WO2023050493A1 - Nanoscale anti-glycation composition, preparation method therefor and application thereof - Google Patents
Nanoscale anti-glycation composition, preparation method therefor and application thereof Download PDFInfo
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- WO2023050493A1 WO2023050493A1 PCT/CN2021/124982 CN2021124982W WO2023050493A1 WO 2023050493 A1 WO2023050493 A1 WO 2023050493A1 CN 2021124982 W CN2021124982 W CN 2021124982W WO 2023050493 A1 WO2023050493 A1 WO 2023050493A1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Definitions
- the invention relates to the technical field of cosmetics, in particular to a nano-sized anti-glycation composition and its preparation method and application.
- the saccharification reaction on human skin refers to "a non-enzymatic reaction between the aldehyde (ketone) group of reducing sugar and the amine group of amine-containing substances (such as proteins, nucleic acids, etc.).
- Enzymatic glycosylation and non-enzymatic glycosylation are the process of attaching sugars to proteins or lipids.
- Non-enzymatic glycosylation is a series of complex non-enzymatic reactions, and proteins and glucose occur non-enzymatically in vivo
- the enzymatic reaction goes through oxidation, rearrangement, cross-linking and other processes to form irreversible non-enzymatic glycosylated end products (advanced glycated end products, AGEs).
- the glycosylation reaction proceeds slowly in the body, and the generated AGEs can normally be excreted through metabolism .
- the metabolic function of the skin in vivo and in vitro decreases, leading to the accumulation of AGEs on the skin in vitro, causing protein cross-linking damage and binding to specific receptors, causing many problems in the skin, resulting in dark yellow skin , Wrinkles, decreased elasticity of collagen fibers, dark brown spots, and even promote the production of matrix metalloproteinase (matrix metalloproteinase) that can decompose collagen and elastin, and increase the secretion of cytokines that can cause inflammation.
- matrix metalloproteinase matrix metalloproteinase
- the anti-glycation performance is mainly reflected in skin elasticity and skin brightness. Therefore, skin elasticity and skin brightness are often used as indicators of anti-glycation performance.
- Chinese patent CN110522700A discloses an anti-glycation whitening cosmetic composition and an anti-glycation whitening cosmetic containing it.
- the formula includes: 0.001-15 parts of an anti-glycation agent; whitening cosmetics containing an anti-glycation whitening cosmetic composition, including an anti-glycation cosmetic composition substance, cosmetic base and water; the parts by weight of the cosmetic base are 0.0001-70 parts;
- the anti-glycation agent A includes sunflower seed extract, nicotinamide, acetylglucosamine, bark extract, mulberry bark extract extract, apple fruit extract, camellia flower extract, tea extract, japonica extract, madecassoside, ethylhexylglycerin, matsutake mushroom extract; the invention can effectively improve the anti- Glycation effect, preventing, inhibiting or improving skin dark yellow and uneven skin tone caused by glycation and oxidation.
- this composition has no data support related to skin brightness effect and skin elasticity
- the invention provides a nanometerization anti-glycation composition and its preparation method and application, so as to solve the problem that the anti-glycation effect of the composition is not obvious in the prior art.
- a nano-sized anti-glycation composition in parts by weight, comprising the following components:
- Plant extracts 20-30 parts
- Oligopeptide-1 1.0-2.0 parts
- Polyol preservative 2.0 to 5.0 parts
- the plant extracts include Okinawa Bergamot extract, Satsuma citrus peel extract, Rosa rose flower extract, sweet tea leaf extract, Brazil cherimoya peel extract, loquat leaf extract, rosemary leaf extract and seabuckthorn fruit extract, the weight ratio of each extract is 10:(3.5 ⁇ 4.5):(0.5 ⁇ 1.5):(2.5 ⁇ 3.5):(2.5 ⁇ 3.5):(1.5 ⁇ 2.5):(0.5 ⁇ 1.5) : (3.5 ⁇ 4.5).
- Okinawa bergamot is distributed in the Hyundaira area in the northern part of Okinawa Main Island. It is rich in vitamin C and citric acid. In particular, the content of nobiletin, which belongs to flavonoids, is much higher than that of other citrus fruits. Nobiletin has many benefits for beauty and health.
- the ingredients can be purchased commercially. The applicant found through experiments that the Okinawa bergamot extract has an excellent anti-glycation effect after being added to the composition.
- Satsuma citrus, loquat leaves, rosebushes, sweet tea leaves, rosemary leaves and seabuckthorn fruits can all be purchased from the market.
- the commonly used methods for extracting plant extracts include solvent extraction, ultrasonic extraction, microwave extraction, enzyme extraction, and supercritical fluid extraction.
- the plant extracts are all prepared by subcritical water extraction.
- Subcritical water extraction technology is widely used in the extraction of plant active substances, and will not be repeated here.
- the nano co-solvent is propylene glycol, dipropylene glycol, pentaerythritol tetraisostearate, pentaerythritol tetraester, squalane, hydrogenated lecithin, polydimethylsiloxane, octyl polymethyl Any of silicone, PPG-6-decyltetradeceth-30, and phytosterol macadamia oleate.
- the polyol preservative includes at least two components of ethylhexylglycerin, caprylyl glycol, 1,2-pentanediol, 1,2-hexanediol, and isopentyl glycol.
- the weight ratio of oligopeptide-1 to fullerene is 1:1.1-1.5.
- step S2 Add the material body obtained in step S1 to a high-pressure homogenizer for high-pressure homogenization until the material body is translucent;
- step S3. Filtering and outputting the processed material in step S2.
- the material obtained in step S1 is quantitatively added to the high-pressure homogenizer at 1.5ml/sec through a peristaltic pump; the high-pressure homogenization treatment in step S2 needs to meet the conditions: the control pressure range is 100-300Mpa; the control temperature range is 4- 5°C; repeat the operation for 5-10 cycles, control the viscosity at 30-80cps, and control the particle size of the material at 50-100nm.
- the control pressure range is 100-300Mpa
- the control temperature range is 4- 5°C
- nanometerized anti-glycation composition according to any one of claims 1 to 5, wherein the nanometerized anti-glycation composition is used for preparing cosmetics.
- the weight of the nanometerized anti-glycation composition accounts for 1.5%-4.5% of the total weight of the cosmetic.
- the cosmetics are lotion, essence, lotion, face cream, eye cream or mask.
- the nanometerized anti-glycation composition involved in the present invention is compounded through a specific ratio test and prepared through a nanometerization process. It is easier to add to the commonly used dosage forms of cosmetics, and it is easier to penetrate into the stratum corneum of the skin to exert its effect without adding chemical substances. Synthetic preservatives are mild and non-irritating. Compared with commercially available products, the present invention can significantly improve dull skin tone, improve skin elasticity and firmness, and increase skin anti-glycation ability.
- the plant extract of the present invention is composed of two core components of Okinawa bergamot extract, acai apple peel extract and other plant extracts, so that the nano-sized anti-glycation composition has a more excellent skin improvement effect.
- This embodiment relates to a nano-sized anti-glycation composition, which includes by weight: 5 parts of nano co-solvent, 28 parts of plant extracts, 10 parts of hydroxypropyltetrahydropyrantriol, and 1.4 parts of oligopeptide-1 , 1.8 parts of fullerene, 3.2 parts of polyol preservatives.
- the nano co-solvent is propylene glycol
- the polyol preservative includes 1.6 parts of ethylhexylglycerin and 1.6 parts of caprylyl glycol.
- the plant extracts include 10 parts of Okinawa bergamot extract, 4 parts of Wenzhou mandarin orange peel extract, 1 part of rose flower extract, 3 parts of sweet tea leaf extract, 3 parts of Brazilian cherimoya peel extract, 2 parts of loquat leaf extract, 1 part rosemary leaf extract, and 4 parts sea buckthorn fruit extract.
- This embodiment relates to a nano-sized anti-glycation composition, which includes by weight: 5 parts of nano co-solvent, 27.4 parts of plant extracts, 10 parts of hydroxypropyltetrahydropyrantriol, and 1.9 parts of oligopeptide-1 , 2.9 parts of fullerene, 2 parts of polyol preservatives.
- the nano co-solvent is pentaerythritol tetraester
- the polyalcohol preservative includes 1 part of 1,2-pentanediol and 1 part of 1,2-hexanediol.
- the plant extracts include 10 parts of Okinawa bergamot extract, 4.5 parts of Wenzhou mandarin orange peel extract, 0.5 part of rose flower extract, 2.5 parts of sweet tea leaf extract, 3.4 parts of Brazilian custard fruit peel extract, 1.6 parts of loquat leaf extract, 0.5 parts rosemary leaf extract and 4.4 parts sea buckthorn fruit extract.
