CN113712875A - Nanocrystallized anti-saccharification composition and preparation method and application thereof - Google Patents
Nanocrystallized anti-saccharification composition and preparation method and application thereof Download PDFInfo
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- CN113712875A CN113712875A CN202111142638.5A CN202111142638A CN113712875A CN 113712875 A CN113712875 A CN 113712875A CN 202111142638 A CN202111142638 A CN 202111142638A CN 113712875 A CN113712875 A CN 113712875A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention relates to a nano anti-saccharification composition and a preparation method and application thereof, wherein the nano anti-saccharification composition comprises the following components: 5 parts of a nano cosolvent; 20-30 parts of plant extract; 10-15 parts of hydroxypropyl tetrahydropyrane triol; 1.0-3.0 parts of fullerene; 11.0-2.0 parts of oligopeptide; 2.0-5.0 parts of a polyol preservative; wherein the plant extract comprises Choline lemon extract, Citrus unshiu pericarp extract, flos Rosae Davuricae extract, folium Camelliae sinensis extract, Annona bracteata pericarp extract, folium Eriobotryae extract, herba Rosmarini officinalis leaf extract and fructus Hippophae extract. The skin care product is easier to add into common cosmetic formulations, is easier to permeate into skin cuticle to exert the effect, does not need to add a chemical synthesis preservative, is mild and non-irritant, and can remarkably improve dark skin color, improve skin elasticity and firmness and increase skin anti-saccharification capacity.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a nano anti-saccharification composition and a preparation method and application thereof.
Background
The glycation reaction on human skin refers to a non-enzymatic reaction between aldehyde (ketone) group of reducing sugar and amine group of amino group-containing substance (such as protein, nucleic acid, etc.), which is divided into enzymatic glycosylation reaction and non-enzymatic glycosylation reaction according to the participation of enzyme, and is a process of adding sugar to protein or lipid. Non-enzymatic glycosylation is a series of complex non-enzymatic reactions, and proteins and glucose undergo non-enzymatic reactions in vivo and then undergo processes such as oxidation, rearrangement, crosslinking and the like to form irreversible non-enzymatic glycosylation end products (AGEs). The glycation reaction proceeds slowly in vivo, and the produced AGEs can be normally excreted out of the body through metabolism, but, with the aging, the metabolism function of the skin in vivo and in vitro is reduced, so that AGEs are accumulated in vitro and day after day, the cross-linking damage of protein is caused to be combined with specific receptors, so that a plurality of problems are caused to the skin, the skin is dark yellow, wrinkles are generated, the elasticity of collagen fibers is reduced, dark brown spots are generated, and even matrix metalloproteinases (matrix metalloproteinases) which can decompose collagen and elastin are promoted to generate and the secretion of cytokines which can cause inflammatory reaction is increased. These factors also eventually cause problems such as accelerated skin aging, and thus the conventional skin care products are required to have an anti-glycation effect, and the anti-glycation performance is mainly expressed by skin elasticity and skin brightness, and thus the skin elasticity and skin brightness are also often used as indicators of the anti-glycation performance.
Chinese patent CN110522700A discloses an anti-glycation whitening cosmetic composition and an anti-glycation whitening cosmetic containing the same, the formula comprises: 0.001-15 parts of an anti-glycation agent; a whitening cosmetic containing an anti-glycation whitening cosmetic composition comprises an anti-glycation cosmetic composition, a cosmetic base and water; the cosmetic matrix accounts for 0.0001-70 parts by weight; the anti-glycation agent A comprises one or more of sunflower seed extract, nicotinamide, acetyl chitosamine, Broussonetia papyrifera extract, mulberry bark extract, apple fruit extract, camellia extract, tea leaf extract, rhus chinensis extract, madecassoside, ethylhexyl glycerol and Tricholoma matsutake extract; the invention can effectively improve the anti-glycation efficacy, and prevent, inhibit or improve the problems of dark and yellow skin, uneven skin color and the like caused by glycation and oxidation. However, the composition has no data support related to skin brightness effect and skin elasticity effect, and the specific effect is not detailed.
Disclosure of Invention
The invention provides a nano anti-saccharification composition, a preparation method and an application thereof, and aims to solve the problem that the anti-saccharification effect of the composition in the prior art is not obvious.
