KR101993699B1 - Composition for improving skin - Google Patents
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- KR101993699B1 KR101993699B1 KR1020170050220A KR20170050220A KR101993699B1 KR 101993699 B1 KR101993699 B1 KR 101993699B1 KR 1020170050220 A KR1020170050220 A KR 1020170050220A KR 20170050220 A KR20170050220 A KR 20170050220A KR 101993699 B1 KR101993699 B1 KR 101993699B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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Abstract
The present invention relates to a skin improving composition. According to the present invention, it is possible to enhance skin barrier function, effectively inhibit melanin production, improve color and skin tone, exhibit excellent synergism, And thus can be usefully used as a cosmetic composition.
Description
The present invention relates to a composition for improving skin, which has no side effects and exhibits an excellent effect on skin whitening effect and skin moisturizing effect.
Human skin plays a very important role as a barrier function to protect individuals from the outside. Such a skin barrier function may be a protective function to protect against various stimuli from outside (chemicals, air pollutants, dry environment, ultraviolet rays, etc.) and excessive divergence of body water through the skin, The function can be maintained only when the stratum corneum composed of cells is normally formed.
The stratum corneum (horney layer), which is the outermost part of the epidermis, is formed from keratinocytes and consists of keratinocytes with complete differentiation and a surrounding lipid layer.
The keratinocyte is a characteristic cell in which basal cells continuously proliferating in the lowest epidermis undergo a stepwise change in morphology and function and are elevated to the surface of the skin. After a certain period of time, And the new keratinocyte replaces its function. This repetitive sequence of changes is called "epidermal cell differentiation" or "keratinization".
In addition, during keratinization, keratinocytes produce natural moisturizing factors (NMF) and intercellular lipids (ceramides, cholesterol, fatty acids, etc.) and form stratum corneum to make the stratum corneum firm and flexible, barrier function.
Such stratum corneum can easily lose its function due to environmental factors such as excessive washing, bathing and other lifestyle factors, dry air pollutants, and endogenous diseases such as atopic skin and senile skin. In fact, Due to the increasing number of factors, dry skin symptoms and their complaints have been increasing recently.
Therefore, in order to maintain proper skin moisture, various studies have been made to supply water from the outside or to prevent water loss from the body. Various moisturizers having moisture retention ability have been developed.
As such a moisturizing agent, it is common to use a substance capable of increasing water retention in the stratum corneum such as ceramide and essential fatty acid and lipid complex.
Recently, the harmful factors for skin have been increasing, and the changes in the dietary pattern slowed down the generation and detachment of the stratum corneum, and the function of the keratinocyte decreased the amount of the moisturizing factor and lipid in the stratum corneum, Although people with various skin diseases such as dry skin, atopic dermatitis, contact dermatitis and psoriasis are increasing in number, the conventional moisturizing agents having moisture retention function are expected to provide symptom relief Although it is possible, fundamental healing is difficult.
The human skin color is determined by various factors such as the activity of melanocyte making melanocyte, the distribution of blood vessels, the thickness of skin, the presence or absence of pigment inside and outside the body such as carotenoid or bilirubin. In particular, melanin, which is produced by the action of various enzymes such as tyrosinase in melanocytes, is the most important factor. The formation of melanin pigment is affected by environmental factors such as genetic factors, hormonal secretion, physiological factors such as stress, and ultraviolet irradiation. Melanin exists in the skin and protects the body from ultraviolet rays. However, it is known that melanin is overproduced, thereby accelerating pigmentation and aging of the skin and leading to skin cancer induction. In order to treat or relieve excessive melanin pigmentation caused by skin pigmentation abnormalities and ultraviolet exposure, it has been known that ascorbic acid, kojic acid, arbutin, hydroquinone (hydroquinone) ), Glutathione, or derivatives thereof, have been used in cosmetics or medicines in combination with thyrosinase-inhibiting substances, and they have been used as an inadequate whitening effect, a safety problem to the skin, And its stability is limited.
Thus, the present applicant has found that the present applicant is safe in the living body, has an effective ingredient stable in the formulation and, above all, enhances the existing skin, that is, enhances the skin barrier function by promoting the function of keratinocyte, We have intensified research on inhibiting substances. As a result, it was confirmed that when a mixture of glyceryl glucoside and catechin is used, the synergistic effect is enhanced, and the present invention has been completed.