- This embodiment relates to a nano-sized anti-glycation composition, which includes by weight: 5 parts of nano co-solvent, 28.7 parts of plant extracts, 15 parts of hydroxypropyltetrahydropyrantriol, and 1.1 parts of oligopeptide-1 , 1.2 parts fullerene, 5.0 parts polyol preservative.
- the nano co-solvent is dipropylene glycol
- the polyol preservative includes 2 parts of 1,2-hexanediol and 3 parts of isoprene glycol.
- the plant extracts include 10 parts of Okinawa bergamot extract, 3.7 parts of Wenzhou mandarin orange peel extract, 1.5 parts of rose flower extract, 3.5 parts of sweet tea leaf extract, 2.7 parts of Brazilian cherimoya peel extract, 2.4 parts of loquat leaf extract, 1.4 parts rosemary leaf extract and 3.5 parts sea buckthorn fruit extract.
- This embodiment relates to a nano-sized anti-glycation composition, which includes by weight: 5 parts of nano co-solvent, 27.9 parts of plant extracts, 13 parts of hydroxypropyl tetrahydropyrantriol, and 1.4 parts of oligopeptide-1 , 1.8 parts of fullerene, 3.1 parts of polyol preservative.
- the nano co-solvent is squalane
- the polyol preservative includes 2 parts of 1,2-hexanediol and 1.1 parts of isoprene glycol.
- the plant extracts include 10 parts of Okinawa bergamot extract, 4.2 parts of Wenzhou mandarin orange peel extract, 1.2 parts of rose flower extract, 3.1 parts of sweet tea leaf extract, 2.4 parts of Brazilian custard fruit peel extract, 2.1 parts of loquat leaf extract, 0.7 parts rosemary leaf extract and 4.2 parts sea buckthorn fruit extract.
- This embodiment relates to a nano-sized anti-glycation composition, which includes by weight: 5 parts of nano co-solvent, 28 parts of plant extracts, 10 parts of hydroxypropyltetrahydropyrantriol, and 1.4 parts of oligopeptide-1 , 1.8 parts of fullerene, 4.1 parts of polyol preservatives.
- the nano co-solvent is polydimethylsiloxane
- the polyol preservative includes 2 parts of 1,2-hexanediol and 2.1 parts of isoprene glycol.
- the plant extracts include 10 parts of Okinawa bergamot extract, 4.2 parts of Wenzhou mandarin orange peel extract, 0.8 part of rose flower extract, 3.1 parts of sweet tea leaf extract, 2.7 parts of Brazilian custard fruit peel extract, 1.7 parts of loquat leaf extract, 1.3 parts rosemary leaf extract and 4.2 parts sea buckthorn fruit extract.
- This embodiment relates to a nano-sized anti-glycation composition, which includes by weight: 5 parts of nano co-solvent, 27.5 parts of plant extracts, 10 parts of hydroxypropyltetrahydropyranotriol, and 1.4 parts of oligopeptide-1 , 1.8 parts of fullerene, 4.5 parts of polyol preservatives.
- the nano co-solvent is hydrogenated lecithin
- the polyalcohol preservative includes 2 parts of ethylhexylglycerin and 2.5 parts of caprylyl glycol.
- the plant extracts include 10 parts of Okinawa bergamot extract, 3.6 parts of Wenzhou mandarin orange peel extract, 0.9 part of rose flower extract, 3.0 parts of sweet tea leaf extract, 3.3 parts of Brazilian custard fruit peel extract, 1.8 parts of loquat leaf extract, 1.2 parts rosemary leaf extract and 3.7 parts sea buckthorn fruit extract.
- This comparative example relates to a nano-sized anti-glycation composition.
- the difference from Example 1 is that the content of Okinawa lemon extract components is zero, and the content of other components is the same as that of Example 1.
- This comparative example relates to a nano-sized anti-glycation composition.
- the difference from Example 1 is that the content of the component of the acacia fruit peel extract is zero, and the content of the remaining components is the same as that of Example 1.
- This comparative example relates to a nano-sized anti-glycation composition.
- the difference from Example 1 is that the contents of Okinawa bergamot extract and acacia fruit peel extract are all zero, and the contents of other components are the same as in Example 1.
- This comparative example relates to a nano-sized anti-glycation composition.
- the difference from Example 1 is that the content of sweet tea leaf extract components is zero, and the content of other components is the same as that of Example 1.
- This comparative example relates to a nano-sized anti-glycation composition.
- the difference from Example 1 is that the content of the Wenzhou Satsuma mandarin peel extract component is zero, and the content of other components is the same as that of Example 1.
- This comparative example relates to a nano-sized anti-glycation composition.
- the difference from Example 1 is that the content of loquat leaf extract components is zero, and the content of other components is the same as that of Example 1.
- This comparative example relates to a nano-sized anti-glycation composition.
- the difference from Example 1 is that the content of rosemary leaf extract components is zero, and the content of other components is the same as that of Example 1.
- This comparative example relates to a nano-sized anti-glycation composition, which differs from Example 1 in that the content of seabuckthorn fruit extract is zero, and the contents of other components are the same as in Example 1.
- This embodiment relates to a nano-sized anti-glycation composition, which includes by weight: 5 parts of nano co-solvent, 24 parts of plant extracts, 10 parts of hydroxypropyltetrahydropyranotriol, and 1.4 parts of oligopeptide-1 , 1.8 parts of fullerene, 3.2 parts of polyol preservatives.
- the nano co-solvent is propylene glycol
- the polyol preservative includes 1.6 parts of ethylhexylglycerin and 1.6 parts of caprylyl glycol.
- the plant extracts include 3 parts of Okinawa bergamot extracts, 3 parts of Wenzhou mandarin orange peel extracts, 3 parts of rose flower extracts, 3 parts of sweet tea leaf extracts, 3 parts of Brazilian cherimoya peel extracts, 3 parts of loquat leaf extract, 3 parts rosemary leaf extract, and 3 parts sea buckthorn fruit extract.
- This comparative example relates to a nano-sized anti-glycation composition, which does not include plant extracts compared with Example 1, and the other components are the same as Example 1.
- step S2 Put the material prepared in step S1 into the feed port of the high-pressure homogenizer quantitatively at 1.5ml/sec through the peristaltic pump, open the pressure control valve and the temperature-controlled internal circulation machine, and control the pressure of the high-pressure homogenizer to 120Mpa.
- the temperature of the cyclic external freezer is controlled at 5°C; when the appearance of the material body is translucent, repeat the internal cycle for 5-10 times, the viscosity is controlled at 30-80cps, and the particle size of the material body is controlled within the range of 50-100nm;
- Application examples 1 to 6 all relate to a moisturizing lotion, including 8 parts by weight of 1,3 butanediol, 0.2 part of sodium hyaluronate, 0.05 part of EDTA-2NA (disodium ethylenediaminetetraacetate), 91.75 parts of purified water, 3 parts of nano-sized anti-glycation composition, and the nano-sized anti-glycation composition in Examples 1-6 are respectively used in Examples 1-6.
- EDTA-2NA sodium ethylenediaminetetraacetate
- Application comparative examples 1 to 10 all involve a moisturizing lotion, including 8 parts by weight of 1,3-butanediol, 0.2 parts of sodium hyaluronate, 0.05 parts of EDTA-2NA, 91.75 parts of purified water, and 3 parts of nano-sized
- the nano-sized anti-glycation composition in Examples 1-10 was used respectively in the nano-sized anti-glycation composition in Comparative Examples 1-10.
- the test principle is based on the principle of suction and stretching.
- a negative pressure is generated on the surface of the tested skin to suck the skin into a specific test probe.
- the depth of the skin sucked into the test probe is measured by a non-contact optical test system. Got it.
- the test probe includes a light transmitter and a receiver, and the ratio of light (the ratio of emitted light to received light) is proportional to the depth of the skin being sucked in, so that a relationship curve between the length of the skin being stretched and the time is obtained.
- the elastic properties of the skin were then determined by analysis with MPA software.
- R2 Ua/Uf
- R5 Ur/Ue
- R2 and R5 are the skin elasticity index, the closer to 1, the better the skin elasticity.
- Melanin is the main pigment that affects the skin color of the human body. Its amount determines whether the skin color is bright or dull. Therefore, the degree of skin lightness can be reflected by melanin.
- melanin Based on the principle of spectral absorption (RGB), light of three wavelengths of 568nm (green light), 660nm (red light) and 880nm (infrared light) emitted by the transmitter of the instrument probe is irradiated on the skin surface, and the skin reflection is measured by the receiver of light. The position of the transmitter and receiver ensures that only diffuse light and scattered light can be measured. Since the amount of emitted light is constant, the amount of light absorbed by the skin can be measured. The content of melanin is related to the amount of light absorbed by the skin. Light is proportional.