In order to solve the technical problems, the technical scheme provided by the invention is as follows:
a nanocrystallized anti-saccharification composition comprises the following components in parts by weight:
5 parts of nano cosolvent;
20-30 parts of plant extract;
10-15 parts of hydroxypropyl tetrahydropyrane triol;
1.0-3.0 parts of fullerene;
1, 1.0-2.0 parts of oligopeptide;
2.0-5.0 parts of a polyol preservative;
wherein the plant extracts comprise a Choline bergamot extract, a wenzhou mandarin orange peel extract, a rosa multiflora flower extract, a sweet tea leaf extract, a brazil sweetsop peel extract, a loquat leaf extract, a rosemary leaf extract and a sea buckthorn fruit extract, and the weight ratio of the extracts is 10: (3.5-4.5): (0.5-1.5): (2.5-3.5): (2.5-3.5): (1.5-2.5): (0.5-1.5): (3.5-4.5).
The Okinawa fragrant lemons are distributed in mountain areas in the north of the Okinawa Bendao, are rich in vitamin C and citric acid, particularly contain nobiletin which belongs to flavonoids and is greatly higher than other citrus fruits, and the nobiletin contains a plurality of components beneficial to beauty and health and can be purchased in the market. The applicant experiments show that the extract of the Chongguo lemon has excellent anti-saccharification effect after being added into the composition.
Annona squamosa is a species of Annona squamosa grown on the grassland of the tropical zone of Brazil, is rich in procyanidins, and is commercially available. The applicant tests and finds that the combination of the Annona bracteata extract and the Choline lemon extract has excellent anti-saccharification effect.
In addition, wenzhou mandarin orange, loquat leaf, rosa multiflora flower, sweet tea leaf, rosemary leaf and sea buckthorn fruit are commercially available.
The current methods for extracting plant extracts include solvent extraction, ultrasonic extraction, microwave extraction, enzyme extraction, supercritical fluid extraction, and the like. Preferably, the plant extracts are all prepared by a subcritical water extraction method. The subcritical water extraction technology is widely applied to the extraction of plant active substances, and is not described herein again.
Preferably, the nano cosolvent is any one of propylene glycol, dipropylene glycol, pentaerythritol tetraisostearate, pentaerythritol tetraester, squalane, hydrogenated lecithin, polydimethylsiloxane, octyl methicone, PPG-6-decyltetradecyltetraeth-30 and phytosterol macadamia oleate.
Preferably, the polyol preservative comprises at least 2 ingredients of ethylhexyl glycerol, octyl glycol, 1, 2-pentanediol, 1, 2-hexanediol, and isoprene glycol.
Preferably, the weight ratio of the oligopeptide-1 to the fullerene is 1: 1.1-1.5.
A method for preparing a nanosized antiglycation composition according to any one of claims 1 to 5, comprising the steps of:
s1, heating the nano cosolvent to 45 ℃, adding the plant extract, the hydroxypropyl tetrahydropyrane triol, the fullerene, the oligopeptide-1 and the polyol preservative in sequence, fully stirring and dissolving until no particles exist, and controlling the temperature to 40 ℃;
s2, adding the material obtained in the step S1 into a high-pressure homogenizer for high-pressure homogenizing treatment until the material is semitransparent;
and S3, outputting the treated material body processed in the step S2.
Preferably, the material obtained in step S1 is dosed into the high-pressure homogenizer at 1.5ml/sec by a peristaltic pump; the high-pressure homogenization processing in step S2 needs to satisfy the condition: controlling the pressure range to be 100-300 Mpa; controlling the temperature range to be 4-5 ℃; the operation is repeated for 5 to 10 times for circulation, the viscosity is controlled to be 30 to 80cps, and the particle size of the material body is controlled to be 50 to 100 nm.
Use of a nanosized antiglycation composition according to any one of claims 1 to 5 for the preparation of a cosmetic.
Preferably, the weight of the nano anti-saccharification composition accounts for 1.5-4.5% of the total weight of the cosmetic.
Preferably, the cosmetic is a lotion, essence, emulsion, cream, eye cream or mask.