It is an object of the present invention to provide a composition for skin improvement which does not cause side effects of skin and maximizes skin whitening effect and skin moisturizing effect.
In order to solve the above object, the present invention provides a cosmetic composition comprising glyceryl glucoside and catechin as an active ingredient.
The composition according to an embodiment of the present invention may be a cosmetic composition for skin whitening.
The composition according to an embodiment of the present invention may be a cosmetic composition for skin moisturizing.
INDUSTRIAL APPLICABILITY According to the present invention, it has excellent efficacy and effect on skin whitening and skin moisturizing effect. These efficacy and effects are remarkable synergistic effects when each single component is used as an active ingredient.
In addition, according to the present invention, the combination of each of the active ingredients obtained from the naturally-occurring component is effective in suppressing browning of the catechin as well as causing no adverse effect by canceling the problem of safety such as irritation or redness to the skin, It is expected that the composition can be stably applied to the composition.
The composition for improving skin according to the present invention will be described in detail below. Unless otherwise defined in the technical terms and scientific terms used herein, the term " composition " In the following description, well-known functions and constructions which may unnecessarily obscure the gist of the present invention will not be described.
In the present invention, the term 'skin improvement' means to smooth the surface of the skin by suppressing or inhibiting roughness of the skin surface due to aging, stress, etc., giving skin moisturization and gloss, and brightening the skin tone As well as any action that improves or alters the condition of the skin.
In the present invention, the term 'moisturizing' refers to inhibiting or reducing the decrease of moisture in the skin or increasing the moisture content of the skin to smooth and smooth the surface of the skin.
In the present invention, 'whitening' means not only brightening the skin tone but also improving skin hyperpigmentation such as stain or freckles due to ultraviolet rays, hormones or heredity.
The term "Camellia sinensis" used in the present invention is an evergreen dew perceived from Camellia sinensis, and generally refers to green tea that has not been subjected to fermentation during its production process. The green tea has been reported to have drunk from the new agriculture of China in 2700 BC, and it is said that Korea drank tea from the time of Silla Dynasty. In addition, green tea contains catechin, flavonoid, theanine, GABA, caffeine, tannin, and various vitamins, which are used for anticancer, antioxidant, antibacterial, deodorant, blood pressure And is known to have a variety of effects such as improving immune function. In particular, catechin is a major functional ingredient of green tea and is known to exhibit various pharmacological actions ranging from antioxidant, anti-cancer, antibacterial, and inhibition of heart disease.
The term "extract" used in the present invention refers to an extract obtained by adding an extraction solvent to at least one selected from plant leaves, flowers, stems, branches, roots, outposts, bark and fruits, Respectively. That is, it may be extracted by methods such as cold extraction, ultrasonic extraction, reflux cooling extraction, hot water extraction, room temperature extraction, warm-up extraction, supercritical extraction, etc. using a conventional solvent under ordinary temperature and pressure conditions, It is not. The extraction solvent may be, but is not limited to, water, anhydrous or lower alcohol having 1 to 7 carbon atoms, hexane, chloroform, ethyl ether, acetone, ethyl acetate, butyl acetate, 1,3-butylene glycol, Propylene glycol, and 1,3-propylene glycol. Of these, lower alcohols and water selected from methanol, ethanol, propanol and butanol are preferable. In addition, the extract extracted with the above-mentioned extraction solvent includes all the extracts, fractions, purified products, their diluted solutions, concentrated liquids or dried products obtained in each step of fractionation or purification, and if necessary, they are subjected to freeze-drying, vacuum drying , Dried by hot air drying, spray drying, vacuum drying, foam drying, high frequency drying, infrared drying, and the like, and further pulverizing the dried extract. Accordingly, the extract is characterized by having a liquid phase, a concentrated solid phase, and a lyophilized powder phase, as the extract has additional steps such as drying and grinding according to the case after filtration.
As used herein, the terms 'lipophilic nonionic surfactant' and 'hydrophilic nonionic surfactant' can be classified and defined by hydrophilic-lipophilic-balance (HLB) values unless otherwise defined. At this time, the lipophilic nonionic surfactant may have an HLB value of 0 to 10, preferably an HLB value of 2 to 7. In addition, the hydrophilic nonionic surfactant may have an HLB value of 10 to 20, preferably an HLB value of 13 to 18.