- the subjects were tested at the 1st, 6th, and 12th weeks, and the average value of each test was taken six times.
- MI Melanin Index
- infrared infrared light
- infrared-reflection reflected light of infrared light
- L * Lightness, mainly affected by the content of melanin, and positively correlated with the degree of skin brightness
- Chroma which reflects the yellowness of the skin color, and is positively correlated with the content of melanin and the dark yellowness of the skin.
- Example 3 Compared with Example 1, it can be seen that in the application of Comparative Example 3, when the plant extract lacks both the Okinawa lemon extract and the Brazilian custard fruit peel extract, the improvement effect on the elasticity and gloss of the skin is compared to that of the example 1 is greatly discounted;
- Application Comparative Example 10 is a blank group. Compared with Example 1, it can be seen that the nano-sized anti-glycation composition involved in the present invention has a significant effect of improving the elasticity and gloss of the skin; Application Comparative Example 9 and Application Example 1 It can be seen from the comparison that the 8 components need to be formulated according to specific ratios to exert a better anti-glycation effect, for example, according to the component ratios of Example 1.
- the nanometerization anti-glycation composition involved in the present invention has the effect of significantly enhancing skin elasticity and reducing melanin and brightening the skin, while skin elasticity and melanin content are usually used as indicators for evaluating the anti-glycation effect, that is, the present invention has obvious anti-glycation performance.
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Abstract
A nanoscale anti-glycation composition comprising the following components: 5 parts nano-cosolvent; 20 to 30 parts plant extract; 10 to 15 parts hydroxypropyl tetrahydropyranitol; 1.0 to 3.0 parts fullerene; 1.0 to 2.0 parts oligopeptide-1; and 2.0 to 5.0 parts polyol preservative. The plant extract comprises shikuwasa extract, satsuma peel extract, Rosa centifolia flower extract, sweet leaf extract, Annona montana peel extract, loquat leaf extract, rosemary leaf extract and sea buckthorn fruit extract. The composition is more easily added to common cosmetic formulations, more easily permeates the stratum corneum of the skin to take effect, does not need any added chemical synthetic preservative, is mild and non-irritating, and is capable of significantly improving skin color darkening, improving skin elasticity and tightness, and increasing the skin's anti-glycation ability.
Description
本发明涉及化妆品技术领域，尤其涉及一种纳米化抗糖化组合物及其制备方法与应用。The invention relates to the technical field of cosmetics, in particular to a nano-sized anti-glycation composition and its preparation method and application.
人体皮肤上的糖化反应是指“还原糖的醛(酮)基与含胺基物质(例如蛋白质、核酸等)的胺基之间的一种非酵素性反应，根据酶的参与与否，分为酶促糖基化反应与非酶促糖基化反应，是蛋白质或脂质附加上糖类的过程。非酶糖基化是一系列复杂的非酶促反应，蛋白质和葡萄糖在体内发生非酶促反应进而经过氧化、重排、交联等过程，形成不可逆的非酶糖基化终产物(advanced glycated end products，AGEs)。糖化反应在体内进行缓慢，生成的AGEs正常可以通过代谢排出体外，但是，随着年龄的增长，体内与体外肌肤新陈代谢功能下降，导致AGEs在皮肤体外上日积月累的积累，造成蛋白质的交联损伤与特异受体的结合，使皮肤产生很多问题，导致皮肤暗黄、产生皱纹、胶原纤维弹性下降、暗褐色斑点、甚至会促进可分解胶原蛋白与弹性蛋白的基质金属蛋白酶(matrix metalloproteinase)生成以及增加可引起发炎反应的细胞因子分泌。这些因素最终也会产生皮肤老化加速等问题，因而现有护肤品需要具有抗糖化的效果，抗糖化性能主要从皮肤弹性、皮肤亮度来表现，因此皮肤弹性、皮肤亮度也常常作为抗糖化能力表现的指标。The saccharification reaction on human skin refers to "a non-enzymatic reaction between the aldehyde (ketone) group of reducing sugar and the amine group of amine-containing substances (such as proteins, nucleic acids, etc.). Enzymatic glycosylation and non-enzymatic glycosylation are the process of attaching sugars to proteins or lipids. Non-enzymatic glycosylation is a series of complex non-enzymatic reactions, and proteins and glucose occur non-enzymatically in vivo The enzymatic reaction goes through oxidation, rearrangement, cross-linking and other processes to form irreversible non-enzymatic glycosylated end products (advanced glycated end products, AGEs). The glycosylation reaction proceeds slowly in the body, and the generated AGEs can normally be excreted through metabolism , However, with age, the metabolic function of the skin in vivo and in vitro decreases, leading to the accumulation of AGEs on the skin in vitro, causing protein cross-linking damage and binding to specific receptors, causing many problems in the skin, resulting in dark yellow skin , Wrinkles, decreased elasticity of collagen fibers, dark brown spots, and even promote the production of matrix metalloproteinase (matrix metalloproteinase) that can decompose collagen and elastin, and increase the secretion of cytokines that can cause inflammation. These factors will eventually produce skin Due to problems such as accelerated aging, existing skin care products need to have anti-glycation effects. The anti-glycation performance is mainly reflected in skin elasticity and skin brightness. Therefore, skin elasticity and skin brightness are often used as indicators of anti-glycation performance.
中国专利CN110522700A公开了抗糖化的美白化妆品组合物及含其的抗糖化美白化妆品，配方包括：0.001-15份的抗糖化剂；含有抗糖化的美白化妆品组合物的美白化妆品，包括抗糖化化妆品组合物、化妆品基质和水；所述化妆品基质的重量份数为0.0001-70份；所述抗糖化剂A包括向日葵籽提取物、烟酰胺、乙酰壳糖胺、构树皮提取物、桑树皮提取物、苹果果提取物、山茶花提取物、茶叶提取物、盐肤木提取物、羟基积雪草甙、乙基己基甘油、松口蘑提取物中的一种或多种；该发明能有效提高抗糖化效力，预防、抑制或改善因糖化以及氧化所引起的皮肤黯黄、肤色不均等问题。但是，该组合物没有皮肤亮度效果、皮肤弹性效果相关的数据支撑，具体效果不详。Chinese patent CN110522700A discloses an anti-glycation whitening cosmetic composition and an anti-glycation whitening cosmetic containing it. The formula includes: 0.001-15 parts of an anti-glycation agent; whitening cosmetics containing an anti-glycation whitening cosmetic composition, including an anti-glycation cosmetic composition substance, cosmetic base and water; the parts by weight of the cosmetic base are 0.0001-70 parts; the anti-glycation agent A includes sunflower seed extract, nicotinamide, acetylglucosamine, bark extract, mulberry bark extract extract, apple fruit extract, camellia flower extract, tea extract, japonica extract, madecassoside, ethylhexylglycerin, matsutake mushroom extract; the invention can effectively improve the anti- Glycation effect, preventing, inhibiting or improving skin dark yellow and uneven skin tone caused by glycation and oxidation. However, this composition has no data support related to skin brightness effect and skin elasticity effect, and the specific effect is unknown.
发明内容Contents of the invention
本发明提供一种纳米化抗糖化组合物及其制备方法与应用，以解决现有技术中组合物抗糖化效果不明显的问题。The invention provides a nanometerization anti-glycation composition and its preparation method and application, so as to solve the problem that the anti-glycation effect of the composition is not obvious in the prior art.
为解决上述技术问题，本发明提供的技术方案为：In order to solve the problems of the technologies described above, the technical solution provided by the invention is:
一种纳米化抗糖化组合物，按重量计份，包括以下组分：A nano-sized anti-glycation composition, in parts by weight, comprising the following components:
纳米助溶剂，5份；Nano co-solvent, 5 parts;
植物提取物，20～30份；Plant extracts, 20-30 parts;
羟丙基四氢吡喃三醇，10～15份；Hydroxypropyltetrahydropyranotriol, 10-15 parts;
富勒烯，1.0～3.0份；Fullerene, 1.0-3.0 parts;
寡肽-1，1.0～2.0份；Oligopeptide-1, 1.0-2.0 parts;
多元醇防腐剂，2.0～5.0份；Polyol preservative, 2.0 to 5.0 parts;
其中，所述的植物提取物包括冲绳香檬提取物、温州蜜柑果皮提取物、洋蔷薇花提取物、甜茶叶提取物、巴西番荔枝果皮提取物、枇杷叶提取物、迷迭香叶提取物和沙棘果提取物，各提取物的重量比为10：(3.5～4.5)：(0.5～1.5)：(2.5～3.5)：(2.5～3.5)：(1.5～2.5)：(0.5～1.5)：(3.5～4.5)。Wherein, the plant extracts include Okinawa Bergamot extract, Satsuma citrus peel extract, Rosa rose flower extract, sweet tea leaf extract, Brazil cherimoya peel extract, loquat leaf extract, rosemary leaf extract and seabuckthorn fruit extract, the weight ratio of each extract is 10:(3.5～4.5):(0.5～1.5):(2.5～3.5):(2.5～3.5):(1.5～2.5):(0.5～1.5) : (3.5～4.5).