Compared with the prior art, the technical scheme provided by the invention has the following beneficial effects:
1. after the nano anti-glycation composition is compounded through a specific proportion test, the nano anti-glycation composition is prepared through a nano process, is easier to add into a common cosmetic preparation form and easier to permeate into a skin cuticle to play a role, does not need to add a chemically synthesized preservative, is mild and non-irritant, and compared with a product sold in the market, the nano anti-glycation composition can obviously improve dark skin color, improve skin elasticity and firmness and increase skin anti-glycation capacity.
2. The plant extract disclosed by the invention is composed of two core components of a Chonghua lemon extract and a Brazilian sweetsop peel extract and other plant extracts, so that the nano anti-saccharification composition has a better skin improvement effect.
Detailed Description
For further understanding of the present invention, the present invention will be described in detail with reference to examples, which are provided for illustration of the present invention but are not intended to limit the scope of the present invention.
Example 1
The embodiment relates to a nanocrystallized anti-saccharification composition which comprises the following components in parts by weight: 5 parts of nano cosolvent, 28 parts of plant extract, 10 parts of hydroxypropyl tetrahydropyrane triol, 1.4 parts of oligopeptide-1, 1.8 parts of fullerene and 3.2 parts of polyol preservative. The nano cosolvent is propylene glycol, and the polyol preservative comprises 1.6 parts of ethylhexyl glycerol and 1.6 parts of octyl glycol.
The plant extracts comprise 10 parts of Chonghua lemon extract, 4 parts of wenzhou mandarin orange peel extract, 1 part of rosa multiflora flower extract, 3 parts of sweet tea leaf extract, 3 parts of custard apple peel extract, 2 parts of loquat leaf extract, 1 part of rosemary leaf extract and 4 parts of sea buckthorn fruit extract.
Example 2
The embodiment relates to a nanocrystallized anti-saccharification composition which comprises the following components in parts by weight: 5 parts of nano cosolvent, 27.4 parts of plant extract, 10 parts of hydroxypropyl tetrahydropyrane triol, 1.9 parts of oligopeptide-1, 2.9 parts of fullerene and 2 parts of polyol preservative. The nano cosolvent is pentaerythritol tetraester, and the polyol preservative comprises 1 part of 1, 2-pentanediol and 1 part of 1, 2-hexanediol.
The plant extracts comprise 10 parts of Choline lemon extract, 4.5 parts of wenzhou mandarin orange peel extract, 0.5 part of flos rosae multiflorae extract, 2.5 parts of sweet tea leaf extract, 3.4 parts of Brazilian sweetsop peel extract, 1.6 parts of folium eriobotryae extract, 0.5 part of rosemary leaf extract and 4.4 parts of seabuckthorn fruit extract.
Example 3
The embodiment relates to a nanocrystallized anti-saccharification composition which comprises the following components in parts by weight: 5 parts of nano cosolvent, 28.7 parts of plant extract, 15 parts of hydroxypropyl tetrahydropyrane triol, 1.1 parts of oligopeptide-1, 1.2 parts of fullerene and 5.0 parts of polyol preservative. The nano cosolvent is dipropylene glycol, and the polyol preservative comprises 2 parts of 1, 2-hexanediol and 3 parts of isoprene glycol.
The plant extracts comprise 10 parts of Choline lemon extract, 3.7 parts of wenzhou mandarin orange peel extract, 1.5 parts of rosa multiflora flower extract, 3.5 parts of sweet tea leaf extract, 2.7 parts of brazilian sweetsop peel extract, 2.4 parts of loquat leaf extract, 1.4 parts of rosemary leaf extract and 3.5 parts of sea buckthorn fruit extract.
Example 4
The embodiment relates to a nanocrystallized anti-saccharification composition which comprises the following components in parts by weight: 5 parts of nano cosolvent, 27.9 parts of plant extract, 13 parts of hydroxypropyl tetrahydropyrane triol, 1.4 parts of oligopeptide-1, 1.8 parts of fullerene and 3.1 parts of polyol preservative. The nano cosolvent is squalane, and the polyol preservative comprises 2 parts of 1, 2-hexanediol and 1.1 part of isoprene glycol.
