CN106999486A - 羟考酮的苯甲酸缀合物、苯甲酸衍生物缀合物和杂芳基羧酸缀合物 - Google Patents

羟考酮的苯甲酸缀合物、苯甲酸衍生物缀合物和杂芳基羧酸缀合物 Download PDF

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Publication number
CN106999486A
CN106999486A CN201580064309.XA CN201580064309A CN106999486A CN 106999486 A CN106999486 A CN 106999486A CN 201580064309 A CN201580064309 A CN 201580064309A CN 106999486 A CN106999486 A CN 106999486A
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CN
China
Prior art keywords
acid
oxycodone
composition
aryl
aryl carboxylic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580064309.XA
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English (en)
Chinese (zh)
Inventor
T·米克尔
S·冈瑟
S·贝拉
B·贝拉
J·堪萨斯
A·K·马丁
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zevra Therapeutics Inc
Original Assignee
KemPharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KemPharm Inc filed Critical KemPharm Inc
Publication of CN106999486A publication Critical patent/CN106999486A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201580064309.XA 2014-11-25 2015-11-25 羟考酮的苯甲酸缀合物、苯甲酸衍生物缀合物和杂芳基羧酸缀合物 Pending CN106999486A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462084216P 2014-11-25 2014-11-25
US201462084246P 2014-11-25 2014-11-25
US62/084,216 2014-11-25
US62/084,246 2014-11-25
PCT/US2015/062637 WO2016086113A1 (en) 2014-11-25 2015-11-25 Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone

Publications (1)

Publication Number Publication Date
CN106999486A true CN106999486A (zh) 2017-08-01

Family

ID=56075034

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580064309.XA Pending CN106999486A (zh) 2014-11-25 2015-11-25 羟考酮的苯甲酸缀合物、苯甲酸衍生物缀合物和杂芳基羧酸缀合物

Country Status (18)

Country Link
US (3) US9850252B2 (https=)
EP (1) EP3223819A4 (https=)
JP (2) JP6400848B2 (https=)
KR (2) KR20190049944A (https=)
CN (1) CN106999486A (https=)
AU (1) AU2015353502B2 (https=)
BR (1) BR112017011069A2 (https=)
CA (1) CA2967424C (https=)
CL (1) CL2017001353A1 (https=)
CO (1) CO2017005201A2 (https=)
IL (1) IL252470B (https=)
MX (1) MX2017006520A (https=)
NZ (1) NZ731591A (https=)
PH (1) PH12017500963A1 (https=)
RU (1) RU2683317C2 (https=)
SG (1) SG11201704178UA (https=)
WO (1) WO2016086113A1 (https=)
ZA (1) ZA201703154B (https=)

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UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
NZ731591A (en) 2014-11-25 2018-06-29 Kempharm Inc Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone
WO2018071879A1 (en) * 2016-10-14 2018-04-19 Kempharm, Inc. Immediate-release abuse deterrent compositions or medicaments for treating pain, add, adhd and other syndromes or disorders
WO2019018638A1 (en) * 2017-07-20 2019-01-24 Suzhou Runxindatai Pharmaceutics Ltd Co. PRODRUGS OF EXTENDED RELEASE OPIOID OPIOIDS RESISTANT TO ABUSE
EP3755704A1 (en) * 2018-02-23 2020-12-30 Rhodes Technologies Inc. Novel opioid compounds and uses thereof

Citations (3)

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EP1782834A2 (en) * 2003-03-13 2007-05-09 Controlled Chemicals, Inc. Oxycodone conjugates with lower abuse potential and extended duration of action
US20120142720A1 (en) * 2009-07-02 2012-06-07 Kempharm, Inc. Phenylethanoic Acid, Phenylpropanoic Acid and Phenylpropenoic Acid Conjugates and Prodrugs of Hydrocodone, Methods of Making and Use Thereof

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AT229496B (de) 1961-03-08 1963-09-25 Lannacher Heilmittel Verfahren zur Darstellung des neuen Nicotinsäureesters des Dihydrohydroxycodeinons
US4668685A (en) 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
SE9003665D0 (sv) 1990-11-16 1990-11-16 Kabivitrum Ab Morphine prodrugs
GB9423542D0 (en) 1994-11-22 1995-01-11 Marples Brian A Pharmaceutical compounds
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KR20040014544A (ko) 2001-06-05 2004-02-14 컨트롤 딜리버리 시스템즈 인코포레이티드 서방 진통제 화합물
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JP5769889B2 (ja) * 2011-10-26 2015-08-26 ケムファーム・インコーポレーテッド ヒドロモルホンの安息香酸、安息香酸誘導体及びヘテロアリールカルボン酸結合体、そのプロドラッグ、製造法及び使用
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Patent Citations (3)

* Cited by examiner, † Cited by third party
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EP1782834A2 (en) * 2003-03-13 2007-05-09 Controlled Chemicals, Inc. Oxycodone conjugates with lower abuse potential and extended duration of action
US20050203115A1 (en) * 2004-03-10 2005-09-15 Sancilio Frederick D. Narcotic-NSAID ion pairs
US20120142720A1 (en) * 2009-07-02 2012-06-07 Kempharm, Inc. Phenylethanoic Acid, Phenylpropanoic Acid and Phenylpropenoic Acid Conjugates and Prodrugs of Hydrocodone, Methods of Making and Use Thereof

Also Published As

Publication number Publication date
JP6400848B2 (ja) 2018-10-03
KR101976101B1 (ko) 2019-05-09
AU2015353502A1 (en) 2017-05-25
RU2017122144A (ru) 2018-12-26
CO2017005201A2 (es) 2017-08-31
NZ731591A (en) 2018-06-29
MX2017006520A (es) 2017-08-09
KR20170094249A (ko) 2017-08-17
US20180065975A1 (en) 2018-03-08
RU2017122144A3 (https=) 2018-12-26
EP3223819A4 (en) 2018-04-25
US10144740B2 (en) 2018-12-04
SG11201704178UA (en) 2017-06-29
ZA201703154B (en) 2019-03-27
CL2017001353A1 (es) 2018-01-05
IL252470B (en) 2019-08-29
WO2016086113A1 (en) 2016-06-02
PH12017500963A1 (en) 2017-10-18
JP2018199719A (ja) 2018-12-20
CA2967424A1 (en) 2016-06-02
RU2683317C2 (ru) 2019-03-28
BR112017011069A2 (pt) 2018-07-10
US20190048018A1 (en) 2019-02-14
EP3223819A1 (en) 2017-10-04
US9850252B2 (en) 2017-12-26
CA2967424C (en) 2023-05-02
US10544153B2 (en) 2020-01-28
JP2017535593A (ja) 2017-11-30
IL252470A0 (en) 2017-07-31
AU2015353502B2 (en) 2018-09-27
KR20190049944A (ko) 2019-05-09
US20160168160A1 (en) 2016-06-16

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