冲绳香檬分布在冲绳本岛北部的山原地区，富含维他命C和柠檬酸，特别是属于黄酮类的川陈皮素含量大大高于其他各种柑橘类水果，川陈皮素拥有许多对美容和健康有益的成分，可通过市售购得。经申请人实验发现，冲绳香檬提取物添加到本组合物后，具有优良的抗糖化效果。Okinawa bergamot is distributed in the Yamahara area in the northern part of Okinawa Main Island. It is rich in vitamin C and citric acid. In particular, the content of nobiletin, which belongs to flavonoids, is much higher than that of other citrus fruits. Nobiletin has many benefits for beauty and health. The ingredients can be purchased commercially. The applicant found through experiments that the Okinawa bergamot extract has an excellent anti-glycation effect after being added to the composition.
巴西番荔枝是生长在巴西热带稀树草原上的一种番荔枝，富含原花青素，可通过市售购得。经申请人试验发现，巴西番荔枝提取物与冲绳香檬提取物组合使用，具有优异的抗糖化效果。Brazilian custard apple is a kind of custard apple that grows on the Brazilian savannah. It is rich in proanthocyanidins and can be purchased commercially. According to the applicant's test, it is found that the combination of the Brazilian custard apple extract and the Okinawa bergamot extract has an excellent anti-glycation effect.
另外，温州蜜柑、枇杷叶、洋蔷薇花、甜茶叶、迷迭香叶和沙棘果均可通过市售购得。In addition, Satsuma citrus, loquat leaves, rosebushes, sweet tea leaves, rosemary leaves and seabuckthorn fruits can all be purchased from the market.
目前提取植物提取物常用的方法有溶剂提取法、超声波提取法、微波提取法和酶提取法、超临界流体萃取法等。优选地，所述的植物提取物均是通过亚临界水提取方法制备而得。亚临界水提取技术广泛应用在植物活性物质的提取上，此处不再赘述。At present, the commonly used methods for extracting plant extracts include solvent extraction, ultrasonic extraction, microwave extraction, enzyme extraction, and supercritical fluid extraction. Preferably, the plant extracts are all prepared by subcritical water extraction. Subcritical water extraction technology is widely used in the extraction of plant active substances, and will not be repeated here.
优选地，所述的纳米助溶剂为丙二醇、双丙甘醇、季戊四醇四异硬脂酸酯、季戊四醇四酯、角鲨烷、氢化卵磷脂、聚二甲基硅氧烷、辛基聚甲基硅氧烷、PPG-6-癸基十四醇聚醚-30和植物甾醇澳洲坚果油酸酯中的任一种。Preferably, the nano co-solvent is propylene glycol, dipropylene glycol, pentaerythritol tetraisostearate, pentaerythritol tetraester, squalane, hydrogenated lecithin, polydimethylsiloxane, octyl polymethyl Any of silicone, PPG-6-decyltetradeceth-30, and phytosterol macadamia oleate.
优选地，所述的多元醇防腐剂包括乙基己基甘油、辛甘醇、1,2-戊二醇、1,2-己二醇、异戊二醇中的至少2种成分。Preferably, the polyol preservative includes at least two components of ethylhexylglycerin, caprylyl glycol, 1,2-pentanediol, 1,2-hexanediol, and isopentyl glycol.
优选地，其中寡肽-1与富勒烯的重量比为1:1.1～1.5。Preferably, the weight ratio of oligopeptide-1 to fullerene is 1:1.1-1.5.
一种根据权利要求1～5任一项所述的纳米化抗糖化组合物的制备方法，其包括以下步骤：A preparation method of the nanometerized anti-glycation composition according to any one of claims 1 to 5, comprising the following steps:
S1、将纳米助溶剂加热至45℃时，依序加入植物提取物、羟丙基四氢吡喃三醇、富勒烯、寡肽-1和多元醇防腐剂后充分搅拌溶解至无颗粒，控温至40℃；S1. When the nano co-solvent is heated to 45°C, add plant extract, hydroxypropyltetrahydropyrantriol, fullerene, oligopeptide-1 and polyol preservative in sequence, then fully stir and dissolve until there are no particles. Control the temperature to 40°C;
S2、将步骤S1获得的料体加入高压均质机进行高压均质处理，直到料体呈半透明状；S2. Add the material body obtained in step S1 to a high-pressure homogenizer for high-pressure homogenization until the material body is translucent;
S3、将步骤S2中处理好的料体过滤输出。S3. Filtering and outputting the processed material in step S2.
优选地，步骤S1获得的料体通过蠕动泵以1.5ml/sec定量加入高压均质机；步骤S2中的高压均质处理需要满足条件：控制压力范围为100～300Mpa；控制温度范围在4～5℃；反复操作5～10次循环，粘度控制在30～80cps，料体粒径控制在50-100nm。Preferably, the material obtained in step S1 is quantitatively added to the high-pressure homogenizer at 1.5ml/sec through a peristaltic pump; the high-pressure homogenization treatment in step S2 needs to meet the conditions: the control pressure range is 100-300Mpa; the control temperature range is 4- 5°C; repeat the operation for 5-10 cycles, control the viscosity at 30-80cps, and control the particle size of the material at 50-100nm.
权利要求1～5任一项所述的纳米化抗糖化组合物的应用，纳米化抗糖化组合物用于制备化妆品。The application of the nanometerized anti-glycation composition according to any one of claims 1 to 5, wherein the nanometerized anti-glycation composition is used for preparing cosmetics.
优选地，纳米化抗糖化组合物的重量占化妆品总重量的1.5％～4.5％。Preferably, the weight of the nanometerized anti-glycation composition accounts for 1.5%-4.5% of the total weight of the cosmetic.
优选地，所述的化妆品为化妆水、精华液、乳液、面霜、眼霜或面膜。Preferably, the cosmetics are lotion, essence, lotion, face cream, eye cream or mask.
采用本发明提供的技术方案，与现有技术相比，具有如下有益效果：Compared with the prior art, the technical solution provided by the invention has the following beneficial effects:
1、本发明所涉及的纳米化抗糖化组合物经由特定比例试验复配后，经由纳米化工艺制备，更容易添加至化妆品常用剂型中，更易渗透至皮肤角质层中发挥功效，不需要添加化学合成防腐剂，温和无刺激，相比于市售产品，本发明能够显著改善肤色暗沉、提升皮肤弹性与紧致度、增加皮肤抗糖化能力。1. The nanometerized anti-glycation composition involved in the present invention is compounded through a specific ratio test and prepared through a nanometerization process. It is easier to add to the commonly used dosage forms of cosmetics, and it is easier to penetrate into the stratum corneum of the skin to exert its effect without adding chemical substances. Synthetic preservatives are mild and non-irritating. Compared with commercially available products, the present invention can significantly improve dull skin tone, improve skin elasticity and firmness, and increase skin anti-glycation ability.
2、本发明的植物提取物由冲绳香檬提取物、巴西番荔枝果皮提取物两种核心组分及其它植物提取物组成，使本纳米化抗糖化组合物具有更加优良的皮肤改 善效果。2. The plant extract of the present invention is composed of two core components of Okinawa bergamot extract, acai apple peel extract and other plant extracts, so that the nano-sized anti-glycation composition has a more excellent skin improvement effect.
为进一步了解本发明的内容，结合实施例对本发明作详细描述，以下实施例用于说明本发明，但不用来限制本发明的范围。In order to further understand the content of the present invention, the present invention is described in detail in conjunction with examples, and the following examples are used to illustrate the present invention, but are not used to limit the scope of the present invention.
实施例1Example 1
本实施例涉及一种纳米化抗糖化组合物，其按照重量计份包括：5份纳米助溶剂，28份植物提取物，10份羟丙基四氢吡喃三醇，1.4份寡肽-1，1.8份富勒烯，3.2份多元醇防腐剂。所述的纳米助溶剂为丙二醇，所述的多元醇防腐剂包括1.6份乙基己基甘油和1.6份辛甘醇。This embodiment relates to a nano-sized anti-glycation composition, which includes by weight: 5 parts of nano co-solvent, 28 parts of plant extracts, 10 parts of hydroxypropyltetrahydropyrantriol, and 1.4 parts of oligopeptide-1 , 1.8 parts of fullerene, 3.2 parts of polyol preservatives. The nano co-solvent is propylene glycol, and the polyol preservative includes 1.6 parts of ethylhexylglycerin and 1.6 parts of caprylyl glycol.