The plant extracts comprise 10 parts of Choline lemon extract, 4.2 parts of wenzhou mandarin orange peel extract, 1.2 parts of flos rosae multiflorae extract, 3.1 parts of sweet tea leaf extract, 2.4 parts of Brazilian sweetsop peel extract, 2.1 parts of folium eriobotryae extract, 0.7 part of rosemary leaf extract and 4.2 parts of seabuckthorn fruit extract.
Example 5
The embodiment relates to a nanocrystallized anti-saccharification composition which comprises the following components in parts by weight: 5 parts of nano cosolvent, 28 parts of plant extract, 10 parts of hydroxypropyl tetrahydropyrane triol, 1.4 parts of oligopeptide-1, 1.8 parts of fullerene and 4.1 parts of polyol preservative. The nano cosolvent is polydimethylsiloxane, and the polyol preservative comprises 2 parts of 1, 2-hexanediol and 2.1 parts of isoprene glycol.
The plant extracts comprise 10 parts of Choline lemon extract, 4.2 parts of wenzhou mandarin orange peel extract, 0.8 part of flos rosae multiflorae extract, 3.1 parts of sweet tea leaf extract, 2.7 parts of Brazilian sweetsop peel extract, 1.7 parts of folium eriobotryae extract, 1.3 parts of rosemary leaf extract and 4.2 parts of seabuckthorn fruit extract.
Example 6
The embodiment relates to a nanocrystallized anti-saccharification composition which comprises the following components in parts by weight: 5 parts of nano cosolvent, 27.5 parts of plant extract, 10 parts of hydroxypropyl tetrahydropyrane triol, 1.4 parts of oligopeptide-1, 1.8 parts of fullerene and 4.5 parts of polyol preservative. The nano cosolvent is hydrogenated lecithin, and the polyol preservative comprises 2 parts of ethylhexyl glycerol and 2.5 parts of octyl glycol.
The plant extracts comprise 10 parts of Chonghua lemon extract, 3.6 parts of wenzhou mandarin orange peel extract, 0.9 part of rosa multiflora flower extract, 3.0 parts of sweet tea leaf extract, 3.3 parts of brazil sweetsop peel extract, 1.8 parts of loquat leaf extract, 1.2 parts of rosemary leaf extract and 3.7 parts of seabuckthorn fruit extract.
Comparative example 1
This comparative example relates to a nanosized anti-glycation composition, which is different from example 1 in that the content of the ingredients of the extract of Okinawa lemon is zero, and the remaining ingredients are the same as in example 1.
Comparative example 2
This comparative example relates to a nanocrystallized anti-glycation composition, which is different from example 1 in that the content of the brazilian annona squamosa pericarp extract component is zero, and the content of the remaining components is the same as example 1.
Comparative example 3
The comparative example relates to a nanocrystallized anti-glycation composition, which is different from the composition of example 1 in that the contents of the ingredients of the extract of the Okinawa lemon and the extract of the pericarp of the Annona bracteata are zero, and the contents of the other ingredients are the same as the composition of example 1.
Comparative example 4
This comparative example relates to a nanosized anti-glycation composition, which is different from example 1 in that the content of the sweet tea leaf extract component is zero and the remaining component content is the same as example 1.
Comparative example 5
The present comparative example relates to a nanocrystallized anti-glycation composition, which is different from example 1 in that the content of the citrus unshiu peel extract component is zero, and the content of the remaining components is the same as example 1.
Comparative example 6
This comparative example relates to a nanosized anti-glycation composition, which is different from example 1 in that the content of the loquat leaf extract component is zero and the remaining component content is the same as example 1.
Comparative example 7
This comparative example relates to a nanosized anti-glycation composition, which is different from example 1 in that the content of rosemary leaf extract component is zero, and the content of the remaining components is the same as example 1.
Comparative example 8
This comparative example relates to a nanocrystallized anti-glycation composition, which is different from example 1 in that the content of the hippophae rhamnoides fruit extract is zero and the contents of the remaining components are the same as example 1.
Comparative example 9
The embodiment relates to a nanocrystallized anti-saccharification composition which comprises the following components in parts by weight: 5 parts of nano cosolvent, 24 parts of plant extract, 10 parts of hydroxypropyl tetrahydropyrane triol, 1.4 parts of oligopeptide-1, 1.8 parts of fullerene and 3.2 parts of polyol preservative. The nano cosolvent is propylene glycol, and the polyol preservative comprises 1.6 parts of ethylhexyl glycerol and 1.6 parts of octyl glycol.
