WO2017110674A1 - Candida microbicide for oral cavity and denture cleanser composition - Google Patents
Candida microbicide for oral cavity and denture cleanser composition Download PDFInfo
- Publication number
- WO2017110674A1 WO2017110674A1 PCT/JP2016/087547 JP2016087547W WO2017110674A1 WO 2017110674 A1 WO2017110674 A1 WO 2017110674A1 JP 2016087547 W JP2016087547 W JP 2016087547W WO 2017110674 A1 WO2017110674 A1 WO 2017110674A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cleaning composition
- denture cleaning
- denture
- candida
- composition according
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds containing nitrogen-to-oxygen bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/131—Amines acyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures
Definitions
- the present invention relates to an oral Candida bactericidal agent having high bactericidal power against Candida bacteria which are resident bacteria in the oral cavity and a denture cleaning composition containing the same.
- Denture plaques which are dirt that adheres to dentures, have a higher proportion of Candida albicans than dental plaques, compared to the microbial composition and structure of normal dental plaques that adhere to teeth. It is reported to be expensive.
- Candida is known to cause oral diseases such as denture stomatitis and stomatitis.
- oral candidiasis is a disease strongly associated with the elderly, It is thought to develop as an opportunistic infection due to abnormal growth. Therefore, the denture cleaning agent is required to have high sterilizing power against Candida bacteria adhering to the denture as well as cleaning power against dirt.
- Fusobacterium nucleatum for dentures, Fusobacterium nucleatum, a bad breath-causing bacterium, porphyromonas gingivalis and Bayonella parvula (P. gingivalis, V. parvula), and Streptococcus mutans (C.
- Various bacteria such as Candida albicans, which are fungi, are established, but fungi such as Candida are less sterilized than other bacteria.
- a cationic bactericidal agent such as a quaternary ammonium salt is necessary for fungi disinfection.
- a cationic bactericide is added to the denture cleaner, substances that affect its bactericidal activity cannot be added, and an anionic surfactant having a high cleaning effect on protein stains cannot be added.
- an anionic surfactant having a high cleaning effect on protein stains cannot be added.
- Patent Document 1 Patent No. 3362403 proposes that sorbic acid or a salt thereof and benzoic acid or a salt thereof are combined in a mouthwash for a denture wearer that prevents the growth of Candida in the oral cavity.
- Patent Document 2 Japanese Patent Application Laid-Open No. 63-147144 proposes a denture cleaning composition containing water-soluble chitin and chitosans and having high ability to desorb Candida bacteria from dentures.
- Japanese Patent No. 3362403 Japanese Unexamined Patent Publication No. 63-14714 JP 2001-510076 JP Japanese Patent No. 5346455 Japanese National Patent Publication No. 11-510550 Special table 2014-520137
- a bactericidal agent for oral cavity that has a high bactericidal power against Candida bacteria, which are adhering to dentures, present in the oral cavity and can be applied to a denture cleaning agent.
- the present invention has been made in view of the above circumstances, and an object thereof is to provide a Candida bactericidal agent for oral cavity and a denture cleaning composition that exhibits a high bactericidal effect against Candida bacteria that are resident bacteria in the oral cavity. .
- alkylamine oxide is higher than the fungus Candida, which is an oral resident bacterium and is a denture-attaching bacterium constituting a denture plaque. It has been found that it has a bactericidal effect and is effective as a Candida fungicide for the oral cavity, particularly for dentures. In addition, it was discovered that by blending this alkylamine oxide into a denture cleaning composition as a Candida fungicide, an excellent bactericidal effect for effectively sterilizing Candida can be provided in a relatively short time. Invented the invention.
- surfactants have some antibacterial and bactericidal action, it is generally not considered and recognized that dentures can be satisfactorily sterilized and washed with surfactants alone.
- the effectiveness of a bactericidal agent differs depending on the bacterial species, and just because a certain bacterium can be sterilized, it does not necessarily mean that a bacterium with a different species can be sterilized.
- the surfactant (A) alkylamine oxide has a remarkable bactericidal effect against Candida bacteria, and is particularly specific in denture cleaning that cannot be achieved with other surfactants. And gives a special effect.
- component (A) when (B) (B-1) anionic surfactant and / or (B-2) betaine amphoteric surfactant are combined with component (A), the combination of such surfactants is excellent. It provides a sterilizing effect and a sufficient and moderate cleaning effect, which makes it possible to effectively sterilize and clean the denture with a relatively gentle action.
- Patent Documents 3 to 6 Japanese Patent Publication No. 2001-510076, Japanese Patent No. 5346455, Japanese Patent Publication No. 11-510550, Japanese Patent Publication No. 2014-520137
- the agent composition can contain an amine oxide surfactant.
- Patent Documents 3 and 4 are antibacterial agents of Escherichia coli, staphylococci, or Pseudomonas aeruginosa
- Patent Document 5 is a detergent and gloss of the surfactant. This is an improvement in performance.
- Patent document 6 is the improvement of the antibacterial and bactericidal properties of a cationic surfactant in a topical antibacterial detergent composition such as hand wash or body wash. From Patent Documents 3 to 6, the specific Candida fungicidal action of alkylamine oxide and its application to a denture cleaning agent cannot be recalled.
- the present invention provides the following oral Candida fungicide and denture cleaning composition.
- A Candida fungicide for oral cavity comprising alkylamine oxide.
- A The Candida fungicide for oral cavity according to [1], wherein the component is an alkyldimethylamine oxide having an alkyl group with 12 to 18 carbon atoms.
- a denture cleaning composition comprising an alkylamine oxide.
- the denture cleaning composition according to [3] wherein the component (A) is an alkyldimethylamine oxide having an alkyl group having 12 to 18 carbon atoms.
- the anionic surfactant is at least one selected from alkyl sulfates, ⁇ -olefin sulfonates and acylamino acid salts;
- (B-2) betaine amphoteric surfactants are alkyl acetate betaines
- the denture cleaning composition according to [6] which is one or more selected from fatty acid amidopropyl betaine and alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine.
- an oral Candida bactericidal agent and a denture cleaning composition that have high bactericidal effects against Candida bacteria that are resident bacteria in the oral cavity and are denture-adhering bacteria. Furthermore, according to the present invention, it is possible to provide a sufficient and appropriate cleaning effect together with the sterilizing effect.
- the alkylamine oxide of component (A) is an active ingredient of a Candida fungicide and is an alkylamine oxide having an alkyl group preferably having 12 to 18 carbon atoms, more preferably 12 to 16 carbon atoms, particularly alkyl Dimethylamine oxide can be used. Specific examples include lauryl dimethylamine oxide.
- alkylamine oxide trade name “Cadenax DM12D-W” (lauryl dimethylamine oxide) manufactured by Lion Specialty Chemicals Co., Ltd. can be used.
- the component (A) alkylamine oxide is preferably used at a concentration of 0.05 to 20% (mass%, the same shall apply hereinafter), more preferably 0.05 to 10%.
- the use concentration is preferably 0.05% or more, and it is 20% or less. It is suitable for preventing the bitterness from remaining.
- the “use concentration” is a sterilization treatment concentration.
- the alkylamine oxide as the component (A) is suitably blended as a Candida fungicide in an oral preparation, particularly a denture cleaning composition.
- the blending amount of the alkylamine oxide as the component (A) in the denture cleaning composition is preferably such that the use concentration of the alkylamine oxide is within the above range, and preferably 0.05 to 20% based on the entire composition. More preferably, it is 0.05 to 10%.
- component alkylamine oxide In addition to (A) component alkylamine oxide, (B) (B-1) anionic surfactant and / or (B-2) betaine amphoteric surfactant are used in the denture cleaning composition. It is preferable to mix. When (B) component is mix
- the component (B) may be (B-1) an anionic surfactant or (B-2) a betaine amphoteric surfactant, but (B-1) an anionic surfactant and (B-2) A betaine amphoteric surfactant may be used in combination.
- Anionic surfactants include alkyl sulfates, ⁇ -olefin sulfonates, acyl amino acid salts, acylmethyl taurine, alkyl phosphates, and the like, one or two selected from these The above can be used.
- alkyl sulfates, ⁇ -olefin sulfonates, and acyl amino acid salts are particularly preferable from the viewpoint of detergency against denture stains.
- Examples of the alkyl sulfate include sodium lauryl sulfate and the like, and commercially available products such as those manufactured by Toho Chemical Industry Co., Ltd. and BASF Corporation can be used.
- alkali metal salts such as sodium and potassium of ⁇ -olefin sulfonic acid having 14 to 16 carbon atoms can be used, preferably ⁇ -olefin sulfonate having 14 carbon atoms, particularly It is a sodium salt (generic name; sodium tetradecene sulfonate).
- Commercial products that can be used for oral preparations can be obtained. For example, “K Liporan PJ-400CJ (powder)” or “Lipolan LB-440 (Liquid)” manufactured by Lion Specialty Chemicals Co., Ltd. ) "Can be used.
- Acyl amino acid salts preferably have an acyl group having 8 to 18 carbon atoms, particularly 12 to 16 carbon atoms, and acyl glutamates, acyl aspartates, acyl sarcosine salts, acyl taurine salts and the like having an acyl group with such carbon number are used.
- Specific examples include lauroyl glutamate, myristoyl glutamate, lauroyl aspartate, lauroyl sarcosine salt, and lauroyl methyl taurate.
- acyl glutamic acid salts and acyl aspartates, particularly acyl glutamates, which are acidic acyl amino acid salts, are preferred, and lauroyl glutamate is particularly preferred.
- As the salt an alkali metal salt is preferable, and a sodium salt is particularly preferable.
- commercially available products such as those manufactured by Asahi Kasei Chemicals Corporation can be used.
- Betaine amphoteric surfactants include alkyl acetate betaine, fatty acid amidopropyl betaine, alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, and the like, one or two selected from these More than seeds can be used.
- the alkyl acetate betaine is preferably an alkyl group having 12 to 16 carbon atoms, and examples thereof include alkylamino acetate betaines such as lauryl dimethylamino acetate betaine. Specifically, commercially available products such as those manufactured by Daiichi Kogyo Seiyaku Co., Ltd. can be used.
- the fatty acid amidopropyl betaine is preferably a fatty acid having 12 to 16 carbon atoms, such as coconut oil fatty acid amidopropyl betaine.
- a fatty acid having 12 to 16 carbon atoms such as coconut oil fatty acid amidopropyl betaine.
- commercially available products such as those manufactured by Sanyo Chemical Industries, Ltd. can be used.
- alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine a commercially available product such as that manufactured by Lion Specialty Chemicals Co., Ltd. can be used.
- the blending amount is preferably 0.005 to 20% of the entire composition, and 0.01 to 10%. More preferably, it is 0.01 to 5%. Within this range, the preferred amount of component (B-1) is 0.005 to 5%, particularly 0.01 to 4% of the total composition, and the preferred amount of component (B-2) Is from 0.01 to 20%, in particular from 0.02 to 10% of the total composition.
- (A) / (B) indicating the blending ratio of the component (A) and the component (B) is preferably 1 to 10 and more preferably 2 to 10 as a mass ratio. Further, within the range of the mass ratio of (A) / (B), (A) / (B-1) is preferably 4 to 10, more preferably 5 to 10, and (A) / (B— 2) is preferably 1 to 5, more preferably 2 to 4. Within this range, the bactericidal effect and the cleaning effect are more excellent.
- the denture cleaning composition of the present invention can be prepared in various dosage forms in the form of solids such as tablets and granules, liquids such as aqueous solutions and emulsions, gels such as pastes and creams, etc. preferable.
- another well-known component can be mix
- flavor, a solvent, a coloring agent etc. are mentioned.
- water is usually used, but about 5 to 20% of polyhydric alcohol or the like can be added.
- Red No. 2 Red No. 3, Red No. 225, Red No. 226, Yellow No. 4, Yellow No. 5, Yellow No. 205, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 204, Green No. 3 etc.
- Legal dye caramel dye, safflower dye, gardenia dye, cochineal dye, anato dye, mica titanium, titanium oxide and the like.
- alkylamine oxide is blended as a Candida fungicide
- a quaternary ammonium salt having a bactericidal action particularly effective for Candida fungicide for example, a cationic surfactant such as cetylpyridinium chloride, or a denture Peroxides such as general sodium percarbonate and sodium perborate as components for cleaning agents, hypochlorous acid or a salt thereof may not be blended, and may be 0%.
- the blending amount is 0.03% or less, particularly 0.01% or less.
- an effective amount of a bactericidal agent such as isopropylmethylphenol, which is a nonionic bactericidal agent effective against oral bacteria other than Candida bacteria, may be added as long as the effects of the present invention are not hindered.
- the pH of the composition at 25 ° C. is preferably 5 to 9, and more preferably 5.5 to 8.
- the pH adjuster include sodium hydroxide, hydrochloric acid, phosphoric acid or a salt thereof, citric acid or a salt thereof, sodium carbonate, sodium bicarbonate, boric acid or a salt thereof.
- the denture cleaning composition of the present invention can be used in a usual manner.
- the denture cleaning composition is used as it is, or the denture cleaning composition is dispersed / dissolved in water as necessary to obtain a diluted aqueous solution.
- the denture can be dipped and then used with water as needed.
- it is desirable that the use concentration of the component (A) is within the above range.