The term " comprising as an active ingredient " used in the present invention means a cosmetic composition containing an effective amount to such an extent that it can exhibit the efficacy and effects according to the present invention.
Glyceryl glucoside is a substance in which glycerol and glucose are combined, and is known to exert a whitening effect by inhibiting the formation of melanin or inhibiting the activity of enzyme tyrosinase. Recently, the increase in the expression of aquaporin-3 by glyceryl glucoside has been found, and thus it has attracted attention as a moisturizing ingredient.
Thus, the present applicant has found that the above-mentioned glyceryl glucoside can be combined with the above-mentioned glyceryl glucoside in combination with the above-mentioned glyceryl glucoside in addition to an increase in whitening and moisturizing effect, as well as an additional function, It is possible to realize the above-mentioned effect by combining with a specific polyphenol, catechin, during the deepening, and thus the present invention has been completed.
Since catechin has a large number of hydroxyl groups (-OH) in its chemical structure, it has a property of easily binding to various substances, and its effects such as antioxidation, anti-cancer, prevention of cardiovascular diseases and detoxification action are known. However, it has been known that when stored for a long time at room temperature, it is oxidized to cause discoloration (e.g., browning) due to the chemical structural features described above. Thus, when it is used in a cosmetic composition, its use amount is limited or its use is limited to transparent or white cosmetic compositions.
However, the cosmetic composition comprising the cosmetic composition according to the present invention, specifically, glyceryl glucoside and catechin as an active ingredient can not only effectively inhibit the catechin problem described above, but also has excellent skin safety, · The effect can affect the skin's biological mechanism in a complex way, resulting in an excellent skin-improving effect.
Further, according to the present invention, an unexpected synergistic effect due to the simple composition of each component is exhibited. In detail, according to the present invention, skin whitening effect and skin moisturizing effect are remarkably improved compared with the case where each component is contained as a single component, and the aged skin can be fundamentally improved.
The kind of the catechin of the cosmetic composition according to an embodiment of the present invention is not limited, but is preferably contained in the form of one or a mixture of two or more selected from epigallocatechin gallate, galocatechin gallate, epicatechin and catechin gallate .
The cosmetic composition according to an embodiment of the present invention may contain glyceryl glucoside and a green tea extract containing the catechin as an active ingredient.
The green tea extract of the cosmetic composition according to an embodiment of the present invention may contain not only (-) catechin, (+) catechin but also epigallocatechin gallate, galocatechin gallate, epicatechin gallate, catechin gallate, (-) epicatechin, (+) epicatechin, and the like.
In the cosmetic composition according to an embodiment of the present invention, when the green tea extract containing various catechins simultaneously is contained, stronger interaction with glyceryl glucoside effectively solves the problems of the catechin described above, The skin whitening effect and the skin moisturizing effect, which are remarkable in the aimed effects and effects of the present invention, and thus it is preferred in the present invention.
In the present invention, catechin derived from the green tea extract is defined as green tea catechin. The green tea extract of the present invention may be prepared by extracting green tea by various methods (for example, cold extraction, ultrasonic extraction, reflux cooling extraction, hot water extraction, room temperature extraction, warming extraction, supercritical extraction, etc.) Quot; means having a liquid form, a concentrated solid form or a lyophilized powder form which has been subjected to a post-drying pulverization process.
The amount of the glyceryl glucoside and the catechin to be used in the cosmetic composition according to an embodiment of the present invention is not limited, but from the viewpoint of maximizing the above-mentioned effects and effects, Preferably in the range of 30 to 150 parts by weight, and more preferably in the range of 50 to 120 parts by weight of catechin.
The cosmetic composition according to an embodiment of the present invention may further include a polyhydric alcohol. Here, the polyhydric alcohol is not limited as long as it is a conventional moisturizing component. Non-limiting examples thereof include glycerin, 1,3-propanediol, 1,3-butanediol, 1,5-pentanediol, 1,2- , 1,8-octanediol and 1,10-decanediol, sorbitol, diglycerin, erythritol, pentaerythritol, polybutylene glycolurate-10, polyglycerin-3, polyglycerin-4, polyglycerin- Mannitol, lactitol, lactose, dihydroxypropyl PG-glucoside, fructose, glucamine, methylglucamine, glucose, xylitol, etc., such as polyglycerin-10, polyglycerin-20, polyglycerin-40, inositol, maltitol, mannan, mannitol, mannose, .