所述的植物提取物包括10份冲绳香檬提取物、4份温州蜜柑果皮提取物、1份洋蔷薇花提取物、3份甜茶叶提取物、3份巴西番荔枝果皮提取物、2份枇杷叶提取物、1份迷迭香叶提取物和4份沙棘果提取物。The plant extracts include 10 parts of Okinawa bergamot extract, 4 parts of Wenzhou mandarin orange peel extract, 1 part of rose flower extract, 3 parts of sweet tea leaf extract, 3 parts of Brazilian cherimoya peel extract, 2 parts of loquat leaf extract, 1 part rosemary leaf extract, and 4 parts sea buckthorn fruit extract.
实施例2Example 2
本实施例涉及一种纳米化抗糖化组合物，其按照重量计份包括：5份纳米助溶剂，27.4份植物提取物，10份羟丙基四氢吡喃三醇，1.9份寡肽-1，2.9份富勒烯，2份多元醇防腐剂。所述的纳米助溶剂为季戊四醇四酯，所述的多元醇防腐剂包括1份1，2-戊二醇和1份1，2-己二醇。This embodiment relates to a nano-sized anti-glycation composition, which includes by weight: 5 parts of nano co-solvent, 27.4 parts of plant extracts, 10 parts of hydroxypropyltetrahydropyrantriol, and 1.9 parts of oligopeptide-1 , 2.9 parts of fullerene, 2 parts of polyol preservatives. The nano co-solvent is pentaerythritol tetraester, and the polyalcohol preservative includes 1 part of 1,2-pentanediol and 1 part of 1,2-hexanediol.
所述的植物提取物包括10份冲绳香檬提取物、4.5份温州蜜柑果皮提取物、0.5份洋蔷薇花提取物、2.5份甜茶叶提取物、3.4份巴西番荔枝果皮提取物、1.6份枇杷叶提取物、0.5份迷迭香叶提取物和4.4份沙棘果提取物。The plant extracts include 10 parts of Okinawa bergamot extract, 4.5 parts of Wenzhou mandarin orange peel extract, 0.5 part of rose flower extract, 2.5 parts of sweet tea leaf extract, 3.4 parts of Brazilian custard fruit peel extract, 1.6 parts of loquat leaf extract, 0.5 parts rosemary leaf extract and 4.4 parts sea buckthorn fruit extract.
实施例3Example 3
本实施例涉及一种纳米化抗糖化组合物，其按照重量计份包括：5份纳米助溶剂，28.7份植物提取物，15份羟丙基四氢吡喃三醇，1.1份寡肽-1，1.2份富勒烯，5.0份多元醇防腐剂。所述的纳米助溶剂为双丙甘醇，所述的多元醇防腐剂包括2份1，2-己二醇和3份异戊二醇。This embodiment relates to a nano-sized anti-glycation composition, which includes by weight: 5 parts of nano co-solvent, 28.7 parts of plant extracts, 15 parts of hydroxypropyltetrahydropyrantriol, and 1.1 parts of oligopeptide-1 , 1.2 parts fullerene, 5.0 parts polyol preservative. The nano co-solvent is dipropylene glycol, and the polyol preservative includes 2 parts of 1,2-hexanediol and 3 parts of isoprene glycol.
所述的植物提取物包括10份冲绳香檬提取物、3.7份温州蜜柑果皮提取物、1.5份洋蔷薇花提取物、3.5份甜茶叶提取物、2.7份巴西番荔枝果皮提取物、2.4份枇杷叶提取物、1.4份迷迭香叶提取物和3.5份沙棘果提取物。The plant extracts include 10 parts of Okinawa bergamot extract, 3.7 parts of Wenzhou mandarin orange peel extract, 1.5 parts of rose flower extract, 3.5 parts of sweet tea leaf extract, 2.7 parts of Brazilian cherimoya peel extract, 2.4 parts of loquat leaf extract, 1.4 parts rosemary leaf extract and 3.5 parts sea buckthorn fruit extract.
实施例4Example 4
本实施例涉及一种纳米化抗糖化组合物，其按照重量计份包括：5份纳米助溶剂，27.9份植物提取物，13份羟丙基四氢吡喃三醇，1.4份寡肽-1，1.8份富勒烯，3.1份多元醇防腐剂。所述的纳米助溶剂为角鲨烷，所述的多元醇防腐剂包括2份1，2-己二醇和1.1份异戊二醇。This embodiment relates to a nano-sized anti-glycation composition, which includes by weight: 5 parts of nano co-solvent, 27.9 parts of plant extracts, 13 parts of hydroxypropyl tetrahydropyrantriol, and 1.4 parts of oligopeptide-1 , 1.8 parts of fullerene, 3.1 parts of polyol preservative. The nano co-solvent is squalane, and the polyol preservative includes 2 parts of 1,2-hexanediol and 1.1 parts of isoprene glycol.
所述的植物提取物包括10份冲绳香檬提取物、4.2份温州蜜柑果皮提取物、1.2份洋蔷薇花提取物、3.1份甜茶叶提取物、2.4份巴西番荔枝果皮提取物、2.1份枇杷叶提取物、0.7份迷迭香叶提取物和4.2份沙棘果提取物。The plant extracts include 10 parts of Okinawa bergamot extract, 4.2 parts of Wenzhou mandarin orange peel extract, 1.2 parts of rose flower extract, 3.1 parts of sweet tea leaf extract, 2.4 parts of Brazilian custard fruit peel extract, 2.1 parts of loquat leaf extract, 0.7 parts rosemary leaf extract and 4.2 parts sea buckthorn fruit extract.
实施例5Example 5
本实施例涉及一种纳米化抗糖化组合物，其按照重量计份包括：5份纳米助溶剂，28份植物提取物，10份羟丙基四氢吡喃三醇，1.4份寡肽-1，1.8份富勒烯，4.1份多元醇防腐剂。所述的纳米助溶剂为聚二甲基硅氧烷，所述的多元醇防腐剂包括2份1，2-己二醇和2.1份异戊二醇。This embodiment relates to a nano-sized anti-glycation composition, which includes by weight: 5 parts of nano co-solvent, 28 parts of plant extracts, 10 parts of hydroxypropyltetrahydropyrantriol, and 1.4 parts of oligopeptide-1 , 1.8 parts of fullerene, 4.1 parts of polyol preservatives. The nano co-solvent is polydimethylsiloxane, and the polyol preservative includes 2 parts of 1,2-hexanediol and 2.1 parts of isoprene glycol.
所述的植物提取物包括10份冲绳香檬提取物、4.2份温州蜜柑果皮提取物、0.8份洋蔷薇花提取物、3.1份甜茶叶提取物、2.7份巴西番荔枝果皮提取物、1.7份枇杷叶提取物、1.3份迷迭香叶提取物和4.2份沙棘果提取物。The plant extracts include 10 parts of Okinawa bergamot extract, 4.2 parts of Wenzhou mandarin orange peel extract, 0.8 part of rose flower extract, 3.1 parts of sweet tea leaf extract, 2.7 parts of Brazilian custard fruit peel extract, 1.7 parts of loquat leaf extract, 1.3 parts rosemary leaf extract and 4.2 parts sea buckthorn fruit extract.
实施例6Example 6
本实施例涉及一种纳米化抗糖化组合物，其按照重量计份包括：5份纳米助溶剂，27.5份植物提取物，10份羟丙基四氢吡喃三醇，1.4份寡肽-1，1.8份富勒烯，4.5份多元醇防腐剂。所述的纳米助溶剂为氢化卵磷脂，所述的多元醇防腐剂包括2份乙基己基甘油和2.5份辛甘醇。This embodiment relates to a nano-sized anti-glycation composition, which includes by weight: 5 parts of nano co-solvent, 27.5 parts of plant extracts, 10 parts of hydroxypropyltetrahydropyranotriol, and 1.4 parts of oligopeptide-1 , 1.8 parts of fullerene, 4.5 parts of polyol preservatives. The nano co-solvent is hydrogenated lecithin, and the polyalcohol preservative includes 2 parts of ethylhexylglycerin and 2.5 parts of caprylyl glycol.
所述的植物提取物包括10份冲绳香檬提取物、3.6份温州蜜柑果皮提取物、0.9份洋蔷薇花提取物、3.0份甜茶叶提取物、3.3份巴西番荔枝果皮提取物、1.8份枇杷叶提取物、1.2份迷迭香叶提取物和3.7份沙棘果提取物。The plant extracts include 10 parts of Okinawa bergamot extract, 3.6 parts of Wenzhou mandarin orange peel extract, 0.9 part of rose flower extract, 3.0 parts of sweet tea leaf extract, 3.3 parts of Brazilian custard fruit peel extract, 1.8 parts of loquat leaf extract, 1.2 parts rosemary leaf extract and 3.7 parts sea buckthorn fruit extract.