- a liquid preparation it may be a type that is used as it is without being diluted, or a concentrated type that is diluted with water at the time of use and applied to a denture.
- the dilution ratio with water is from 5 to 500 times, particularly from 5 to 400 times, particularly from 10 to 200 times from the viewpoint of usability and solubility. It is preferable to design the concentration of the preparation so that the concentration of the component (A) is within the above-mentioned use concentration range.
- the denture is immersed after being dispersed / dissolved in water, and it may be designed so that the concentration of the component (A) at the time of immersion is within the above-mentioned use concentration range.
- the denture immersion time is preferably 1 minute or longer, more preferably 5 minutes or longer.
- Example 1 A denture cleaning composition (test sample) having the composition shown in Table 1 was prepared by the following method, and the bactericidal activity against Candida was evaluated by the following method. The results are also shown in Table 1.
- a 10-fold dilution series was prepared with an inactivated medium, 50 ⁇ L each of the 10 1 , 10 3 , and 10 5 dilutions were smeared onto the PDA medium, cultured at 25 ° C., and the number of grown colonies was counted.
- the logarithmic decrease value was calculated from the counted number of colonies, and the bactericidal effect against Candida was evaluated according to the following criteria. Evaluation criteria for bactericidal effects against Candida albicans ⁇ : ⁇ log reduction by the action of 5 minutes 3 log 10 or more: less than log reduction by the action of 5 minutes 3 log 10
- tannin iron stain-attached acrylic plate prepared in 2-1 above was immersed in a denture cleaning composition of each example shown in Tables 2 and 3 prepared as a sample for cleaning for 5 minutes. Then, after air-drying at room temperature for 1 day, the Lab plate was washed with running water, air-dried again, and dried, and the Lab value (L2) was measured. The tannin iron stain removal rate was calculated
- required by the formula shown below. Tannin iron stain removal rate (%) [(L1-L2) / (L1-L0)] ⁇ 100 From the tannin iron stain removal rate obtained, the cleaning power against denture soil was evaluated according to the following criteria.
- Tannin iron stain removal rate 30% or more
- Tannin iron stain removal rate 20% or more but less than 30%
- Tannin iron stain removal rate 10% or more but less than 20%
- Tannin iron stain removal rate Less than 10%
- the denture cleaning composition of the prescription example was excellent in the bactericidal effect against Candida and the cleaning power against denture soil.
Abstract
Provided are a candida microbicide for the oral cavity comprising (A) an alkylamine oxide that exerts a high microbicidal effect against the candida that are part of the flora of the oral cavity and are microbes that adhere to dentures, a denture cleanser composition containing the same, and the above-mentioned denture cleanser composition that also contains (B) (B-1) an anionic surfactant and/or (B-2) a betaine amphoteric surfactant.
Description
本発明は、口腔内常在菌であるカンジダ菌に対して高い殺菌力を有する口腔用カンジダ菌殺菌剤及びこれを配合した義歯洗浄剤組成物に関する。
The present invention relates to an oral Candida bactericidal agent having high bactericidal power against Candida bacteria which are resident bacteria in the oral cavity and a denture cleaning composition containing the same.
義歯装着者にとって義歯の衛生管理は、口腔の健康を保つ上で重要である。しかし、義歯を装着した高齢者の口腔ケアは、健常者でも十分ではなく、要介護者では更に清掃不良であることが多い。
For dental prosthesis wearers, dental hygiene management is important for maintaining oral health. However, the oral care of elderly people wearing dentures is not sufficient even for healthy people, and the care recipients often have poorer cleaning.
義歯に付着する汚れであるデンチャープラークは、歯に付着する汚れである通常のデンタルプラークに見られる微生物構成や構造と対比すると、デンチャープラークではデンタルプラークよりもカンジダ菌（Ｃａｎｄｉｄａ ａｌｂｉｃａｎｓ）の構成比が高いことが報告されている。カンジダ菌は、義歯性口内炎や口角炎など口腔疾患の原因になることが知られており、中でも口腔カンジダ症は、高齢者に関連の強い疾患であり、口腔内常在菌であるカンジダ菌の異常増殖によって日和見感染症として発症すると考えられている。
よって、義歯洗浄剤には、汚れに対する洗浄力と共に義歯に付着したカンジダ菌に対する高い除菌力が必要とされている。 Denture plaques, which are dirt that adheres to dentures, have a higher proportion of Candida albicans than dental plaques, compared to the microbial composition and structure of normal dental plaques that adhere to teeth. It is reported to be expensive. Candida is known to cause oral diseases such as denture stomatitis and stomatitis. Among them, oral candidiasis is a disease strongly associated with the elderly, It is thought to develop as an opportunistic infection due to abnormal growth.
Therefore, the denture cleaning agent is required to have high sterilizing power against Candida bacteria adhering to the denture as well as cleaning power against dirt.
よって、義歯洗浄剤には、汚れに対する洗浄力と共に義歯に付着したカンジダ菌に対する高い除菌力が必要とされている。 Denture plaques, which are dirt that adheres to dentures, have a higher proportion of Candida albicans than dental plaques, compared to the microbial composition and structure of normal dental plaques that adhere to teeth. It is reported to be expensive. Candida is known to cause oral diseases such as denture stomatitis and stomatitis. Among them, oral candidiasis is a disease strongly associated with the elderly, It is thought to develop as an opportunistic infection due to abnormal growth.
Therefore, the denture cleaning agent is required to have high sterilizing power against Candida bacteria adhering to the denture as well as cleaning power against dirt.
義歯には、口臭原因菌であるフゾバクテリウム ヌクレアタム（Ｆ．ｎｕｃｌｅａｔｕｍ）、歯周病菌であるポルフィロモナス ジンジバリスやベイヨネラ パルビュラ（Ｐ．ｇｉｎｇｉｖａｌｉｓ、Ｖ．ｐａｒｖｕｌａ）、う蝕原因菌であるストレプトコッカス ミュータンス（Ｓ．ｍｕｔａｎｓ）、真菌であるカンジダ アルビカンズ（Ｃ．ａｌｂｉｃａｎｓ）など、様々な細菌が定着しているが、カンジダ菌などの真菌類は、他の細菌に比べて殺菌されにくい。
For dentures, Fusobacterium nucleatum, a bad breath-causing bacterium, porphyromonas gingivalis and Bayonella parvula (P. gingivalis, V. parvula), and Streptococcus mutans (C. Various bacteria such as Candida albicans, which are fungi, are established, but fungi such as Candida are less sterilized than other bacteria.
真菌類の殺菌には、一般的には第４級アンモニウム塩などのカチオン性殺菌剤の使用が必要であると考えられている。しかし、義歯洗浄剤にカチオン性殺菌剤を配合すると、その殺菌活性に影響する物質は配合できず、タンパク汚れに対して高い洗浄効果を有するアニオン性界面活性剤を配合できなくなるため、真菌類に対する高い殺菌効果とタンパク汚れに対する洗浄効果を有する義歯洗浄剤の開発には課題があった。
It is generally considered that the use of a cationic bactericidal agent such as a quaternary ammonium salt is necessary for fungi disinfection. However, if a cationic bactericide is added to the denture cleaner, substances that affect its bactericidal activity cannot be added, and an anionic surfactant having a high cleaning effect on protein stains cannot be added. There was a problem in developing a denture cleaning agent having a high bactericidal effect and a cleaning effect against protein stains.
特許文献１（特許第３３６２４０３号）では、口腔内のカンジダ菌の繁殖を防止する義歯装着者用洗口剤にソルビン酸又はその塩と安息香酸又はその塩とを併用して配合することが提案され、特許文献２（特開昭６３－１４７１４号公報）には、水溶性キチンや、キトサン類を含み、義歯からのカンジダ菌脱着能が高い義歯洗浄剤組成物が提案されている。
Patent Document 1 (Patent No. 3362403) proposes that sorbic acid or a salt thereof and benzoic acid or a salt thereof are combined in a mouthwash for a denture wearer that prevents the growth of Candida in the oral cavity. Patent Document 2 (Japanese Patent Application Laid-Open No. 63-14714) proposes a denture cleaning composition containing water-soluble chitin and chitosans and having high ability to desorb Candida bacteria from dentures.
従って、口腔内に存在する、義歯付着菌であるカンジダ菌に対して高い殺菌力を有する、義歯洗浄剤に応用できる口腔用殺菌剤の開発が望まれた。
Therefore, it has been desired to develop a bactericidal agent for oral cavity that has a high bactericidal power against Candida bacteria, which are adhering to dentures, present in the oral cavity and can be applied to a denture cleaning agent.
本発明は、上記事情に鑑みなされたもので、口腔内常在菌であるカンジダ菌に対して高い殺菌効果を奏する口腔用カンジダ菌殺菌剤及び義歯洗浄剤組成物を提供することを目的とする。
The present invention has been made in view of the above circumstances, and an object thereof is to provide a Candida bactericidal agent for oral cavity and a denture cleaning composition that exhibits a high bactericidal effect against Candida bacteria that are resident bacteria in the oral cavity. .
本発明者らは上記目的を達成するため鋭意検討を行った結果、アルキルアミンオキシドが、口腔内常在菌であって、デンチャープラークを構成する義歯付着菌である真菌のカンジダ菌に対して高い殺菌効果を奏し、口腔用、特に義歯用のカンジダ菌殺菌剤として有効であることを知見した。また、このアルキルアミンオキシドをカンジダ菌殺菌剤として義歯洗浄剤組成物に配合することによって、比較的短時間で効果的にカンジダ菌を殺菌する優れた殺菌効果を付与し得ることを知見し、本発明をなすに至った。
As a result of intensive studies to achieve the above-mentioned object, the present inventors have found that alkylamine oxide is higher than the fungus Candida, which is an oral resident bacterium and is a denture-attaching bacterium constituting a denture plaque. It has been found that it has a bactericidal effect and is effective as a Candida fungicide for the oral cavity, particularly for dentures. In addition, it was discovered that by blending this alkylamine oxide into a denture cleaning composition as a Candida fungicide, an excellent bactericidal effect for effectively sterilizing Candida can be provided in a relatively short time. Invented the invention.
更に詳述すると、界面活性剤にはある程度の抗菌、殺菌作用が認められるものの、界面活性剤だけで義歯を満足に殺菌及び洗浄し得るとは、一般的には考えらず、認識されていない。一方で、殺菌剤の有効性は細菌の菌種によって相違し、ある細菌を殺菌し得るからといって、それとは性質等が異なる菌種の違う細菌まで殺菌できるとは限らないものである。これに対して、本発明では、界面活性剤の（Ａ）アルキルアミンオキシドが、カンジダ菌に対して顕著な殺菌効果を奏し、特に義歯洗浄において、他の界面活性剤では達成し得ない特異的かつ格別な作用効果を与える。
更に、本発明では、（Ａ）成分に（Ｂ）（Ｂ－１）アニオン性界面活性剤及び／又は（Ｂ－２）ベタイン両性界面活性剤を組み合わせると、かかる界面活性剤の組み合わせが優れた殺菌効果及び十分かつ適度な洗浄効果を与え、これにより、比較的穏やかな作用によって、義歯を効果的に殺菌及び洗浄することも可能となる。 More specifically, although surfactants have some antibacterial and bactericidal action, it is generally not considered and recognized that dentures can be satisfactorily sterilized and washed with surfactants alone. . On the other hand, the effectiveness of a bactericidal agent differs depending on the bacterial species, and just because a certain bacterium can be sterilized, it does not necessarily mean that a bacterium with a different species can be sterilized. On the other hand, in the present invention, the surfactant (A) alkylamine oxide has a remarkable bactericidal effect against Candida bacteria, and is particularly specific in denture cleaning that cannot be achieved with other surfactants. And gives a special effect.
Further, in the present invention, when (B) (B-1) anionic surfactant and / or (B-2) betaine amphoteric surfactant are combined with component (A), the combination of such surfactants is excellent. It provides a sterilizing effect and a sufficient and moderate cleaning effect, which makes it possible to effectively sterilize and clean the denture with a relatively gentle action.
更に、本発明では、（Ａ）成分に（Ｂ）（Ｂ－１）アニオン性界面活性剤及び／又は（Ｂ－２）ベタイン両性界面活性剤を組み合わせると、かかる界面活性剤の組み合わせが優れた殺菌効果及び十分かつ適度な洗浄効果を与え、これにより、比較的穏やかな作用によって、義歯を効果的に殺菌及び洗浄することも可能となる。 More specifically, although surfactants have some antibacterial and bactericidal action, it is generally not considered and recognized that dentures can be satisfactorily sterilized and washed with surfactants alone. . On the other hand, the effectiveness of a bactericidal agent differs depending on the bacterial species, and just because a certain bacterium can be sterilized, it does not necessarily mean that a bacterium with a different species can be sterilized. On the other hand, in the present invention, the surfactant (A) alkylamine oxide has a remarkable bactericidal effect against Candida bacteria, and is particularly specific in denture cleaning that cannot be achieved with other surfactants. And gives a special effect.
Further, in the present invention, when (B) (B-1) anionic surfactant and / or (B-2) betaine amphoteric surfactant are combined with component (A), the combination of such surfactants is excellent. It provides a sterilizing effect and a sufficient and moderate cleaning effect, which makes it possible to effectively sterilize and clean the denture with a relatively gentle action.
