KR101920128B1 - 성장 인자 조합을 사용하는 골수 줄기 세포 및 간엽 줄기 세포의 골발생 분화 - Google Patents
성장 인자 조합을 사용하는 골수 줄기 세포 및 간엽 줄기 세포의 골발생 분화 Download PDFInfo
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- KR101920128B1 KR101920128B1 KR1020167008084A KR20167008084A KR101920128B1 KR 101920128 B1 KR101920128 B1 KR 101920128B1 KR 1020167008084 A KR1020167008084 A KR 1020167008084A KR 20167008084 A KR20167008084 A KR 20167008084A KR 101920128 B1 KR101920128 B1 KR 101920128B1
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- Prior art keywords
- cells
- cell
- tgfb
- osteoblast
- bone
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
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- C—CHEMISTRY; METALLURGY
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0664—Dental pulp stem cells, Dental follicle stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
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- C—CHEMISTRY; METALLURGY
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0666—Mesenchymal stem cells from hair follicles
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0668—Mesenchymal stem cells from other natural sources
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0688—Cells from the lungs or the respiratory tract
- C12N5/0689—Stem cells; Progenitors
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/113—Acidic fibroblast growth factor (aFGF, FGF-1)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/148—Transforming growth factor alpha [TGF-a]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Developmental Biology & Embryology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Surgical Instruments (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08000458 | 2008-01-11 | ||
| EP08000458.3 | 2008-01-11 | ||
| PCT/EP2009/050209 WO2009087213A1 (en) | 2008-01-11 | 2009-01-09 | Osteogenic differentiation of bone marrow stem cells and mesenchymal stem cells using a combination of growth factors |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR20107017785A Division KR20100126680A (ko) | 2008-01-11 | 2009-01-09 | 성장 인자 조합을 사용하는 골수 줄기 세포 및 간엽 줄기 세포의 골발생 분화 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187021254A Division KR20180086305A (ko) | 2008-01-11 | 2009-01-09 | 성장 인자 조합을 사용하는 골수 줄기 세포 및 간엽 줄기 세포의 골발생 분화 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20160039699A KR20160039699A (ko) | 2016-04-11 |
| KR101920128B1 true KR101920128B1 (ko) | 2018-11-19 |
Family
ID=39415339
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167008084A Expired - Fee Related KR101920128B1 (ko) | 2008-01-11 | 2009-01-09 | 성장 인자 조합을 사용하는 골수 줄기 세포 및 간엽 줄기 세포의 골발생 분화 |
| KR20107017785A Ceased KR20100126680A (ko) | 2008-01-11 | 2009-01-09 | 성장 인자 조합을 사용하는 골수 줄기 세포 및 간엽 줄기 세포의 골발생 분화 |
| KR1020187021254A Ceased KR20180086305A (ko) | 2008-01-11 | 2009-01-09 | 성장 인자 조합을 사용하는 골수 줄기 세포 및 간엽 줄기 세포의 골발생 분화 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR20107017785A Ceased KR20100126680A (ko) | 2008-01-11 | 2009-01-09 | 성장 인자 조합을 사용하는 골수 줄기 세포 및 간엽 줄기 세포의 골발생 분화 |
| KR1020187021254A Ceased KR20180086305A (ko) | 2008-01-11 | 2009-01-09 | 성장 인자 조합을 사용하는 골수 줄기 세포 및 간엽 줄기 세포의 골발생 분화 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20100278788A1 (enExample) |
| EP (1) | EP2229433B1 (enExample) |
| JP (1) | JP5524079B2 (enExample) |
| KR (3) | KR101920128B1 (enExample) |
| CN (2) | CN101945993A (enExample) |
| AU (2) | AU2009203682B2 (enExample) |
| CA (1) | CA2710571C (enExample) |
| DK (1) | DK2229433T3 (enExample) |
| ES (1) | ES2650235T3 (enExample) |
| NO (1) | NO2229433T3 (enExample) |
| PL (1) | PL2229433T3 (enExample) |
| PT (1) | PT2229433T (enExample) |
| WO (1) | WO2009087213A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0921726B8 (pt) | 2008-10-31 | 2021-07-27 | Synthes Gmbh | método para preparar uma composição de implante para promover o crescimento ósseo em um mamífero |
| EP4086338A1 (en) | 2011-03-17 | 2022-11-09 | Minerva Biotechnologies Corporation | Method for making pluripotent stem cells |
| CN103857788A (zh) | 2011-10-11 | 2014-06-11 | 骨治疗公司 | 生长和分化因子8(gdf-8)的用途 |
| WO2013059373A2 (en) | 2011-10-17 | 2013-04-25 | Minerva Biotechnologies Corporation | Media for stem cell proliferation and induction |
| CA2983373C (en) * | 2015-04-23 | 2018-12-11 | Bone Therapeutics S.A. | In vitro preservation of therapeutic cells |
| CA3030866A1 (en) | 2016-07-21 | 2018-01-25 | Sanbio, Inc. | Msc growth predictor assays |