对比例1Comparative example 1
本对比例涉及一种纳米化抗糖化组合物，与实施例1的区别在于冲绳香檬提取物组分的含量为零，其余组分含量与实施例1相同。This comparative example relates to a nano-sized anti-glycation composition. The difference from Example 1 is that the content of Okinawa lemon extract components is zero, and the content of other components is the same as that of Example 1.
对比例2Comparative example 2
本对比例涉及一种纳米化抗糖化组合物，与实施例1的区别在于巴西番荔枝果皮提取物组分的含量为零，其余组分含量与实施例1相同。This comparative example relates to a nano-sized anti-glycation composition. The difference from Example 1 is that the content of the component of the acacia fruit peel extract is zero, and the content of the remaining components is the same as that of Example 1.
对比例3Comparative example 3
本对比例涉及一种纳米化抗糖化组合物，与实施例1的区别在于冲绳香檬提取物和巴西番荔枝果皮提取物组分的含量均为零，其余组分含量与实施例1相同。This comparative example relates to a nano-sized anti-glycation composition. The difference from Example 1 is that the contents of Okinawa bergamot extract and acacia fruit peel extract are all zero, and the contents of other components are the same as in Example 1.
对比例4Comparative example 4
本对比例涉及一种纳米化抗糖化组合物，与实施例1的区别在于甜茶叶提取物组分的含量为零，其余组分含量与实施例1相同。This comparative example relates to a nano-sized anti-glycation composition. The difference from Example 1 is that the content of sweet tea leaf extract components is zero, and the content of other components is the same as that of Example 1.
对比例5Comparative example 5
本对比例涉及一种纳米化抗糖化组合物，与实施例1的区别在于温州蜜柑果皮提取物组分的含量为零，其余组分含量与实施例1相同。This comparative example relates to a nano-sized anti-glycation composition. The difference from Example 1 is that the content of the Wenzhou Satsuma mandarin peel extract component is zero, and the content of other components is the same as that of Example 1.
对比例6Comparative example 6
本对比例涉及一种纳米化抗糖化组合物，与实施例1的区别在于枇杷叶提取物组分的含量为零，其余组分含量与实施例1相同。This comparative example relates to a nano-sized anti-glycation composition. The difference from Example 1 is that the content of loquat leaf extract components is zero, and the content of other components is the same as that of Example 1.
对比例7Comparative example 7
本对比例涉及一种纳米化抗糖化组合物，与实施例1的区别在于迷迭香叶提取物组分的含量为零，其余组分含量与实施例1相同。This comparative example relates to a nano-sized anti-glycation composition. The difference from Example 1 is that the content of rosemary leaf extract components is zero, and the content of other components is the same as that of Example 1.
对比例8Comparative example 8
本对比例涉及一种纳米化抗糖化组合物，与实施例1的区别在于沙棘果提取物的含量为零，其余组分含量与实施例1相同。This comparative example relates to a nano-sized anti-glycation composition, which differs from Example 1 in that the content of seabuckthorn fruit extract is zero, and the contents of other components are the same as in Example 1.
对比例9Comparative example 9
本实施例涉及一种纳米化抗糖化组合物，其按照重量计份包括：5份纳米助溶剂，24份植物提取物，10份羟丙基四氢吡喃三醇，1.4份寡肽-1，1.8份富勒烯，3.2份多元醇防腐剂。所述的纳米助溶剂为丙二醇，所述的多元醇防腐剂包括1.6份乙基己基甘油和1.6份辛甘醇。This embodiment relates to a nano-sized anti-glycation composition, which includes by weight: 5 parts of nano co-solvent, 24 parts of plant extracts, 10 parts of hydroxypropyltetrahydropyranotriol, and 1.4 parts of oligopeptide-1 , 1.8 parts of fullerene, 3.2 parts of polyol preservatives. The nano co-solvent is propylene glycol, and the polyol preservative includes 1.6 parts of ethylhexylglycerin and 1.6 parts of caprylyl glycol.
所述的植物提取物包括3份冲绳香檬提取物、3份温州蜜柑果皮提取物、3份洋蔷薇花提取物、3份甜茶叶提取物、3份巴西番荔枝果皮提取物、3份枇杷叶提取物、3份迷迭香叶提取物和3份沙棘果提取物。The plant extracts include 3 parts of Okinawa bergamot extracts, 3 parts of Wenzhou mandarin orange peel extracts, 3 parts of rose flower extracts, 3 parts of sweet tea leaf extracts, 3 parts of Brazilian cherimoya peel extracts, 3 parts of loquat leaf extract, 3 parts rosemary leaf extract, and 3 parts sea buckthorn fruit extract.
对比例10Comparative example 10
本对比例涉及一种纳米化抗糖化组合物，与实施例1相比不包括植物提取物，其余各组分与实施例1相同。This comparative example relates to a nano-sized anti-glycation composition, which does not include plant extracts compared with Example 1, and the other components are the same as Example 1.
各实施例和对比例涉及的抗糖化组合物的制备方法为以下步骤：The preparation method of the anti-glycation composition involved in each embodiment and comparative example is the following steps:
S1、将精准称量的5份纳米助溶剂加热至45℃，依序加入精准称量的植物提取物、羟丙基四氢吡喃三醇、富勒烯、寡肽-1、多元醇防腐剂充分搅拌溶解至无颗粒，控温至40℃备用；S1. Heat 5 parts of precisely weighed nano co-solvent to 45°C, and then add precisely weighed plant extracts, hydroxypropyl tetrahydropyrantriol, fullerene, oligopeptide-1, and polyol for antiseptic The agent is fully stirred and dissolved until there are no particles, and the temperature is controlled to 40°C for later use;
S2、将步骤S1制备的料体透过蠕动泵以1.5ml/sec定量加入高压均质机入料口内，开启压力控制阀与温控内循环机，高压均质机压力控制为120Mpa，料体内循环外接冷冻机控温于5℃；待料体外观完成半透明状，反复操作5～10次内循环，粘度控制在30～80cps，料体粒径控制在50～100nm区间即完成；S2. Put the material prepared in step S1 into the feed port of the high-pressure homogenizer quantitatively at 1.5ml/sec through the peristaltic pump, open the pressure control valve and the temperature-controlled internal circulation machine, and control the pressure of the high-pressure homogenizer to 120Mpa. The temperature of the cyclic external freezer is controlled at 5°C; when the appearance of the material body is translucent, repeat the internal cycle for 5-10 times, the viscosity is controlled at 30-80cps, and the particle size of the material body is controlled within the range of 50-100nm;
S3、再通过外循环转子泵输送过滤出料，即得一种纳米化抗糖化组合物。S3, conveying and filtering the material through the external circulation rotor pump to obtain a nano-sized anti-glycation composition.
应用实施例Application example
应用实施例1～6均涉及一种保湿化妆水，按照重量计份包括8份1，3丁二醇，0.2份透明质酸钠，0.05份EDTA-2NA(乙二胺四乙酸二钠)，91.75份精制水，3份纳米化抗糖化组合物，应用实施例1～6中的纳米化抗糖化组合物分别采用实施例1～6中的纳米化抗糖化组合物。Application examples 1 to 6 all relate to a moisturizing lotion, including 8 parts by weight of 1,3 butanediol, 0.2 part of sodium hyaluronate, 0.05 part of EDTA-2NA (disodium ethylenediaminetetraacetate), 91.75 parts of purified water, 3 parts of nano-sized anti-glycation composition, and the nano-sized anti-glycation composition in Examples 1-6 are respectively used in Examples 1-6.
应用对比例Application comparison
应用对比例1～10均涉及一种保湿化妆水，按照重量计份包括8份1，3丁二醇，0.2份透明质酸钠，0.05份EDTA-2NA，91.75份精制水，3份纳米化抗糖化组合物，应用实施例1～10中的纳米化抗糖化组合物分别采用对比例1～10中的纳米化抗糖化组合物。Application comparative examples 1 to 10 all involve a moisturizing lotion, including 8 parts by weight of 1,3-butanediol, 0.2 parts of sodium hyaluronate, 0.05 parts of EDTA-2NA, 91.75 parts of purified water, and 3 parts of nano-sized For the anti-glycation composition, the nano-sized anti-glycation composition in Examples 1-10 was used respectively in the nano-sized anti-glycation composition in Comparative Examples 1-10.
