KR101899237B1 - Organic acid composition to be added to antimicrobial toothpaste and method for producing the same - Google Patents

Abstract

The present invention relates to an organic acid composition to be added to an antimicrobial toothpaste and a method for preparing the same. More particularly, the present invention relates to a method for producing an antibacterial dentifrice which comprises Helicobacter pylori as a cause of gastric ulcer and duodenal ulcer, Porphyromonas gingivalis ), A sterilization effect against Streptococcus mutans, which is a causative organism of tooth decay, a method for producing the same, an antimicrobial toothpaste containing the same, and an oral cleansing agent.

Description

[0001] The present invention relates to an organic acid composition to be added to an antimicrobial toothpaste,

The present invention relates to an organic acid composition to be added to an antimicrobial toothpaste and a method for preparing the same. More particularly, the present invention relates to a method for producing an antibacterial dentifrice which comprises Helicobacter pylori as a cause of gastric ulcer and duodenal ulcer, Porphyromonas gingivalis ), A sterilization effect against Streptococcus mutans, which is a causative organism of tooth decay, a method for producing the same, an antimicrobial toothpaste containing the same, and an oral cleansing agent.

The following description merely provides background information related to the present invention and does not constitute the prior art.

Many modern people use toothpaste and mouthwash to clean teeth and mouth. In addition, toothpaste and mouthwashing detergents have been studied for functional toothpastes and mouthwash detergents having various functions in order to meet various demands of consumers.

For example, toothpastes and mouthwashes having a sterilizing effect against Helicobacter pylori, a causative organ of gastric ulcer and duodenal ulcer, and toothpastes and mouthwashes having a sterilizing effect against Porphyromonas gingivalis, And toothpaste and mouthwash with sterilization effect against Streptococcus mutans, the cause of tooth decay, are sold.

Fluorine, which is typically used in toothpaste and mouthwash and has a germicidal effect, is one of the halogen elements. It has a pungent green color with a distinctive irritating odor. Its chemical reactivity is very strong and it is used as a disinfectant or adhesive. These fluorides are used in the form of colorless, irritating, toxic gaseous compounds, which are especially added to toothpastes to strengthen tooth surfaces and prevent tooth decay. These fluorides are suggested to be used at the pet food store under 1,000 ppm or less. This is because when the content of fluoride is high, the bactericidal effect on the bacteria in the oral cavity is high, but the chemical reaction weakens the teeth, and the gums are damaged. On the contrary, if the content is too small, the antibacterial effect in the mouth drops.

To date, a variety of toothpastes and mouthwash detergents having a sterilizing effect have been introduced for Helicobacter pylori, Jinji valerius, and Mytilus spp., Respectively. However, at the same time, the antibacterial effect against Helicobacter pylori, Jinji valerius, Toothbrushes and mouthwash detergents are rare, and even if they are effective, it is difficult to have a sterilizing effect that can satisfy consumer needs.

The object of the present invention is to provide an antimicrobial toothpaste which is useful as an antimicrobial dentifrice for the treatment of Helicobacter pylori which is a cause of gastric ulcer and duodenal ulcer, Porphyromonas gingivalis which is a cause of gum disease, Streptococcus mutans The present invention also provides an organic acid composition having an excellent germicidal effect.

It is another object of the present invention to provide a process for producing the organic acid composition.

The present invention also relates to a composition for preventing or treating gastric ulcer or Helicobacter pylori, a causative organ of gastric ulcer or duodenal ulcer, Porphyromonas gingivalis, a causative organism of gum disease, or Streptococcus mutans, It is an object of the present invention to provide an antimicrobial toothpaste having an excellent germicidal effect.

The present invention also relates to a composition for preventing or treating gastric ulcer or Helicobacter pylori, a causative organ of gastric ulcer or duodenal ulcer, Porphyromonas gingivalis, a causative organism of gum disease, or Streptococcus mutans, And an object of the present invention is to provide an oral cleaning agent having an excellent sterilization effect.

In order to solve such a problem,

A first step of adding 30 to 50% by weight of citric acid based on the whole composition to water and stirring at a low speed for 24 to 48 hours at room temperature;

A second step of adding 1 to 15% by weight of lactic acid, 1 to 5% by weight of malic acid, 1 to 5% by weight of ascorbic acid, and 0.1 to 3% by weight of the herbal extracts to the solution of the first step;

A third step of adding 20 to 50% by weight of a polar solvent to the solution of the second step based on the total composition;

A fourth step of reacting the solution of the third step at 100 to 120 ° C under a pressure of 5 to 10 atm for 24 to 48 hours;

Wherein the organic acid composition is prepared by dissolving the organic acid in an organic solvent.

The present invention also provides an organic acid composition prepared by the above-mentioned method.

