KR101981943B1 - 항-cd43 항체 및 이의 암 치료 용도 - Google Patents

항-cd43 항체 및 이의 암 치료 용도 Download PDF

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KR101981943B1
KR101981943B1 KR1020187011372A KR20187011372A KR101981943B1 KR 101981943 B1 KR101981943 B1 KR 101981943B1 KR 1020187011372 A KR1020187011372 A KR 1020187011372A KR 20187011372 A KR20187011372 A KR 20187011372A KR 101981943 B1 KR101981943 B1 KR 101981943B1
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antibody
seq
cancer
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antigen
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KR20180083315A (ko
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홍권표
윤상순
카우카우라스아이린
바토리빈센트
크리스티아노브리오니
주니어 데이비드 에스 윌슨
조지 캅시다스
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주식회사 에이프로젠케이아이씨
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • A61K47/6825—Ribosomal inhibitory proteins, i.e. RIP-I or RIP-II, e.g. Pap, gelonin or dianthin
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • G—PHYSICS
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KR1020187011372A 2015-10-12 2016-10-12 항-cd43 항체 및 이의 암 치료 용도 Active KR101981943B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562240276P 2015-10-12 2015-10-12
US62/240,276 2015-10-12
AU2016901555A AU2016901555A0 (en) 2016-04-28 CD43 binding proteins and uses thereof
AU2016901555 2016-04-28
PCT/KR2016/011428 WO2017065493A1 (ko) 2015-10-12 2016-10-12 항-cd43 항체 및 이의 암 치료 용도

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KR20180083315A KR20180083315A (ko) 2018-07-20
KR101981943B1 true KR101981943B1 (ko) 2019-05-24

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US (2) US10676531B2 (https=)
EP (1) EP3363461A4 (https=)
JP (2) JP6758388B2 (https=)
KR (1) KR101981943B1 (https=)
CN (1) CN108472364B (https=)
AU (1) AU2016339513B2 (https=)
BR (1) BR122021000898A8 (https=)
CA (1) CA3001676C (https=)
IL (1) IL258642B (https=)
MX (1) MX392348B (https=)
NZ (1) NZ741573A (https=)
RU (1) RU2694903C1 (https=)
SG (1) SG11201803008RA (https=)
WO (1) WO2017065493A1 (https=)
ZA (1) ZA201802618B (https=)

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Publication number Priority date Publication date Assignee Title
AU2017383142A1 (en) 2016-12-22 2019-07-04 Università Degli Studi Magna Graecia Catanzaro A monoclonal antibody targeting a unique sialoglycosilated cancer-associated epitope of CD43
WO2020210719A1 (en) 2019-04-10 2020-10-15 Elevatebio Management, Inc. Flt3-specific chimeric antigen receptors and methods of using the same
CN114127110B (zh) * 2019-05-30 2022-07-01 山东博安生物技术股份有限公司 抗cgrp抗体及其应用
WO2020254670A1 (en) * 2019-06-21 2020-12-24 Università Degli Studi Magna Graecia Catanzaro Monoclonal antibody targeting a unique cancer-associated epitope of cd43
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