抗糖化效能测试Anti-glycation efficacy test
选择32名年龄在25-55岁的健康女性受试者。测试当天，受试者在不使用任何化妆品的情况下接受皮肤测试，获得受试者面部皮肤的初始相关数值，此后受试者每两人接受同一种试验样品，按照要求使用试验样品，并对受试者进行长期的跟进测试。32 healthy female subjects aged 25-55 were selected. On the day of the test, the subject underwent a skin test without using any cosmetics to obtain the initial relevant value of the subject's facial skin. After that, every two subjects received the same test sample, used the test sample as required, and applied the test sample Subjects undergo long-term follow-up testing.
一、皮肤弹性测试1. Skin Elasticity Test
1、测试原理1. Test principle
测试原理是基于吸力和拉伸原理，在被测试的皮肤表面产生一个负压将皮肤吸进一个特定测试探头内，皮肤被吸进测试探头内的深度是通过一个非接触式的光学测试系统测得的。测试探头内包括光的发射器和接收器，光的比率(发射光和接收光之比)同被吸入皮肤的深度成正比，这样就得到了一条皮肤被拉伸的长度和时间的关系曲线，然后通过MPA软件分析来确定皮肤的弹性性能。The test principle is based on the principle of suction and stretching. A negative pressure is generated on the surface of the tested skin to suck the skin into a specific test probe. The depth of the skin sucked into the test probe is measured by a non-contact optical test system. Got it. The test probe includes a light transmitter and a receiver, and the ratio of light (the ratio of emitted light to received light) is proportional to the depth of the skin being sucked in, so that a relationship curve between the length of the skin being stretched and the time is obtained. The elastic properties of the skin were then determined by analysis with MPA software.
2、测试仪器2. Test equipment
德国Courage+Khazaka公司的皮肤弹性测试仪MPA580、Reviscometer+RV600弹性纤维组织测试探头。German Courage+Khazaka company's skin elasticity tester MPA580, Reviscometer+RV600 elastic fiber tissue test probe.
3、测试方法3. Test method
对受试者进行每六周一次的跟进测试，每次测试六次取平均值。Follow-up tests were performed on subjects every six weeks, and the average value of six tests was taken for each test.
4、测试数据说明：4. Test data description:
Uf-——皮肤最大拉伸量；Uf——the maximum stretching amount of the skin;
Ue——恒定负压加到皮肤上后，0.1秒钟时皮肤的拉伸量，定位弹性部分拉量；Ue——after the constant negative pressure is applied to the skin, the stretching amount of the skin in 0.1 second, and the stretching amount of the positioning elastic part;
Uv——为皮肤粘弹性部分或称为塑性部分的拉伸量，Uv＝Uf-Ue；Uv——is the stretching amount of the viscoelastic part of the skin or the plastic part, Uv=Uf-Ue;
Ur——取消负压后，皮肤就会迅速恢复原状态，同样分为弹性部分值Ur，即取消负压0.1秒后，皮肤的恢复值和粘弹性部分值，或称塑性部分值；Ur——After the negative pressure is canceled, the skin will quickly return to its original state, which is also divided into the elastic part value Ur, that is, the recovery value of the skin and the viscoelastic part value, or the plastic part value, after the negative pressure is canceled for 0.1 seconds;
Ua——从取消负压到下一次连续测试皮肤表面再加负压时皮肤的恢复值；Ua - the recovery value of the skin from the cancellation of negative pressure to the next continuous test of the skin surface when negative pressure is added;
Ur＝Uf-U
1.1，U
1.1为取消负压1.1秒时皮肤的拉伸量；Ua＝Uf-U
2.0，U
2.0为取消负压肤2.0秒时皮肤的拉伸量；
Ur＝Uf-U 1.1 , U 1.1 is the stretching amount of the skin when the negative pressure is canceled for 1.1 seconds; Ua=Uf-U 2.0 , U 2.0 is the stretching amount of the skin when the negative pressure is canceled for 2.0 seconds;
R2＝Ua/Uf；R5＝Ur/Ue，R2、R5为皮肤弹性指数，越接近于1则皮肤弹性越好。R2=Ua/Uf; R5=Ur/Ue, R2 and R5 are the skin elasticity index, the closer to 1, the better the skin elasticity.
5、测试结果5. Test results
测试结果如下表所示。The test results are shown in the table below.
表1 皮肤弹性测试数据Table 1 Skin elasticity test data
二、皮肤黑色素及光泽度测试2. Skin melanin and gloss test
1、测试原理1. Test principle
黑色素是影响人体肤色的主要色素，它的量决定了是肤色是亮白还是暗淡，因此皮肤亮白程度可以通过黑色素来反应。基于光谱吸收的原理(RGB)，通过仪器探头的发射器发出的568nm(绿光)、660nm(红光)、880nm(红外光)三种波长的光照射在皮肤表面，接收器测得皮肤反射的光。发射器和接收器的位置保证了只有漫射光和散射光可以被测到，由于发射光的量是一定的，因此就可以测出被皮肤吸收的光的量，黑色素的含量与被皮肤吸收的光成正比。Melanin is the main pigment that affects the skin color of the human body. Its amount determines whether the skin color is bright or dull. Therefore, the degree of skin lightness can be reflected by melanin. Based on the principle of spectral absorption (RGB), light of three wavelengths of 568nm (green light), 660nm (red light) and 880nm (infrared light) emitted by the transmitter of the instrument probe is irradiated on the skin surface, and the skin reflection is measured by the receiver of light. The position of the transmitter and receiver ensures that only diffuse light and scattered light can be measured. Since the amount of emitted light is constant, the amount of light absorbed by the skin can be measured. The content of melanin is related to the amount of light absorbed by the skin. Light is proportional.
2、测试仪器2. Test equipment
德国Courage+Khazaka公司的皮肤红黑色素测试仪及测试探头Mexameter MX18、皮肤色差测试探头。German Courage+Khazaka company's skin red melanin tester and test probe Mexameter MX18, skin color difference test probe.
3、测试方法3. Test method
受试者在第1、6、12周进行测试，每次测试六次取平均值。The subjects were tested at the 1st, 6th, and 12th weeks, and the average value of each test was taken six times.
4、测试数据说明4. Test data description
黑素指数(MI)＝500/log5×(log infrared-reflection/red-reflection+log5) (1)Melanin Index (MI)＝500/log5×(log infrared-reflection/red-reflection+log5) (1)
黑色素变化率/％＝(MI
n-MI
0)/(MI
0) (2)
Change rate of melanin/%＝(MI n -MI 0 )/(MI 0 ) (2)
式中：infrared——红外光；In the formula: infrared——infrared light;
red——红光；red - red light;
infrared-reflection——红外光的反射光；infrared-reflection——reflected light of infrared light;
red-reflection——红光的反射光；red-reflection——reflected light of red light;
MI
0——初始黑素指数；
MI 0 - initial melanin index;
MI
n——第n周测得的黑素指数；
MI n - the melanin index measured in the nth week;
L
*——明度，主要受黑色素含量影响，与皮肤亮白程度呈正相关；
L * ——Lightness, mainly affected by the content of melanin, and positively correlated with the degree of skin brightness;
b
*——色度，反应肤色的黄色程度，与皮肤黑色素的含量和暗黄程度呈正相关。
b * —— Chroma, which reflects the yellowness of the skin color, and is positively correlated with the content of melanin and the dark yellowness of the skin.
5、测试结果5. Test results
经过测试和处理得到如下表所示的数据：After testing and processing, the data shown in the following table are obtained:
表2 黑色素含量变化Table 2 Changes in melanin content
表3 L*、b*值变化对比Table 3 Comparison of changes in L* and b* values
由表1～3中试验数据可以看出，应用实施例1在第12周时的皮肤弹性指数增长率为86％，黑色素变化率为-48.12％，L*获得较大增长，其所对应的实施例1为最佳实施例。From the test data in Tables 1 to 3, it can be seen that the growth rate of skin elasticity index in application example 1 at the 12th week was 86%, the change rate of melanin was -48.12%, and L* was greatly increased, and the corresponding Embodiment 1 is the best embodiment.