なお、特許文献３～６（特表２００１－５１００７６号公報、特許第５３４６４５５号公報、特表平１１－５１０５５０号公報、特表２０１４－５２０１３７号公報）に開示された洗浄剤組成物、抗菌洗浄剤組成物は、アミンオキシド界面活性剤を配合し得るものであるが、特許文献３、４は大腸菌、ブドウ球菌又は緑膿菌の抗菌であり、特許文献５は界面活性剤の洗浄性及び光沢性能の向上である。特許文献６は、ハンドウオッシュ、ボディーウオッシュ等の局所抗菌洗浄剤組成物における、カチオン界面活性剤の抗菌及び殺菌特性の改善である。特許文献３～６から、アルキルアミンオキシドの特異的なカンジダ菌殺菌作用、その義歯洗浄剤への応用を想起することはできない。
Note that the detergent composition and antibacterial cleaning disclosed in Patent Documents 3 to 6 (Japanese Patent Publication No. 2001-510076, Japanese Patent No. 5346455, Japanese Patent Publication No. 11-510550, Japanese Patent Publication No. 2014-520137) The agent composition can contain an amine oxide surfactant. Patent Documents 3 and 4 are antibacterial agents of Escherichia coli, staphylococci, or Pseudomonas aeruginosa, and Patent Document 5 is a detergent and gloss of the surfactant. This is an improvement in performance. Patent document 6 is the improvement of the antibacterial and bactericidal properties of a cationic surfactant in a topical antibacterial detergent composition such as hand wash or body wash. From Patent Documents 3 to 6, the specific Candida fungicidal action of alkylamine oxide and its application to a denture cleaning agent cannot be recalled.
従って、本発明は、下記の口腔用カンジダ菌殺菌剤及び義歯洗浄剤組成物を提供する。
〔１〕
（Ａ）アルキルアミンオキシドからなる口腔用カンジダ菌殺菌剤。
〔２〕
（Ａ）成分が、アルキル基の炭素数が１２～１８であるアルキルジメチルアミンオキシドである〔１〕に記載の口腔用カンジダ菌殺菌剤。
〔３〕
（Ａ）アルキルアミンオキシドを含有してなる義歯洗浄剤組成物。
〔４〕
（Ａ）成分が、アルキル基の炭素数が１２～１８であるアルキルジメチルアミンオキシドである〔３〕に記載の義歯洗浄剤組成物。
〔５〕
（Ａ）成分を０．０５～２０質量％含有する〔３〕又は〔４〕に記載の義歯洗浄剤組成物。
〔６〕
更に、（Ｂ）（Ｂ－１）アニオン性界面活性剤及び／又は（Ｂ－２）ベタイン両性界面活性剤を含有する〔３〕、〔４〕又は〔５〕に記載の義歯洗浄剤組成物。
〔７〕
（Ｂ－１）アニオン性界面活性剤が、アルキル硫酸塩、α－オレフィンスルホン酸塩及びアシルアミノ酸塩から選ばれる１種以上であり、（Ｂ－２）ベタイン両性界面活性剤が、アルキル酢酸ベタイン、脂肪酸アミドプロピルベタイン及びアルキル－Ｎ－カルボキシメチル－Ｎ－ヒドロキシエチルイミダゾリニウムベタインから選ばれる１種以上である〔６〕に記載の義歯洗浄剤組成物。
〔８〕
（Ａ）成分と（Ｂ）成分との配合比率を示す（Ａ）／（Ｂ）が、質量比として１～１０である〔６〕又は〔７〕に記載の義歯洗浄剤組成物。
〔９〕
（Ｂ）成分を０．０１～１０質量％含有する〔６〕、〔７〕又は〔８〕に記載の義歯洗浄剤組成物。
〔１０〕
カチオン性界面活性剤を含有しないか、又はカチオン性界面活性剤を含有しその含有量が０．０３質量％以下である〔３〕～〔９〕のいずれかに記載の義歯洗浄剤組成物。
〔１１〕
過酸化物を含有しないか、又は過酸化物を含有しその含有量が０．０３質量％以下である〔３〕～〔１０〕のいずれかに記載の義歯洗浄剤組成物。
〔１２〕
組成物の２５℃におけるｐＨが５～９である〔３〕～〔１１〕のいずれかに記載の義歯洗浄剤組成物。
〔１３〕
液体製剤である〔３〕～〔１２〕のいずれかに記載の義歯洗浄剤組成物。 Accordingly, the present invention provides the following oral Candida fungicide and denture cleaning composition.
[1]
(A) Candida fungicide for oral cavity comprising alkylamine oxide.
[2]
(A) The Candida fungicide for oral cavity according to [1], wherein the component is an alkyldimethylamine oxide having an alkyl group with 12 to 18 carbon atoms.
[3]
(A) A denture cleaning composition comprising an alkylamine oxide.
[4]
The denture cleaning composition according to [3], wherein the component (A) is an alkyldimethylamine oxide having an alkyl group having 12 to 18 carbon atoms.
[5]
The denture cleaning composition according to [3] or [4], which contains 0.05 to 20% by mass of component (A).
[6]
The denture cleaning composition according to [3], [4] or [5], further comprising (B) (B-1) an anionic surfactant and / or (B-2) a betaine amphoteric surfactant .
[7]
(B-1) the anionic surfactant is at least one selected from alkyl sulfates, α-olefin sulfonates and acylamino acid salts; (B-2) betaine amphoteric surfactants are alkyl acetate betaines The denture cleaning composition according to [6], which is one or more selected from fatty acid amidopropyl betaine and alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine.
[8]
The denture cleaning composition according to [6] or [7], wherein (A) / (B) indicating the blending ratio of component (A) and component (B) is 1 to 10 as a mass ratio.
[9]
The denture cleaning composition according to [6], [7] or [8], which contains 0.01 to 10% by mass of component (B).
[10]
The denture cleaning composition according to any one of [3] to [9], which does not contain a cationic surfactant or contains a cationic surfactant and has a content of 0.03% by mass or less.
[11]
The denture cleaning composition according to any one of [3] to [10], which does not contain a peroxide or contains a peroxide and has a content of 0.03% by mass or less.
[12]
The denture cleaning composition according to any one of [3] to [11], wherein the composition has a pH of 5 to 9 at 25 ° C.
[13]
The denture cleaning composition according to any one of [3] to [12], which is a liquid preparation.
〔１〕
（Ａ）アルキルアミンオキシドからなる口腔用カンジダ菌殺菌剤。
〔２〕
（Ａ）成分が、アルキル基の炭素数が１２～１８であるアルキルジメチルアミンオキシドである〔１〕に記載の口腔用カンジダ菌殺菌剤。
〔３〕
（Ａ）アルキルアミンオキシドを含有してなる義歯洗浄剤組成物。
〔４〕
（Ａ）成分が、アルキル基の炭素数が１２～１８であるアルキルジメチルアミンオキシドである〔３〕に記載の義歯洗浄剤組成物。
〔５〕
（Ａ）成分を０．０５～２０質量％含有する〔３〕又は〔４〕に記載の義歯洗浄剤組成物。
〔６〕
更に、（Ｂ）（Ｂ－１）アニオン性界面活性剤及び／又は（Ｂ－２）ベタイン両性界面活性剤を含有する〔３〕、〔４〕又は〔５〕に記載の義歯洗浄剤組成物。
〔７〕
（Ｂ－１）アニオン性界面活性剤が、アルキル硫酸塩、α－オレフィンスルホン酸塩及びアシルアミノ酸塩から選ばれる１種以上であり、（Ｂ－２）ベタイン両性界面活性剤が、アルキル酢酸ベタイン、脂肪酸アミドプロピルベタイン及びアルキル－Ｎ－カルボキシメチル－Ｎ－ヒドロキシエチルイミダゾリニウムベタインから選ばれる１種以上である〔６〕に記載の義歯洗浄剤組成物。
〔８〕
（Ａ）成分と（Ｂ）成分との配合比率を示す（Ａ）／（Ｂ）が、質量比として１～１０である〔６〕又は〔７〕に記載の義歯洗浄剤組成物。
〔９〕
（Ｂ）成分を０．０１～１０質量％含有する〔６〕、〔７〕又は〔８〕に記載の義歯洗浄剤組成物。
〔１０〕
カチオン性界面活性剤を含有しないか、又はカチオン性界面活性剤を含有しその含有量が０．０３質量％以下である〔３〕～〔９〕のいずれかに記載の義歯洗浄剤組成物。
〔１１〕
過酸化物を含有しないか、又は過酸化物を含有しその含有量が０．０３質量％以下である〔３〕～〔１０〕のいずれかに記載の義歯洗浄剤組成物。
〔１２〕
組成物の２５℃におけるｐＨが５～９である〔３〕～〔１１〕のいずれかに記載の義歯洗浄剤組成物。
〔１３〕
液体製剤である〔３〕～〔１２〕のいずれかに記載の義歯洗浄剤組成物。 Accordingly, the present invention provides the following oral Candida fungicide and denture cleaning composition.
[1]
(A) Candida fungicide for oral cavity comprising alkylamine oxide.
[2]
(A) The Candida fungicide for oral cavity according to [1], wherein the component is an alkyldimethylamine oxide having an alkyl group with 12 to 18 carbon atoms.
[3]
(A) A denture cleaning composition comprising an alkylamine oxide.
[4]
The denture cleaning composition according to [3], wherein the component (A) is an alkyldimethylamine oxide having an alkyl group having 12 to 18 carbon atoms.
[5]
The denture cleaning composition according to [3] or [4], which contains 0.05 to 20% by mass of component (A).
[6]
The denture cleaning composition according to [3], [4] or [5], further comprising (B) (B-1) an anionic surfactant and / or (B-2) a betaine amphoteric surfactant .
[7]
(B-1) the anionic surfactant is at least one selected from alkyl sulfates, α-olefin sulfonates and acylamino acid salts; (B-2) betaine amphoteric surfactants are alkyl acetate betaines The denture cleaning composition according to [6], which is one or more selected from fatty acid amidopropyl betaine and alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine.
[8]
The denture cleaning composition according to [6] or [7], wherein (A) / (B) indicating the blending ratio of component (A) and component (B) is 1 to 10 as a mass ratio.
[9]
The denture cleaning composition according to [6], [7] or [8], which contains 0.01 to 10% by mass of component (B).
[10]
The denture cleaning composition according to any one of [3] to [9], which does not contain a cationic surfactant or contains a cationic surfactant and has a content of 0.03% by mass or less.
[11]
The denture cleaning composition according to any one of [3] to [10], which does not contain a peroxide or contains a peroxide and has a content of 0.03% by mass or less.
[12]
The denture cleaning composition according to any one of [3] to [11], wherein the composition has a pH of 5 to 9 at 25 ° C.
[13]
The denture cleaning composition according to any one of [3] to [12], which is a liquid preparation.
本発明によれば、口腔内常在菌であって、義歯付着菌であるカンジダ菌に対して高い殺菌効果を奏する口腔用カンジダ菌殺菌剤及び義歯洗浄剤組成物を提供できる。更に、本発明によれば、前記殺菌効果と共に十分かつ適度な洗浄効果を与えることも可能である。
According to the present invention, it is possible to provide an oral Candida bactericidal agent and a denture cleaning composition that have high bactericidal effects against Candida bacteria that are resident bacteria in the oral cavity and are denture-adhering bacteria. Furthermore, according to the present invention, it is possible to provide a sufficient and appropriate cleaning effect together with the sterilizing effect.
以下、本発明につき更に詳述する。
本発明において、（Ａ）成分のアルキルアミンオキシドは、カンジダ菌殺菌剤の有効成分であり、アルキル基の炭素数が好ましくは１２～１８、より好ましくは１２～１６であるアルキルアミンオキシド、特にアルキルジメチルアミンオキシドを用いることができる。具体的には、ラウリルジメチルアミンオキシド等が挙げられる。
アルキルアミンオキシドとしては、ライオン・スペシャリティ・ケミカルズ（株）製の商品名「カデナックスＤＭ１２Ｄ－Ｗ」（ラウリルジメチルアミンオキシド）等を使用し得る。 The present invention will be described in further detail below.
In the present invention, the alkylamine oxide of component (A) is an active ingredient of a Candida fungicide and is an alkylamine oxide having an alkyl group preferably having 12 to 18 carbon atoms, more preferably 12 to 16 carbon atoms, particularly alkyl Dimethylamine oxide can be used. Specific examples include lauryl dimethylamine oxide.
As the alkylamine oxide, trade name “Cadenax DM12D-W” (lauryl dimethylamine oxide) manufactured by Lion Specialty Chemicals Co., Ltd. can be used.
本発明において、（Ａ）成分のアルキルアミンオキシドは、カンジダ菌殺菌剤の有効成分であり、アルキル基の炭素数が好ましくは１２～１８、より好ましくは１２～１６であるアルキルアミンオキシド、特にアルキルジメチルアミンオキシドを用いることができる。具体的には、ラウリルジメチルアミンオキシド等が挙げられる。
アルキルアミンオキシドとしては、ライオン・スペシャリティ・ケミカルズ（株）製の商品名「カデナックスＤＭ１２Ｄ－Ｗ」（ラウリルジメチルアミンオキシド）等を使用し得る。 The present invention will be described in further detail below.