| AU2018351804B2 (en) | 2017-10-20 | 2020-07-09 | Bone Therapeutics Sa | Methods for differentiating mesenchymal stem cells |
| KR20210076018A (ko) | 2018-09-25 | 2021-06-23 | 본 테라퓨틱스 소시에테아노님 | 체외 분화 세포의 골형성능을 판정하기 위한 방법 및 용도 |
| BR112021005697A2 (pt) | 2018-09-25 | 2021-06-22 | Bone Therapeutics Sa | métodos para obter células derivadas de células-tronco mesenquimais (msc) de linhagem condro-osteoblástica a partir de msc, populações de células derivadas de msc de linhagem condro-osteoblástica e formulação farmacêutica |
| CN111357990A (zh) * | 2019-12-26 | 2020-07-03 | 浙江欧谱生物科技有限公司 | 增加骨量的保健食品组合物及其应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007093431A1 (en) * | 2006-02-16 | 2007-08-23 | Universite Libre De Bruxelles | A method for osteogenic differentiation of bone marrow stem cells (bmsc) and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5837539A (en) * | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
| US5811094A (en) * | 1990-11-16 | 1998-09-22 | Osiris Therapeutics, Inc. | Connective tissue regeneration using human mesenchymal stem cell preparations |
| US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5972703A (en) * | 1994-08-12 | 1999-10-26 | The Regents Of The University Of Michigan | Bone precursor cells: compositions and methods |
| US5736396A (en) * | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| US5827740A (en) * | 1996-07-30 | 1998-10-27 | Osiris Therapeutics, Inc. | Adipogenic differentiation of human mesenchymal stem cells |
| AU6144698A (en) * | 1997-02-05 | 1998-08-25 | Case Western Reserve University | Stimulatory effects of bfgf and bmp-2 on osteogenic differentiation of mesenchymal stem cells |
| US20070275462A1 (en) * | 2003-10-02 | 2007-11-29 | Hall Christopher L | Human Prostate Cancer Cell Factor(s) that Induce Stem Cell Commitment and Osteogenesis |
| JP2006346420A (ja) * | 2005-06-13 | 2006-12-28 | Univ Nagoya | 移植材料及び骨質改善剤 |
| WO2007002210A2 (en) * | 2005-06-20 | 2007-01-04 | Bresagen, Inc. | Embryonic stem cell culture compositions and methods of use thereof |
| TW200726474A (en) * | 2005-07-15 | 2007-07-16 | Cognate Therapeutics Inc | The immunophenotype and immunogenicity of human adipose derived cells |
-
2008
- 2008-01-01 US US12/811,724 patent/US20100278788A1/en not_active Abandoned
-
2009
- 2009-01-09 DK DK09700353.7T patent/DK2229433T3/da active
- 2009-01-09 KR KR1020167008084A patent/KR101920128B1/ko not_active Expired - Fee Related
- 2009-01-09 KR KR20107017785A patent/KR20100126680A/ko not_active Ceased
- 2009-01-09 PL PL09700353T patent/PL2229433T3/pl unknown
- 2009-01-09 AU AU2009203682A patent/AU2009203682B2/en not_active Ceased
- 2009-01-09 ES ES09700353.7T patent/ES2650235T3/es active Active
- 2009-01-09 CN CN2009801051722A patent/CN101945993A/zh active Pending
- 2009-01-09 EP EP09700353.7A patent/EP2229433B1/en active Active
- 2009-01-09 WO PCT/EP2009/050209 patent/WO2009087213A1/en not_active Ceased
- 2009-01-09 PT PT97003537T patent/PT2229433T/pt unknown
- 2009-01-09 JP JP2010541790A patent/JP5524079B2/ja not_active Expired - Fee Related
- 2009-01-09 KR KR1020187021254A patent/KR20180086305A/ko not_active Ceased
- 2009-01-09 CN CN201410427665.0A patent/CN104250633A/zh active Pending
- 2009-01-09 NO NO09700353A patent/NO2229433T3/no unknown
- 2009-01-09 CA CA2710571A patent/CA2710571C/en active Active
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2013
- 2013-03-13 US US13/802,602 patent/US20130266544A1/en not_active Abandoned
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2014
- 2014-07-17 AU AU2014204491A patent/AU2014204491B2/en not_active Ceased
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2020
- 2020-07-14 US US16/929,042 patent/US20200407688A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007093431A1 (en) * | 2006-02-16 | 2007-08-23 | Universite Libre De Bruxelles | A method for osteogenic differentiation of bone marrow stem cells (bmsc) and uses thereof |
Non-Patent Citations (1)
| Title |
|---|
| Front. Biosci. 13:2001-2021(2008.01.01.)* |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014204491A1 (en) | 2014-08-07 |
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| WO2009087213A1 (en) | 2009-07-16 |
| EP2229433B1 (en) | 2017-09-20 |
| KR20100126680A (ko) | 2010-12-02 |
| US20100278788A1 (en) | 2010-11-04 |
| CN101945993A (zh) | 2011-01-12 |
| EP2229433A1 (en) | 2010-09-22 |
| JP5524079B2 (ja) | 2014-06-18 |
| PT2229433T (pt) | 2017-12-12 |
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