KR101912978B1 - 페닐보론산기가 도입된 블록 공중합체 및 그의 용도 - Google Patents

페닐보론산기가 도입된 블록 공중합체 및 그의 용도 Download PDF

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Publication number
KR101912978B1
KR101912978B1 KR1020147013186A KR20147013186A KR101912978B1 KR 101912978 B1 KR101912978 B1 KR 101912978B1 KR 1020147013186 A KR1020147013186 A KR 1020147013186A KR 20147013186 A KR20147013186 A KR 20147013186A KR 101912978 B1 KR101912978 B1 KR 101912978B1
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South Korea
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group
amino acid
block copolymer
substituted
acid
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KR1020147013186A
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Korean (ko)
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KR20140106511A (ko
Inventor
가즈노리 가타오카
다케히코 이시이
미츠루 나이토
아키라 마츠모토
야스키 가토
Original Assignee
도꾜 다이가꾸
고쿠리츠 다이가쿠호우징 도쿄이카시카다이가쿠
나노캬리아 가부시키가이샤
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Publication of KR20140106511A publication Critical patent/KR20140106511A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A61K47/6455—Polycationic oligopeptides, polypeptides or polyamino acids, e.g. for complexing nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/40—Polyamides containing oxygen in the form of ether groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/42—Polyamides containing atoms other than carbon, hydrogen, oxygen, and nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)
KR1020147013186A 2011-11-17 2012-11-19 페닐보론산기가 도입된 블록 공중합체 및 그의 용도 Expired - Fee Related KR101912978B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161561022P 2011-11-17 2011-11-17
US61/561,022 2011-11-17
PCT/JP2012/079897 WO2013073697A1 (ja) 2011-11-17 2012-11-19 フェニルボロン酸基が導入されたブロックコポリマーおよびその使用

Publications (2)

Publication Number Publication Date
KR20140106511A KR20140106511A (ko) 2014-09-03
KR101912978B1 true KR101912978B1 (ko) 2018-10-29

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KR1020147013186A Expired - Fee Related KR101912978B1 (ko) 2011-11-17 2012-11-19 페닐보론산기가 도입된 블록 공중합체 및 그의 용도

Country Status (13)

Country Link
US (1) US9114177B2 (enExample)
EP (1) EP2781536B1 (enExample)
JP (1) JP5481614B2 (enExample)
KR (1) KR101912978B1 (enExample)
CN (1) CN104093768B (enExample)
AU (1) AU2012337721B2 (enExample)
BR (1) BR112014011831A2 (enExample)
CA (1) CA2853902A1 (enExample)
ES (1) ES2603632T3 (enExample)
IN (1) IN2014CN03580A (enExample)
MX (1) MX2014005540A (enExample)
RU (1) RU2014124333A (enExample)
WO (1) WO2013073697A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5086497B1 (ja) 2011-03-31 2012-11-28 ナノキャリア株式会社 ボロン酸化合物を含有したブロック共重合体を含む医薬組成物
JP6195171B2 (ja) 2012-04-27 2017-09-13 国立大学法人 東京大学 核酸デリバリー用ユニット構造型医薬組成物
JPWO2015121924A1 (ja) 2014-02-12 2017-03-30 アキュルナ株式会社 ｍＲＮＡ送達用組成物
US10993960B1 (en) 2014-05-08 2021-05-04 Kawasaki Institute Of Industrial Promotion Pharmaceutical composition
KR101891655B1 (ko) * 2016-05-17 2018-08-24 기초과학연구원 페닐보론산이 결합된 고분자를 포함하는 약물 전달체
US10973762B2 (en) 2016-08-02 2021-04-13 Nippon Kayaku Kabushiki Kaisha Active-targeting-type polymer derivative, composition containing said polymer derivative, and uses of said polymer derivative and said composition
EP3501544B1 (en) * 2016-08-22 2021-07-28 Tokyo Institute of Technology Ligand capable of multivalently binding to glutamine transporter, and composition comprising same
EP3677268A4 (en) * 2017-08-31 2021-04-21 The University Of Tokyo UNIT POLYIONIC COMPLEX FILLED WITH NUCLEIC ACID
KR102075476B1 (ko) * 2017-12-29 2020-02-10 포항공과대학교 산학협력단 페닐보론산이 결합된 고분자를 포함하는 하이드로겔
IL314291A (en) 2018-04-27 2024-09-01 Genedit Inc Cationic polymer and use for biomolecule delivery
JP2022502384A (ja) 2018-09-25 2022-01-11 国立大学法人 東京大学 両親媒性ポリアミノ酸、該両親媒性ポリアミノ酸を用いたブロックコポリマー、および該両親媒性ポリアミノ酸または該ブロックコポリマーと核酸とを含む複合体
EP3978078A4 (en) 2019-05-29 2023-08-02 Tokyo Institute of Technology Complex, medicine, therapeutic agent for cancer, kit and conjugate
IL322632A (en) 2019-09-20 2025-10-01 Glyscend Inc Modified phenyl boronic acid containing polymers and methods of use
JP7739406B2 (ja) * 2021-03-10 2025-09-16 Ａｇｃ株式会社 含ハロゲン部位を有するポリマーおよび該ポリマーを用いた医薬組成物
CN114163591B (zh) * 2021-11-29 2023-08-01 南方医科大学 一种嵌段共聚物、嵌段共聚物载药胶束及其制备方法和应用
CN114533669B (zh) * 2022-01-18 2022-11-04 武汉大学 一种口腔护理组合物及其制备方法和应用
CN114632145B (zh) * 2022-03-07 2024-02-27 浙江大学 一种负载胰岛素的苯硼酸/脂肪酸双改性ε-聚赖氨酸颗粒及其制备方法