In the present invention, the alkylamine oxide of component (A) is an active ingredient of a Candida fungicide and is an alkylamine oxide having an alkyl group preferably having 12 to 18 carbon atoms, more preferably 12 to 16 carbon atoms, particularly alkyl Dimethylamine oxide can be used. Specific examples include lauryl dimethylamine oxide.
As the alkylamine oxide, trade name “Cadenax DM12D-W” (lauryl dimethylamine oxide) manufactured by Lion Specialty Chemicals Co., Ltd. can be used.
（Ａ）成分のアルキルアミンオキシドは、濃度０．０５～２０％（質量％、以下同様。）で使用することが好ましく、より好ましくは０．０５～１０％である。カンジダ菌への殺菌効果を十分に発現させるには、使用濃度が０．０５％以上であることが好ましく、２０％以下であることが、義歯洗浄剤に配合した際に義歯へのヌルつきや苦味が残るのを防止するには好適である。前記「使用濃度」は、殺菌処理濃度である。
The component (A) alkylamine oxide is preferably used at a concentration of 0.05 to 20% (mass%, the same shall apply hereinafter), more preferably 0.05 to 10%. In order to sufficiently exhibit the bactericidal effect on Candida, the use concentration is preferably 0.05% or more, and it is 20% or less. It is suitable for preventing the bitterness from remaining. The “use concentration” is a sterilization treatment concentration.
本発明において、（Ａ）成分のアルキルアミンオキシドは、カンジダ菌殺菌剤として口腔用製剤、特に義歯洗浄剤組成物に好適に配合される。
義歯洗浄剤組成物への（Ａ）成分のアルキルアミンオキシドの配合量は、アルキルアミンオキシドの使用濃度が上記範囲内であることが好ましく、組成物全体に対して好ましくは０．０５～２０％、より好ましくは０．０５～１０％である。 In the present invention, the alkylamine oxide as the component (A) is suitably blended as a Candida fungicide in an oral preparation, particularly a denture cleaning composition.
The blending amount of the alkylamine oxide as the component (A) in the denture cleaning composition is preferably such that the use concentration of the alkylamine oxide is within the above range, and preferably 0.05 to 20% based on the entire composition. More preferably, it is 0.05 to 10%.
義歯洗浄剤組成物への（Ａ）成分のアルキルアミンオキシドの配合量は、アルキルアミンオキシドの使用濃度が上記範囲内であることが好ましく、組成物全体に対して好ましくは０．０５～２０％、より好ましくは０．０５～１０％である。 In the present invention, the alkylamine oxide as the component (A) is suitably blended as a Candida fungicide in an oral preparation, particularly a denture cleaning composition.
The blending amount of the alkylamine oxide as the component (A) in the denture cleaning composition is preferably such that the use concentration of the alkylamine oxide is within the above range, and preferably 0.05 to 20% based on the entire composition. More preferably, it is 0.05 to 10%.
義歯洗浄剤組成物には、（Ａ）成分のアルキルアミンオキシドに加えて、更に、（Ｂ）（Ｂ－１）アニオン性界面活性剤及び／又は（Ｂ－２）ベタイン両性界面活性剤を併用配合することが好ましい。（Ｂ）成分を配合すると、義歯汚れに対する洗浄効果が向上する。なお、（Ｂ）成分は（Ｂ－１）アニオン性界面活性剤又は（Ｂ－２）ベタイン両性界面活性剤の単独でもよいが、効果発現の点で（Ｂ－１）アニオン性界面活性剤及び（Ｂ－２）ベタイン両性界面活性剤を併用してもよい。
In addition to (A) component alkylamine oxide, (B) (B-1) anionic surfactant and / or (B-2) betaine amphoteric surfactant are used in the denture cleaning composition. It is preferable to mix. When (B) component is mix | blended, the cleaning effect with respect to denture dirt will improve. The component (B) may be (B-1) an anionic surfactant or (B-2) a betaine amphoteric surfactant, but (B-1) an anionic surfactant and (B-2) A betaine amphoteric surfactant may be used in combination.
（Ｂ－１）アニオン性界面活性剤としては、アルキル硫酸塩、α－オレフィンスルホン酸塩、アシルアミノ酸塩、アシルメチルタウリン、アルキルリン酸塩等が挙げられ、これらから選ばれる１種又は２種以上を使用し得る。中でも、義歯汚れに対する洗浄力の点から、特にアルキル硫酸塩、α－オレフィンスルホン酸塩、アシルアミノ酸塩が好ましい。
アルキル硫酸塩としては、ラウリル硫酸ナトリウム等が挙げられ、東邦化学工業（株）製やＢＡＳＦ社製などの市販品を用いることができる。
α－オレフィンスルホン酸塩としては、炭素数が１４～１６のα－オレフィンスルホン酸のナトリウム、カリウム等のアルカリ金属塩を用いることができ、好ましくは炭素数１４のα－オレフィンスルホン酸塩、特にナトリウム塩（一般名；テトラデセンスルホン酸ナトリウム）である。これらは口腔用製剤に使用可能な市販品を入手することができ、例えばライオン・スペシャリティ・ケミカルズ（株）製の商品名「ＫリポランＰＪ－４００ＣＪ（粉体）」や「リポランＬＢ－４４０（液体）」を使用し得る。
アシルアミノ酸塩は、アシル基の炭素数が好ましくは８～１８、特に１２～１６であり、かかる炭素数のアシル基を有するアシルグルタミン酸塩、アシルアスパラギン酸塩、アシルサルコシン塩、アシルタウリン塩等が挙げられる。具体的には、ラウロイルグルタミン酸塩、ミリストイルグルタミン酸塩、ラウロイルアスパラギン酸塩、ラウロイルサルコシン塩、ラウロイルメチルタウリン塩等が挙げられる。中でも、酸性アシルアミノ酸塩であるアシルグルタミン酸塩、アシルアスパラギン酸塩、特にアシルグルタミン酸塩が好ましく、とりわけラウロイルグルタミン酸塩が好ましい。塩としては、アルカリ金属塩が好ましく、ナトリウム塩が特に好ましい。具体的には、旭化成ケミカルズ（株）製等の市販品を使用できる。 (B-1) Anionic surfactants include alkyl sulfates, α-olefin sulfonates, acyl amino acid salts, acylmethyl taurine, alkyl phosphates, and the like, one or two selected from these The above can be used. Of these, alkyl sulfates, α-olefin sulfonates, and acyl amino acid salts are particularly preferable from the viewpoint of detergency against denture stains.
Examples of the alkyl sulfate include sodium lauryl sulfate and the like, and commercially available products such as those manufactured by Toho Chemical Industry Co., Ltd. and BASF Corporation can be used.
As the α-olefin sulfonate, alkali metal salts such as sodium and potassium of α-olefin sulfonic acid having 14 to 16 carbon atoms can be used, preferably α-olefin sulfonate having 14 carbon atoms, particularly It is a sodium salt (generic name; sodium tetradecene sulfonate). Commercial products that can be used for oral preparations can be obtained. For example, “K Liporan PJ-400CJ (powder)” or “Lipolan LB-440 (Liquid)” manufactured by Lion Specialty Chemicals Co., Ltd. ) "Can be used.
Acyl amino acid salts preferably have an acyl group having 8 to 18 carbon atoms, particularly 12 to 16 carbon atoms, and acyl glutamates, acyl aspartates, acyl sarcosine salts, acyl taurine salts and the like having an acyl group with such carbon number are used. Can be mentioned. Specific examples include lauroyl glutamate, myristoyl glutamate, lauroyl aspartate, lauroyl sarcosine salt, and lauroyl methyl taurate. Of these, acyl glutamic acid salts and acyl aspartates, particularly acyl glutamates, which are acidic acyl amino acid salts, are preferred, and lauroyl glutamate is particularly preferred. As the salt, an alkali metal salt is preferable, and a sodium salt is particularly preferable. Specifically, commercially available products such as those manufactured by Asahi Kasei Chemicals Corporation can be used.
アルキル硫酸塩としては、ラウリル硫酸ナトリウム等が挙げられ、東邦化学工業（株）製やＢＡＳＦ社製などの市販品を用いることができる。
α－オレフィンスルホン酸塩としては、炭素数が１４～１６のα－オレフィンスルホン酸のナトリウム、カリウム等のアルカリ金属塩を用いることができ、好ましくは炭素数１４のα－オレフィンスルホン酸塩、特にナトリウム塩（一般名；テトラデセンスルホン酸ナトリウム）である。これらは口腔用製剤に使用可能な市販品を入手することができ、例えばライオン・スペシャリティ・ケミカルズ（株）製の商品名「ＫリポランＰＪ－４００ＣＪ（粉体）」や「リポランＬＢ－４４０（液体）」を使用し得る。
アシルアミノ酸塩は、アシル基の炭素数が好ましくは８～１８、特に１２～１６であり、かかる炭素数のアシル基を有するアシルグルタミン酸塩、アシルアスパラギン酸塩、アシルサルコシン塩、アシルタウリン塩等が挙げられる。具体的には、ラウロイルグルタミン酸塩、ミリストイルグルタミン酸塩、ラウロイルアスパラギン酸塩、ラウロイルサルコシン塩、ラウロイルメチルタウリン塩等が挙げられる。中でも、酸性アシルアミノ酸塩であるアシルグルタミン酸塩、アシルアスパラギン酸塩、特にアシルグルタミン酸塩が好ましく、とりわけラウロイルグルタミン酸塩が好ましい。塩としては、アルカリ金属塩が好ましく、ナトリウム塩が特に好ましい。具体的には、旭化成ケミカルズ（株）製等の市販品を使用できる。 (B-1) Anionic surfactants include alkyl sulfates, α-olefin sulfonates, acyl amino acid salts, acylmethyl taurine, alkyl phosphates, and the like, one or two selected from these The above can be used. Of these, alkyl sulfates, α-olefin sulfonates, and acyl amino acid salts are particularly preferable from the viewpoint of detergency against denture stains.
Examples of the alkyl sulfate include sodium lauryl sulfate and the like, and commercially available products such as those manufactured by Toho Chemical Industry Co., Ltd. and BASF Corporation can be used.
As the α-olefin sulfonate, alkali metal salts such as sodium and potassium of α-olefin sulfonic acid having 14 to 16 carbon atoms can be used, preferably α-olefin sulfonate having 14 carbon atoms, particularly It is a sodium salt (generic name; sodium tetradecene sulfonate). Commercial products that can be used for oral preparations can be obtained. For example, “K Liporan PJ-400CJ (powder)” or “Lipolan LB-440 (Liquid)” manufactured by Lion Specialty Chemicals Co., Ltd. ) "Can be used.
Acyl amino acid salts preferably have an acyl group having 8 to 18 carbon atoms, particularly 12 to 16 carbon atoms, and acyl glutamates, acyl aspartates, acyl sarcosine salts, acyl taurine salts and the like having an acyl group with such carbon number are used. Can be mentioned. Specific examples include lauroyl glutamate, myristoyl glutamate, lauroyl aspartate, lauroyl sarcosine salt, and lauroyl methyl taurate. Of these, acyl glutamic acid salts and acyl aspartates, particularly acyl glutamates, which are acidic acyl amino acid salts, are preferred, and lauroyl glutamate is particularly preferred. As the salt, an alkali metal salt is preferable, and a sodium salt is particularly preferable. Specifically, commercially available products such as those manufactured by Asahi Kasei Chemicals Corporation can be used.
（Ｂ－２）ベタイン両性界面活性剤としては、アルキル酢酸ベタイン、脂肪酸アミドプロピルベタイン、アルキル－Ｎ－カルボキシメチル－Ｎ－ヒドロキシエチルイミダゾリニウムベタイン等が挙げられ、これらから選ばれる１種又は２種以上を使用し得る。
アルキル酢酸ベタインとしては、アルキル基の炭素数１２～１６のものが好ましく、例えばラウリルジメチルアミノ酢酸ベタイン等のアルキルアミノ酢酸ベタインなどが挙げられる。具体的には、第一工業製薬（株）製などの市販品を用いることができる。
脂肪酸アミドプロピルベタインとしては、脂肪酸の炭素数１２～１６のものが好ましく、例えばヤシ油脂肪酸アミドプロピルベタイン等が挙げられる。具体的には、三洋化成工業（株）製などの市販品を用いることができる。
アルキル－Ｎ－カルボキシメチル－Ｎ－ヒドロキシエチルイミダゾリニウムベタインとしては、具体的にライオン・スペシャリティ・ケミカルズ（株）製などの市販品を用いることができる。 (B-2) Betaine amphoteric surfactants include alkyl acetate betaine, fatty acid amidopropyl betaine, alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, and the like, one or two selected from these More than seeds can be used.
The alkyl acetate betaine is preferably an alkyl group having 12 to 16 carbon atoms, and examples thereof include alkylamino acetate betaines such as lauryl dimethylamino acetate betaine. Specifically, commercially available products such as those manufactured by Daiichi Kogyo Seiyaku Co., Ltd. can be used.
The fatty acid amidopropyl betaine is preferably a fatty acid having 12 to 16 carbon atoms, such as coconut oil fatty acid amidopropyl betaine. Specifically, commercially available products such as those manufactured by Sanyo Chemical Industries, Ltd. can be used.
As the alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, a commercially available product such as that manufactured by Lion Specialty Chemicals Co., Ltd. can be used.
