KR101810381B1 - 연령-관련 망막 기능장애의 치료 및 예방 방법 - Google Patents

연령-관련 망막 기능장애의 치료 및 예방 방법 Download PDF

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Publication number
KR101810381B1
KR101810381B1 KR1020107019972A KR20107019972A KR101810381B1 KR 101810381 B1 KR101810381 B1 KR 101810381B1 KR 1020107019972 A KR1020107019972 A KR 1020107019972A KR 20107019972 A KR20107019972 A KR 20107019972A KR 101810381 B1 KR101810381 B1 KR 101810381B1
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cis
delete delete
retinyl
pharmaceutical composition
retinal
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Korean (ko)
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KR20100126358A (ko
Inventor
다다오 마에다
데이비드 사퍼스테인
크르지츠토프 팔체브스키
Original Assignee
유니버시티 오브 워싱톤 스루 이츠 센터 포 커머셜리제이션
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020107019972A 2008-02-11 2009-02-10 연령-관련 망막 기능장애의 치료 및 예방 방법 Expired - Fee Related KR101810381B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2762508P 2008-02-11 2008-02-11
US61/027,625 2008-02-11
PCT/US2009/000824 WO2009102418A1 (en) 2008-02-11 2009-02-10 Methods for the treatment and prevention of age-related retinal dysfunction

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020167019984A Division KR20160092032A (ko) 2008-02-11 2009-02-10 연령-관련 망막 기능장애의 치료 및 예방 방법

Publications (2)

Publication Number Publication Date
KR20100126358A KR20100126358A (ko) 2010-12-01
KR101810381B1 true KR101810381B1 (ko) 2017-12-19

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KR1020107019972A Expired - Fee Related KR101810381B1 (ko) 2008-02-11 2009-02-10 연령-관련 망막 기능장애의 치료 및 예방 방법
KR1020167019984A Ceased KR20160092032A (ko) 2008-02-11 2009-02-10 연령-관련 망막 기능장애의 치료 및 예방 방법

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KR1020167019984A Ceased KR20160092032A (ko) 2008-02-11 2009-02-10 연령-관련 망막 기능장애의 치료 및 예방 방법

Country Status (14)

Country Link
US (7) US8324270B2 (https=)
EP (1) EP2252276B1 (https=)
JP (3) JP6022746B2 (https=)
KR (2) KR101810381B1 (https=)
CN (1) CN101969938A (https=)
AU (1) AU2009213138B2 (https=)
BR (1) BRPI0908154A2 (https=)
CA (2) CA3018374A1 (https=)
IL (2) IL207220B (https=)
MX (1) MX337656B (https=)
NZ (3) NZ587376A (https=)
RU (1) RU2565448C2 (https=)
WO (1) WO2009102418A1 (https=)
ZA (1) ZA201005434B (https=)

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US8329938B2 (en) * 2011-02-21 2012-12-11 Eastman Chemical Company Hydroxyalkanoic acid and hydroxyalkanoice acid oligomer esters of retinol
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US10471118B2 (en) 2014-05-30 2019-11-12 Case Western Reserve University Retinylamine derivitives for treatment of ocular disorders
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US11407786B2 (en) 2015-06-18 2022-08-09 Case Western Reserve University Compositions and methods for the delivery of nucleic acids
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US12060318B2 (en) 2015-10-09 2024-08-13 Case Western Reserve University Compositions and methods for the delivery of nucleic acids
CA3022665A1 (en) 2016-05-09 2017-11-16 Aldeyra Therapeutics, Inc. Combination treatment of ocular inflammatory disorders and diseases
CA3054811A1 (en) 2017-03-16 2018-09-20 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
WO2019075136A1 (en) 2017-10-10 2019-04-18 Aldeyra Therapeutics, Inc. TREATMENT OF INFLAMMATORY DISORDERS
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WO2020223717A1 (en) 2019-05-02 2020-11-05 Aldeyra Therapeutics, Inc. Process for preparation of aldehyde scavenger and intermediates
JP2022530967A (ja) 2019-05-02 2022-07-05 アルデイラ セラピューティクス， インコーポレイテッド 多形化合物およびその使用
WO2021062022A1 (en) * 2019-09-25 2021-04-01 The Board Of Trustees Of The Leland Stanford Junior University Metabolic rescue of retinal degeneration
WO2021231792A1 (en) 2020-05-13 2021-11-18 Aldeyra Therapeutics, Inc. Pharmaceutical formulations and uses thereof
CN116056691A (zh) * 2020-06-09 2023-05-02 典晶生物医药科技(苏州)有限公司 使用每日低剂量的类视黄醇化合物治疗视觉障碍的方法

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Also Published As

Publication number Publication date
US20160331713A1 (en) 2016-11-17
WO2009102418A1 (en) 2009-08-20
US20130072557A1 (en) 2013-03-21
KR20100126358A (ko) 2010-12-01
US9855239B2 (en) 2018-01-02
JP2014221828A (ja) 2014-11-27
JP5934304B2 (ja) 2016-06-15
CA2714530C (en) 2018-09-25
IL258356A (en) 2018-05-31
CA3018374A1 (en) 2009-08-20
IL207220B (en) 2018-04-30
CA2714530A1 (en) 2009-08-20
NZ587376A (en) 2012-06-29
US20100035986A1 (en) 2010-02-11
JP6022746B2 (ja) 2016-11-09
US9233091B2 (en) 2016-01-12
EP2252276A1 (en) 2010-11-24
CN101969938A (zh) 2011-02-09
MX2010008847A (es) 2010-11-30
AU2009213138B2 (en) 2014-11-06
JP2011511789A (ja) 2011-04-14
ZA201005434B (en) 2011-11-30
NZ617701A (en) 2015-06-26
NZ600498A (en) 2014-01-31
US8324270B2 (en) 2012-12-04
US20130072561A1 (en) 2013-03-21
JP2016190852A (ja) 2016-11-10
US20130072558A1 (en) 2013-03-21
BRPI0908154A2 (pt) 2015-08-11
US20180098955A1 (en) 2018-04-12
EP2252276B1 (en) 2019-03-27
US20190133986A1 (en) 2019-05-09
JP6272943B2 (ja) 2018-01-31
KR20160092032A (ko) 2016-08-03
RU2010137842A (ru) 2012-03-20
AU2009213138A1 (en) 2009-08-20
US9408821B2 (en) 2016-08-09
IL207220A0 (en) 2010-12-30
RU2565448C2 (ru) 2015-10-20
MX337656B (es) 2016-03-14

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