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WO2009140421A2 (en) 2008-05-13 2009-11-19 University Of Washington Polymeric carrier
JP2011173960A (ja) 2010-02-23 2011-09-08 Univ Of Tsukuba 高分子ミセル型光刺激応答性一酸化窒素供与体

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JP3257029B2 (ja) * 1992-04-22 2002-02-18 日本油脂株式会社 フェニルボロン酸誘導体及び製造方法
JPH083172A (ja) * 1994-06-15 1996-01-09 Nippon Oil & Fats Co Ltd フェニルボロン酸誘導体および製造方法
US6083903A (en) 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
JP2002179683A (ja) * 2000-12-13 2002-06-26 Japan Science & Technology Corp ポリアミノ酸誘導体から成る核酸関連物質反応試薬
WO2008047948A1 (en) 2006-10-19 2008-04-24 Nanocarrier Co., Ltd. Block copolymer for drug complex and pharmaceutical composition
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JP5737705B2 (ja) 2008-05-02 2015-06-17 国立大学法人 筑波大学 高分子化環状ニトロキシドラジカル化合物およびその使用
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JP5086497B1 (ja) 2011-03-31 2012-11-28 ナノキャリア株式会社 ボロン酸化合物を含有したブロック共重合体を含む医薬組成物

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Publication number Priority date Publication date Assignee Title
WO2009140421A2 (en) 2008-05-13 2009-11-19 University Of Washington Polymeric carrier
JP2011173960A (ja) 2010-02-23 2011-09-08 Univ Of Tsukuba 高分子ミセル型光刺激応答性一酸化窒素供与体

Also Published As

Publication number Publication date
US9114177B2 (en) 2015-08-25
WO2013073697A1 (ja) 2013-05-23
EP2781536A1 (en) 2014-09-24
US20150051347A1 (en) 2015-02-19
CN104093768A (zh) 2014-10-08
KR20140106511A (ko) 2014-09-03
AU2012337721A1 (en) 2014-05-22
EP2781536A4 (en) 2015-06-10
ES2603632T3 (es) 2017-02-28
JP5481614B2 (ja) 2014-04-23
RU2014124333A (ru) 2015-12-27
AU2012337721B2 (en) 2015-12-10
CA2853902A1 (en) 2013-05-23
BR112014011831A2 (pt) 2017-05-09
JPWO2013073697A1 (ja) 2015-04-02
IN2014CN03580A (enExample) 2015-10-09
EP2781536B1 (en) 2016-08-17
CN104093768B (zh) 2016-09-21
MX2014005540A (es) 2014-09-22

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