The plant extracts comprise 3 parts of Chonghua lemon extract, 3 parts of wenzhou mandarin orange peel extract, 3 parts of rosa multiflora flower extract, 3 parts of sweet tea leaf extract, 3 parts of custard apple peel extract, 3 parts of loquat leaf extract, 3 parts of rosemary leaf extract and 3 parts of sea buckthorn fruit extract.
Comparative example 10
This comparative example relates to a nanosized anti-glycation composition, which did not include plant extracts as compared with example 1, and the remaining components were the same as example 1.
The anti-glycation compositions according to the examples and comparative examples were prepared by the following steps:
s1, heating 5 accurately weighed nanometer latent solvent to 45 ℃, sequentially adding the accurately weighed plant extract, hydroxypropyl tetrahydropyrane triol, fullerene, oligopeptide-1 and polyol preservative, fully stirring and dissolving until no particles exist, and controlling the temperature to 40 ℃ for later use;
s2, quantitatively adding the material prepared in the step S1 into a feed inlet of a high-pressure homogenizer at a rate of 1.5ml/sec through a peristaltic pump, starting a pressure control valve and a temperature control internal circulation machine, controlling the pressure of the high-pressure homogenizer to be 120Mpa, and controlling the temperature of an external refrigerator of the material internal circulation machine to be 5 ℃; when the appearance of the material body is semitransparent, repeatedly operating for 5-10 times for internal circulation, controlling the viscosity to be 30-80 cps, and controlling the particle size of the material body to be 50-100 nm;
s3, and conveying, filtering and discharging the material through an external circulation rotor pump to obtain the nano anti-saccharification composition.
Application examples
Application examples 1 to 6 each relate to a moisturizing lotion which comprises, by weight, 8 parts of 1, 3-butanediol, 0.2 part of sodium hyaluronate, 0.05 part of EDTA-2NA (disodium ethylene diamine tetraacetate), 91.75 parts of refined water and 3 parts of a nanocrystallized anti-glycation composition, and the nanocrystallized anti-glycation compositions in application examples 1 to 6 are the nanocrystallized anti-glycation compositions in examples 1 to 6, respectively.
Comparative application
Application comparative examples 1 to 10 all relate to moisturizing lotion which comprises 8 parts by weight of 1, 3-butanediol, 0.2 part by weight of sodium hyaluronate, 0.05 part by weight of EDTA-2NA, 91.75 parts by weight of refined water and 3 parts by weight of nano anti-saccharification composition, and the nano anti-saccharification composition in the application examples 1 to 10 is respectively the nano anti-saccharification composition in the comparative examples 1 to 10.
Anti-glycation potency assay
32 healthy female subjects aged 25-55 years were selected. On the day of the test, the subject was subjected to a skin test without any cosmetic use, initial correlation values of the facial skin of the subject were obtained, after which the subject received the same test sample every two persons, used the test samples as required, and subjected to a long follow-up test on the subject.
First, skin elasticity test
1. Principle of testing
The test principle is based on the principle of suction and stretching, where a negative pressure is generated on the skin surface to be tested to suck the skin into a specific test probe, and the depth of the skin sucked into the test probe is measured by a non-contact optical test system. The test probe includes a light emitter and a light receiver, the ratio of light (the ratio of emitted light to received light) is proportional to the depth of skin being absorbed, thus obtaining a curve of the length of skin stretched versus time, which is then analyzed by the MPA software to determine the elastic properties of the skin.
2. Testing instrument
Skin elasticity tester MPA580, Revisometer + RV600 elastic fiber tissue test probe from Courage + Khazaka, Germany.
3. Test method
Subjects were tested for follow-up every six weeks, with six tests averaged.