アルキル酢酸ベタインとしては、アルキル基の炭素数１２～１６のものが好ましく、例えばラウリルジメチルアミノ酢酸ベタイン等のアルキルアミノ酢酸ベタインなどが挙げられる。具体的には、第一工業製薬（株）製などの市販品を用いることができる。
脂肪酸アミドプロピルベタインとしては、脂肪酸の炭素数１２～１６のものが好ましく、例えばヤシ油脂肪酸アミドプロピルベタイン等が挙げられる。具体的には、三洋化成工業（株）製などの市販品を用いることができる。
アルキル－Ｎ－カルボキシメチル－Ｎ－ヒドロキシエチルイミダゾリニウムベタインとしては、具体的にライオン・スペシャリティ・ケミカルズ（株）製などの市販品を用いることができる。 (B-2) Betaine amphoteric surfactants include alkyl acetate betaine, fatty acid amidopropyl betaine, alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, and the like, one or two selected from these More than seeds can be used.
The alkyl acetate betaine is preferably an alkyl group having 12 to 16 carbon atoms, and examples thereof include alkylamino acetate betaines such as lauryl dimethylamino acetate betaine. Specifically, commercially available products such as those manufactured by Daiichi Kogyo Seiyaku Co., Ltd. can be used.
The fatty acid amidopropyl betaine is preferably a fatty acid having 12 to 16 carbon atoms, such as coconut oil fatty acid amidopropyl betaine. Specifically, commercially available products such as those manufactured by Sanyo Chemical Industries, Ltd. can be used.
As the alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, a commercially available product such as that manufactured by Lion Specialty Chemicals Co., Ltd. can be used.
（Ｂ）成分（（Ｂ－１）及び／又は（Ｂ－２）成分）を配合する場合、その配合量は、組成物全体の０．００５～２０％が好ましく、０．０１～１０％がより好ましく、更に好ましくは０．０１～５％である。なお、この範囲内において、（Ｂ－１）成分の好ましい配合量は、組成物全体の０．００５～５％、特に０．０１～４％であり、（Ｂ－２）成分の好ましい配合量は、組成物全体の０．０１～２０％、特に０．０２～１０％である。
When the component (B) (the component (B-1) and / or the component (B-2)) is blended, the blending amount is preferably 0.005 to 20% of the entire composition, and 0.01 to 10%. More preferably, it is 0.01 to 5%. Within this range, the preferred amount of component (B-1) is 0.005 to 5%, particularly 0.01 to 4% of the total composition, and the preferred amount of component (B-2) Is from 0.01 to 20%, in particular from 0.02 to 10% of the total composition.
更に、（Ｂ）成分を配合する場合は、（Ａ）成分と（Ｂ）成分（（Ｂ－１）及び／又は（Ｂ－２）成分）との配合比率が特定範囲内であると、カンジダ菌に対する殺菌効果及び義歯汚れに対する洗浄効果がより向上する。
（Ａ）成分と（Ｂ）成分との配合割合を示す（Ａ）／（Ｂ）は、質量比として１～１０が好ましく、より好ましくは２～１０である。
また、上記（Ａ）／（Ｂ）の質量比の範囲内において、（Ａ）／（Ｂ－１）は好ましくは４～１０、より好ましくは５～１０であり、（Ａ）／（Ｂ－２）は好ましくは１～５、より好ましくは２～４である。この範囲内で、殺菌効果及び洗浄効果がより優れる。 Further, when blending the component (B), if the blending ratio of the component (A) and the component (B) (the component (B-1) and / or (B-2)) is within a specific range, Candida The bactericidal effect against bacteria and the cleaning effect against denture dirt are further improved.
(A) / (B) indicating the blending ratio of the component (A) and the component (B) is preferably 1 to 10 and more preferably 2 to 10 as a mass ratio.
Further, within the range of the mass ratio of (A) / (B), (A) / (B-1) is preferably 4 to 10, more preferably 5 to 10, and (A) / (B— 2) is preferably 1 to 5, more preferably 2 to 4. Within this range, the bactericidal effect and the cleaning effect are more excellent.
（Ａ）成分と（Ｂ）成分との配合割合を示す（Ａ）／（Ｂ）は、質量比として１～１０が好ましく、より好ましくは２～１０である。
また、上記（Ａ）／（Ｂ）の質量比の範囲内において、（Ａ）／（Ｂ－１）は好ましくは４～１０、より好ましくは５～１０であり、（Ａ）／（Ｂ－２）は好ましくは１～５、より好ましくは２～４である。この範囲内で、殺菌効果及び洗浄効果がより優れる。 Further, when blending the component (B), if the blending ratio of the component (A) and the component (B) (the component (B-1) and / or (B-2)) is within a specific range, Candida The bactericidal effect against bacteria and the cleaning effect against denture dirt are further improved.
(A) / (B) indicating the blending ratio of the component (A) and the component (B) is preferably 1 to 10 and more preferably 2 to 10 as a mass ratio.
Further, within the range of the mass ratio of (A) / (B), (A) / (B-1) is preferably 4 to 10, more preferably 5 to 10, and (A) / (B— 2) is preferably 1 to 5, more preferably 2 to 4. Within this range, the bactericidal effect and the cleaning effect are more excellent.
本発明の義歯洗浄剤組成物は、錠剤、粒状剤等の固形、水溶液、乳化液等の液体、ペースト、クリーム等のゲル状などの形態で様々な剤型に調製できるが、特に液体製剤が好ましい。また、形態、剤型に応じ、上記成分に加えてその他の公知成分を必要に応じて配合することができる。例えば、液体製剤では、香料、溶剤、着色剤等が挙げられる。
The denture cleaning composition of the present invention can be prepared in various dosage forms in the form of solids such as tablets and granules, liquids such as aqueous solutions and emulsions, gels such as pastes and creams, etc. preferable. Moreover, according to a form and dosage form, in addition to the said component, another well-known component can be mix | blended as needed. For example, in a liquid formulation, a fragrance | flavor, a solvent, a coloring agent etc. are mentioned.
香料としては、スペアミント油、ペパーミント油、アニス油、ユーカリ油、ウィンターグリーン油、カシア油、クローブ油、タイム油、セージ油、レモン油、オレンジ油、ハッカ油、カルダモン油、コリアンダー油、マンダリン油、ライム油、ラベンダー油、ローズマリー油、ローレル油、カモミル油、キャラウェイ油、マジョラム油、ベイ油、レモングラス油、オリガナム油、パインニードル油、シンナモンバーク油等の天然香料、及び、メントール、メントン、カルボン、エチルブチレート、バニリン、エチルマルトール、アネトール、サリチル酸メチル、シンナミックアルデヒド、シネオール、オイゲノール、エチルバニリン、マルトール、リモネン、シトロネロール、リナロール、リナリールアセテート、メンチルアセテート、ピネン、オクチルアルデヒド、シトラール、プレゴン、カルビールアセテート、アニスアルデヒド、ジンジャーオレオレジン、クレオソール、ｄｌ－カンファー等の単品香料、更に、エチルアセテート、アリルシクロヘキサンプロピオネート、メチルアンスラニレート、エチルメチルフェニルグリシデート、ウンデカラクトン、ヘキサナール、エチルアルコール、プロピルアルコール、ブタノール、イソアミルアルコール等の単品香料及び／又は天然香料も含む各種調合香料等、口腔用製剤に用いられる公知の香料を通常量で使用することができる。
As perfumes, spearmint oil, peppermint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Natural flavors such as lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, cinnamon bark oil, and menthol, Menthone, Carvone, Ethylbutyrate, Vanillin, Ethylmaltol, Anethole, Methyl salicylate, Cynamic aldehyde, Cineol, Eugenol, Ethylvanillin, Maltol, Limonene, Citronellol, Linalol, Linalyl acetate, Menthyl acetate, Pic Single fragrances such as ethyl, octyl aldehyde, citral, pregon, carbyl acetate, anisaldehyde, ginger oleoresin, creosol, dl-camphor, and also ethyl acetate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl phenyl Known amounts of fragrances used in oral preparations such as glycidates, undecalactones, hexanals, ethyl alcohol, propyl alcohol, butanol, isoamyl alcohol, etc. be able to.
溶剤としては、通常、水（イオン交換水）が用いられるが、多価アルコールなどを５～２０％程度、添加することもできる。
As the solvent, water (ion-exchanged water) is usually used, but about 5 to 20% of polyhydric alcohol or the like can be added.
着色剤としては、赤色２号、赤色３号、赤色２２５号、赤色２２６号、黄色４号、黄色５号、黄色２０５号、青色１号、青色２号、青色２０１号、青色２０４号、緑色３号等の法定色素、カラメル色素、ベニバナ色素、クチナシ色素、コチニール色素、アナトー色素、雲母チタン、酸化チタン等が挙げられる。
As colorants, Red No. 2, Red No. 3, Red No. 225, Red No. 226, Yellow No. 4, Yellow No. 5, Yellow No. 205, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 204, Green No. 3 etc. Legal dye, caramel dye, safflower dye, gardenia dye, cochineal dye, anato dye, mica titanium, titanium oxide and the like.
本発明では、アルキルアミンオキシドがカンジダ菌殺菌剤として配合されることから、特にカンジダ菌殺菌に有効な殺菌作用を有する第四級アンモニウム塩、例えば塩化セチルピリジニウム等のカチオン性界面活性剤や、義歯洗浄剤用成分として一般的な過炭酸ナトリウム、過ホウ酸ナトリウム等の過酸化物、次亜塩素酸又はその塩などは、配合しなくてもよく０％でもよいが、配合する場合はそれぞれの配合量が０．０３％以下、特に０．０１％以下が好ましい。
また、カンジダ菌以外の口腔内細菌に有効な非イオン性殺菌剤であるイソプロピルメチルフェノール等の殺菌剤は、本発明の効果を妨げない範囲で有効量添加してもよい。 In the present invention, since alkylamine oxide is blended as a Candida fungicide, a quaternary ammonium salt having a bactericidal action particularly effective for Candida fungicide, for example, a cationic surfactant such as cetylpyridinium chloride, or a denture Peroxides such as general sodium percarbonate and sodium perborate as components for cleaning agents, hypochlorous acid or a salt thereof may not be blended, and may be 0%. The blending amount is 0.03% or less, particularly 0.01% or less.
Further, an effective amount of a bactericidal agent such as isopropylmethylphenol, which is a nonionic bactericidal agent effective against oral bacteria other than Candida bacteria, may be added as long as the effects of the present invention are not hindered.
また、カンジダ菌以外の口腔内細菌に有効な非イオン性殺菌剤であるイソプロピルメチルフェノール等の殺菌剤は、本発明の効果を妨げない範囲で有効量添加してもよい。 In the present invention, since alkylamine oxide is blended as a Candida fungicide, a quaternary ammonium salt having a bactericidal action particularly effective for Candida fungicide, for example, a cationic surfactant such as cetylpyridinium chloride, or a denture Peroxides such as general sodium percarbonate and sodium perborate as components for cleaning agents, hypochlorous acid or a salt thereof may not be blended, and may be 0%. The blending amount is 0.03% or less, particularly 0.01% or less.
Further, an effective amount of a bactericidal agent such as isopropylmethylphenol, which is a nonionic bactericidal agent effective against oral bacteria other than Candida bacteria, may be added as long as the effects of the present invention are not hindered.
組成物の２５℃におけるｐＨは好ましくは５～９、より好ましくは５．５～８である。なお、ｐＨ調整剤を添加してｐＨ調整してもよい。ｐＨ調整剤としては、水酸化ナトリウム、塩酸、リン酸又はその塩、クエン酸又はその塩、炭酸ナトリウム、炭酸水素ナトリウム、ホウ酸又はその塩等が挙げられる。
The pH of the composition at 25 ° C. is preferably 5 to 9, and more preferably 5.5 to 8. In addition, you may adjust pH by adding a pH adjuster. Examples of the pH adjuster include sodium hydroxide, hydrochloric acid, phosphoric acid or a salt thereof, citric acid or a salt thereof, sodium carbonate, sodium bicarbonate, boric acid or a salt thereof.
本発明の義歯洗浄剤組成物は、通常の方法で使用することができ、義歯洗浄剤組成物をそのまま、又は義歯洗浄剤組成物を必要に応じて水に分散・溶解し、希釈した水溶液に義歯を浸漬し、その後、必要に応じて水で漱いで使用することができる。なお、この場合、義歯を浸漬時には、（Ａ）成分の使用濃度が上記範囲内であることが望ましい。
液体製剤の場合、希釈せずにそのまま使用するタイプでも、あるいは使用時に水で希釈し、義歯に適用する濃縮タイプでもよい。濃縮タイプとする場合は、水による希釈倍率が、使用性及び溶解性の点から、組成物の５～５００倍希釈、特に５～４００倍希釈、とりわけ１０～２００倍希釈であり、このときに（Ａ）成分の濃度が上記使用濃度範囲内となるよう、製剤濃度を設計することが好ましい。
固形製剤の場合は、水に分散・溶解させた後に義歯を浸漬するが、この浸漬時の（Ａ）成分の濃度が上記使用濃度範囲内となるよう、設計すればよい。
義歯の浸漬時間は１分間以上とすることが好ましく、５分間以上がより好ましい。 The denture cleaning composition of the present invention can be used in a usual manner. The denture cleaning composition is used as it is, or the denture cleaning composition is dispersed / dissolved in water as necessary to obtain a diluted aqueous solution. The denture can be dipped and then used with water as needed. In this case, when the denture is immersed, it is desirable that the use concentration of the component (A) is within the above range.