In particular, the cosmetic composition according to one embodiment of the present invention not only provides a moisturizing effect by enhancing formulation stability with an excellent compatibility, a synergistic effect of improved moisturizing power, but also provides a cosmetic composition containing catechin Glycerin, 1,2-hexanediol or a mixture thereof may be preferably used from the viewpoint of effectively suppressing problems such as sedimentation and discoloration, and it is of course possible to use a mixture further containing the above-mentioned polyhydric alcohol to be.
The cosmetic composition according to an embodiment of the present invention may contain 0.1 to 30% by weight, preferably 0.1 to 20% by weight, more preferably 0.5 to 10% by weight, based on the total weight of the composition, of the polyhydric alcohol But is not limited thereto.
In addition, the cosmetic composition according to an embodiment of the present invention may further comprise a nonionic surfactant. The non-ionic surfactant may include, but is not limited to, a lipophilic nonionic surfactant, a hydrophilic nonionic surfactant, or both.
The cosmetic composition according to an embodiment of the present invention can improve the stability of a formulation by further including the nonionic surfactant and can be used as a precipitant that can be induced from polyphenols (e.g., tannin, etc.) other than catechins contained in catechin or green tea extract Can be effectively suppressed.
In particular, when the green tea extract is contained in the cosmetic composition according to an embodiment of the present invention, it has been confirmed that the polyol and the nonionic surfactant are used at the same time, and thus the unexpected remarkable effect is exhibited in the effect described above.
In the cosmetic composition according to an embodiment of the present invention, the nonionic surfactant may have a hydroxy value (OHV, measured by ISO 4629-1978, mg KOH / g) of 250 or less, preferably 200 or less And more preferably 50 or more and 150 or less.
Non-limiting examples of nonionic surfactants satisfying the above conditions include polysorbate-based, polyoxyethylene-polyoxypropylene-based, glycerin fatty acid ester-based, and polyoxyethylene-glycerin fatty acid ester-based ones. But are not limited to, polysorbate 20, polysorbate 40, polysorbate 60, polysorbate 65, polysorbate 80, polysorbate 85, and the like, as polysorbate nonionic surfactants.
In this case, the total amount of the nonionic surfactant may be in the range of 0.1 to 10 wt%, preferably 0.5 to 10 wt%, more preferably 0.5 to 8 wt%, based on the total weight of the composition. But is not limited thereto.
The cosmetic composition according to an embodiment of the present invention may be used for skin whitening. According to the present invention, not only the inhibition of melanin production but also the suppression of melanogenesis can be suppressed by suppressing melanin production by inhibiting melanin production by inhibiting melanin production And exhibits a remarkably improved effect compared to the case, and particularly excellent in suppression of melanin production.
It is needless to say that the cosmetic composition according to an embodiment of the present invention may further include a known whitening component in order to maximize the skin whitening effect.
The whitening component is not particularly limited as long as it has a whitening effect, and examples thereof include, but are not limited to, a mulberry extract, a useful licorice extract, a rice bran extract, a brown rice extract, a ginseng extract, a red ginseng extract, a black ginseng extract, , Extracts of Saururus chinensis, extracts of agaricus, extracts of Indian kannapurii, extracts of Jeju bokbun, extracts of gosam, extracts of wool, extracts of wheat, extracts of wheat germ, extracts of plum, arbutin, ethyl ascorbyl ether, ascorbyl glucoside, magnesium ascorbyl phosphate , Ascorbyl tetraisopalmitate, niacinamide, alpha-bisabolol, acetyl tyrosine, furyline, orzanol, methoxypigi-7 ascovanic acid, dihydroxymethoxaconic acid, acetyl phytosphingosine, Methine, azelaic acid, and mace lignan. .
The cosmetic composition according to an embodiment of the present invention may be for skin moisturizing. INDUSTRIAL APPLICABILITY According to the present invention, a skin moisturizing effect remarkably improved as compared with the case of using glyceryl glucoside or catechin alone is provided, and the above-mentioned effects and effects are simultaneously provided. That is, according to the present invention, the effect on the biological mechanism of the skin is complex, and the effect of improving skin color and skin tone as well as skin moisturizing effect can be exhibited.