4. Description of the test data:
uf — maximum amount of skin stretch;
ue — the amount of stretching of the skin at 0.1 second after constant negative pressure is applied to the skin, the amount of stretching of the elastic portion is located;
uv — the amount of stretch in the viscoelastic part of the skin or the part called plastic, Uv-Ue;
ur-after negative pressure is eliminated, the skin can quickly recover to the original state, and the skin is also divided into an elastic part value Ur, namely, after the negative pressure is eliminated for 0.1 second, the recovery value and the viscoelastic part value, or called as a plastic part value, of the skin;
ua-the recovery value of the skin when negative pressure is added on the skin surface from the elimination of negative pressure to the next continuous test;
Ur＝Uf-U1.1，U1.1the stretching amount of the skin is reduced when the negative pressure is removed for 1.1 seconds; ua ═ Uf-U2.0，U2.0The stretching amount of the skin is reduced when the negative pressure is removed for 2.0 seconds;
r2 ═ Ua/Uf; r5 ═ Ur/Ue, R2, R5 are skin elasticity indexes, and the closer to 1, the better the skin elasticity.
5. Test results
The test results are shown in the following table.
Table 1 skin elasticity test data
Second, skin melanin and gloss testing
1. Principle of testing
Melanin is a main pigment affecting the skin color of a human body, and its amount determines whether the skin color is bright white or dull, so that the degree of skin brightness can be reflected by melanin. Based on the principle of spectral absorption (RGB), three wavelengths of light, namely 568nm (green light), 660nm (red light) and 880nm (infrared light), emitted by a transmitter of an instrument probe are irradiated on the surface of the skin, and the receiver measures the light reflected by the skin. The positioning of the emitter and the receiver ensures that only diffuse and scattered light can be detected, and that the amount of light absorbed by the skin is determined, since the amount of emitted light is constant, the amount of melanin being proportional to the light absorbed by the skin.
2. Testing instrument
Skin red melanin tester and test probe Mexameter MX18, skin color difference test probe from Courage + Khazaka, germany.
3. Test method
Subjects were tested on weeks 1, 6, and 12, with an average taken six times per test.
4. Description of test data
Melanin Index (MI) 500/log5 × (log extracted-reflection/red-reflection + log5) (1)
Melanin change rate/% (MI)n-MI0)/(MI0) (2)
In the formula: infrared-infrared light;
red-red light;
infra-reflection of infrared light;
red-reflection-the reflected light of red light;
MI0-an initial melanin index;
MIn-melanin index measured at week n;
L*lightness, which is mainly affected by melanin content, is positively correlated with skin lightening;
b*the chroma reflects the yellow degree of skin color and is positively correlated with the content of skin melanin and the dark yellow degree.
5. Test results
The following data were obtained by testing and processing:
TABLE 2 changes in melanin content
TABLE 3 comparison of change in L and b values
As can be seen from the test data in tables 1 to 3, the skin elasticity index increase rate at week 12 of application example 1 was 86%, the melanin change rate was-48.12%, and L × obtained a large increase, which corresponds to example 1 being the best example.
In tables 1 to 3, it can be seen that the application examples 1 to 2 respectively compare with the application example 1 that the improvement effect on the elasticity and the glossiness of the skin is inferior to that of the example 1 when the plant extract lacks the chong rope lemon extract or brazil sweetsop peel extract;
application comparative example 3 as compared with example 1, it can be seen that when both the chongliang lemon extract and the annona squamosa pericarp extract are absent in the plant extract, the improvement effect on the elasticity and gloss of the skin is greatly compromised as compared with example 1;
using comparative example 10 as a blank group, it can be seen that the nano-sized anti-glycation composition according to the present invention has a significant effect of improving elasticity and glossiness of skin, compared to example 1; as can be seen from comparison of application example 9 with application example 1, 8 components need to be formulated in a specific ratio to exert a better anti-glycation effect, as in example 1.
In conclusion, the nano anti-glycation composition has the remarkable effects of enhancing the skin elasticity and reducing the melanin lightening skin, and the skin elasticity and the melanin content are generally used as indexes for evaluating the anti-glycation effect, namely, the nano anti-glycation composition has obvious anti-glycation performance.
The present invention has been described in detail with reference to the embodiments, but the description is only for the preferred embodiments of the present invention and should not be construed as limiting the scope of the present invention. All equivalent changes and modifications made within the scope of the present invention shall fall within the scope of the present invention.