In the case of a liquid preparation, it may be a type that is used as it is without being diluted, or a concentrated type that is diluted with water at the time of use and applied to a denture. In the case of a concentrated type, the dilution ratio with water is from 5 to 500 times, particularly from 5 to 400 times, particularly from 10 to 200 times from the viewpoint of usability and solubility. It is preferable to design the concentration of the preparation so that the concentration of the component (A) is within the above-mentioned use concentration range.
In the case of a solid preparation, the denture is immersed after being dispersed / dissolved in water, and it may be designed so that the concentration of the component (A) at the time of immersion is within the above-mentioned use concentration range.
The denture immersion time is preferably 1 minute or longer, more preferably 5 minutes or longer.
液体製剤の場合、希釈せずにそのまま使用するタイプでも、あるいは使用時に水で希釈し、義歯に適用する濃縮タイプでもよい。濃縮タイプとする場合は、水による希釈倍率が、使用性及び溶解性の点から、組成物の５～５００倍希釈、特に５～４００倍希釈、とりわけ１０～２００倍希釈であり、このときに（Ａ）成分の濃度が上記使用濃度範囲内となるよう、製剤濃度を設計することが好ましい。
固形製剤の場合は、水に分散・溶解させた後に義歯を浸漬するが、この浸漬時の（Ａ）成分の濃度が上記使用濃度範囲内となるよう、設計すればよい。
義歯の浸漬時間は１分間以上とすることが好ましく、５分間以上がより好ましい。 The denture cleaning composition of the present invention can be used in a usual manner. The denture cleaning composition is used as it is, or the denture cleaning composition is dispersed / dissolved in water as necessary to obtain a diluted aqueous solution. The denture can be dipped and then used with water as needed. In this case, when the denture is immersed, it is desirable that the use concentration of the component (A) is within the above range.
In the case of a liquid preparation, it may be a type that is used as it is without being diluted, or a concentrated type that is diluted with water at the time of use and applied to a denture. In the case of a concentrated type, the dilution ratio with water is from 5 to 500 times, particularly from 5 to 400 times, particularly from 10 to 200 times from the viewpoint of usability and solubility. It is preferable to design the concentration of the preparation so that the concentration of the component (A) is within the above-mentioned use concentration range.
In the case of a solid preparation, the denture is immersed after being dispersed / dissolved in water, and it may be designed so that the concentration of the component (A) at the time of immersion is within the above-mentioned use concentration range.
The denture immersion time is preferably 1 minute or longer, more preferably 5 minutes or longer.
以下、実験例、実施例及び比較例、処方例を示し、本発明を具体的に説明するが、本発明は下記の実施例に制限されるものではない。なお、下記の例において％は特に断らない限りいずれも質量％を示す。
Hereinafter, although an experimental example, an Example, a comparative example, a formulation example is shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.
［実験例１］
表１に示す組成の義歯洗浄剤組成物（被検サンプル）を下記方法で調製し、下記方法によってカンジダ菌に対する殺菌力を評価した。結果を表１に併記した。 [Experimental Example 1]
A denture cleaning composition (test sample) having the composition shown in Table 1 was prepared by the following method, and the bactericidal activity against Candida was evaluated by the following method. The results are also shown in Table 1.
表１に示す組成の義歯洗浄剤組成物（被検サンプル）を下記方法で調製し、下記方法によってカンジダ菌に対する殺菌力を評価した。結果を表１に併記した。 [Experimental Example 1]
A denture cleaning composition (test sample) having the composition shown in Table 1 was prepared by the following method, and the bactericidal activity against Candida was evaluated by the following method. The results are also shown in Table 1.
〈１．カンジダ菌に対する殺菌効果の評価方法〉
１－１．被検菌液の調製
カンジダ菌（Ｃａｎｄｉｄａ ａｌｂｉｃａｎｓ ＡＴＣＣ１０２３１）をＤｉｆｃｏ社製のＰｏｔａｔｏ Ｄｅｘｔｒｏｓｅ Ａｇａｒ培地（ＰＤＡ培地）に白金耳にて植菌し、２５℃で前培養した。白金耳を用いて増殖したコロニーを採取して生理食塩水に懸濁し、６６０ｎｍでの濁度を２．０に調整した。
１－２．被検サンプルの調製
表１に示す界面活性剤を、表中のＡＩ（純分）濃度になるように配合し、ｐＨ（２５℃）を表中の値になるように調整したものをサンプルとした。
１－３．殺菌力の評価方法
上記１－２にて調製した被検サンプル４ｍＬ中に、上記１－１にて調製した被検菌液０．１ｍＬを添加し、ボルテックスミキサーにて混和後、室温にて５分間放置した。その後、上記混合液０．４４４ｍＬをダイゴ社製のＳＣＤＬＰ（Ｓｏｙｂｅａｎ－Ｃａｓｅｉｎ Ｄｉｇｅｓｔ Ａｇａｒ ｗｉｔｈ Ｌｅｃｉｔｈｉｎ＆Ｐｏｌｙｓｏｒｂａｔｅ８０）液体培地４ｍＬと混合し、反応を不活化させた（この段階で１０1希釈。）。続いて、不活化培地にて１０倍希釈系列を作製し、１０1、１０3、１０5希釈液を５０μＬずつＰＤＡ培地に塗抹し、２５℃にて培養後、生育したコロニー数をカウントした。
カウントしたコロニー数から、対数減少値を求め、下記基準によってカンジダ菌に対する殺菌効果を評価した。
カンジダ菌に対する殺菌効果の評価基準
○：５分間の作用で対数減少値が３Ｌｏｇ10以上
×：５分間の作用で対数減少値が３Ｌｏｇ10未満 <1. Evaluation Method of Bactericidal Effect against Candida>
1-1. Preparation of Test Bacterial Solution Candida albicans ATCC 10231 was inoculated with Difco's Potato Dextrose Agar medium (PDA medium) with a platinum loop and pre-cultured at 25 ° C. Colonies grown using platinum ears were collected and suspended in physiological saline, and the turbidity at 660 nm was adjusted to 2.0.
1-2. Preparation of sample to be tested The surfactant shown in Table 1 was blended so as to have an AI (pure content) concentration in the table, and the pH (25 ° C.) adjusted to the value in the table was taken as a sample. did.
1-3. Method for evaluating bactericidal activity To 4 mL of the test sample prepared in 1-2 above, 0.1 mL of the test bacterial solution prepared in 1-1 above is added, mixed with a vortex mixer, and then mixed at room temperature. Left for a minute. Thereafter, the mixed solution 0.444mL the Daigo Co. SCDLP was mixed with (Soybean-Casein Digest Agar with Lecithin & Polysorbate80) liquid medium 4 mL, the reaction was allowed to inactivated (at this stage 10 1 dilution.). Subsequently, a 10-fold dilution series was prepared with an inactivated medium, 50 μL each of the 10 1 , 10 3 , and 10 5 dilutions were smeared onto the PDA medium, cultured at 25 ° C., and the number of grown colonies was counted.
The logarithmic decrease value was calculated from the counted number of colonies, and the bactericidal effect against Candida was evaluated according to the following criteria.
Evaluation criteria for bactericidal effects against Candida albicans ○: × log reduction by the action of 5 minutes 3 log 10 or more: less than log reduction by the action of 5 minutes 3 log 10
１－１．被検菌液の調製
カンジダ菌（Ｃａｎｄｉｄａ ａｌｂｉｃａｎｓ ＡＴＣＣ１０２３１）をＤｉｆｃｏ社製のＰｏｔａｔｏ Ｄｅｘｔｒｏｓｅ Ａｇａｒ培地（ＰＤＡ培地）に白金耳にて植菌し、２５℃で前培養した。白金耳を用いて増殖したコロニーを採取して生理食塩水に懸濁し、６６０ｎｍでの濁度を２．０に調整した。
１－２．被検サンプルの調製
表１に示す界面活性剤を、表中のＡＩ（純分）濃度になるように配合し、ｐＨ（２５℃）を表中の値になるように調整したものをサンプルとした。
１－３．殺菌力の評価方法
上記１－２にて調製した被検サンプル４ｍＬ中に、上記１－１にて調製した被検菌液０．１ｍＬを添加し、ボルテックスミキサーにて混和後、室温にて５分間放置した。その後、上記混合液０．４４４ｍＬをダイゴ社製のＳＣＤＬＰ（Ｓｏｙｂｅａｎ－Ｃａｓｅｉｎ Ｄｉｇｅｓｔ Ａｇａｒ ｗｉｔｈ Ｌｅｃｉｔｈｉｎ＆Ｐｏｌｙｓｏｒｂａｔｅ８０）液体培地４ｍＬと混合し、反応を不活化させた（この段階で１０1希釈。）。続いて、不活化培地にて１０倍希釈系列を作製し、１０1、１０3、１０5希釈液を５０μＬずつＰＤＡ培地に塗抹し、２５℃にて培養後、生育したコロニー数をカウントした。
カウントしたコロニー数から、対数減少値を求め、下記基準によってカンジダ菌に対する殺菌効果を評価した。
カンジダ菌に対する殺菌効果の評価基準
○：５分間の作用で対数減少値が３Ｌｏｇ10以上
×：５分間の作用で対数減少値が３Ｌｏｇ10未満 <1. Evaluation Method of Bactericidal Effect against Candida>
1-1. Preparation of Test Bacterial Solution Candida albicans ATCC 10231 was inoculated with Difco's Potato Dextrose Agar medium (PDA medium) with a platinum loop and pre-cultured at 25 ° C. Colonies grown using platinum ears were collected and suspended in physiological saline, and the turbidity at 660 nm was adjusted to 2.0.
1-2. Preparation of sample to be tested The surfactant shown in Table 1 was blended so as to have an AI (pure content) concentration in the table, and the pH (25 ° C.) adjusted to the value in the table was taken as a sample. did.
1-3. Method for evaluating bactericidal activity To 4 mL of the test sample prepared in 1-2 above, 0.1 mL of the test bacterial solution prepared in 1-1 above is added, mixed with a vortex mixer, and then mixed at room temperature. Left for a minute. Thereafter, the mixed solution 0.444mL the Daigo Co. SCDLP was mixed with (Soybean-Casein Digest Agar with Lecithin & Polysorbate80) liquid medium 4 mL, the reaction was allowed to inactivated (at this stage 10 1 dilution.). Subsequently, a 10-fold dilution series was prepared with an inactivated medium, 50 μL each of the 10 1 , 10 3 , and 10 5 dilutions were smeared onto the PDA medium, cultured at 25 ° C., and the number of grown colonies was counted.
The logarithmic decrease value was calculated from the counted number of colonies, and the bactericidal effect against Candida was evaluated according to the following criteria.
Evaluation criteria for bactericidal effects against Candida albicans ○: × log reduction by the action of 5 minutes 3 log 10 or more: less than log reduction by the action of 5 minutes 3 log 10
［実験例２］
表２、３に示す組成の義歯洗浄剤組成物（被検サンプル）を下記方法で調製し、上記方法によってカンジダ菌に対する殺菌効果を評価した。また、下記方法によって義歯汚れに対する洗浄力を評価した。結果を表２、３に併記した。なお、表中の成分量（％）は、全て使用濃度（浸漬時の濃度）である（以下、同様）。
また、義歯洗浄剤組成物のｐＨ（２５℃）はいずれも５～９の範囲内であった。 [Experiment 2]
Denture cleaning compositions (test samples) having the compositions shown in Tables 2 and 3 were prepared by the following method, and the bactericidal effect against Candida was evaluated by the above method. Moreover, the cleaning power with respect to denture dirt was evaluated by the following method. The results are shown in Tables 2 and 3. The component amounts (%) in the table are all used concentrations (concentrations when immersed) (hereinafter the same).
Further, the pH (25 ° C.) of the denture cleaning composition was in the range of 5-9.
表２、３に示す組成の義歯洗浄剤組成物（被検サンプル）を下記方法で調製し、上記方法によってカンジダ菌に対する殺菌効果を評価した。また、下記方法によって義歯汚れに対する洗浄力を評価した。結果を表２、３に併記した。なお、表中の成分量（％）は、全て使用濃度（浸漬時の濃度）である（以下、同様）。
また、義歯洗浄剤組成物のｐＨ（２５℃）はいずれも５～９の範囲内であった。 [Experiment 2]
Denture cleaning compositions (test samples) having the compositions shown in Tables 2 and 3 were prepared by the following method, and the bactericidal effect against Candida was evaluated by the above method. Moreover, the cleaning power with respect to denture dirt was evaluated by the following method. The results are shown in Tables 2 and 3. The component amounts (%) in the table are all used concentrations (concentrations when immersed) (hereinafter the same).
Further, the pH (25 ° C.) of the denture cleaning composition was in the range of 5-9.