In addition, the cosmetic composition according to an embodiment of the present invention may further include an additional moisturizing component that not only moisturizes the skin but also helps maintain the barrier function by external stimulation by promoting the proliferation and differentiation of the epidermis, to be.
Such moisturizing ingredients include, but are not limited to, isoflavones selected from among, but not limited to, jenithin, daidzin, glycitin, genistein, daidzein, gristin; And compound K; And the like.
The cosmetic composition according to an embodiment of the present invention may be prepared as an emulsified or solubilized formulation. Examples of the cosmetic composition of the emulsified form include nutrient lotion, essence, eye cream, nutritional cream, massage cream, cleansing cream, and cleansing foam. Examples of the cosmetic composition of the solubilized formulation include softening lotion, Water and the like. It is of course also possible to prepare it in the form of a topical or systemic adjuvant which is formulated in the form of a pack, spray, conceal stick or the like and is conventionally used in the field of dermatology.
At this time, the cosmetic composition according to an embodiment of the present invention may contain 0.001 to 50% by weight, preferably 0.01 to 30.0% by weight, of the cosmetic composition containing glyceryl glucoside and catechin as an active ingredient in the formulation, May be included in an amount of 0.01 to 20.0% by weight.
Hereinafter, preferred embodiments of the present invention will be described in order to facilitate understanding of the present invention. However, the following examples are provided only for the purpose of easier understanding of the present invention, and the following examples are merely illustrative and not intended to limit the scope of the present invention in any way. In the present invention, the amount of each component is based on the weight (g) unit unless otherwise defined.
(Skin whitening effect)
Evaluation 1. Inhibition of melanin formation
Each of the cosmetic composition prepared in the following Examples and Comparative Examples was added to the culture solution of mouse melanoma cell (B-16 mouse melanoma cell) to test the whitening effect at the cellular level. At this time, the toxicity of the melanoma cells of the rats before the experiment was evaluated, and the skin whitening effect was examined by selecting the concentration without toxicity.
The final concentration (based on the active ingredient) of each of the cosmetic compositions was 10 μg / ml and 20 μg / ml. Arbutin, a positive control, was added to the medium to a concentration of 200 μg / ml and treated with B-16 melanoma cells And cultured for 3 days.
Cells were then trypsinized, detached from the culture, centrifuged, and extracted with melanin. The removed cells were incubated with 1 mL of sodium hydroxide solution (1N), boiled for 10 minutes to dissolve melanin, and the absorbance was measured at 400 nm using a spectrophotometer to determine the amount of melanin produced.
The amount of melanin was measured by the absorbance of 10 6 cells per unit cell, and the amount of melanin produced relative to the negative control (no addition) was calculated as inhibition (%) (see Table 2).
[Equation 1]
Inhibition rate (%) = 100 - {(absorbance of test substance / absorbance of negative control) x 100}
(Skin moisturizing effect)
Evaluation 2. Short-term moisturizing
Nourishing creams were prepared using the compositions of the following examples and comparative examples in the compositions shown in the following Table 7 and subjected to a short-term moisturizing test in order to evaluate the skin moisturizing power.
Each subject was washed with soap, and the skin was adapted at a temperature of about 20 ° C and a humidity of about 40%. The skin softening effect was evaluated together with the moisture test. The test site was defined by a rectangle of 4 x 3 cm 2 on the lateral side of the hump and the skin surface capacitance was measured three times by using a corneometer (CM825). 24 μL (2 mg / cm 2) of the samples of Examples 1 to 3 and Comparative Examples 1 and 4 was applied to the test site.
After 6 hours of application, the skin surface capacitance was measured three times in the same manner as before application. The average value of the capacitance measured three times was determined, and the water content was determined. The initial moisture content before coating and the moisture content of the non-wiping area were corrected to obtain the moisture increase / decrease ratio, and skin moisture resistance of each of the cosmetic compositions was judged based on this. At this time, the moisture increase / decrease rate was calculated by the following formula (2) (see Table 4).
