KR101854228B1 - 신규 아밀로이드 친화성 화합물 - Google Patents

신규 아밀로이드 친화성 화합물 Download PDF

Info

Publication number
KR101854228B1
KR101854228B1 KR1020137032274A KR20137032274A KR101854228B1 KR 101854228 B1 KR101854228 B1 KR 101854228B1 KR 1020137032274 A KR1020137032274 A KR 1020137032274A KR 20137032274 A KR20137032274 A KR 20137032274A KR 101854228 B1 KR101854228 B1 KR 101854228B1
Authority
KR
South Korea
Prior art keywords
compound
pyridine
pyridin
triazol
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020137032274A
Other languages
English (en)
Korean (ko)
Other versions
KR20140040735A (ko
Inventor
유키 오쿠무라
요시후미 마야
요시나리 쇼야마
타카코 오니시
Original Assignee
니혼 메디피직스 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 니혼 메디피직스 가부시키가이샤 filed Critical 니혼 메디피직스 가부시키가이샤
Publication of KR20140040735A publication Critical patent/KR20140040735A/ko
Application granted granted Critical
Publication of KR101854228B1 publication Critical patent/KR101854228B1/ko
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020137032274A 2011-06-24 2012-05-29 신규 아밀로이드 친화성 화합물 Expired - Fee Related KR101854228B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2011-140069 2011-06-24
JP2011140069 2011-06-24
PCT/JP2012/063726 WO2012176587A1 (ja) 2011-06-24 2012-05-29 新規アミロイド親和性化合物

Publications (2)

Publication Number Publication Date
KR20140040735A KR20140040735A (ko) 2014-04-03
KR101854228B1 true KR101854228B1 (ko) 2018-05-03

Family

ID=47422429

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020137032274A Expired - Fee Related KR101854228B1 (ko) 2011-06-24 2012-05-29 신규 아밀로이드 친화성 화합물

Country Status (11)

Country Link
US (1) US9211350B2 (enExample)
EP (1) EP2725027B1 (enExample)
JP (1) JP5167436B2 (enExample)
KR (1) KR101854228B1 (enExample)
CN (1) CN103596950B (enExample)
AU (1) AU2012274639B2 (enExample)
CA (1) CA2839199C (enExample)
ES (1) ES2619830T3 (enExample)
IN (1) IN2014DN00185A (enExample)
TW (1) TWI554511B (enExample)
WO (1) WO2012176587A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3197277T3 (pl) * 2014-08-29 2022-04-04 Chdi Foundation, Inc. Sondy do obrazowania molekularnego białka huntingtyny
WO2019056098A1 (en) * 2017-09-19 2019-03-28 The Governors Of The University Of Alberta BIOREDUCTION-ACTIVATED COMPOUNDS, THEIR PRODRUGS, RADIOPHARMACEUTICAL PRODUCTS, COMPOSITIONS AND THEIR APPLICATIONS IN THE MULTIMODAL THERANOSTIC MANAGEMENT OF HYPOXIA, INCLUDING CANCER
JP6831802B2 (ja) * 2018-01-12 2021-02-17 上海富吉医療器械有限公司Ｓｈａｎｇｈａｉ Ｃｈａｒｔｗｅｌｌ Ｍｅｄｉｃａｌ Ｉｎｓｔｒｕｍｅｎｔ Ｃｏ．， Ｌｔｄ． 放射性核種標識化合物及びこれを含有するイメージング剤
WO2022244680A1 (ja) * 2021-05-18 2022-11-24 国立大学法人大阪大学 画像診断用磁気ナノ粒子及び画像診断用造影剤

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100249419A1 (en) 2007-10-30 2010-09-30 Nihon Medi-Physics Co., Ltd. Utilization of novel compounds with amyloid affinity and method of producing the same