Claims (10)
1. A nanocrystallized anti-glycation composition, characterized in that: the paint comprises the following components in parts by weight:
5 parts of nano cosolvent;
20-30 parts of plant extract;
10-15 parts of hydroxypropyl tetrahydropyrane triol;
1.0-3.0 parts of fullerene;
1, 1.0-2.0 parts of oligopeptide;
2.0-5.0 parts of a polyol preservative;
wherein the plant extracts comprise a Choline bergamot extract, a wenzhou mandarin orange peel extract, a rosa multiflora flower extract, a sweet tea leaf extract, a brazil sweetsop peel extract, a loquat leaf extract, a rosemary leaf extract and a sea buckthorn fruit extract, and the weight ratio of the extracts is 10: (3.5-4.5): (0.5-1.5): (2.5-3.5): (2.5-3.5): (1.5-2.5): (0.5-1.5): (3.5-4.5).
2. The nanosized anti-glycation composition according to claim 1, characterized in that: the nano cosolvent is any one of propylene glycol, dipropylene glycol, pentaerythritol tetraisostearate, pentaerythritol tetraester, squalane, hydrogenated lecithin, polydimethylsiloxane, octyl methicone, PPG-6-decyl tetradecanol polyether-30 and phytosterol macadamia nut oleate.
3. The nanosized anti-glycation composition according to claim 1, characterized in that: the polyalcohol preservative comprises at least 2 components of ethylhexyl glycerol, caprylyl glycol, 1, 2-pentanediol, 1, 2-hexanediol and isoprene glycol.
4. The nanosized anti-glycation composition according to claim 1, characterized in that: wherein the weight ratio of the oligopeptide-1 to the fullerene is 1: 1.1-1.5.
5. The nanosized anti-glycation composition according to claim 1, characterized in that: the plant extracts are all prepared by a subcritical water extraction method.
6. A method for preparing a nanometerized anti-glycation composition according to any one of claims 1 to 5, characterized by comprising the steps of:
s1, heating the nano cosolvent to 45 ℃, adding the plant extract, the hydroxypropyl tetrahydropyrane triol, the fullerene, the oligopeptide-1 and the polyol preservative in sequence, fully stirring and dissolving until no particles exist, and controlling the temperature to 40 ℃;
s2, adding the material obtained in the step S1 into a high-pressure homogenizer for high-pressure homogenizing treatment until the material is semitransparent;
and S3, outputting the treated material body processed in the step S2.
7. The method for producing a nanometerized glycation-resistant composition according to claim 6, characterized in that: the material obtained in step S1 was metered into a high-pressure homogenizer at 1.5ml/sec by a peristaltic pump; the high-pressure homogenization processing in step S2 needs to satisfy the condition: controlling the pressure range to be 100-300 Mpa; controlling the temperature range to be 4-5 ℃; the operation is repeated for 5 to 10 times for circulation, the viscosity is controlled to be 30 to 80cps, and the particle size of the material body is controlled to be 50 to 100 nm.
8. Use of a nanosized antiglycation composition according to any one of claims 1 to 5, characterized in that: the nanometer anti-saccharification composition is used for preparing cosmetics.
9. Use of a nanosized antiglycation composition according to claim 8, characterized in that: the weight of the nano anti-saccharification composition accounts for 1.5-4.5% of the total weight of the cosmetic.
10. Use of a nanosized antiglycation composition according to claim 7, characterized in that: the cosmetic is astringent, essence, lotion, cream, eye cream or facial mask.
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| CN202111142638.5A CN113712875A (en) | 2021-09-28 | 2021-09-28 | Nanocrystallized anti-saccharification composition and preparation method and application thereof |
| PCT/CN2021/124982 WO2023050493A1 (en) | 2021-09-28 | 2021-10-20 | Nanoscale anti-glycation composition, preparation method therefor and application thereof |
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| CN202111142638.5A CN113712875A (en) | 2021-09-28 | 2021-09-28 | Nanocrystallized anti-saccharification composition and preparation method and application thereof |
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| CN114983893A (en) * | 2022-06-22 | 2022-09-02 | 可可琪可思曼中华有限公司 | Method and apparatus for preparing anti-sugar composition |
| CN115192491A (en) * | 2022-08-05 | 2022-10-18 | 广东北工商绿色护肤品研究院有限公司 | Cosmetic composition and preparation method and application thereof |
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| WO2023050493A1 (en) | 2023-04-06 |
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