&Quot; (2) "
Water change ratio (%) =
Td0) - (Ntdi-NTd0)] / [(Ntdi-NTd0) + Td0]} * 100
Tdi = n-th measurement value of sample application area
Td0 = Before measurement value of sample application area
NTdi = n-th measurement value of the portion not coated with the sample
NTd0 = before measured value of the portion not coated with the sample
(Formulation stability)
Evaluation 3. Visual evaluation of discoloration and phase separation
Using the cosmetic compositions prepared in the following examples and comparative examples, nutritional creams were prepared with the compositions shown in the following Table 7, and their formulation stability was compared. The formulation stability was determined by circulating the solution at room temperature (20 ± 2 ° C), cooling / heating (4 ± 2 ° C), high temperature (45 ± 2 ° C) and freeze-thaw chambers ), And discoloration and phase separation of each sample were visually observed at intervals of one week (see Table 5).
(Examples 1-8)
After preparing the cosmetic composition in the composition shown in the following Table 1, the efficacy and effects were evaluated by the above-mentioned method, and the results are shown in Tables 2 to 3 below.
In addition, the nutritional creams were prepared with the compositions shown in the following Table 7, and short-term moisturizing evaluation and formulation stability were evaluated by the above methods, and the results are shown in Tables 4 to 5 below.
(Comparative Example 1-3)
The compositions were prepared according to the compositions shown in Table 1 below, and their efficacy and efficacy were evaluated by the above-mentioned methods. The results are shown in Tables 2 to 3 below.
In addition, the nutritional creams were prepared with the compositions shown in the following Table 7, and short-term moisturizing evaluation and formulation stability were evaluated by the above methods, and the results are shown in Tables 4 to 5 below.
As shown in Table 2, the cosmetic composition according to the present invention exhibits remarkably improved melanin production inhibitory ability as compared with the negative control, and exhibits superior melanin production inhibitory ability at a lower test concentration than that of arbutin, which is known as a whitening ingredient .
The efficacy and effect of the cosmetic composition according to the present invention described above corresponds to a remarkable synergistic effect with respect to the cosmetic composition comprising EGCG or glyceryl glucoside alone. In other words, the cosmetic composition according to the present invention can improve not only the skin moisturizing effect but also the improvement of the skin texture by inducing the improvement of the skin brightness.
As shown in Table 3, the cosmetic composition according to the present invention shows a lower IC 50 value than vitamin C, which is conventionally known as an antioxidant component. In addition, it can be seen that the catechin alone exhibits a more remarkable free radical scavenging ability than the catechin alone.
Furthermore, it can be seen that the cosmetic composition according to the present invention exhibits excellent activity in the above-mentioned effects, especially when catechins derived from green tea extract are included. This is expected to be a synergistic effect of active ingredients such as green tea saponin as well as various types of catechins derived from green tea extract.
As shown in Table 4, the cosmetic composition according to the present invention shows remarkably improved short-term moisturizing effect as compared with the cosmetic composition comprising EGCG or glyceryl glucoside alone. Further, it is understood that the inclusion of glycerin, which is known as a moisturizing component, not only exhibits a synergistic effect of not less than 106.5% at maximum, but also exhibits a synergistic effect of not less than 113.9% at a maximum by incorporating a predetermined nonionic surfactant.
According to the results shown in Table 5, the cosmetic composition according to the present invention maintains the formulation stable even though a long time has passed without being limited by temperature, and it is confirmed that the formulation does not cause discoloration of the formulation which can be caused by catechin, can do. However, in the case of the comparative example, not only the instability of the formulation of the cosmetic composition but also discoloration was observed.
In short, the cosmetic composition according to the present invention effectively exerts a whitening effect on melanin synthesis of the skin, and is superior in improving the skin texture by improving the skin moisturizing effect by enhancing the skin barrier function. Thus, It is anticipated that it will be possible to provide multi-functional cosmetics.
(Formulation Example 1)
Lotion was prepared according to a conventional method with the composition shown in Table 6 below.
(Formulation Example 2)
Nutrition cream was prepared according to a conventional method with the composition shown in Table 7 below.
While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the technical scope of the present invention is not limited to the disclosed exemplary embodiments. Accordingly, the actual scope of the present invention will be defined by the appended claims and their equivalents.
Claims (9)
Wherein the epigallocatechin gallate is obtained from green tea extract.
A cosmetic composition comprising a polyhydric alcohol.
A cosmetic composition further comprising a nonionic surfactant.
Wherein the composition is for skin whitening.
