KR101981378B1 - 간 질환 치료용 약학 조성물 - Google Patents

간 질환 치료용 약학 조성물 Download PDF

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KR101981378B1
KR101981378B1 KR1020167033543A KR20167033543A KR101981378B1 KR 101981378 B1 KR101981378 B1 KR 101981378B1 KR 1020167033543 A KR1020167033543 A KR 1020167033543A KR 20167033543 A KR20167033543 A KR 20167033543A KR 101981378 B1 KR101981378 B1 KR 101981378B1
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South Korea
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proanthocyanidin
pharmaceutical composition
bel
liver
group
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Korean (ko)
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KR20160143868A (ko
Inventor
창샤우펑
마춘씨엔
양쿠오이
린시홍
린첸퉁
황카이웬
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재단법인 공업기술연구원
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y10S514/893—

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
KR1020167033543A 2011-03-22 2011-03-22 간 질환 치료용 약학 조성물 Active KR101981378B1 (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2011/072045 WO2012126178A2 (zh) 2011-03-22 2011-03-22 减缓肝癌恶化、改善肝功能、改善肝纤维化、改善肝硬化、改善肝发炎及促进受损肝脏再生之药物组合物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020137027665A Division KR20140020966A (ko) 2011-03-22 2011-03-22 간 질환 치료용 약학 조성물

Publications (2)

Publication Number Publication Date
KR20160143868A KR20160143868A (ko) 2016-12-14
KR101981378B1 true KR101981378B1 (ko) 2019-05-22

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KR1020167033543A Active KR101981378B1 (ko) 2011-03-22 2011-03-22 간 질환 치료용 약학 조성물
KR1020137027665A Ceased KR20140020966A (ko) 2011-03-22 2011-03-22 간 질환 치료용 약학 조성물

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Country Status (13)

Country Link
EP (1) EP2689777B1 (OSRAM)
JP (1) JP6166251B2 (OSRAM)
KR (2) KR101981378B1 (OSRAM)
CN (1) CN103442709B (OSRAM)
AU (1) AU2011362905B2 (OSRAM)
CA (1) CA2830616C (OSRAM)
DK (1) DK2689777T3 (OSRAM)
ES (1) ES2668785T3 (OSRAM)
NO (1) NO2689777T3 (OSRAM)
PL (1) PL2689777T3 (OSRAM)
RU (1) RU2561688C2 (OSRAM)
SG (1) SG193486A1 (OSRAM)
WO (1) WO2012126178A2 (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140179774A1 (en) 2012-12-26 2014-06-26 Industrial Technology Research Institute Methods for inhibition of shc-1/p66 to combat aging-related diseases
CN104774909A (zh) * 2014-10-17 2015-07-15 江苏大学 一种原花青素诱导肝癌细胞自噬性死亡的分析方法及应用
GB201909709D0 (en) * 2019-07-05 2019-08-21 Univ Liverpool Biomarkers for irritable bowel syndrome
WO2022080846A1 (ko) * 2020-10-13 2022-04-21 서울대학교병원 플라본을 포함하는 섬유증의 예방 또는 치료용 조성물
WO2022205137A1 (zh) * 2021-03-31 2022-10-06 贝尔克斯生技股份有限公司 高聚原花青素组合物及其应用
CN115010720B (zh) * 2022-06-02 2023-08-11 中国科学院昆明植物研究所 中甸艾中倍半萜二聚体及其药物组合物与其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713506B2 (en) * 2000-10-11 2004-03-30 University Of South Florida Tea polyphenol esters and analogs thereof for cancer prevention and treatment
CN1443533A (zh) * 2002-03-07 2003-09-24 程彦杰 原花青素类化合物在用于制备解酒保肝产品方面的用途
TW200505468A (en) * 2003-08-11 2005-02-16 Suntory Ltd Agent for improving hepato-bililary dysfunction
CN1933818A (zh) * 2004-01-30 2007-03-21 马尔斯公司 用于治疗癌症的方法和组合物
US20070054868A1 (en) * 2005-06-20 2007-03-08 The Trustees Of Columbia University In The City Of New York Synergistic polyphenol compounds, compositions thereof, and uses thereof
JP2008156265A (ja) * 2006-12-22 2008-07-10 Yamagata Prefecture Ａ型プロアントシアニジンオリゴマー画分及びその製造方法
JP2008195672A (ja) * 2007-02-14 2008-08-28 Okayama Univ 経口摂取用組成物及び経口摂取用組成物の製造方法
JP4822291B2 (ja) * 2008-03-14 2011-11-24 財団法人宮崎県産業支援財団 肝線維化抑制剤
TWI370736B (en) * 2008-12-31 2012-08-21 Ind Tech Res Inst Pharmaceutical composition for treating hepatitis b and heath food for inhibiting hepatitis b virus
CN101822372A (zh) * 2009-03-05 2010-09-08 财团法人工业技术研究院 用以治疗b型肝炎的药学组合物与抑制b型肝炎病毒的保健食品
CN101507730B (zh) * 2009-03-26 2011-01-26 复旦大学 表没食子儿茶素没食子酸酯与柔红霉素的组合物及其应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Archives of Pharmacal Research, Vol. 33(1), pp. 167-173(2010년)*

Also Published As

Publication number Publication date
SG193486A1 (en) 2013-10-30
ES2668785T3 (es) 2018-05-22
KR20160143868A (ko) 2016-12-14
WO2012126178A2 (zh) 2012-09-27
CA2830616C (en) 2017-02-21
WO2012126178A3 (zh) 2012-11-22
EP2689777B1 (en) 2018-03-28
CA2830616A1 (en) 2012-09-27
CN103442709B (zh) 2018-10-19
RU2013146602A (ru) 2015-04-27
PL2689777T3 (pl) 2018-08-31
JP6166251B2 (ja) 2017-07-19
EP2689777A4 (en) 2014-09-17
CN103442709A (zh) 2013-12-11
AU2011362905A1 (en) 2013-10-31
RU2561688C2 (ru) 2015-08-27
JP2014508785A (ja) 2014-04-10
KR20140020966A (ko) 2014-02-19
DK2689777T3 (en) 2018-05-22
NO2689777T3 (OSRAM) 2018-08-25
EP2689777A2 (en) 2014-01-29
AU2011362905B2 (en) 2015-11-12

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