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1105163A4 (en) 1998-08-20 2003-05-02 Univ California METHOD FOR MARKING AMYLOID PLAQUES AND NEUROFIBRILLIC GIFTS
RU2324686C2 (ru) 2000-08-24 2008-05-20 Юнивесити Оф Питсбэг ПРОИЗВОДНЫЕ ТИОФЛАВИНА, СВЯЗЫВАЮЩИЕ АМИЛОИД, СПОСОБ ОБНАРУЖЕНИЯ in vivo ОТЛОЖЕНИЙ АМИЛОИДА И СПОСОБ РАСПОЗНАВАНИЯ БОЛЕЗНИ АЛЬЦГЕЙМЕРА
CA2444214A1 (en) 2001-04-23 2002-10-31 The Trustees Of The University Of Pennsylvania Amyloid plaque aggregation inhibitors and diagnostic imaging agents
AU2002323417B2 (en) 2001-08-27 2008-05-15 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
WO2007033080A2 (en) * 2005-09-12 2007-03-22 Emory University Alzheimer's disease imaging agents
US8022075B2 (en) * 2005-11-30 2011-09-20 Fujifilm Ri Pharma Co., Ltd. Diagnostic and remedy for disease caused by amyloid aggregation and/or deposition
JP5238496B2 (ja) 2006-05-19 2013-07-17 日本メジフィジックス株式会社 新規アミロイド親和性化合物
CN101501033B (zh) 2006-06-21 2012-08-01 通用电气医疗有限公司 对淀粉状蛋白具有亲和性的化合物
CN101595108A (zh) 2006-11-30 2009-12-02 日本医事物理股份有限公司 对淀粉状蛋白具有亲和性的新化合物
AU2008208091A1 (en) 2007-01-22 2008-07-31 Astrazeneca Ab Novel heteroaryl substituted imidazo [1,2 -a] pyridine derivatives
TW200918102A (en) 2007-10-24 2009-05-01 Nihon Mediphysics Co Ltd Novel compound having affinity for amyloid
CN101903383A (zh) 2007-10-26 2010-12-01 日本医事物理股份有限公司 对淀粉样蛋白具有亲和性的新化合物
CA2704168A1 (en) 2007-10-30 2009-05-07 Nihon Medi-Physics Co., Ltd. Use of novel compound having affinity for amyloid, and process for production of the same
KR20100089858A (ko) 2007-10-30 2010-08-12 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물의 사용 및 제조 방법
EP2296474A1 (en) * 2008-05-30 2011-03-23 Merck Sharp & Dohme Corp. Novel substituted indoles
EP2218464A1 (en) * 2009-02-11 2010-08-18 Technische Universität München Compounds for non-invasive measurement of aggregates of amyloid peptides
JPWO2010128595A1 (ja) * 2009-05-07 2012-11-01 富士フイルムＲｉファーマ株式会社 放射性ヨウ素標識イミダゾピリジン誘導体の製造法
US20120263646A1 (en) 2009-10-15 2012-10-18 Guerbet Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
KR20140040722A (ko) * 2011-05-20 2014-04-03 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100249419A1 (en) 2007-10-30 2010-09-30 Nihon Medi-Physics Co., Ltd. Utilization of novel compounds with amyloid affinity and method of producing the same

Also Published As

Publication number Publication date
IN2014DN00185A (enExample) 2015-07-10
TWI554511B (zh) 2016-10-21
TW201300388A (zh) 2013-01-01
WO2012176587A1 (ja) 2012-12-27
CA2839199A1 (en) 2012-12-27
EP2725027A1 (en) 2014-04-30
AU2012274639A1 (en) 2014-02-06
KR20140040735A (ko) 2014-04-03
US9211350B2 (en) 2015-12-15
US20140121377A1 (en) 2014-05-01
CA2839199C (en) 2018-11-06
AU2012274639B2 (en) 2016-08-11
CN103596950B (zh) 2017-12-19
CN103596950A (zh) 2014-02-19
JPWO2012176587A1 (ja) 2015-02-23
JP5167436B2 (ja) 2013-03-21
ES2619830T3 (es) 2017-06-27
EP2725027A4 (en) 2015-02-25
EP2725027B1 (en) 2017-03-01

Similar Documents

Publication Publication Date Title
JP5272110B2 (ja) 新規アミロイド親和性化合物
KR20100091965A (ko) 신규 아밀로이드 친화성 화합물
JP5048655B2 (ja) 新規アミロイド親和性化合物
JP5180838B2 (ja) 新規アミロイド親和性化合物
KR20100101577A (ko) 신규 아밀로이드 친화성 화합물의 사용 및 제조 방법
JP5167436B2 (ja) 新規アミロイド親和性化合物
US20100267952A1 (en) Use of novel compound having affinity for amyloid, and process for production of the same
US20100249408A1 (en) Use of novel compound having affinity for amyloid, and process for production of the same
CN101466711A (zh) 对淀粉状蛋白具有亲和性的新化合物
HK1193605A (en) Novel compound with amyloid affinity
HK1193605B (en) Novel compound with amyloid affinity
HK1193815B (en) Compound having affinity for amyloid
HK1148950A (en) Use of novel compound having affinity for amyloid, and process for production of the same
HK1148949A (en) Use of novel compound having affinity for amyloid, and process for production of the same
HK1148952A (en) Utilization of novel compounds with amyloid affinity and mehtod of producing the same

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20210427

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20210427