Ginseng extract, ginseng extract, crude ginseng extract, crude ginseng extract, ginseng extract, brown rice extract, ginseng extract, red ginseng extract, black ginseng extract, wild ginseng extract, agar ginseng extract, Saururus chinensis extract, Wherein the extract is at least one selected from the group consisting of extracts, extracts, extracts of wheat germ, extracts of plum, arbutin, ethyl ascorbyl ether, ascorbyl glucoside, magnesium ascorbyl phosphate, ascorbyl tetraisopalmitate, niacinamide, alpha-bisabolol, acetyl tyrosine, Wherein the cosmetic composition further comprises at least one whitening component selected from the group consisting of oryzanol, oryzanol, methoxyphei-7 ascovanic acid, dihydroxymethoxaconic acid, acetyl phytosphingosine, polyadatine, diosmetin, azelaic acid and macelignan .
Wherein the composition is skin moisturizing.
Wherein the cosmetic composition further comprises at least one moisturizing component selected from genistin, daidzin, gristin, genistein, daidzein, gristitine and compound K.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020170050220A KR101993699B1 (en) | 2017-04-19 | 2017-04-19 | Composition for improving skin |
| PCT/KR2018/004478 WO2018194360A1 (en) | 2017-04-19 | 2018-04-18 | Skin-improving composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020170050220A KR101993699B1 (en) | 2017-04-19 | 2017-04-19 | Composition for improving skin |
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| Publication Number | Publication Date |
|---|---|
| KR20180117296A KR20180117296A (en) | 2018-10-29 |
| KR101993699B1 true KR101993699B1 (en) | 2019-06-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| KR1020170050220A KR101993699B1 (en) | 2017-04-19 | 2017-04-19 | Composition for improving skin |
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| Country | Link |
|---|---|
| KR (1) | KR101993699B1 (en) |
| WO (1) | WO2018194360A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023282528A1 (en) * | 2021-07-09 | 2023-01-12 | 코스맥스 주식회사 | Skin whitening composition comprising extract from white leaf of saururus chinensis (lour.) baill |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113081884B (en) * | 2021-04-26 | 2022-05-24 | 北京中医药大学 | Anti-melanin composition, preparation method and application |
| CN113712875A (en) * | 2021-09-28 | 2021-11-30 | 蔻蔻琪生物科技(杭州)有限公司 | Nanocrystallized anti-saccharification composition and preparation method and application thereof |
| CN115252466A (en) * | 2022-08-22 | 2022-11-01 | 青岛中科蓝智生物科技发展有限公司 | Application of polysaccharides and derivatives thereof in freckle removing and whitening products |
| CN115444772B (en) * | 2022-10-26 | 2023-07-14 | 广州艾卓生物科技股份有限公司 | Moisturizing and whitening composition and application thereof in radio frequency beauty and medical skin care |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004331581A (en) * | 2003-05-08 | 2004-11-25 | Noevir Co Ltd | Bleaching agent |
| JP2014524466A (en) * | 2011-08-24 | 2014-09-22 | 株式会社アモーレパシフィック | Cosmetic composition containing green tea ingredients |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2032119A1 (en) * | 2006-04-27 | 2009-03-11 | Beiersdorf AG | Cosmetic preparation with aquaporin stimulators and the use thereof |
| JP6134943B2 (en) * | 2013-05-23 | 2017-05-31 | 株式会社サイエンスリン | Topical skin preparation |
| JP6570186B2 (en) * | 2014-03-31 | 2019-09-04 | カーリットホールディングス株式会社 | Glyceryl glucoside-containing composition and method for producing the same |
| KR20160081176A (en) * | 2014-12-31 | 2016-07-08 | (주)아모레퍼시픽 | Skin external composition for moisturing skin or whitening skin comprising catechins and panaxydol |
-
2017
- 2017-04-19 KR KR1020170050220A patent/KR101993699B1/en active IP Right Grant
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2018
- 2018-04-18 WO PCT/KR2018/004478 patent/WO2018194360A1/en active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004331581A (en) * | 2003-05-08 | 2004-11-25 | Noevir Co Ltd | Bleaching agent |
| JP2014524466A (en) * | 2011-08-24 | 2014-09-22 | 株式会社アモーレパシフィック | Cosmetic composition containing green tea ingredients |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023282528A1 (en) * | 2021-07-09 | 2023-01-12 | 코스맥스 주식회사 | Skin whitening composition comprising extract from white leaf of saururus chinensis (lour.) baill |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018194360A1 (en) | 2018-10-25 |
| KR20180117296A (en) | 2018-10-29 |
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