KR101855242B1 - 펩타이드 호르몬의 칼시토닌 cgrp 패밀리의 펩타이드 길항제 및 그의 용도 - Google Patents
펩타이드 호르몬의 칼시토닌 cgrp 패밀리의 펩타이드 길항제 및 그의 용도 Download PDFInfo
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- NDACAFBDTQIYCQ-YVQXRMNASA-N val(8)-phe(37)-cgrp Chemical compound C([C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C1=CN=CN1 NDACAFBDTQIYCQ-YVQXRMNASA-N 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57527—Calcitonin gene related peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/225—Calcitonin gene related peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A61P5/22—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of calcitonin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/585—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261591236P | 2012-01-26 | 2012-01-26 | |
| US61/591,236 | 2012-01-26 | ||
| PCT/US2013/023260 WO2013112912A1 (en) | 2012-01-26 | 2013-01-25 | Peptide antagonists of the calcitonin cgrp family of peptide hormones and their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020177016079A Division KR102052983B1 (ko) | 2012-01-26 | 2013-01-25 | 펩타이드 호르몬의 칼시토닌 cgrp 패밀리의 펩타이드 길항제 및 그의 용도 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20140132342A KR20140132342A (ko) | 2014-11-17 |
| KR101855242B1 true KR101855242B1 (ko) | 2018-05-09 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020147023782A Active KR101855242B1 (ko) | 2012-01-26 | 2013-01-25 | 펩타이드 호르몬의 칼시토닌 cgrp 패밀리의 펩타이드 길항제 및 그의 용도 |
| KR1020177016079A Active KR102052983B1 (ko) | 2012-01-26 | 2013-01-25 | 펩타이드 호르몬의 칼시토닌 cgrp 패밀리의 펩타이드 길항제 및 그의 용도 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020177016079A Active KR102052983B1 (ko) | 2012-01-26 | 2013-01-25 | 펩타이드 호르몬의 칼시토닌 cgrp 패밀리의 펩타이드 길항제 및 그의 용도 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US9193776B2 (OSRAM) |
| EP (2) | EP2807187B1 (OSRAM) |
| JP (3) | JP6025871B2 (OSRAM) |
| KR (2) | KR101855242B1 (OSRAM) |
| CN (2) | CN108997490A (OSRAM) |
| AU (2) | AU2013211929B2 (OSRAM) |
| CA (1) | CA2861392C (OSRAM) |
| DK (1) | DK2807187T3 (OSRAM) |
| ES (2) | ES2819825T3 (OSRAM) |
| IL (2) | IL233655A (OSRAM) |
| MX (1) | MX347229B (OSRAM) |
| NO (1) | NO2864579T3 (OSRAM) |
| RU (2) | RU2624016C2 (OSRAM) |
| WO (1) | WO2013112912A1 (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013112912A1 (en) | 2012-01-26 | 2013-08-01 | Soares Christopher J | Peptide antagonists of the calcitonin cgrp family of peptide hormones and their use |
| JP6538682B2 (ja) * | 2013-07-30 | 2019-07-03 | ソアレス クリストファー ジェイ． | Ｃｇｒｐアゴニストペプチド |
| JO3669B1 (ar) | 2015-01-06 | 2020-08-27 | Ferring Bv | بيبتيدات مضَادَّة لببتيد المرتبط بجين الكالسيتونين |
| JP7360794B2 (ja) * | 2016-01-04 | 2023-10-13 | アデプセラ エルエルシー | ペプチド類似体 |
| JP7123932B2 (ja) * | 2016-09-02 | 2022-08-23 | クリストファー ジェイ． ソアレス | 神経保護及び神経疾患におけるｃｇｒｐ受容体アンタゴニストの使用 |
| CA2967616A1 (en) * | 2016-09-19 | 2018-03-19 | The Governors Of The University Of Alberta | Brain penetrant amylin receptor based peptides for alzheimer's disease |
| EP3707157A4 (en) * | 2017-11-06 | 2021-08-18 | Auckland Uniservices Limited | PEPTIDIC CONJUGATES AS ANAGONISTS OF THE CGRP RECEIVER, THEIR PREPARATION METHODS AND THEIR USES |
| JP7214100B2 (ja) * | 2019-01-18 | 2023-01-30 | 株式会社大一商会 | 遊技機 |
| JP7214102B2 (ja) * | 2019-01-18 | 2023-01-30 | 株式会社大一商会 | 遊技機 |
| JP7214104B2 (ja) * | 2019-01-18 | 2023-01-30 | 株式会社大一商会 | 遊技機 |
| CN116456981A (zh) * | 2020-11-19 | 2023-07-18 | 辉瑞爱尔兰制药公司 | 用于改善的grp抑制剂递送的组合物 |
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| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| NO812612L (no) | 1980-08-06 | 1982-02-08 | Ferring Pharma Ltd | Enzym-inhibitorer. |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| CH657779A5 (de) | 1982-10-05 | 1986-09-30 | Sandoz Ag | Galenische zusammensetzungen enthaltend calcitonin. |
| IT1164225B (it) | 1983-05-13 | 1987-04-08 | Anic Spa | Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione |
| US4530838A (en) | 1983-07-08 | 1985-07-23 | The Salk Institute For Biological Studies | Synthetic calcitonin-gene-related peptides for lowering blood pressure or gastric acid secretion in mammals |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
