KR101976101B1 - 옥시코돈의 벤조산, 벤조산 유도체 및 헤테로아릴 카르복실산 콘쥬게이트 - Google Patents

옥시코돈의 벤조산, 벤조산 유도체 및 헤테로아릴 카르복실산 콘쥬게이트 Download PDF

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KR101976101B1
KR101976101B1 KR1020177017408A KR20177017408A KR101976101B1 KR 101976101 B1 KR101976101 B1 KR 101976101B1 KR 1020177017408 A KR1020177017408 A KR 1020177017408A KR 20177017408 A KR20177017408 A KR 20177017408A KR 101976101 B1 KR101976101 B1 KR 101976101B1
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acid
oxycodone
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composition
conjugate
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KR20170094249A (ko
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트래비스 미클
스벤 귄터
산지브 베라
빈두 베라
야로슬라프 칸스키
안드레아 케이 마틴
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켐팜 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020177017408A 2014-11-25 2015-11-25 옥시코돈의 벤조산, 벤조산 유도체 및 헤테로아릴 카르복실산 콘쥬게이트 Expired - Fee Related KR101976101B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462084246P 2014-11-25 2014-11-25
US201462084216P 2014-11-25 2014-11-25
US62/084,216 2014-11-25
US62/084,246 2014-11-25
PCT/US2015/062637 WO2016086113A1 (en) 2014-11-25 2015-11-25 Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone

Related Child Applications (1)

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KR1020197012631A Division KR20190049944A (ko) 2014-11-25 2015-11-25 옥시코돈의 벤조산, 벤조산 유도체 및 헤테로아릴 카르복실산 콘쥬게이트

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KR20170094249A KR20170094249A (ko) 2017-08-17
KR101976101B1 true KR101976101B1 (ko) 2019-05-09

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KR1020177017408A Expired - Fee Related KR101976101B1 (ko) 2014-11-25 2015-11-25 옥시코돈의 벤조산, 벤조산 유도체 및 헤테로아릴 카르복실산 콘쥬게이트
KR1020197012631A Withdrawn KR20190049944A (ko) 2014-11-25 2015-11-25 옥시코돈의 벤조산, 벤조산 유도체 및 헤테로아릴 카르복실산 콘쥬게이트

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Country Status (18)

Country Link
US (3) US9850252B2 (https=)
EP (1) EP3223819A4 (https=)
JP (2) JP6400848B2 (https=)
KR (2) KR101976101B1 (https=)
CN (1) CN106999486A (https=)
AU (1) AU2015353502B2 (https=)
BR (1) BR112017011069A2 (https=)
CA (1) CA2967424C (https=)
CL (1) CL2017001353A1 (https=)
CO (1) CO2017005201A2 (https=)
IL (1) IL252470B (https=)
MX (1) MX2017006520A (https=)
NZ (1) NZ731591A (https=)
PH (1) PH12017500963A1 (https=)
RU (1) RU2683317C2 (https=)
SG (1) SG11201704178UA (https=)
WO (1) WO2016086113A1 (https=)
ZA (1) ZA201703154B (https=)

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UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
RU2683317C2 (ru) 2014-11-25 2019-03-28 Кемфарм, Инк. Конъюгаты оксикодона с бензойной кислотой, производными бензойной кислоты и гетероарилкарбоновой кислотой
US20200038383A1 (en) * 2016-10-14 2020-02-06 Kempharm, Inc. Immediate-release abuse deterrent compositions or medicaments for treating pain, add, adhd and other syndromes or disorders
US11254685B2 (en) * 2017-07-20 2022-02-22 Suzhou Runxindatai Pharmaceutics Ltd Co. Abuse-resistant long-acting release opioid prodrugs
AU2019224127B2 (en) 2018-02-23 2021-12-09 Rhodes Technologies Novel opioid compounds and uses thereof

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EP1782834A2 (en) * 2003-03-13 2007-05-09 Controlled Chemicals, Inc. Oxycodone conjugates with lower abuse potential and extended duration of action
US20120142720A1 (en) * 2009-07-02 2012-06-07 Kempharm, Inc. Phenylethanoic Acid, Phenylpropanoic Acid and Phenylpropenoic Acid Conjugates and Prodrugs of Hydrocodone, Methods of Making and Use Thereof

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RU2683317C2 (ru) 2014-11-25 2019-03-28 Кемфарм, Инк. Конъюгаты оксикодона с бензойной кислотой, производными бензойной кислоты и гетероарилкарбоновой кислотой

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JP2006520392A (ja) * 2003-03-13 2006-09-07 コントロールド・ケミカルズ・インコーポレーテッド 薬物の乱用可能性を低下させ且つ作用持続時間を延長する化合物および方法
EP1782834A2 (en) * 2003-03-13 2007-05-09 Controlled Chemicals, Inc. Oxycodone conjugates with lower abuse potential and extended duration of action
US20120142720A1 (en) * 2009-07-02 2012-06-07 Kempharm, Inc. Phenylethanoic Acid, Phenylpropanoic Acid and Phenylpropenoic Acid Conjugates and Prodrugs of Hydrocodone, Methods of Making and Use Thereof

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Publication number Publication date
US20160168160A1 (en) 2016-06-16
CO2017005201A2 (es) 2017-08-31
WO2016086113A1 (en) 2016-06-02
US10544153B2 (en) 2020-01-28
EP3223819A1 (en) 2017-10-04
KR20190049944A (ko) 2019-05-09
EP3223819A4 (en) 2018-04-25
US20180065975A1 (en) 2018-03-08
US9850252B2 (en) 2017-12-26
JP2018199719A (ja) 2018-12-20
NZ731591A (en) 2018-06-29
MX2017006520A (es) 2017-08-09
SG11201704178UA (en) 2017-06-29
RU2017122144A (ru) 2018-12-26
US10144740B2 (en) 2018-12-04
AU2015353502A1 (en) 2017-05-25
PH12017500963A1 (en) 2017-10-18
IL252470A0 (en) 2017-07-31
CA2967424A1 (en) 2016-06-02
BR112017011069A2 (pt) 2018-07-10
RU2683317C2 (ru) 2019-03-28
JP6400848B2 (ja) 2018-10-03
US20190048018A1 (en) 2019-02-14
CA2967424C (en) 2023-05-02
RU2017122144A3 (https=) 2018-12-26
AU2015353502B2 (en) 2018-09-27
JP2017535593A (ja) 2017-11-30
ZA201703154B (en) 2019-03-27
CN106999486A (zh) 2017-08-01
KR20170094249A (ko) 2017-08-17
CL2017001353A1 (es) 2018-01-05
IL252470B (en) 2019-08-29

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