表1～3中，应用对比例1～2分别与应用实施例1相比可以看出，植物提取物中缺少冲绳香檬提取物或巴西番荔枝果皮提取物时，对于皮肤的弹性和光泽度 的改善效果相比于实施例1有所逊色；In Tables 1 to 3, compared with Application Example 1 in Application Comparative Examples 1 to 2, it can be seen that when the plant extract lacks Okinawa lemon extract or Brazilian custard apple peel extract, the elasticity and gloss of the skin The improvement effect is inferior to some extent compared to embodiment 1;
应用对比例3相比于实施例1可以看出，当植物提取物中同时缺少冲绳香檬提取物和巴西番荔枝果皮提取物时，对于皮肤的弹性和光泽度的改善效果相比于实施例1就大打折扣了；Compared with Example 1, it can be seen that in the application of Comparative Example 3, when the plant extract lacks both the Okinawa lemon extract and the Brazilian custard fruit peel extract, the improvement effect on the elasticity and gloss of the skin is compared to that of the example 1 is greatly discounted;
应用对比例10为空白组，相比于实施例1可以看出，本发明涉及的纳米化抗糖化组合物具有显著的改善皮肤的弹性和光泽度的效果；应用对比例9与应用实施例1相比可以看出，8种组分需要按照特定的比例配制才能发挥更好的抗糖化效果，如按照实施例1的组分比例配制。Application Comparative Example 10 is a blank group. Compared with Example 1, it can be seen that the nano-sized anti-glycation composition involved in the present invention has a significant effect of improving the elasticity and gloss of the skin; Application Comparative Example 9 and Application Example 1 It can be seen from the comparison that the 8 components need to be formulated according to specific ratios to exert a better anti-glycation effect, for example, according to the component ratios of Example 1.
综上，本发明所涉及的纳米化抗糖化组合物具有显著的增强皮肤弹性和减少黑色素亮白皮肤的效果，而皮肤弹性和黑色素含量通常用作评价抗糖化效果的指标，即本发明具有明显的抗糖化表现。In summary, the nanometerization anti-glycation composition involved in the present invention has the effect of significantly enhancing skin elasticity and reducing melanin and brightening the skin, while skin elasticity and melanin content are usually used as indicators for evaluating the anti-glycation effect, that is, the present invention has obvious anti-glycation performance.
以上结合实施例对本发明进行了详细说明，但所述内容仅为本发明的较佳实施例，不能被认为用于限定本发明的实施范围。凡依本发明申请范围所作的均等变化与改进等，均应仍属于本发明的专利涵盖范围之内。The present invention has been described in detail above in conjunction with the embodiments, but the content described is only a preferred embodiment of the present invention, and cannot be considered as limiting the implementation scope of the present invention. All equivalent changes and improvements made according to the application scope of the present invention should still fall within the scope of the patent of the present invention.
Claims (10)
- 一种纳米化抗糖化组合物，其特征在于：按重量计份，包括以下组分：A nano-sized anti-glycation composition, characterized in that: by weight, it includes the following components:纳米助溶剂，5份；Nano co-solvent, 5 parts;植物提取物，20～30份；Plant extracts, 20-30 parts;羟丙基四氢吡喃三醇，10～15份；Hydroxypropyltetrahydropyranotriol, 10-15 parts;富勒烯，1.0～3.0份；Fullerene, 1.0-3.0 parts;寡肽-1，1.0～2.0份；Oligopeptide-1, 1.0-2.0 parts;多元醇防腐剂，2.0～5.0份；Polyol preservative, 2.0 to 5.0 parts;其中，所述的植物提取物包括冲绳香檬提取物、温州蜜柑果皮提取物、洋蔷薇花提取物、甜茶叶提取物、巴西番荔枝果皮提取物、枇杷叶提取物、迷迭香叶提取物和沙棘果提取物，各提取物的重量比为10：(3.5～4.5)：(0.5～1.5)：(2.5～3.5)：(2.5～3.5)：(1.5～2.5)：(0.5～1.5)：(3.5～4.5)。Wherein, the plant extracts include Okinawa Bergamot extract, Satsuma citrus peel extract, Rosa rose flower extract, sweet tea leaf extract, Brazil cherimoya peel extract, loquat leaf extract, rosemary leaf extract and seabuckthorn fruit extract, the weight ratio of each extract is 10:(3.5～4.5):(0.5～1.5):(2.5～3.5):(2.5～3.5):(1.5～2.5):(0.5～1.5) : (3.5～4.5).
- 根据权利要求1所述的纳米化抗糖化组合物，其特征在于：所述的纳米助溶剂为丙二醇、双丙甘醇、季戊四醇四异硬脂酸酯、季戊四醇四酯、角鲨烷、氢化卵磷脂、聚二甲基硅氧烷、辛基聚甲基硅氧烷、PPG-6-癸基十四醇聚醚-30和植物甾醇澳洲坚果油酸酯中的任一种。The nano anti-glycation composition according to claim 1, characterized in that: the nano co-solvent is propylene glycol, dipropylene glycol, pentaerythritol tetraisostearate, pentaerythritol tetraester, squalane, hydrogenated egg Any one of phospholipids, dimethicone, caprylmethicone, PPG-6-decyltetraeth-30, and phytosterol macadamia nut oleate.
- 根据权利要求1所述的纳米化抗糖化组合物，其特征在于：所述的多元醇防腐剂包括乙基己基甘油、辛甘醇、1,2-戊二醇、1,2-己二醇、异戊二醇中的至少2种成分。The nano anti-glycation composition according to claim 1, characterized in that: the polyol preservative comprises ethylhexylglycerin, caprylyl glycol, 1,2-pentanediol, 1,2-hexanediol , At least two components in isopentyl glycol.
- 根据权利要求1所述的纳米化抗糖化组合物，其特征在于：其中寡肽-1与富勒烯的重量比为1:1.1～1.5。The nano-sized anti-glycation composition according to claim 1, wherein the weight ratio of oligopeptide-1 to fullerene is 1:1.1-1.5.
- 根据权利要求1所述的纳米化抗糖化组合物，其特征在于：所述的植物提取物均是通过亚临界水提取方法制备而得。The nano-sized anti-glycation composition according to claim 1, characterized in that: the plant extracts are all prepared by a subcritical water extraction method.
- 一种根据权利要求1～5任一项所述的纳米化抗糖化组合物的制备方法，其特征在于包括以下步骤：A method for preparing the nanometerized anti-glycation composition according to any one of claims 1 to 5, characterized in that it comprises the following steps:S1、将纳米助溶剂加热至45℃时，依序加入植物提取物、羟丙基四氢吡喃三醇、富勒烯、寡肽-1和多元醇防腐剂后充分搅拌溶解至无颗粒，控温至40℃；S1. When the nano co-solvent is heated to 45°C, add plant extract, hydroxypropyltetrahydropyrantriol, fullerene, oligopeptide-1 and polyol preservative in sequence, then fully stir and dissolve until there are no particles. Control the temperature to 40°C;S2、将步骤S1获得的料体加入高压均质机进行高压均质处理，直到料体呈半透明状；S2. Add the material body obtained in step S1 to a high-pressure homogenizer for high-pressure homogenization until the material body is translucent;S3、将步骤S2中处理好的料体过滤输出。S3. Filtering and outputting the processed material in step S2.
- 根据权利要求6所述的纳米化抗糖化组合物的制备方法，其特征在于：步骤S1获得的料体通过蠕动泵以1.5ml/sec定量加入高压均质机；步骤S2中的高压均质处理需要满足条件：控制压力范围为100～300Mpa；控制温度范围在4～5℃；反复操作5～10次循环，粘度控制在30～80cps，料体粒径控制在50～100nm。The preparation method of the nano-anti-glycation composition according to claim 6, characterized in that: the material obtained in step S1 is quantitatively added to a high-pressure homogenizer at 1.5ml/sec through a peristaltic pump; the high-pressure homogenization treatment in step S2 Conditions to be met: the control pressure range is 100-300Mpa; the control temperature range is 4-5°C; the operation is repeated for 5-10 cycles, the viscosity is controlled at 30-80cps, and the particle size of the material is controlled at 50-100nm.
- 权利要求1～5任一项所述的纳米化抗糖化组合物的应用，其特征在于：纳米化抗糖化组合物用于制备化妆品。The application of the nanometerized anti-glycation composition according to any one of claims 1 to 5, characterized in that the nanometerized anti-glycation composition is used to prepare cosmetics.
- 根据权利要求8所述的纳米化抗糖化组合物的应用，其特征在于：纳米化抗糖化组合物的重量占化妆品总重量的1.5％～4.5％。The application of the nanometerized anti-glycation composition according to claim 8, characterized in that the weight of the nanometerized anti-glycation composition accounts for 1.5% to 4.5% of the total weight of the cosmetic.
- 根据权利要求7所述的纳米化抗糖化组合物的应用，其特征在于：所述的化妆品为化妆水、精华液、乳液、面霜、眼霜或面膜。The application of the nano-sized anti-glycation composition according to claim 7, characterized in that: the cosmetic is lotion, essence, lotion, face cream, eye cream or mask.
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| CN114983893B (en) * | 2022-06-22 | 2023-06-16 | 可可琪可思曼中华有限公司 | Preparation method and preparation device of anti-sugar composition |
| CN115192491B (en) * | 2022-08-05 | 2023-09-26 | 广东北工商绿色护肤品研究院有限公司 | Cosmetic composition, and preparation method and application thereof |
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