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| JPS62129297A (ja) * | 1985-08-09 | 1987-06-11 | Toyo Jozo Co Ltd | カルシトニン遺伝子関連ペプチド誘導体 |
| JPS62231168A (ja) | 1986-03-21 | 1987-10-09 | ハイブリテツク・インコ−ポレイテツド | アナライト−レセプタ−分析用内部標準を設けるための改良法 |
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| JPH07507806A (ja) | 1992-06-11 | 1995-08-31 | アルカーメス コントロールド セラピューティクス，インコーポレイテッド | エリスロポエチン薬物送達システム |
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| US5698401A (en) | 1995-11-14 | 1997-12-16 | Abbott Laboratories | Use of nuclear magnetic resonance to identify ligands to target biomolecules |
| US5910482A (en) * | 1996-03-19 | 1999-06-08 | Board Of Regents, The University Of Texas System | Treatment or prevention of preeclampsia, eclampsia with calcitonin gene related peptide, CGRP analog, progestational agent, nitric oxide source, and cyclooxygenase inhibitor |
| WO1997041223A1 (en) | 1996-04-15 | 1997-11-06 | The University Of Miami | Molecular clone of cgrp receptor component protein and uses thereof |
| US20050054557A1 (en) | 2002-05-09 | 2005-03-10 | Goldberg Michael M. | Compositions for delivering parathyroid hormone and calcitonin |
| WO2004084859A2 (en) | 2003-03-21 | 2004-10-07 | Nastech Pharmaceutical Company Inc. | Nasal calcitonin formulations containing chlorobutanol |
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| EP2233497A3 (en) * | 2004-02-11 | 2011-01-12 | Amylin Pharmaceuticals, Inc. | Amylin family peptides and methods for making and using them |
| CA2584806C (en) | 2004-11-01 | 2014-06-17 | Amylin Pharmaceuticals, Inc. | Treatment of obesity and related disorders |
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| WO2013059336A1 (en) | 2011-10-18 | 2013-04-25 | Amylin Pharmaceuticals, Llc | Amylin-calcitonin chimeric peptides conjugated to duration enchancing moieties |
| WO2013112912A1 (en) | 2012-01-26 | 2013-08-01 | Soares Christopher J | Peptide antagonists of the calcitonin cgrp family of peptide hormones and their use |
| KR102076118B1 (ko) | 2012-02-27 | 2020-02-11 | 브리스톨-마이어스 스큅 컴퍼니 | N-(5S,6S,9R)-5-아미노-6-(2,3-디플루오로페닐)-6,7,8,9-테트라히드로-5H-시클로헵타[b]피리딘-9-일-4-(2-옥소-2,3-디히드로-1H-이미다조[4,5-b]피리딘-1-일)피페리딘-1-카르복실레이트, 헤미술페이트 염 |
-
2013
- 2013-01-25 WO PCT/US2013/023260 patent/WO2013112912A1/en not_active Ceased
- 2013-01-25 EP EP13703494.8A patent/EP2807187B1/en active Active
- 2013-01-25 DK DK13703494.8T patent/DK2807187T3/en active
- 2013-01-25 JP JP2014554880A patent/JP6025871B2/ja active Active
- 2013-01-25 MX MX2014008960A patent/MX347229B/es active IP Right Grant
- 2013-01-25 RU RU2014131605A patent/RU2624016C2/ru active
- 2013-01-25 KR KR1020147023782A patent/KR101855242B1/ko active Active
- 2013-01-25 ES ES17175988T patent/ES2819825T3/es active Active
- 2013-01-25 EP EP17175988.9A patent/EP3272769B1/en active Active
- 2013-01-25 ES ES13703494.8T patent/ES2641325T3/es active Active
- 2013-01-25 US US13/821,936 patent/US9193776B2/en active Active
- 2013-01-25 CA CA2861392A patent/CA2861392C/en active Active
- 2013-01-25 AU AU2013211929A patent/AU2013211929B2/en not_active Ceased
- 2013-01-25 CN CN201810931542.9A patent/CN108997490A/zh active Pending
- 2013-01-25 KR KR1020177016079A patent/KR102052983B1/ko active Active
- 2013-01-25 CN CN201380010942.1A patent/CN104271596B/zh active Active
- 2013-06-18 NO NO13806163A patent/NO2864579T3/no unknown
-
2014
- 2014-07-15 IL IL233655A patent/IL233655A/en active IP Right Grant
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2015
- 2015-11-20 US US14/948,032 patent/US20160145315A1/en not_active Abandoned
-
2016
- 2016-07-18 AU AU2016205801A patent/AU2016205801A1/en not_active Abandoned
- 2016-10-07 JP JP2016199234A patent/JP6411425B2/ja active Active
-
2017
- 2017-04-03 US US15/478,053 patent/US10370425B2/en active Active
- 2017-05-28 IL IL252555A patent/IL252555B/en active IP Right Grant
- 2017-06-06 RU RU2017119773A patent/RU2742826C2/ru active
-
2018
- 2018-09-21 JP JP2018177504A patent/JP2019006821A/ja active Pending
Non-Patent Citations (2)
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|---|
| Journal of Medicinal Chemistry, Vol.46(12):2427-2435 (2003. 06. 05.) |
| Journal of Pharmacology and Experimental Therapeutics, Vol.319(2):749-747 (2006. 11. 01.) |
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