The present invention also provides an antimicrobial toothpaste comprising the organic acid composition.

The present invention also provides an oral cleaning agent comprising the organic acid composition.

The organic acid composition according to the present invention is excellent in sterilization simultaneously against Helicobacter pylori which is a causative organ of gastric ulcer and duodenal ulcer, Porphyromonas gingivalis which is a causative organ of gum disease, and Streptococcus mutans which is a causative organ of cavity It can be effectively applied to antibacterial toothpaste or mouthwash.

1 is a schematic flow chart of a method for producing an organic acid composition according to an embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those skilled in the art can easily carry out the present invention. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. In order to clearly illustrate the present invention, parts not related to the description are omitted, and similar parts are denoted by like reference characters throughout the specification.

Throughout the specification, when an element is referred to as "comprising ", it means that it can include other elements as well, without excluding other elements unless specifically stated otherwise.

1 is a schematic flow chart of a method for producing an organic acid composition according to the present invention.

In the first step of the production method of the present invention, 30 to 50% by weight of citric acid is added to water, stirred at a low speed, and stored at room temperature for 24 to 48 hours. The citric acid may be a known citric acid which can be used in toothpaste or mouthwash. If the content of citric acid is within the above range, the citric acid may exhibit an excellent sterilizing effect against Helicobacter pylori, Jinji valerius and Streptococcus mutans at the same time have.

In the second step of the production method of the present invention, 1 to 15% by weight of lactic acid, 1 to 5% by weight of malic acid, 1 to 5% by weight of ascorbic acid, and 0.1 to 3% . The lactic acid, malic acid, ascorbic acid, and menorrhea used in the second step may be any known materials that can be used in toothpaste or mouthwash. Preferably, the extract is a hot-water extract It is good. In the present invention, when it is out of the above range of lactic acid, malic acid, ascorbic acid and menstruum, it may be difficult to simultaneously exhibit an excellent sterilizing effect against Helicobacter pylori, Streptococcus mutans and Streptococcus mutans. Particularly, when the content of the extracts is within the above range, it has not only an excellent sterilizing effect on Helicobacter pylori, Streptococcus mutans, and Streptococcus mutans but also has excellent antimicrobial persistence.

The third step in the production method of the present invention is a step of adding 20 to 50% by weight of a polar solvent to the solution of the second step based on the total composition. The polar solvent may be water, glycerin, propylene glycol, or butylene glycol. The polar solvent may be used alone or in admixture of two or more. . Preferably, the polar solvent is water. In the present invention, when the content of the polar solvent is within the above range, the sterilizing effect against Helicobacter pylori, Streptococcus mutans, and Streptococcus mutans can be simultaneously exhibited.

In the manufacturing method of the present invention, the fourth step is a step of reacting the solution of the third step at 100 to 120 ° C under a pressure of 5 to 10 atm for 24 to 48 hours. When the reaction conditions are within the above ranges, the organic acid composition to be produced is excellent in long-term stability, and can exhibit excellent sterilization effect and antimicrobial persistence simultaneously against Helicobacter pylori, Streptococcus mutans, and Streptococcus mutans.

When the citric acid, lactic acid, and malic acid of the first or second step are added in the form of a metal salt such as sodium, potassium, calcium, magnesium or the like, or when separate metal ions are added to the first to third May be added to one of the steps to adjust the pH of the organic acid composition suitable for application as a dentifrice or mouthwash to about 6-8.

An embodiment of the method for producing an organic acid composition according to the present invention may be as follows.

30 to 50% by weight of citric acid was added to water and stirred at low speed for 24 to 48 hours at room temperature. To this solution, 1 to 15% by weight of lactic acid, 1 to 5% by weight of malic acid, 1 to 5% by weight of ascorbic acid, 0.1 to 3% by weight of an extract at the beginning of the month, water is added to the solution in an amount of 20 to 50% by weight of a polar solvent relative to the total composition, and the solution of the third step is heated at 100 to 120 ° C under a pressure of 5 to 10 For 24 to 48 hours to prepare an organic acid composition.

Another embodiment of the method for producing an organic acid composition according to the present invention may be as follows.

30 to 50% by weight of citric acid was added to water and stirred at low speed for 24 to 48 hours at room temperature. To this solution, 1 to 15% by weight of lactic acid, 1 to 5% by weight of malic acid, 1 to 5% by weight of ascorbic acid, 0.1 to 3% by weight of the extract is added to the solution, and a mixture of water and glycerin is added to the solution in an amount of 20 to 50% by weight of a polar solvent based on the whole composition. The solution of the third step is heated at 100 to 120 ° C, At a pressure of 10 atm for 24 to 48 hours to prepare an organic acid composition.

Another embodiment of the method for producing an organic acid composition according to the present invention may be as follows.