〈２．義歯汚れに対する洗浄力の評価方法〉
２－１．タンニン鉄ステイン付着アクリル板の作製方法
アクリル板表面（（株）クラレ製、縦１０ｍｍ×横１０ｍｍ×厚さ５ｍｍ）をサンドブラストにて処理後、中性洗剤を入れた超音波洗浄器（商品名：超音波洗浄器ＡＵ－８０Ｃ、アイワ医科工業（株）製）に５分間かけ、水で漱いで洗浄した。前記超音波洗浄を３回繰り返した後、自然乾燥し、タンニン鉄ステイン付着前のアクリル板のＬａｂ値（Ｌ０）を測定した。上記のアクリル板に対し、０．５％アルブミン水溶液→タンニン抽出液→０．６％クエン酸鉄（ＩＩＩ）アンモニウム水溶液という順番で、これらに３０分間ずつ繰り返し浸漬する操作を１０回繰り返し、常温で１日風乾した後、流水で洗浄し、再び風乾して着色アクリル板を作製した。
タンニン抽出液は、沸騰させたイオン交換水１，２００ｍＬ中に、日本茶（（株）伊藤園製）５０ｇ、紅茶（リプトン社製、ブリスクティーバック）５袋、インスタントコーヒー（ネスレ社製、ネスカフェ）１２ｇを入れ一晩放置し、日本茶及び紅茶をろ過にて取り除き作製した。
作製した着色アクリル板の表面の色を測定し、その値をＬａｂ値（Ｌ１）とした。
２－２．被検サンプルの調製
表２、３に示す洗浄剤組成を表中のＡＩ濃度になるよう配合し、調製した。 <2. Evaluation Method of Detergency for Denture Dirt>
2-1. Preparation method of tannin iron stain-attached acrylic plate Ultrasonic cleaner with neutral detergent after treating the acrylic plate surface (manufactured by Kuraray Co., Ltd., vertical 10 mm x horizontal 10 mm x thickness 5 mm) with sandblasting (trade name: It was placed in an ultrasonic cleaner AU-80C (manufactured by Aiwa Medical Industry Co., Ltd.) for 5 minutes and rinsed with water. The ultrasonic cleaning was repeated three times, followed by natural drying, and the Lab value (L0) of the acrylic plate before adhesion of tannin iron stain was measured. In the order of 0.5% albumin aqueous solution → tannin extract → 0.6% iron (III) ammonium citrate aqueous solution in the above-described acrylic plate, the operation of repeatedly immersing in each of these for 30 minutes was repeated 10 times at room temperature. After air-drying for 1 day, it was washed with running water and air-dried again to produce a colored acrylic plate.
The tannin extract is in 1,200 mL of boiled ion-exchanged water. 12 g was added and left overnight, and Japanese tea and black tea were removed by filtration.
The color of the surface of the produced colored acrylic board was measured, and the value was defined as the Lab value (L1).
2-2. Preparation of test samples The cleaning compositions shown in Tables 2 and 3 were formulated and prepared so as to have the AI concentrations in the tables.
２－１．タンニン鉄ステイン付着アクリル板の作製方法
アクリル板表面（（株）クラレ製、縦１０ｍｍ×横１０ｍｍ×厚さ５ｍｍ）をサンドブラストにて処理後、中性洗剤を入れた超音波洗浄器（商品名：超音波洗浄器ＡＵ－８０Ｃ、アイワ医科工業（株）製）に５分間かけ、水で漱いで洗浄した。前記超音波洗浄を３回繰り返した後、自然乾燥し、タンニン鉄ステイン付着前のアクリル板のＬａｂ値（Ｌ０）を測定した。上記のアクリル板に対し、０．５％アルブミン水溶液→タンニン抽出液→０．６％クエン酸鉄（ＩＩＩ）アンモニウム水溶液という順番で、これらに３０分間ずつ繰り返し浸漬する操作を１０回繰り返し、常温で１日風乾した後、流水で洗浄し、再び風乾して着色アクリル板を作製した。
タンニン抽出液は、沸騰させたイオン交換水１，２００ｍＬ中に、日本茶（（株）伊藤園製）５０ｇ、紅茶（リプトン社製、ブリスクティーバック）５袋、インスタントコーヒー（ネスレ社製、ネスカフェ）１２ｇを入れ一晩放置し、日本茶及び紅茶をろ過にて取り除き作製した。
作製した着色アクリル板の表面の色を測定し、その値をＬａｂ値（Ｌ１）とした。
２－２．被検サンプルの調製
表２、３に示す洗浄剤組成を表中のＡＩ濃度になるよう配合し、調製した。 <2. Evaluation Method of Detergency for Denture Dirt>
2-1. Preparation method of tannin iron stain-attached acrylic plate Ultrasonic cleaner with neutral detergent after treating the acrylic plate surface (manufactured by Kuraray Co., Ltd., vertical 10 mm x horizontal 10 mm x thickness 5 mm) with sandblasting (trade name: It was placed in an ultrasonic cleaner AU-80C (manufactured by Aiwa Medical Industry Co., Ltd.) for 5 minutes and rinsed with water. The ultrasonic cleaning was repeated three times, followed by natural drying, and the Lab value (L0) of the acrylic plate before adhesion of tannin iron stain was measured. In the order of 0.5% albumin aqueous solution → tannin extract → 0.6% iron (III) ammonium citrate aqueous solution in the above-described acrylic plate, the operation of repeatedly immersing in each of these for 30 minutes was repeated 10 times at room temperature. After air-drying for 1 day, it was washed with running water and air-dried again to produce a colored acrylic plate.
The tannin extract is in 1,200 mL of boiled ion-exchanged water. 12 g was added and left overnight, and Japanese tea and black tea were removed by filtration.
The color of the surface of the produced colored acrylic board was measured, and the value was defined as the Lab value (L1).
2-2. Preparation of test samples The cleaning compositions shown in Tables 2 and 3 were formulated and prepared so as to have the AI concentrations in the tables.
２－３．タンニン鉄ステイン除去効果の評価法
サンプルとして調製した表２、３に示す各例の義歯洗浄剤組成物中に、上記２－１にて作製したタンニン鉄ステイン付着アクリル板を５分間浸漬して洗浄し、常温で１日風乾した後、流水で洗浄し、再び風乾して乾燥した後のアクリル板のＬａｂ値（Ｌ２）を測定した。
下記に示す式により、タンニン鉄ステイン除去率を求めた。
タンニン鉄ステイン除去率（％）＝〔（Ｌ１－Ｌ２）／（Ｌ１－Ｌ０）〕×１００
得られたタンニン鉄ステイン除去率から、下記の基準に従い、義歯汚れに対する洗浄力を評価した。
義歯汚れに対する洗浄力の評価基準
◎：タンニン鉄ステイン除去率３０％以上
○：タンニン鉄ステイン除去率２０％以上３０％未満
△：タンニン鉄ステイン除去率１０％以上２０％未満
×：タンニン鉄ステイン除去率１０％未満 2-3. Method for evaluating the effect of removing tannin iron stain The tannin iron stain-attached acrylic plate prepared in 2-1 above was immersed in a denture cleaning composition of each example shown in Tables 2 and 3 prepared as a sample for cleaning for 5 minutes. Then, after air-drying at room temperature for 1 day, the Lab plate was washed with running water, air-dried again, and dried, and the Lab value (L2) was measured.
The tannin iron stain removal rate was calculated | required by the formula shown below.
Tannin iron stain removal rate (%) = [(L1-L2) / (L1-L0)] × 100
From the tannin iron stain removal rate obtained, the cleaning power against denture soil was evaluated according to the following criteria.
Evaluation criteria for detergency against denture dirt ◎: Tannin iron stain removal rate of 30% or more ○: Tannin iron stain removal rate of 20% or more but less than 30% Δ: Tannin iron stain removal rate of 10% or more but less than 20% ×: Tannin iron stain removal rate Less than 10%
サンプルとして調製した表２、３に示す各例の義歯洗浄剤組成物中に、上記２－１にて作製したタンニン鉄ステイン付着アクリル板を５分間浸漬して洗浄し、常温で１日風乾した後、流水で洗浄し、再び風乾して乾燥した後のアクリル板のＬａｂ値（Ｌ２）を測定した。
下記に示す式により、タンニン鉄ステイン除去率を求めた。
タンニン鉄ステイン除去率（％）＝〔（Ｌ１－Ｌ２）／（Ｌ１－Ｌ０）〕×１００
得られたタンニン鉄ステイン除去率から、下記の基準に従い、義歯汚れに対する洗浄力を評価した。
義歯汚れに対する洗浄力の評価基準
◎：タンニン鉄ステイン除去率３０％以上
○：タンニン鉄ステイン除去率２０％以上３０％未満
△：タンニン鉄ステイン除去率１０％以上２０％未満
×：タンニン鉄ステイン除去率１０％未満 2-3. Method for evaluating the effect of removing tannin iron stain The tannin iron stain-attached acrylic plate prepared in 2-1 above was immersed in a denture cleaning composition of each example shown in Tables 2 and 3 prepared as a sample for cleaning for 5 minutes. Then, after air-drying at room temperature for 1 day, the Lab plate was washed with running water, air-dried again, and dried, and the Lab value (L2) was measured.
The tannin iron stain removal rate was calculated | required by the formula shown below.
Tannin iron stain removal rate (%) = [(L1-L2) / (L1-L0)] × 100
From the tannin iron stain removal rate obtained, the cleaning power against denture soil was evaluated according to the following criteria.
Evaluation criteria for detergency against denture dirt ◎: Tannin iron stain removal rate of 30% or more ○: Tannin iron stain removal rate of 20% or more but less than 30% Δ: Tannin iron stain removal rate of 10% or more but less than 20% ×: Tannin iron stain removal rate Less than 10%
使用した主原料の詳細を下記に示す。
（Ａ）ラウリルジメチルアミンオキシド：
ライオン・スペシャリティ・ケミカルズ（株）製（商品名：カデナッ
クスＤＭ１２Ｄ－Ｗ）
（Ｂ）
（Ｂ－１）α－オレフィンスルホン酸ナトリウム：
ライオン・スペシャリティ・ケミカルズ（株）製（商品名：リポ
ランＬＢ－４４０）
（Ｂ－１）ラウリル硫酸ナトリウム：東邦化学工業（株）製
（Ｂ－１）ラウロイルグルタミン酸ナトリウム：旭化成ケミカルズ（株）製
（Ｂ－２）ラウリルジメチルアミノ酢酸ベタイン：
第一工業製薬（株）（商品名：アモーゲンＳ－Ｈ）
（Ｂ－２）アルキル－Ｎ－カルボキシメチル－Ｎ－ヒドロキシエチルイミダ
ゾリニウムベタイン（３０％水溶液）：
ライオン・スペシャリティ・ケミカルズ（株）製（商品名：エナ
ジコールＣ－４０Ｈ）
（Ｂ－２）ヤシ油脂肪酸アミドプロピルベタイン（３０％水溶液）：
三洋化成工業（株）製（商品名：レボン２０００） Details of the main raw materials used are shown below.
(A) Lauryldimethylamine oxide:
Product made by Lion Specialty Chemicals Co., Ltd. (trade name: Kadenax DM12D-W)
(B)
(B-1) Sodium α-olefin sulfonate:
Lion Specialty Chemicals Co., Ltd. (trade name: Liporan LB-440)
(B-1) Sodium lauryl sulfate: manufactured by Toho Chemical Co., Ltd. (B-1) Sodium lauroyl glutamate: manufactured by Asahi Kasei Chemicals Co., Ltd. (B-2) lauryldimethylaminoacetic acid betaine:
Daiichi Kogyo Seiyaku Co., Ltd. (trade name: Amorgen SH)
(B-2) Alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine (30% aqueous solution):
Lion Specialty Chemicals Co., Ltd. (trade name: Enigol C-40H)
(B-2) Coconut oil fatty acid amidopropyl betaine (30% aqueous solution):
Sanyo Chemical Industries Co., Ltd. (trade name: Levon 2000)
（Ａ）ラウリルジメチルアミンオキシド：
ライオン・スペシャリティ・ケミカルズ（株）製（商品名：カデナッ
クスＤＭ１２Ｄ－Ｗ）
（Ｂ）
（Ｂ－１）α－オレフィンスルホン酸ナトリウム：
ライオン・スペシャリティ・ケミカルズ（株）製（商品名：リポ
ランＬＢ－４４０）
（Ｂ－１）ラウリル硫酸ナトリウム：東邦化学工業（株）製
（Ｂ－１）ラウロイルグルタミン酸ナトリウム：旭化成ケミカルズ（株）製
（Ｂ－２）ラウリルジメチルアミノ酢酸ベタイン：
第一工業製薬（株）（商品名：アモーゲンＳ－Ｈ）
（Ｂ－２）アルキル－Ｎ－カルボキシメチル－Ｎ－ヒドロキシエチルイミダ
ゾリニウムベタイン（３０％水溶液）：
ライオン・スペシャリティ・ケミカルズ（株）製（商品名：エナ
ジコールＣ－４０Ｈ）
（Ｂ－２）ヤシ油脂肪酸アミドプロピルベタイン（３０％水溶液）：
三洋化成工業（株）製（商品名：レボン２０００） Details of the main raw materials used are shown below.
