CN103596950B - 对淀粉状蛋白具有亲和性的化合物 - Google Patents

对淀粉状蛋白具有亲和性的化合物 Download PDF

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Publication number
CN103596950B
CN103596950B CN201280027545.0A CN201280027545A CN103596950B CN 103596950 B CN103596950 B CN 103596950B CN 201280027545 A CN201280027545 A CN 201280027545A CN 103596950 B CN103596950 B CN 103596950B
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pyridine
compound
triazol
iodo
imidazo
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CN103596950A (zh
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奥村侑纪
真矢启史
正山祥生
大西崇子
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Nihon Medi Physics Co Ltd
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Nihon Medi Physics Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201280027545.0A 2011-06-24 2012-05-29 对淀粉状蛋白具有亲和性的化合物 Active CN103596950B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011-140069 2011-06-24
JP2011140069 2011-06-24
PCT/JP2012/063726 WO2012176587A1 (ja) 2011-06-24 2012-05-29 新規アミロイド親和性化合物

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CN103596950A CN103596950A (zh) 2014-02-19
CN103596950B true CN103596950B (zh) 2017-12-19

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US (1) US9211350B2 (enExample)
EP (1) EP2725027B1 (enExample)
JP (1) JP5167436B2 (enExample)
KR (1) KR101854228B1 (enExample)
CN (1) CN103596950B (enExample)
AU (1) AU2012274639B2 (enExample)
CA (1) CA2839199C (enExample)
ES (1) ES2619830T3 (enExample)
IN (1) IN2014DN00185A (enExample)
TW (1) TWI554511B (enExample)
WO (1) WO2012176587A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3197277T3 (pl) * 2014-08-29 2022-04-04 Chdi Foundation, Inc. Sondy do obrazowania molekularnego białka huntingtyny
WO2019056098A1 (en) * 2017-09-19 2019-03-28 The Governors Of The University Of Alberta BIOREDUCTION-ACTIVATED COMPOUNDS, THEIR PRODRUGS, RADIOPHARMACEUTICAL PRODUCTS, COMPOSITIONS AND THEIR APPLICATIONS IN THE MULTIMODAL THERANOSTIC MANAGEMENT OF HYPOXIA, INCLUDING CANCER
JP6831802B2 (ja) * 2018-01-12 2021-02-17 上海富吉医療器械有限公司Ｓｈａｎｇｈａｉ Ｃｈａｒｔｗｅｌｌ Ｍｅｄｉｃａｌ Ｉｎｓｔｒｕｍｅｎｔ Ｃｏ．， Ｌｔｄ． 放射性核種標識化合物及びこれを含有するイメージング剤
WO2022244680A1 (ja) * 2021-05-18 2022-11-24 国立大学法人大阪大学 画像診断用磁気ナノ粒子及び画像診断用造影剤

Citations (3)

* Cited by examiner, † Cited by third party
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WO2007033080A2 (en) * 2005-09-12 2007-03-22 Emory University Alzheimer's disease imaging agents
WO2010128595A1 (ja) * 2009-05-07 2010-11-11 富士フイルムＲｉファーマ株式会社 放射性ヨウ素標識イミダゾピリジン誘導体の製造法
CN101909659A (zh) * 2007-10-30 2010-12-08 日本医事物理股份有限公司 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法

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EP1105163A4 (en) 1998-08-20 2003-05-02 Univ California METHOD FOR MARKING AMYLOID PLAQUES AND NEUROFIBRILLIC GIFTS
RU2324686C2 (ru) 2000-08-24 2008-05-20 Юнивесити Оф Питсбэг ПРОИЗВОДНЫЕ ТИОФЛАВИНА, СВЯЗЫВАЮЩИЕ АМИЛОИД, СПОСОБ ОБНАРУЖЕНИЯ in vivo ОТЛОЖЕНИЙ АМИЛОИДА И СПОСОБ РАСПОЗНАВАНИЯ БОЛЕЗНИ АЛЬЦГЕЙМЕРА
CA2444214A1 (en) 2001-04-23 2002-10-31 The Trustees Of The University Of Pennsylvania Amyloid plaque aggregation inhibitors and diagnostic imaging agents
AU2002323417B2 (en) 2001-08-27 2008-05-15 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
US8022075B2 (en) * 2005-11-30 2011-09-20 Fujifilm Ri Pharma Co., Ltd. Diagnostic and remedy for disease caused by amyloid aggregation and/or deposition
JP5238496B2 (ja) 2006-05-19 2013-07-17 日本メジフィジックス株式会社 新規アミロイド親和性化合物
CN101501033B (zh) 2006-06-21 2012-08-01 通用电气医疗有限公司 对淀粉状蛋白具有亲和性的化合物
CN101595108A (zh) 2006-11-30 2009-12-02 日本医事物理股份有限公司 对淀粉状蛋白具有亲和性的新化合物
AU2008208091A1 (en) 2007-01-22 2008-07-31 Astrazeneca Ab Novel heteroaryl substituted imidazo [1,2 -a] pyridine derivatives
TW200918102A (en) 2007-10-24 2009-05-01 Nihon Mediphysics Co Ltd Novel compound having affinity for amyloid
CN101903383A (zh) 2007-10-26 2010-12-01 日本医事物理股份有限公司 对淀粉样蛋白具有亲和性的新化合物
CA2704168A1 (en) 2007-10-30 2009-05-07 Nihon Medi-Physics Co., Ltd. Use of novel compound having affinity for amyloid, and process for production of the same
KR20100089858A (ko) 2007-10-30 2010-08-12 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물의 사용 및 제조 방법
EP2296474A1 (en) * 2008-05-30 2011-03-23 Merck Sharp & Dohme Corp. Novel substituted indoles
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KR20140040722A (ko) * 2011-05-20 2014-04-03 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007033080A2 (en) * 2005-09-12 2007-03-22 Emory University Alzheimer's disease imaging agents
CN101909659A (zh) * 2007-10-30 2010-12-08 日本医事物理股份有限公司 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法
WO2010128595A1 (ja) * 2009-05-07 2010-11-11 富士フイルムＲｉファーマ株式会社 放射性ヨウ素標識イミダゾピリジン誘導体の製造法

Also Published As

Publication number Publication date
IN2014DN00185A (enExample) 2015-07-10
TWI554511B (zh) 2016-10-21
TW201300388A (zh) 2013-01-01
WO2012176587A1 (ja) 2012-12-27
CA2839199A1 (en) 2012-12-27
KR101854228B1 (ko) 2018-05-03
EP2725027A1 (en) 2014-04-30
AU2012274639A1 (en) 2014-02-06
KR20140040735A (ko) 2014-04-03
US9211350B2 (en) 2015-12-15
US20140121377A1 (en) 2014-05-01
CA2839199C (en) 2018-11-06
AU2012274639B2 (en) 2016-08-11
CN103596950A (zh) 2014-02-19
JPWO2012176587A1 (ja) 2015-02-23
JP5167436B2 (ja) 2013-03-21
ES2619830T3 (es) 2017-06-27
EP2725027A4 (en) 2015-02-25
EP2725027B1 (en) 2017-03-01

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