en) * | 2000-04-13 | 2001-11-06 | Allergan Sales, Inc. | Methods and compositions for modulating alpha adrenergic receptor activity |
US7335803B2 (en) | 2001-10-19 | 2008-02-26 | Allergan, Inc. | Methods and compositions for modulating alpha adrenergic receptor activity |
US6545182B2 (en) * | 2000-04-13 | 2003-04-08 | Allergan Sales, Inc. | Methods and compositions for modulating alpha adrenergic receptor activity |
US6787517B1 (en) | 2000-12-29 | 2004-09-07 | Allergan, Inc. | Agent and methods for treating pain |
US6534542B2 (en) | 2001-02-27 | 2003-03-18 | Allergen Sales, Inc. | (2-hydroxy)ethyl-thioureas useful as modulators of α2B adrenergic receptors |
US7276522B2 (en) | 2002-05-21 | 2007-10-02 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones, 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
US7091232B2 (en) | 2002-05-21 | 2006-08-15 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
BRPI0414277A (pt) | 2003-09-12 | 2006-11-07 | Allergan Inc | métodos e composições para o tratamento de dor e outras condições mediadas adrenérgicas alfa 2 |
US7105183B2 (en) * | 2004-02-03 | 2006-09-12 | The Regents Of The University Of California | Chlorite in the treatment of neurodegenerative disease |
AU2005290075A1 (en) * | 2004-09-24 | 2006-04-06 | Allergan, Inc. | 4-(phenylmethyl and substituted phenylmethyl)-imidazole-2-thiones acting as specific alpha2 adrenergic agonists |
KR101202066B1 (ko) * | 2004-09-28 | 2012-11-15 | 알러간, 인코포레이티드 | 특이적인 또는 선택적인 알파2 아드레날린성아고니스트로서 작용하는 비치환된 및 치환된4-벤질-1,3-디히드로-이미다졸-2-티온 및 이를 사용하는방법 |
US20070032531A1 (en) * | 2005-08-04 | 2007-02-08 | Apogee Biotechnology Corporation | Sphingosine kinase inhibitors and methods of their use |
CN101432281B (zh) * | 2006-04-19 | 2013-08-28 | 诺瓦提斯公司 | 6-0-取代的苯并*唑和苯并噻唑化合物以及抑制csf-1r信号传导的方法 |
AU2007332641A1 (en) * | 2006-12-13 | 2008-06-19 | F. Hoffmann-La Roche Ag | Novel 2 -imidazoles as ligands for trace amine associated receptors (TAAR) |
US20080269241A1 (en) * | 2007-02-15 | 2008-10-30 | Darin Allen | Bicyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s |
MX2010001351A (es) | 2007-08-03 | 2010-06-25 | Mill Steel Co | Aparato para determinar el perfil de calibre para material enrollado plano. |
US8809379B2 (en) * | 2008-01-18 | 2014-08-19 | Allergan, Inc. | Selective subtype alpha 2 adrenergic agents and methods for use thereof |
BRPI0906875A2 (pt) * | 2008-01-18 | 2015-07-07 | Allergan Inc | Agentes adrenérgicos alfa 2 de subtipo seletivo de oxazolidina e tiazolidina e métodos para uso dos mesmos |
US9034910B2 (en) | 2008-06-09 | 2015-05-19 | Allergan, Inc. | Methods of treating alpha adrenergic mediated conditions |
PT2605771T (pt) | 2010-08-16 | 2018-07-09 | Allergan Inc | Método de ativação de células t reguladoras com agonistas dos recetores adrenérgicos alfa-2b |
-
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Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002036162A2 (en) | 2000-11-01 | 2002-05-10 | Allergan, Inc. | Compositions for treatment of ocular neovascularization and neural injury |
WO2002076950A2 (en) | 2001-03-21 | 2002-10-03 | Allergan, Inc. | Imidiazole derivatives and their use as agonists selective at alpha 2b or 2b/2c adrenergic receptors |
WO2003099289A2 (en) | 2002-05-21 | 2003-12-04 | Allergan, Inc. | Compositions and their uses for alleviating pain |
WO2009020578A1 (en) | 2007-08-06 | 2009-02-12 | Schering Corporation | Alpha2c adrenoreceptor agonists |
WO2009052075A2 (en) | 2007-10-18 | 2009-04-23 | Allergan, Inc. | Method of treating motor disorders with alpha-2b adrenergic receptor agonists |
US20090306398A1 (en) | 2008-06-09 | 2009-12-10 | Allergan, Inc. | Methods of treating alpha adrenergic mediated conditions |
US20090306161A1 (en) | 2008-06-09 | 2009-12-10 | Allergan, Inc. | Methods of treating alpha adrenergic mediated conditions |
WO2011014332A1 (en) | 2009-07-30 | 2011-02-03 | Allergan, Inc. | Selective alpha 2b/2c agonists |
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