(A) Lauryldimethylamine oxide:
Product made by Lion Specialty Chemicals Co., Ltd. (trade name: Kadenax DM12D-W)
(B)
(B-1) Sodium α-olefin sulfonate:
Lion Specialty Chemicals Co., Ltd. (trade name: Liporan LB-440)
(B-1) Sodium lauryl sulfate: manufactured by Toho Chemical Co., Ltd. (B-1) Sodium lauroyl glutamate: manufactured by Asahi Kasei Chemicals Co., Ltd. (B-2) lauryldimethylaminoacetic acid betaine:
Daiichi Kogyo Seiyaku Co., Ltd. (trade name: Amorgen SH)
(B-2) Alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine (30% aqueous solution):
Lion Specialty Chemicals Co., Ltd. (trade name: Enigol C-40H)
(B-2) Coconut oil fatty acid amidopropyl betaine (30% aqueous solution):
Sanyo Chemical Industries Co., Ltd. (trade name: Levon 2000)
次に、処方例を示す。処方例の義歯洗浄剤組成物は、カンジダ菌に対する殺菌効果が優れ、義歯汚れに対する洗浄力も良好であった。
Next, a prescription example is shown. The denture cleaning composition of the prescription example was excellent in the bactericidal effect against Candida and the cleaning power against denture soil.
［処方例１］液体義歯洗浄剤（１～２００倍に水で希釈し、義歯を浸漬する。）
（Ａ）ラウリルジメチルアミンオキシド １０％
ヒドロキシエタンジホスホン酸 ５
水酸化ナトリウム ２．５
イオン交換水 適量
合計 １００．０％
ｐＨ（２５℃）：６．０ [Formulation Example 1] Liquid denture cleaner (diluted 1 to 200 times with water and immersing denture)
(A) Lauryldimethylamine oxide 10%
Hydroxyethane diphosphonic acid 5
Sodium hydroxide 2.5
Ion exchange water
Total 100.0%
pH (25 ° C.): 6.0
（Ａ）ラウリルジメチルアミンオキシド １０％
ヒドロキシエタンジホスホン酸 ５
水酸化ナトリウム ２．５
イオン交換水 適量
合計 １００．０％
ｐＨ（２５℃）：６．０ [Formulation Example 1] Liquid denture cleaner (diluted 1 to 200 times with water and immersing denture)
(A) Lauryldimethylamine oxide 10%
Hydroxyethane diphosphonic acid 5
Sodium hydroxide 2.5
Ion exchange water
Total 100.0%
pH (25 ° C.): 6.0
［処方例２］液体義歯洗浄剤（１～２００倍に水で希釈し、義歯を浸漬する。）
（Ａ）ラウリルジメチルアミンオキシド ２０％
（Ｂ）（Ｂ－１）ラウリル硫酸ナトリウム ５％
ヒドロキシエタンジホスホン酸 ５
水酸化ナトリウム ２．５
イオン交換水 適量
合計 １００．０％
（Ａ）／（Ｂ）＝５
ｐＨ（２５℃）：６．０ [Prescription Example 2] Liquid denture cleaning agent (diluted 1 to 200 times with water and immersed in denture)
(A) Lauryldimethylamine oxide 20%
(B) (B-1) Sodium lauryl sulfate 5%
Hydroxyethane diphosphonic acid 5
Sodium hydroxide 2.5
Ion exchange water
Total 100.0%
(A) / (B) = 5
pH (25 ° C.): 6.0
（Ａ）ラウリルジメチルアミンオキシド ２０％
（Ｂ）（Ｂ－１）ラウリル硫酸ナトリウム ５％
ヒドロキシエタンジホスホン酸 ５
水酸化ナトリウム ２．５
イオン交換水 適量
合計 １００．０％
（Ａ）／（Ｂ）＝５
ｐＨ（２５℃）：６．０ [Prescription Example 2] Liquid denture cleaning agent (diluted 1 to 200 times with water and immersed in denture)
(A) Lauryldimethylamine oxide 20%
(B) (B-1) Sodium lauryl sulfate 5%
Hydroxyethane diphosphonic acid 5
Sodium hydroxide 2.5
Ion exchange water
Total 100.0%
(A) / (B) = 5
pH (25 ° C.): 6.0
Claims (13)
- （Ａ）アルキルアミンオキシドからなる口腔用カンジダ菌殺菌剤。 (A) Candida fungicide for oral cavity comprising alkylamine oxide.
- （Ａ）成分が、アルキル基の炭素数が１２～１８であるアルキルジメチルアミンオキシドである請求項１記載の口腔用カンジダ菌殺菌剤。 The oral Candida fungicide according to claim 1, wherein the component (A) is an alkyldimethylamine oxide having an alkyl group with 12 to 18 carbon atoms.
- （Ａ）アルキルアミンオキシドを含有してなる義歯洗浄剤組成物。 (A) Denture cleaning composition containing alkylamine oxide.
- （Ａ）成分が、アルキル基の炭素数が１２～１８であるアルキルジメチルアミンオキシドである請求項３記載の義歯洗浄剤組成物。 The denture cleaning composition according to claim 3, wherein the component (A) is an alkyldimethylamine oxide having an alkyl group having 12 to 18 carbon atoms.
- （Ａ）成分を０．０５～２０質量％含有する請求項３又は４記載の義歯洗浄剤組成物。 The denture cleaning composition according to claim 3 or 4, comprising 0.05 to 20% by mass of component (A).
- 更に、（Ｂ）（Ｂ－１）アニオン性界面活性剤及び／又は（Ｂ－２）ベタイン両性界面活性剤を含有する請求項３、４又は５記載の義歯洗浄剤組成物。 The denture cleaning composition according to claim 3, 4 or 5, further comprising (B) (B-1) an anionic surfactant and / or (B-2) a betaine amphoteric surfactant.
- （Ｂ－１）アニオン性界面活性剤が、アルキル硫酸塩、α－オレフィンスルホン酸塩及びアシルアミノ酸塩から選ばれる１種以上であり、（Ｂ－２）ベタイン両性界面活性剤が、アルキル酢酸ベタイン、脂肪酸アミドプロピルベタイン及びアルキル－Ｎ－カルボキシメチル－Ｎ－ヒドロキシエチルイミダゾリニウムベタインから選ばれる１種以上である請求項６記載の義歯洗浄剤組成物。 (B-1) the anionic surfactant is at least one selected from alkyl sulfates, α-olefin sulfonates and acylamino acid salts; (B-2) betaine amphoteric surfactants are alkyl acetate betaines The denture cleaning composition according to claim 6, wherein the composition is one or more selected from fatty acid amidopropyl betaine and alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine.
- （Ａ）成分と（Ｂ）成分との配合比率を示す（Ａ）／（Ｂ）が、質量比として１～１０である請求項６又は７記載の義歯洗浄剤組成物。 The denture cleaning composition according to claim 6 or 7, wherein (A) / (B) indicating a blending ratio of the component (A) and the component (B) is 1 to 10 as a mass ratio.
- （Ｂ）成分を０．０１～１０質量％含有する請求項６、７又は８記載の義歯洗浄剤組成物。 The denture cleaning composition according to claim 6, 7 or 8, comprising 0.01 to 10% by mass of component (B).
- カチオン性界面活性剤を含有しないか、又はカチオン性界面活性剤を含有しその含有量が０．０３質量％以下である請求項３～９のいずれか１項記載の義歯洗浄剤組成物。 The denture cleaning composition according to any one of claims 3 to 9, which does not contain a cationic surfactant or contains a cationic surfactant and has a content of 0.03% by mass or less.
- 過酸化物を含有しないか、又は過酸化物を含有しその含有量が０．０３質量％以下である請求項３～１０のいずれか１項記載の義歯洗浄剤組成物。 The denture cleaning composition according to any one of claims 3 to 10, which does not contain a peroxide or contains a peroxide and has a content of 0.03% by mass or less.
- 組成物の２５℃におけるｐＨが５～９である請求項３～１１のいずれか１項記載の義歯洗浄剤組成物。 The denture cleaning composition according to any one of claims 3 to 11, wherein the composition has a pH of 5 to 9 at 25 ° C.
- 液体製剤である請求項３～１２のいずれか１項記載の義歯洗浄剤組成物。 The denture cleaning composition according to any one of claims 3 to 12, which is a liquid preparation.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015254496A JP2019043848A (en) | 2015-12-25 | 2015-12-25 | Oral candida bactericide and denture detergent composition |
| JP2015-254496 | 2015-12-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2017110674A1 true WO2017110674A1 (en) | 2017-06-29 |
Family
ID=59090348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2016/087547 WO2017110674A1 (en) | 2015-12-25 | 2016-12-16 | Candida microbicide for oral cavity and denture cleanser composition |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP2019043848A (en) |
| WO (1) | WO2017110674A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021024818A (en) * | 2019-08-06 | 2021-02-22 | ライオン株式会社 | Sheet-like preparation for oral device |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10511351A (en) * | 1994-12-22 | 1998-11-04 | ザ、プロクター、エンド、ギャンブル、カンパニー | Oral composition |
| JPH11504323A (en) * | 1995-04-28 | 1999-04-20 | ザ、プロクター、エンド、ギャンブル、カンパニー | Oral composition |
| WO2010073825A1 (en) * | 2008-12-25 | 2010-07-01 | 国立大学法人広島大学 | Antibacterial composition and antiviral composition each containing silicon-containing compound, antibacterializing method, cleaning/mouth cleaning method, and method for immobilizing antibacterial agent or antiviral agent |
| WO2014191096A1 (en) * | 2013-05-28 | 2014-12-04 | Thor Gmbh | Microbicidal composition comprising 2-methyl-4-isothiazolin-3-one and an amineoxide |
-
2015
- 2015-12-25 JP JP2015254496A patent/JP2019043848A/en active Pending
-
2016
- 2016-12-16 WO PCT/JP2016/087547 patent/WO2017110674A1/en active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10511351A (en) * | 1994-12-22 | 1998-11-04 | ザ、プロクター、エンド、ギャンブル、カンパニー | Oral composition |
| JPH11504323A (en) * | 1995-04-28 | 1999-04-20 | ザ、プロクター、エンド、ギャンブル、カンパニー | Oral composition |
| WO2010073825A1 (en) * | 2008-12-25 | 2010-07-01 | 国立大学法人広島大学 | Antibacterial composition and antiviral composition each containing silicon-containing compound, antibacterializing method, cleaning/mouth cleaning method, and method for immobilizing antibacterial agent or antiviral agent |
| WO2014191096A1 (en) * | 2013-05-28 | 2014-12-04 | Thor Gmbh | Microbicidal composition comprising 2-methyl-4-isothiazolin-3-one and an amineoxide |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021024818A (en) * | 2019-08-06 | 2021-02-22 | ライオン株式会社 | Sheet-like preparation for oral device |
| JP7287173B2 (en) | 2019-08-06 | 2023-06-06 | ライオン株式会社 | Sheet formulation for oral wear device |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019043848A (en) | 2019-03-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20080118591A1 (en) | Bactericidal Formulations | |
| EP1473998B1 (en) | Enhanced activity hydrogen peroxide disinfectant | |
| EP1765081B1 (en) | Hydrogen peroxide-based skin disinfectant | |
| EP1856236B1 (en) | Aqueous disinfectants and sterilants | |
| WO2013129245A1 (en) | Bactericidal agent composition | |
| EP0136231B1 (en) | Composition with high bactericidal power containing a biguanide and a pyrimidine | |
| WO2016124764A1 (en) | Method for disinfecting a surface, and composition suitable for use therein | |
| JP2009256228A (en) | Liquid composition for oral cavity | |
| JP2010006720A (en) | Liquid composition for cleaning denture | |
| CN106572954B (en) | Mouthwash composition comprising a peroxide source and an alkyl ester salt of N-acetyl-L-arginine | |
| WO2011094838A1 (en) | Disinfectant cleaner | |
| WO2017110674A1 (en) | Candida microbicide for oral cavity and denture cleanser composition | |
| JP5051347B2 (en) | Liquid oral composition | |
| CN113423469A (en) | Topical disinfectant compositions | |
| JP2008179615A (en) | Dentures cleaning liquid composition | |
| WO2004000372A2 (en) | Disinfecting composition, cleaning tablet produced therefrom, and use thereof | |
| JP7124466B2 (en) | Denture composition and denture biofilm formation inhibitor | |
| KR101899237B1 (en) | Organic acid composition to be added to antimicrobial toothpaste and method for producing the same | |
| Darout et al. | Survival rate of oral bacteria on toothbrush and miswak stick | |
| KR20200093521A (en) | Skirt composition | |
| WO2018101392A1 (en) | Denture-cleaning liquid composition, denture-cleaning set, and denture-cleaning method | |
| JP2021104937A (en) | Denture cleanser composition as well as agent for sterilizing candida biofilm of denture, for inhibiting candida biofilm formation and for removing stain precipitate | |
| BE1017325A3 (en) | Toothpaste, contains mosquito repellent substance preferably having an odor masking effect | |
| US10071176B2 (en) | Disinfection composition, disinfection method, disinfection protocol for tooth brushes, and disinfection product | |
| JP6926457B2 (en) | Concentrated liquid denture cleanser composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 16878563 Country of ref document: EP Kind code of ref document: A1 |
|
| NENP | Non-entry into the national phase |
Ref country code: DE |
|
| 122 | Ep: pct application non-entry in european phase |
Ref document number: 16878563 Country of ref document: EP Kind code of ref document: A1 |
|
| NENP | Non-entry into the national phase |
Ref country code: JP |