30 to 50% by weight of citric acid was added to water and stirred at low speed for 24 to 48 hours at room temperature. To this solution, 1 to 15% by weight of lactic acid, 1 to 5% by weight of malic acid, 1 to 5% by weight of ascorbic acid, 0.1 to 3% by weight of an extract at the beginning of the month, water is added to the solution in an amount of 20 to 50% by weight of a polar solvent relative to the total composition, and the solution of the third step is heated at 100 to 120 ° C under a pressure of 5 to 10 After the reaction is carried out for 24 to 48 hours, an organic acid composition in which the pH is adjusted to 7 by adding metal ions such as sodium, potassium, calcium and magnesium can be prepared.

Another embodiment of the method for producing an organic acid composition according to the present invention may be as follows.

30 to 50% by weight of citric acid metal salt is added to water and stirred at low speed for 24 to 48 hours at room temperature. To this solution, 1 to 15% by weight of lactic acid metal salt, 1 to 5% by weight of malic acid metal salt, 1 to 5% by weight of ascorbic acid %, And 0.1 to 3% by weight of the extract from the beginning of the month, adding water to the solution with a polar solvent in an amount of 20 to 50% by weight based on the total composition, The organic acid composition can be prepared by adjusting the pH to 7 by reacting at atmospheric pressure for 24 to 48 hours.

The organic acid composition prepared by the above-mentioned method may be a composition in which citric acid, lactic acid, malic acid, ascorbic acid, acaricide extract, water and polar solvent are mixed evenly and the pH is adjusted to 6 to 8 as necessary. The organic acid composition of the present invention exhibited 100% mortality when treated with Helicobacter pylori KCTC12083 for 1 minute and 100% mortality when treated with Porphyromonas gingivalis KCTC5352 for 1 minute And it was confirmed that 100% of the killed strain of Streptococcus mutans KCTC3065 was treated for 1 minute and had a very excellent sterilization effect.

In addition, the toothpaste and mouthwash detergent containing the organic acid composition according to the present invention may include known components generally included in toothpaste or mouthwash detergent in addition to the organic acid. The content of the organic acid composition in toothpaste or mouthwash can be adjusted by a person skilled in the art Can be suitably adjusted, and can be preferably from 5 to 10% by weight. The toothpaste and mouthwash according to the present invention are not only excellent in long-term stability, but also exhibit excellent sterilization effect and antimicrobial persistence against Helicobacter pylori, Streptococcus mutans, and Streptococcus mutans. In addition, the toothpaste and mouthwash according to the present invention have remarkably excellent sterilizing effect as compared with the use of citric acid, lactic acid, malic acid, ascorbic acid, and menorrhiza extract alone or two or three, and are harmless to human body, The tooth is particularly suitable for use with the weaker elderly.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, It belongs to the scope of right.

Claims (15)

A first step of adding 30 to 50% by weight of citric acid based on the whole composition to water and stirring at a low speed for 24 to 48 hours at room temperature;
A second step of adding 1 to 15% by weight of lactic acid, 1 to 5% by weight of malic acid, 1 to 5% by weight of ascorbic acid, and 0.1 to 3% by weight of the herbal extracts to the solution of the first step;
A third step of adding 20 to 50% by weight of a polar solvent to the solution of the second step based on the total composition;
A fourth step of reacting the solution of the third step at 100 to 120 ° C under a pressure of 5 to 10 atm for 24 to 48 hours;
/ RTI >
The above-mentioned water extract of Seorak is a hot-water extract,
Wherein one or more metal ions selected from sodium, potassium, calcium, and magnesium are added to any one of the first step and the third step,
Wherein the pH of the composition is from 6 to 8. < RTI ID = 0.0 > 11. < / RTI > The method according to claim 1,
Wherein the polar solvent is at least one selected from the group consisting of water, glycerin, propylene glycol and butylene glycol, or a mixture of two or more thereof. delete delete The method according to claim 1,
Wherein the citric acid, lactic acid or malic acid is added in the form of sodium, potassium, calcium or magnesium metal salt. delete Wherein the composition comprises 30 to 50 wt% of citric acid, 1 to 15 wt% of lactic acid, 1 to 5 wt% of malic acid, 1 to 5 wt% of ascorbic acid, 0.1 to 3 wt% of perennial extract, 20 to 50 wt% of polar solvent, / RTI >
Further comprising at least one metal ion selected from sodium, potassium, calcium, and magnesium,
wherein the pH of the organic acid composition is from 6 to 8. The method of claim 7,
An organic acid composition as claimed in any one of claims 1 to 6. delete delete delete A toothpaste comprising 5 to 10% by weight of the organic acid composition according to claim 7. delete An oral cleaning agent comprising 5 to 10% by weight of an organic acid composition according to claim 7. delete

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